BR0317514A - Derivado de tetraidroquinolina, composição farmacêutica, e, uso do derivado de tetraidroquinolina - Google Patents

Derivado de tetraidroquinolina, composição farmacêutica, e, uso do derivado de tetraidroquinolina

Info

Publication number
BR0317514A
BR0317514A BR0317514-6A BR0317514A BR0317514A BR 0317514 A BR0317514 A BR 0317514A BR 0317514 A BR0317514 A BR 0317514A BR 0317514 A BR0317514 A BR 0317514A
Authority
BR
Brazil
Prior art keywords
alkyl
alkylamino
tetrahydroquinoline derivative
tetrahydroquinoline
pharmaceutical composition
Prior art date
Application number
BR0317514-6A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of BR0317514A publication Critical patent/BR0317514A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADO DE TETRAIDROQUINOLINA, COMPOSIçãO FARMACêUTICA, E, USO DO DERIVADO DE TETRAIDROQUINOLINA". A presente invenção diz respeito aos derivados de tetraidroquinolina tendo fórmula geral (I) ou um sal farmaceuticamente aceitável destes em que R¬ 1¬ e R¬ 2¬ são H, Me; R¬ 3¬ é (2-6C)heterocicloalquil(1-4C)alquila, (2-5C)heteroaril(1-4C)alquila, (6C)aril(1-4C)alquila, (1-4C)(di) alquilamínocarbonilamino(2-4C) alquila, (2-6C)heterocicloalquilcarbonilamino(2-4C)alquila, R¬ 5¬-(2-4C)alquila ou R¬ 5¬carbonil(1-4C)alquila; R¬ 4¬ é (2-5C)heteroarila, (6C)arila, (3-8C)cicloalquila, (2-6C)heterocicloalquila ou (1-6C)alquila e R¬ 5¬ é (di)(1-4C) alquilamino, (1-4C)alcóxi, amino, hidróxi, (6C)arilamino, (di)(3-4C)alquenilamino, (2-5C) heteroaril(1-4C)alquilamino, (6C)aril(1-4C)alquilamino, (di)¢(1-4C) alcóxi(2-4C)alquillamino, (di)¢(1-4C) alquilamino(2-4C)alquil!amino, (di)¢amino(2-4C)alquil!amino ou (di)¢hidróxi(2-4C)alquil!amino. A presente invenção também diz respeito às composições farmacêuticas compreendendo os ditos derivados e ao uso destes derivados para regular fertilidade.
BR0317514-6A 2002-12-20 2003-12-16 Derivado de tetraidroquinolina, composição farmacêutica, e, uso do derivado de tetraidroquinolina BR0317514A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43547902P 2002-12-20 2002-12-20
EP02102865 2002-12-20
PCT/EP2003/051024 WO2004056779A2 (en) 2002-12-20 2003-12-16 Tetrahydroquinoline derivatives and their use as fsh receptor modulators

Publications (1)

Publication Number Publication Date
BR0317514A true BR0317514A (pt) 2005-11-16

Family

ID=38799446

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317514-6A BR0317514A (pt) 2002-12-20 2003-12-16 Derivado de tetraidroquinolina, composição farmacêutica, e, uso do derivado de tetraidroquinolina

Country Status (23)

Country Link
US (1) US7674909B2 (pt)
EP (1) EP1578727B1 (pt)
JP (1) JP4545000B2 (pt)
AR (1) AR042629A1 (pt)
AT (1) ATE392416T1 (pt)
AU (1) AU2003303221B2 (pt)
BR (1) BR0317514A (pt)
CA (1) CA2508923C (pt)
CL (1) CL43546B (pt)
DE (1) DE60320457T2 (pt)
DK (1) DK1578727T3 (pt)
ES (1) ES2304544T3 (pt)
MX (1) MXPA05006772A (pt)
NZ (1) NZ540577A (pt)
PE (1) PE20040799A1 (pt)
PL (1) PL376997A1 (pt)
PT (1) PT1578727E (pt)
RS (1) RS51196B (pt)
RU (1) RU2328487C2 (pt)
SI (1) SI1578727T1 (pt)
TW (1) TWI322012B (pt)
UA (1) UA80303C2 (pt)
WO (1) WO2004056779A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK286759B6 (sk) * 2001-07-02 2009-05-07 N.V. Organon Tetrahydrochinolínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
TWI306855B (en) * 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
DE10260739B3 (de) 2002-12-23 2004-09-16 Outokumpu Oy Verfahren und Anlage zur Herstellung von Metalloxid aus Metallverbindungen
US7691848B2 (en) 2005-03-02 2010-04-06 Wyeth Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92009C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
SI1879866T1 (sl) * 2005-05-04 2011-06-30 Organon Nv Dihidropiridinski derivati
EP1879898A2 (en) 2005-05-12 2008-01-23 Wyeth a Corporation of the State of Delaware Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (fsh-r) antagonists
JP2008540564A (ja) * 2005-05-12 2008-11-20 ワイス 卵胞刺激ホルモン受容体（ｆｓｈ−ｒ）アンタゴニストとしてのピロロベンゾジアゼピン、ヘテロアリール、アリールおよびシクロアルキルアミノケトン誘導体
WO2006135687A1 (en) 2005-06-09 2006-12-21 Wyeth Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists
TW200918058A (en) * 2007-08-31 2009-05-01 Organon Nv TSH receptor antagonizing tetrahydroquinoline compounds
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
EP3071205B1 (en) 2013-11-18 2020-02-05 Forma Therapeutics, Inc. Benzopiperazine compositions as bet bromodomain inhibitors
JP6553632B2 (ja) 2013-11-18 2019-07-31 フォーマ セラピューティクス，インコーポレイテッド Ｂｅｔブロモドメイン阻害剤としてのテトラヒドロキノリン組成物
CA3075880A1 (en) 2017-09-15 2019-03-21 Forma Therapeutics, Inc. Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors
WO2020006483A1 (en) 2018-06-29 2020-01-02 Forma Therapeutics, Inc. Inhibiting creb binding protein (cbp)
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686182A (en) 1950-12-07 1954-08-10 Basf Ag O-hydroxy-dihydro-quinoline carboxylic acids
DE3879031T2 (de) 1987-08-08 1993-06-24 Akzo Nv Kontrazeptives implantat.
PT800519E (pt) * 1994-12-22 2004-03-31 Ligand Pharm Inc Compostos moduladores de receptores de esteroides e metodos
JP4511042B2 (ja) * 1998-08-07 2010-07-28 メルク セローノ ソシエテ アノニム 不妊症の治療のためのｆｓｈ模倣物
US6200963B1 (en) * 1999-03-31 2001-03-13 American Home Products Corporation Aryl sulfonic acids as FSH antagonists
SK286759B6 (sk) * 2001-07-02 2009-05-07 N.V. Organon Tetrahydrochinolínové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
TWI306855B (en) 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
PT1578727E (pt) 2008-05-23
CA2508923C (en) 2011-09-20
NZ540577A (en) 2006-12-22
PE20040799A1 (es) 2004-12-02
EP1578727B1 (en) 2008-04-16
EP1578727A2 (en) 2005-09-28
RS51196B (sr) 2010-12-31
RS20050458A (en) 2007-08-03
UA80303C2 (en) 2007-09-10
US20060167047A1 (en) 2006-07-27
TW200418471A (en) 2004-10-01
TWI322012B (en) 2010-03-21
AU2003303221A1 (en) 2004-07-14
SI1578727T1 (sl) 2008-08-31
DE60320457D1 (de) 2008-05-29
ATE392416T1 (de) 2008-05-15
PL376997A1 (pl) 2006-01-23
DE60320457T2 (de) 2009-06-04
US7674909B2 (en) 2010-03-09
CL43546B (es) 2005-04-08
WO2004056779A2 (en) 2004-07-08
ES2304544T3 (es) 2008-10-16
AU2003303221B2 (en) 2009-09-17
WO2004056779A3 (en) 2004-08-12
DK1578727T3 (da) 2008-08-04
JP4545000B2 (ja) 2010-09-15
JP2006512346A (ja) 2006-04-13
RU2328487C2 (ru) 2008-07-10
CA2508923A1 (en) 2004-07-08
AR042629A1 (es) 2005-06-29
RU2005122924A (ru) 2006-01-27
MXPA05006772A (es) 2005-09-08

Similar Documents

Publication Publication Date Title
BR0317514A (pt) Derivado de tetraidroquinolina, composição farmacêutica, e, uso do derivado de tetraidroquinolina
BR0009558A (pt) Composto derivado bicìclico heteroaromático, composição farmacêutica, e, uso de compostos derivados bicìclicos heteroaromáticos
BR0010520A (pt) Novos compostos farmaceuticamente ativos
ECSP034932A (es) Derivados de tetrahidroquinolina
HUP0402336A2 (hu) Tieno[2,3-d]pirimidin-2,4-dion-származékok, eljárás előállításukra, alkalmazásuk autoimmun betegségek modulálására és a vegyületeket tartalmazó gyógyszerkészítmények
RS51795B (en) 2-AMINO-7,8-DIHYDRO-6H-PIRIDO [4,3-D] PYRIMIDINE-5-ONE, A PROCEDURE FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BR0208678A (pt) Composto, composição farmacêutica, uso de um composto
BR0317518A (pt) Derivado de tetraidroquinolina, composição farmacêutica, e, uso do derivado de tetraidroquinolina
BR0012697A (pt) Inibidores da diferenciação de th2
BRPI0209216B8 (pt) derivados de quinolina e de quinazolina, composições farmacêuticas compreendendo os mesmos e seus usos
BR9912729A (pt) Derivado de amida, processo para prepará-lo, e, uso do mesmo
MXPA03011638A (es) Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6.
BRPI0509364B8 (pt) derivados de tetraidroquinolina, composição farmacêutica que os compreende e um processo por preparar os referidos derivados
WO2003008407A3 (fr) Derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique
HUP0204283A2 (hu) (Kinolil-propil)-piperidin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HRP20110344T1 (hr) Derivati dihidropiridina
UA92007C2 (ru) Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
NO20040589L (no) Arylsulfonylderivater med 5-HT6 reseptor affinitet.
KR920019746A (ko) 신규한 시클로헥실벤즈아미드 유도체, 그의 제조방법 및 약제로서의 용도
BRPI0406875A (pt) Derivados de monossacarìdeo de avermectina tendo propriedades pesticidas
AU4459296A (en) 2-substituted vitamin d3 derivatives
HUP0001386A2 (hu) N-szulfonilindolin-származékokat tartalmazó gyógyászati készítmények
AU1018497A (en) Quinolinone derivative and anti-allergic agent with said quinolinone derivative as the active ingredient
ECSP055870A (es) Derivados de tetrahidroquinolina
KR930021629A (ko) 피페라진 유도체

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: N.V. ORGANON (NL)

Free format text: TRANSFERIDO DE: AKZO NOBEL N.V.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.