BR0312675A - Composto ou um sal de adição de ácido farmacêutico do mesmo,m e, métodos para tratar endometriose, e para tratar leiomioma uterino - Google Patents
Composto ou um sal de adição de ácido farmacêutico do mesmo,m e, métodos para tratar endometriose, e para tratar leiomioma uterinoInfo
- Publication number
- BR0312675A BR0312675A BR0312675-7A BR0312675A BR0312675A BR 0312675 A BR0312675 A BR 0312675A BR 0312675 A BR0312675 A BR 0312675A BR 0312675 A BR0312675 A BR 0312675A
- Authority
- BR
- Brazil
- Prior art keywords
- treating
- acid addition
- addition salt
- compound
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39786902P | 2002-07-22 | 2002-07-22 | |
| US45023303P | 2003-02-25 | 2003-02-25 | |
| PCT/IB2003/003349 WO2004009086A1 (en) | 2002-07-22 | 2003-07-16 | Selective estrogen receptor modulators containing a phenylsulfonyl group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312675A true BR0312675A (pt) | 2005-05-03 |
Family
ID=30773044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312675-7A BR0312675A (pt) | 2002-07-22 | 2003-07-16 | Composto ou um sal de adição de ácido farmacêutico do mesmo,m e, métodos para tratar endometriose, e para tratar leiomioma uterino |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7399867B2 (enExample) |
| EP (1) | EP1530470B9 (enExample) |
| JP (2) | JP4656939B2 (enExample) |
| CN (1) | CN1668303B (enExample) |
| AT (1) | ATE433322T1 (enExample) |
| AU (1) | AU2003253129B2 (enExample) |
| BR (1) | BR0312675A (enExample) |
| CA (1) | CA2490580C (enExample) |
| CO (1) | CO5680445A2 (enExample) |
| CR (1) | CR7657A (enExample) |
| DE (1) | DE60327931D1 (enExample) |
| EA (1) | EA008024B1 (enExample) |
| EC (1) | ECSP055549A (enExample) |
| ES (1) | ES2326593T3 (enExample) |
| HR (1) | HRP20041233A2 (enExample) |
| IL (1) | IL165745A0 (enExample) |
| MX (1) | MXPA05000898A (enExample) |
| MY (1) | MY141879A (enExample) |
| NO (1) | NO20050832L (enExample) |
| NZ (1) | NZ537138A (enExample) |
| PE (1) | PE20040678A1 (enExample) |
| PL (1) | PL374845A1 (enExample) |
| TW (1) | TWI314860B (enExample) |
| WO (1) | WO2004009086A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL374845A1 (en) * | 2002-07-22 | 2005-11-14 | Eli Lilly And Company | Selective estrogen receptor modulators containing a phenylsulfonyl group |
| EA007978B1 (ru) * | 2003-02-25 | 2007-02-27 | Эли Лилли Энд Компани | Кристаллический несольватированный гидрохлорид 1-(4-(2-пиперидинилэтокси)фенокси)-2-(4-метансульфонилфенил)-6-гидроксинафталина |
| HRP20050675A2 (en) * | 2003-02-25 | 2005-10-31 | Eli Lilly And Company | Crystalline non-solavated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride |
| ATE448215T1 (de) * | 2004-01-22 | 2009-11-15 | Lilly Co Eli | Selektive östrogen-rezeptor-modulatoren |
| CN1910167B (zh) * | 2004-01-22 | 2011-08-10 | 伊莱利利公司 | 用于治疗血管舒缩症状的选择性雌激素受体调节剂 |
| EA012262B1 (ru) | 2004-01-22 | 2009-08-28 | Эли Лилли Энд Компани | Селективные модуляторы рецепторов эстрогена для лечения вазомоторных симптомов |
| WO2005073190A1 (en) * | 2004-01-29 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
| MXPA06015152A (es) | 2004-06-22 | 2007-02-28 | Smithkline Beecham Corp | Compuestos quimicos. |
| WO2007016139A2 (en) * | 2005-07-29 | 2007-02-08 | Eli Lilly And Company | Crystalline non-solvated methanesulfonic acid salt of 1-(4-(2-piperidinylethoxy)phenoxy)-2-(3-hydroxyphenyl)-6-hydroxynaphthalene |
