BR0314269A - Cápsulas contendo composições aquosas de recheio estabilizadas com ciclodextrina derivatizada - Google Patents
Cápsulas contendo composições aquosas de recheio estabilizadas com ciclodextrina derivatizadaInfo
- Publication number
- BR0314269A BR0314269A BR0314269-8A BR0314269A BR0314269A BR 0314269 A BR0314269 A BR 0314269A BR 0314269 A BR0314269 A BR 0314269A BR 0314269 A BR0314269 A BR 0314269A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatized cyclodextrin
- cyclodextrin
- water
- filler composition
- shell
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"CáPSULAS CONTENDO COMPOSIçõES AQUOSAS DE RECHEIO ESTABILIZADAS COM CICLODEXTRINA DERIVATIZADA". Uma cápsula que contém uma composição aquosa de enchimento que compreende água, uma ciclodextrina derivatizada, tal como sulfoalquil éter ciclodextrina (SAE-CD) ou hidroxipropil ciclodextrina (HPCD), opcionalmente um ou mais agentes ativos e opcionalmente um ou mais excipientes é estabilizada contra degradação, erosão, inchação ou dissolução de sua casca durante armazenagem. A ciclodextrina derivatizada está presente em uma quantidade suficiente para reduzir, eliminar ou inibir degradação, erosão, inchação ou dissolução da casca pela água presente na composição de enchimento. Alternativamente, a ciclodextrina derivatizada e um outro material estabilizador de casca juntos estabilizam a casca contra degradação, erosão, inchação e/ou dissolução pela água presente na composição de enchimento. A ciclodextrina derivatizada pode reduzir a atividade em água da composição de enchimento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41085002P | 2002-09-13 | 2002-09-13 | |
PCT/US2003/030960 WO2004024126A1 (en) | 2002-09-13 | 2003-09-12 | Capsules containing aqueous fill compositions stabilized with derivatized cyclodextrin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0314269A true BR0314269A (pt) | 2005-07-26 |
Family
ID=31994217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0314269-8A BR0314269A (pt) | 2002-09-13 | 2003-09-12 | Cápsulas contendo composições aquosas de recheio estabilizadas com ciclodextrina derivatizada |
Country Status (11)
Country | Link |
---|---|
US (1) | US7829114B2 (pt) |
EP (1) | EP1545477A4 (pt) |
JP (1) | JP2006503047A (pt) |
KR (1) | KR20050046776A (pt) |
CN (1) | CN100344328C (pt) |
AU (1) | AU2003275329B2 (pt) |
BR (1) | BR0314269A (pt) |
CA (1) | CA2498410A1 (pt) |
MX (1) | MXPA05002728A (pt) |
RU (1) | RU2359698C2 (pt) |
WO (1) | WO2004024126A1 (pt) |
Families Citing this family (62)
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US20030133974A1 (en) * | 1997-07-01 | 2003-07-17 | Curatolo William John | Encapsulated solution dosage forms of sertraline |
US8618085B2 (en) | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
US20070020299A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
US20070020298A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid |
US7172773B2 (en) * | 2004-04-26 | 2007-02-06 | Renew Life Inc. | Food supplement formulation |
WO2005117911A2 (en) * | 2004-05-06 | 2005-12-15 | Cydex, Inc. | Taste-masked formulations containing sertraline and sulfoalkyl ether cyclodextrin |
US20080132527A1 (en) * | 2004-05-19 | 2008-06-05 | Emisphere Technologies, Inc. | Compositions For Delivering Acyclovir |
US8231896B2 (en) * | 2004-11-08 | 2012-07-31 | R.P. Scherer Technologies, Llc | Non-gelatin soft capsule system |
UA89513C2 (uk) * | 2004-12-03 | 2010-02-10 | Элан Фарма Интернешнл Лтд. | Стабільна композиція з наночастинок ралоксифену гідрохлориду |
US8080560B2 (en) | 2004-12-17 | 2011-12-20 | 3M Innovative Properties Company | Immune response modifier formulations containing oleic acid and methods |
JP2006182679A (ja) * | 2004-12-27 | 2006-07-13 | Daicho Kikaku:Kk | ストレス性胃炎予防・治療剤 |
US20090252807A1 (en) * | 2005-04-13 | 2009-10-08 | Elan Pharma International Limited | Nanoparticulate and Controlled Release Compositions Comprising Prostaglandin Derivatives |
ATE459341T1 (de) * | 2005-06-03 | 2010-03-15 | Elan Pharma Int Ltd | Nanoteilchenförmige imatinib-mesylat- formulierungen |
WO2006138534A2 (en) | 2005-06-15 | 2006-12-28 | Morton Grove Pharmaceuticals, Inc. | Stable warfarin sodium liquid formulation and method of making same |
TW200727900A (en) * | 2005-07-27 | 2007-08-01 | Yakult Honsha Kk | Aqueous solution preparation containing camptothecins |
US7473684B2 (en) | 2005-09-16 | 2009-01-06 | Selamine Limited | Bisphosphonate formulation |
WO2007061829A2 (en) | 2005-11-17 | 2007-05-31 | Novartis Ag | Pharmaceutical composition |
EP1959953A2 (en) * | 2005-12-02 | 2008-08-27 | Alembic Limited | Stabilized pharmaceutical composition of pramipexole and method of preparation thereof |
EP1973524B1 (en) * | 2006-01-06 | 2011-08-10 | Intervet International BV | Concentrated liquid thyroid hormone composition |
WO2007133944A2 (en) * | 2006-05-09 | 2007-11-22 | Emisphere Technologies, Inc. | Topical administration of acyclovir |
US20090239942A1 (en) | 2006-09-15 | 2009-09-24 | Cloyd James C | Topiramate Compositions and Methods of Making and Using the Same |
WO2008070543A1 (en) * | 2006-12-01 | 2008-06-12 | Emisphere Technologies Inc. | Improved acyclovir formulations |
KR20150041173A (ko) | 2007-04-27 | 2015-04-15 | 사이덱스 파마슈티칼스, 인크. | 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법 |
ES2493641T3 (es) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Administración nasal de soluciones acuosas de corticosteroides |
PL2215047T3 (pl) * | 2007-11-02 | 2014-05-30 | Emisphere Tech Inc | Sposób leczenia niedoborów witaminy b12 |
WO2009100245A1 (en) * | 2008-02-05 | 2009-08-13 | Emisphere Technologies Inc. | Low dose hmg-coa reductase inhibitor with reduced side effects |
MX2010009848A (es) * | 2008-03-21 | 2010-09-30 | Elan Pharma Int Ltd | Composiciones para el suministro especifico en sitio de imatinib y metodos de uso. |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
US20110224232A1 (en) * | 2008-05-06 | 2011-09-15 | Board Of Regents, The University Of Texas System | Treatment of Pulmonary Fungal Infection With Voriconazole via Inhalation |
US10463677B2 (en) | 2008-11-07 | 2019-11-05 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
MX342002B (es) | 2008-11-10 | 2016-09-09 | Colgate Palmolive Co | Capsulas no perecederas. |
KR101743591B1 (ko) | 2009-05-13 | 2017-06-20 | 사이덱스 파마슈티칼스, 인크. | 프라수그렐 및 사이클로덱스트린 유도체를 포함하는 약학 조성물 및 그의 제조 및 사용 방법 |
CN102458114A (zh) * | 2009-05-29 | 2012-05-16 | 锡德克斯药物公司 | 包含环糊精衍生物的可注射美法仑组合物及其制备和使用方法 |
US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
EP2461803B1 (en) * | 2009-08-03 | 2018-10-17 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
US20110207760A1 (en) * | 2010-02-23 | 2011-08-25 | Valery Alakhov | Sn-38 compositions |
RU2576511C2 (ru) * | 2010-02-24 | 2016-03-10 | Эмисфире Текнолоджис, Инк. | Пероральная терапия недостаточности витамина в12 |
SI2680832T1 (sl) * | 2011-03-04 | 2019-11-29 | Gruenenthal Gmbh | Vodna farmacevtska formulacija tapentadola za peroralno dovajanje |
PT2680834T (pt) | 2011-03-04 | 2018-01-25 | Gruenenthal Gmbh | Composição farmacêutica aquosa semissólida contendo tapentadol |
CN102139115B (zh) * | 2011-03-30 | 2012-12-05 | 天津红日药业股份有限公司 | 阿托伐他汀的环糊精包合物及其口服固体制剂的制备方法 |
TWI544922B (zh) | 2011-05-19 | 2016-08-11 | 愛爾康研究有限公司 | 高濃度歐羅派特錠(olopatadine)眼用組成物 |
US8883177B2 (en) * | 2011-06-28 | 2014-11-11 | Nian Wu | Pharmaceutical compositions for parenteral administration |
RS60294B1 (sr) * | 2011-08-01 | 2020-07-31 | Hb Biotechnologies Corp | Nesvarljive kapsule za isporuku materijala koji apsorbuju tečnosti |
KR101390766B1 (ko) * | 2012-01-06 | 2014-05-19 | 한국콜마주식회사 | 수중유형 에멀젼 화장료 조성물 |
DK3702374T3 (da) | 2012-02-15 | 2022-06-27 | Cydex Pharmaceuticals Inc | Fremsgangsmåde til fremstilling for cyclodextrin-derivater |
KR20200106100A (ko) | 2012-02-28 | 2020-09-10 | 사이덱스 파마슈티칼스, 인크. | 알킬화된 시클로덱스트린 조성물 및 이의 제조 및 사용 방법 |
CA2888822C (en) | 2012-10-22 | 2021-01-26 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
CN103109805B (zh) * | 2013-02-25 | 2015-05-06 | 杨凌国泰农林科技有限公司 | 一种现代中药农残降解剂及其制备方法 |
EP3038611B1 (en) | 2013-08-30 | 2024-04-17 | Yale University | Sustained-release pharmaceutical composition comprising 2,4-dinitrophenol |
WO2015031598A2 (en) | 2013-08-30 | 2015-03-05 | Yale University | Therapeutic dnp derivatives and methods using same |
WO2016029179A1 (en) | 2014-08-22 | 2016-02-25 | Cydex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
CN107847471A (zh) | 2015-03-27 | 2018-03-27 | 格吕伦塔尔有限公司 | 他喷他多肠胃外给药的稳定制剂 |
WO2016209732A1 (en) * | 2015-06-23 | 2016-12-29 | Wu Nian | Polymer-cyclodextrin-lipid conjugates |
RU2615368C1 (ru) * | 2016-03-25 | 2017-04-04 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Способ получения фармацевтической композиции глибенкламида в форме раствора для инъекций |
EP3515412A1 (en) | 2016-09-23 | 2019-07-31 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
IT201700015145A1 (it) * | 2017-02-10 | 2018-08-10 | Altergon Sa | Capsule di gelatina molle ad elevata stabilità |
AU2018263924B2 (en) * | 2017-05-03 | 2024-07-04 | Cydex Pharmaceuticals, Inc. | Composition containing cyclodextrin and busulfan |
CN109106693A (zh) * | 2017-06-23 | 2019-01-01 | 重庆华邦制药有限公司 | 利福平胶囊及其制备方法 |
US20240115499A1 (en) * | 2019-10-15 | 2024-04-11 | Capsugel Belgium Nv | DHA and Choline Emulsion |
WO2023205165A1 (en) * | 2022-04-22 | 2023-10-26 | Brii Biosciences Offshore Limited | A polymyxin composition and methods for producing the same |
CN117153285B (zh) * | 2023-10-30 | 2024-01-23 | 江苏辰星药业股份有限公司 | 植物空心胶囊的特定成分分析方法及系统 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3426011A (en) * | 1967-02-13 | 1969-02-04 | Corn Products Co | Cyclodextrins with anionic properties |
US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
DE4313408A1 (de) * | 1993-04-23 | 1994-10-27 | Boehringer Mannheim Gmbh | Cyclodextrin-Biocid-Komplex |
GB9711643D0 (en) * | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
ATE429210T1 (de) * | 1998-01-20 | 2009-05-15 | Applied Analytical Ind Inc | Orale flüssige zusammensetzungen |
US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
JP4447322B2 (ja) | 2001-12-28 | 2010-04-07 | 湧永製薬株式会社 | 硬カプセル剤 |
-
2003
- 2003-09-12 EP EP03759605A patent/EP1545477A4/en not_active Withdrawn
- 2003-09-12 WO PCT/US2003/030960 patent/WO2004024126A1/en active Application Filing
- 2003-09-12 JP JP2004536643A patent/JP2006503047A/ja not_active Abandoned
- 2003-09-12 RU RU2005110945/15A patent/RU2359698C2/ru not_active IP Right Cessation
- 2003-09-12 CA CA002498410A patent/CA2498410A1/en not_active Abandoned
- 2003-09-12 MX MXPA05002728A patent/MXPA05002728A/es unknown
- 2003-09-12 AU AU2003275329A patent/AU2003275329B2/en not_active Ceased
- 2003-09-12 CN CNB038251418A patent/CN100344328C/zh not_active Expired - Fee Related
- 2003-09-12 BR BR0314269-8A patent/BR0314269A/pt not_active IP Right Cessation
- 2003-09-12 KR KR1020057004362A patent/KR20050046776A/ko not_active Application Discontinuation
-
2005
- 2005-03-09 US US11/076,072 patent/US7829114B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2004024126B1 (en) | 2004-07-22 |
KR20050046776A (ko) | 2005-05-18 |
EP1545477A1 (en) | 2005-06-29 |
RU2005110945A (ru) | 2005-10-27 |
WO2004024126A1 (en) | 2004-03-25 |
EP1545477A4 (en) | 2006-11-22 |
AU2003275329B2 (en) | 2008-04-03 |
CN1694688A (zh) | 2005-11-09 |
CN100344328C (zh) | 2007-10-24 |
US20050186267A1 (en) | 2005-08-25 |
JP2006503047A (ja) | 2006-01-26 |
US7829114B2 (en) | 2010-11-09 |
MXPA05002728A (es) | 2005-07-25 |
AU2003275329A1 (en) | 2004-04-30 |
CA2498410A1 (en) | 2004-03-25 |
RU2359698C2 (ru) | 2009-06-27 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA:INT.CI. A61K 9/48, A61K 9/52, A61P 25/24, A61P 29/00, A61P 37/08, A61P 9/02 Ipc: A61K 9/48 (2011.01), A61K 9/52 (2011.01), A61P 25/ |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |