BR0316739A - Produção por planta de imunoglobulinas com fucosilação reduzida - Google Patents

Produção por planta de imunoglobulinas com fucosilação reduzida

Info

Publication number
BR0316739A
BR0316739A BR0316739-9A BR0316739A BR0316739A BR 0316739 A BR0316739 A BR 0316739A BR 0316739 A BR0316739 A BR 0316739A BR 0316739 A BR0316739 A BR 0316739A
Authority
BR
Brazil
Prior art keywords
immunoglobulins
immunoglobulin
plant production
production
plant
Prior art date
Application number
BR0316739-9A
Other languages
English (en)
Inventor
Kristen Briggs
Todd Glancy
Mich B Hein
Andrew C Hiatt
Anton S Karnoup
W H Kerr Anderson
Dayakar Pareddy
Joseph Petolino
Elizabeth Rubin-Wilson
Doug Taylor
Jean L Roberts
Original Assignee
Dow Chemical Co
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co, Dow Agrosciences Llc filed Critical Dow Chemical Co
Publication of BR0316739A publication Critical patent/BR0316739A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/087—Herpes simplex virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

"PRODUçãO POR PLANTA DE IMUNOGLOBULINAS COM FUCOSILAçãO REDUZIDA". Esta invenção apresenta a produção por planta de imunoglobulinas, em que pelo menos uma parte dos glicanos ligados às imunoglobulinas não possuem fucose. A invenção também apresenta os construtos; plasmídios; vetores; células vegetais transformadas, calos vegetais transformados, tecidos vegetais transformados (por exemplo, folhas, sementes, tubérculos e outros) e plantas inteiras transformadas usadas para produzir essas imunoglobulinas; processos de produção das imunoglobulinas; as imunoglobulinas produzidas pelos processos apresentados; e o uso dessas imunoglobulinas.
BR0316739-9A 2002-11-27 2003-11-28 Produção por planta de imunoglobulinas com fucosilação reduzida BR0316739A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42938502P 2002-11-27 2002-11-27
PCT/US2003/037905 WO2004050838A2 (en) 2002-11-27 2003-11-28 Plant production of immunoglobulins with reduced fucosylation

Publications (1)

Publication Number Publication Date
BR0316739A true BR0316739A (pt) 2005-10-18

Family

ID=32469313

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316739-9A BR0316739A (pt) 2002-11-27 2003-11-28 Produção por planta de imunoglobulinas com fucosilação reduzida

Country Status (10)

Country Link
US (1) US8106169B2 (pt)
EP (1) EP1606385A4 (pt)
JP (1) JP2006517392A (pt)
CN (1) CN1984993A (pt)
AR (1) AR042145A1 (pt)
AU (1) AU2003298727A1 (pt)
BR (1) BR0316739A (pt)
CA (1) CA2506744A1 (pt)
CL (1) CL2003002461A1 (pt)
WO (1) WO2004050838A2 (pt)

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Also Published As

Publication number Publication date
CN1984993A (zh) 2007-06-20
WO2004050838A3 (en) 2006-08-03
CL2003002461A1 (es) 2005-01-07
EP1606385A4 (en) 2008-08-13
CA2506744A1 (en) 2004-06-17
AR042145A1 (es) 2005-06-08
WO2004050838A2 (en) 2004-06-17
AU2003298727A1 (en) 2004-06-23
US20070089201A1 (en) 2007-04-19
JP2006517392A (ja) 2006-07-27
EP1606385A2 (en) 2005-12-21
US8106169B2 (en) 2012-01-31

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