| MX2011003383A (es) * | 2008-09-29 | 2011-04-21 | Lilly Co Eli | Modulador selectivo del receptor de estrogeno para el tratamiento de osteoartritis. |
| DE102008057230A1 (de) | 2008-11-11 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin |
| EP2406230A1 (en) | 2009-03-11 | 2012-01-18 | Pfizer Inc. | Substituted indazole amides and their use as glucokinase activators |
| SG186333A1 (en) | 2010-06-16 | 2013-01-30 | Endorech Inc | Methods of treating or preventing estrogen-related diseases |
| JP6292744B2 (ja) * | 2012-09-19 | 2018-03-14 | 富士カプセル株式会社 | 医薬品組成物 |
| NZ710385A (en) | 2013-02-19 | 2016-10-28 | Novartis Ag | Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders |
| WO2020182649A1 (en) | 2019-03-08 | 2020-09-17 | Syngenta Crop Protection Ag | Pesticidally active azole-amide compounds |
| US20220183294A1 (en) | 2019-03-20 | 2022-06-16 | Syngenta Crop Protection Ag | Pesticidally active azole amide compounds |
| US20220213063A1 (en) | 2019-03-22 | 2022-07-07 | Syngenta Crop Protection Ag | N-[l-(5-BROMO-2-PYRIMIDIN-2-YL-1,2,4-TRIAZOL-3-YL)ETHYL]-2-CYCLOPROPYL-6-(TRIFLUOROMETHYL)PYRIDINE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INSECTICIDES |
| TWI853009B (zh) | 2019-03-29 | 2024-08-21 | 瑞士商先正達農作物保護公司 | 殺有害生物活性之二-醯胺化合物 |
| WO2020201398A1 (en) | 2019-04-05 | 2020-10-08 | Syngenta Crop Protection Ag | Pesticidally active diazine-amide compounds |
| JP2022545266A (ja) | 2019-08-23 | 2022-10-26 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 殺有害生物的に活性なピラジン－アミド化合物 |
| CN110526881B (zh) * | 2019-08-27 | 2020-09-22 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其生物学可接受的盐，其制备方法和应用 |
| WO2021170881A1 (en) | 2020-02-27 | 2021-09-02 | Syngenta Crop Protection Ag | Pesticidally active diazine-bisamide compounds |
| JP2024518832A (ja) * | 2021-05-14 | 2024-05-07 | 江▲蘇▼▲亞▼虹医▲薬▼科技股▲フン▼有限公司 | ナフタレン環含有化合物、それを含む医薬組成物及びその使用 |
| BR112023025644A2 (pt) | 2021-06-09 | 2024-02-27 | Syngenta Crop Protection Ag | Compostos de diazina-amida pesticidamente ativos |
| WO2023283315A1 (en) * | 2021-07-07 | 2023-01-12 | South Dakota Board Of Regents | Compositions and methods for treatment of cervical and ovarian cancer |
| JP2025526986A (ja) | 2022-08-25 | 2025-08-15 | サノフイ | 新規な置換ベンゾチオフェン－６－カルボン酸誘導体、その調製方法、及びその治療的使用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| WO1993023374A1 (fr) | 1992-05-08 | 1993-11-25 | Otsuka Pharmaceutical Factory, Inc. | Derive d'indole |
| US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US6399634B1 (en) | 1994-09-20 | 2002-06-04 | Eli Lilly And Company | Benzothiophene compounds, compositions, and methods |
| US5552412A (en) | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| US5998401A (en) * | 1995-02-28 | 1999-12-07 | Eli Lilly And Company | Naphthyl compounds, intermediates, compositions, and methods |
| JP3989569B2 (ja) | 1995-02-28 | 2007-10-10 | イーライ リリー アンド カンパニー | ベンゾチオフェン化合物、中間体、組成物および方法 |
| US5599822A (en) | 1995-06-06 | 1997-02-04 | Eli Lilly And Company | Methods for minimizing bone loss |
| JP2002500618A (ja) * | 1995-10-31 | 2002-01-08 | イーライ・リリー・アンド・カンパニー | 抗血栓性ジアミン |
| PT791591E (pt) * | 1996-02-22 | 2001-12-28 | Lilly Co Eli | Benzotiofenos, formulacoes que os contem e metodos |
| SK281737B6 (sk) | 1996-04-19 | 2001-07-10 | American Home Products Corporation | 2-fenylindolové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie |
| CA2214070C (en) | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
| ID19392A (id) | 1996-08-29 | 1998-07-09 | Lilly Co Eli | Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan |
| CA2213810C (en) | 1996-08-29 | 2006-06-06 | Lewis Dale Pennington | Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods |
| CA2213814A1 (en) | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
| CA2217810A1 (en) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| JPH10204082A (ja) | 1996-10-25 | 1998-08-04 | Eli Lilly & Co | 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物 |
| PL374845A1 (en) * | 2002-07-22 | 2005-11-14 | Eli Lilly And Company | Selective estrogen receptor modulators containing a phenylsulfonyl group |
-
2003
- 2003-07-16 PL PL03374845A patent/PL374845A1/xx unknown
- 2003-07-16 DE DE60327931T patent/DE60327931D1/de not_active Expired - Lifetime
- 2003-07-16 BR BR0312675-7A patent/BR0312675A/pt not_active IP Right Cessation
- 2003-07-16 NZ NZ537138A patent/NZ537138A/en not_active IP Right Cessation
- 2003-07-16 AU AU2003253129A patent/AU2003253129B2/en not_active Ceased
- 2003-07-16 CN CN038172011A patent/CN1668303B/zh not_active Expired - Fee Related
- 2003-07-16 HR HR20041233A patent/HRP20041233A2/hr not_active Application Discontinuation
- 2003-07-16 US US10/521,896 patent/US7399867B2/en not_active Expired - Fee Related
- 2003-07-16 WO PCT/IB2003/003349 patent/WO2004009086A1/en not_active Ceased
- 2003-07-16 EP EP03765254A patent/EP1530470B9/en not_active Expired - Lifetime
- 2003-07-16 MX MXPA05000898A patent/MXPA05000898A/es active IP Right Grant
- 2003-07-16 JP JP2004522648A patent/JP4656939B2/ja not_active Expired - Fee Related
- 2003-07-16 AT AT03765254T patent/ATE433322T1/de not_active IP Right Cessation
- 2003-07-16 ES ES03765254T patent/ES2326593T3/es not_active Expired - Lifetime
- 2003-07-16 EA EA200500248A patent/EA008024B1/ru not_active IP Right Cessation
- 2003-07-16 CA CA2490580A patent/CA2490580C/en not_active Expired - Fee Related
- 2003-07-18 TW TW092119725A patent/TWI314860B/zh not_active IP Right Cessation
- 2003-07-18 PE PE2003000717A patent/PE20040678A1/es not_active Application Discontinuation
- 2003-07-18 MY MYPI20032711A patent/MY141879A/en unknown
-
2004
- 2004-12-13 IL IL16574504A patent/IL165745A0/xx unknown
-
2005
- 2005-01-18 CR CR7657A patent/CR7657A/es unknown
- 2005-01-19 EC EC2005005549A patent/ECSP055549A/es unknown
- 2005-01-20 CO CO05004232A patent/CO5680445A2/es not_active Application Discontinuation
- 2005-02-16 NO NO20050832A patent/NO20050832L/no not_active Application Discontinuation
-
2008
- 2008-04-09 US US12/100,093 patent/US7585977B2/en not_active Expired - Fee Related
-
2010
- 2010-05-11 JP JP2010109009A patent/JP5220800B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15I | Others concerning applications: loss of priority |
Free format text: PERDA DAS PRIORIDADES REIVINDICADAS (US 60/397869 DE 22/07/2002 E US 60/450266 DE 25/02/2003) POR NAO ATENDER A DISPOSICAO PREVISTA NO ART. 16 6O E 7O DA LPI. |
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| B150 | Others concerning applications: publication cancelled [chapter 15.30 patent gazette] |
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