BR0316209A - Indolpiridìnio substituìdo como compostos antiinfecciosos - Google Patents
Indolpiridìnio substituìdo como compostos antiinfecciososInfo
- Publication number
- BR0316209A BR0316209A BR0316209-5A BR0316209A BR0316209A BR 0316209 A BR0316209 A BR 0316209A BR 0316209 A BR0316209 A BR 0316209A BR 0316209 A BR0316209 A BR 0316209A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- methanimidamidyl
- amino
- compounds
- mono
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 230000002924 anti-infective effect Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- -1 N-hydroxy-methanimidamidyl Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- HCUOEKSZWPGJIM-YBRHCDHNSA-N (e,2e)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N/O)\C(N)=O HCUOEKSZWPGJIM-YBRHCDHNSA-N 0.000 abstract 1
- 101100162200 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflD gene Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Abstract
"INDOLPIRIDìNIO SUBSTITUìDO COMO COMPOSTOS ANTIINFECCIOSOS". A presente invenção refere-se aos compostos da fórmula (I) (R~3~)~ n~,P(I) N O R~1~, R~ 2~ seus N-óxidos, sais, formas estereoisoméricas, misturas racêmicas, pró medicamentos, ésteres e metabólitos, em que n é 1, 2 ou 3; R~ 1~ é H, CN, halo, aminoC(=O), C(=O)OH, C~ 1-4~ alquilóxi C(=O), C,~ 1-4~ alquil C(=<39>O), mono- ou di(C~ 1-4~ alquil)amino C(=O), arilamino C(=O), N-(aril)-N-(C~ 1-4~ alquil)amino C(=O), metanimidamidila, N-hidróxi-metanimidamidila, mono- ou di(C~ 1-4~ alquil)metanimidamidila, Het~ 1~ ou Het~ 2~; R~ 2~ é H, C~ 1-10~ alquila, C~ 2-10~ alquenila, C~ 3-7~ Cicloalquila, em que as ditas C~ 1-10~ alquila, C~ 2-10~ alquenila e C~ 3-7~ Cicloalquila podem ser opcionalmente substituídas; R~ 3~ é nitro, ciano, amino, halo, hidróxi, C~ 1-4~ alquilóxi, hidroxi C(=0), amino C(=O), C~ 1-4~ alquilóxi C(=O), monoou di(C~ 1-4~-alquil)amino C(=O), C~ 1-4~alquil C(=O), metanimidamidila, mono- ou di(C~ 1-4~ alquil) metanimidamidila, N-hidroximetanimidamidila ou Het~ 1~; para o uso como uma medicina. A invenção também refere-se a um novo subgrupo dos compostos da fórmula (I), e às composições compreendendo os compostos da fórmula (I).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02079783 | 2002-11-15 | ||
| US43495002P | 2002-12-20 | 2002-12-20 | |
| PCT/EP2003/050837 WO2004046143A1 (en) | 2002-11-15 | 2003-11-14 | Substituted indolepyridinium as anti-infective compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0316209A true BR0316209A (pt) | 2005-09-27 |
Family
ID=32327852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0316209-5A BR0316209A (pt) | 2002-11-15 | 2003-11-14 | Indolpiridìnio substituìdo como compostos antiinfecciosos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7608726B2 (pt) |
| EP (1) | EP1594870B1 (pt) |
| JP (1) | JP2006508145A (pt) |
| KR (1) | KR20050084621A (pt) |
| CN (1) | CN100457754C (pt) |
| AP (1) | AP1927A (pt) |
| AU (1) | AU2003296760B2 (pt) |
| BR (1) | BR0316209A (pt) |
| CA (1) | CA2506316A1 (pt) |
| EA (1) | EA009871B1 (pt) |
| HR (1) | HRP20050543A2 (pt) |
| MX (1) | MXPA05005146A (pt) |
| NO (1) | NO20052884L (pt) |
| NZ (1) | NZ540321A (pt) |
| PL (1) | PL376683A1 (pt) |
| WO (1) | WO2004046143A1 (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| KR20070011588A (ko) * | 2004-05-17 | 2007-01-24 | 티보텍 파마슈티칼즈 리미티드 | 치환된 1-페닐-1,5-디히드로-피리도-[3,2-ｂ]인돌-2-온 및다른 ｈｉｖ 억제제의 배합물 |
| CN1953978B (zh) * | 2004-05-17 | 2010-09-29 | 泰博特克药品有限公司 | 作为抗病毒剂的5-取代的1-苯基-1,5-二氢-吡啶并[3,2-b]吲哚-2-酮及其类似物 |
| ATE481403T1 (de) * | 2004-05-17 | 2010-10-15 | Tibotec Pharm Ltd | Substituierte 1-phenyl-1,5-dihydro-pyridoä3,2- büindol-2-on-derivate verwendbar als pharmazeutische antiinfektiva |
| EP1758911A1 (en) * | 2004-05-17 | 2007-03-07 | Tibotec Pharmaceuticals Ltd. | 1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones |
| MXPA06013315A (es) | 2004-05-17 | 2007-02-02 | Tibotec Pharm Ltd | 1,5-dihidro-pirido[3,2-b]indol-2-onas 4-sustituidas. |
| AU2005288864B2 (en) | 2004-09-30 | 2012-08-23 | Janssen Sciences Ireland Uc | HIV inhibiting 5-heterocyclyl pyrimidines |
| CN101027288B (zh) | 2004-09-30 | 2013-04-17 | 泰博特克药品有限公司 | 抑制hiv的5-取代嘧啶 |
| TW200637862A (en) * | 2005-01-10 | 2006-11-01 | Tibotec Pharm Ltd | 1,5,6-substituted-2-oxo-3-cyano-1,6a-diaza-tetrahydro-fluoranthenes |
| EP1853720A1 (en) * | 2005-02-04 | 2007-11-14 | Tibotec Pharmaceuticals Ltd. | Screening method for competitive hiv rt inhibitors |
| US20090012046A1 (en) * | 2006-02-03 | 2009-01-08 | Dirk Edward Desire Jochmans | Methods of Treating Mutated Hiv |
| EP2004632B1 (en) | 2006-03-30 | 2014-03-12 | Janssen R&D Ireland | Hiv inhibiting 5-amido substituted pyrimidines |
| WO2008037783A1 (en) * | 2006-09-29 | 2008-04-03 | Tibotec Pharmaceuticals Ltd. | Process for preparing 2-oxo-2,5-dihydro-1h-pyrido[3,2-b]indole-3-carbonitriles |
| BRPI0720858B8 (pt) | 2006-12-29 | 2021-05-25 | Janssen R & D Ireland | pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende |
| AU2007341228B2 (en) | 2006-12-29 | 2013-04-18 | Janssen Sciences Ireland Uc | HIV inhibiting 5,6-substituted pyrimidines |
| AR065720A1 (es) | 2007-03-14 | 2009-06-24 | Tibotec Pharm Ltd | Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso. |
| US8426434B2 (en) | 2007-07-12 | 2013-04-23 | Tibotec Pharmaceuticals Ltd. | Crystalline form of 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile |
| WO2010085582A1 (en) * | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
| JP2012515789A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | スフィンゴシン−１−リン酸アゴニストとしてのピラゾール−１，２，４−オキサジアゾール誘導体 |
| US8354398B2 (en) | 2009-01-23 | 2013-01-15 | Bristol-Myers Squibb Company | Substituted isoxazole compounds |
| KR20120034592A (ko) | 2009-04-09 | 2012-04-12 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｈｉｖ 복제의 저해제 |
| EP2386541A1 (en) * | 2010-05-14 | 2011-11-16 | Affectis Pharmaceuticals AG | Novel methods for the preparation of P2X7R antagonists |
| CN103025706A (zh) | 2010-07-28 | 2013-04-03 | 住友化学株式会社 | 羧酸酰胺的制造方法 |
| UA115576C2 (uk) | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
| UY36999A (es) * | 2015-12-02 | 2017-06-30 | Syngenta Participations Ag | Derivados de aryl oxadiazol fungicidas |
| US11066396B2 (en) * | 2016-06-23 | 2021-07-20 | Merck Sharp & Dohme Corp. | 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors |
| KR200486209Y1 (ko) | 2016-07-05 | 2018-04-16 | 박우 | 편육 가공기구 |
| CN108299428B (zh) * | 2018-04-04 | 2019-09-27 | 山东大学 | 8-胺基-7-甲酸甲酯-吡嗪骈吡啶酮衍生物及其制备方法与应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002059123A2 (en) * | 2000-12-18 | 2002-08-01 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Benzoylalkylindolepyridinium compounds and pharmaceutical compositions comprising such compounds |
| AU2002246658A1 (en) | 2000-12-18 | 2002-07-24 | Makarov, Vadim | Benzoylalkylindolepyridinium compounds and pharmaceutical compositions comprising such compounds |
-
2003
- 2003-11-14 MX MXPA05005146A patent/MXPA05005146A/es active IP Right Grant
- 2003-11-14 JP JP2004552729A patent/JP2006508145A/ja active Pending
- 2003-11-14 AP AP2005003334A patent/AP1927A/xx active
- 2003-11-14 KR KR1020057007708A patent/KR20050084621A/ko not_active Application Discontinuation
- 2003-11-14 BR BR0316209-5A patent/BR0316209A/pt not_active IP Right Cessation
- 2003-11-14 NZ NZ540321A patent/NZ540321A/en unknown
- 2003-11-14 CA CA002506316A patent/CA2506316A1/en not_active Abandoned
- 2003-11-14 EP EP03811395A patent/EP1594870B1/en not_active Expired - Lifetime
- 2003-11-14 CN CNB2003801086118A patent/CN100457754C/zh not_active Expired - Fee Related
- 2003-11-14 EA EA200500822A patent/EA009871B1/ru not_active IP Right Cessation
- 2003-11-14 WO PCT/EP2003/050837 patent/WO2004046143A1/en active Application Filing
- 2003-11-14 US US10/535,007 patent/US7608726B2/en not_active Expired - Fee Related
- 2003-11-14 PL PL376683A patent/PL376683A1/pl not_active Application Discontinuation
- 2003-11-14 AU AU2003296760A patent/AU2003296760B2/en not_active Ceased
-
2005
- 2005-06-14 NO NO20052884A patent/NO20052884L/no not_active Application Discontinuation
- 2005-06-14 HR HR20050543A patent/HRP20050543A2/xx not_active Application Discontinuation
-
2009
- 2009-08-25 US US12/547,151 patent/US20100048563A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2506316A1 (en) | 2004-06-03 |
| EP1594870B1 (en) | 2011-05-11 |
| HRP20050543A2 (en) | 2006-09-30 |
| AP1927A (en) | 2008-12-10 |
| CN1738816A (zh) | 2006-02-22 |
| JP2006508145A (ja) | 2006-03-09 |
| AP2005003334A0 (en) | 2005-06-30 |
| US20060173000A1 (en) | 2006-08-03 |
| CN100457754C (zh) | 2009-02-04 |
| EA009871B1 (ru) | 2008-04-28 |
| NO20052884D0 (no) | 2005-06-14 |
| PL376683A1 (pl) | 2006-01-09 |
| MXPA05005146A (es) | 2005-07-22 |
| AU2003296760A1 (en) | 2004-06-15 |
| WO2004046143A1 (en) | 2004-06-03 |
| NZ540321A (en) | 2007-09-28 |
| NO20052884L (no) | 2005-08-15 |
| US7608726B2 (en) | 2009-10-27 |
| US20100048563A1 (en) | 2010-02-25 |
| EA200500822A1 (ru) | 2005-12-29 |
| AU2003296760B2 (en) | 2009-11-19 |
| EP1594870A1 (en) | 2005-11-16 |
| KR20050084621A (ko) | 2005-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: TIBOTEC PHARMACEUTICALS LTD. (IE) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070001806/RJ DE 05/01/2007. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |