BR0312365A - Meio de cultura autólogo de células-mães progenitoras autólogas humanas, métodos para a preparação do mesmo e de uma composição de células-mães progenitoras autólogas humanas e para a obtenção de células-mães progenitoras musculares autólogas humanas, emprego de um meio de cultura autólogo de células-mães progenitoras autólogas humanas, procedimento para a obtenção de células-mães progenitoras musculares autólogas humanas e procedimento terapêutico de cardiomioplastia celular autóloga, composição enriquecida com células-mães progenitoras musculares autólogas humanas e composição farmacêutica - Google Patents
Meio de cultura autólogo de células-mães progenitoras autólogas humanas, métodos para a preparação do mesmo e de uma composição de células-mães progenitoras autólogas humanas e para a obtenção de células-mães progenitoras musculares autólogas humanas, emprego de um meio de cultura autólogo de células-mães progenitoras autólogas humanas, procedimento para a obtenção de células-mães progenitoras musculares autólogas humanas e procedimento terapêutico de cardiomioplastia celular autóloga, composição enriquecida com células-mães progenitoras musculares autólogas humanas e composição farmacêuticaInfo
- Publication number
- BR0312365A BR0312365A BR0312365-0A BR0312365A BR0312365A BR 0312365 A BR0312365 A BR 0312365A BR 0312365 A BR0312365 A BR 0312365A BR 0312365 A BR0312365 A BR 0312365A
- Authority
- BR
- Brazil
- Prior art keywords
- autologous
- progenitor
- human
- mother
- mother cells
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 12
- 238000000034 method Methods 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 5
- 210000003205 muscle Anatomy 0.000 title abstract 5
- 210000004027 cell Anatomy 0.000 title abstract 3
- 239000001963 growth medium Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000006143 cell culture medium Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000001413 cellular effect Effects 0.000 abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 102000007327 Protamines Human genes 0.000 abstract 1
- 108010007568 Protamines Proteins 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 229940048914 protamine Drugs 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
- C12N5/0659—Satellite cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"MEIO DE CULTURA AUTóLOGO DE CéLULAS-MãES PROGENITORAS AUTóLOGAS HUMANAS., MéTODOS PARA A PREPARAçãO DO MESMO E DE UMA COMPOSIçãO DE CéLULAS-MãES PROGENITORAS AUTóLOGAS HUMANAS E PARA A OBTENçãO DE CéLULAS-MãES PROGENITORAS MUSCULARES AUTóLOGAS HUMANAS, EMPREGO DE UM MEIO DE CULTURA AUTóLOGO DE CELULAS-MãES PROGENITORAS AUTOLOGAS HUMANAS, PROCEDIMENTO PARA A OBTENçãO DE CéLULAS-MãES PROGENITORAS MUSCULARES AUTóLOGAS HUMANAS E PROCEDIMENTO TERAPêUTICO DE CARDIOMIOPLASTIA CELULAR AUTóLOGA, COMPOSIçãO ENRIQUECIDA COM CELULAS-MãES PROGENITORAS MUSCULARES AUTóLOGAS HUMANAS E COMPOSIçãO FARMACêUTICA". O meio de cultura autólogo de células-mãe progenitoras autólogas humanas compreende: entre 0,1 % e 90 % em peso de soro humano autólogo; entre 0,1 e 10.000 UI/ml de heparina; entre 0,1 e 10.000 UI/ml de protamina; e um meio de cultura com nutrientes básicos com ou sem glutamina, em quantidade suficiente até 100 % em peso, e é útil para cultivar e expandir células-mãe progenitoras autólogas humanas. Composições contendo referidas células podem ser implantadas no paciente mediante um procedimento de cardiomioplastia celular autóloga para criar, regenerar e reparar tecido miocárdico disfuncional.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200201540A ES2198216B1 (es) | 2002-07-02 | 2002-07-02 | Medio de cultivo de celulas madre-progenitoras autologas humanas y sus aplicaciones. |
PCT/ES2003/000285 WO2004005494A1 (es) | 2002-07-02 | 2003-06-11 | Medio de cultivo de células madre-progenitoras autólogas humanas y sus aplicaciones |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0312365A true BR0312365A (pt) | 2005-04-05 |
Family
ID=30011351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0312365-0A BR0312365A (pt) | 2002-07-02 | 2003-06-11 | Meio de cultura autólogo de células-mães progenitoras autólogas humanas, métodos para a preparação do mesmo e de uma composição de células-mães progenitoras autólogas humanas e para a obtenção de células-mães progenitoras musculares autólogas humanas, emprego de um meio de cultura autólogo de células-mães progenitoras autólogas humanas, procedimento para a obtenção de células-mães progenitoras musculares autólogas humanas e procedimento terapêutico de cardiomioplastia celular autóloga, composição enriquecida com células-mães progenitoras musculares autólogas humanas e composição farmacêutica |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060110368A1 (pt) |
EP (1) | EP1972684A1 (pt) |
JP (1) | JP5379340B2 (pt) |
KR (2) | KR100960173B1 (pt) |
CN (1) | CN100572527C (pt) |
AU (1) | AU2003240857B2 (pt) |
BR (1) | BR0312365A (pt) |
ES (1) | ES2198216B1 (pt) |
IL (1) | IL165969A0 (pt) |
MX (1) | MXPA04012601A (pt) |
NZ (1) | NZ537397A (pt) |
RU (1) | RU2312141C2 (pt) |
WO (1) | WO2004005494A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7253735B2 (en) | 2003-03-24 | 2007-08-07 | Alien Technology Corporation | RFID tags and processes for producing RFID tags |
DE102004025684A1 (de) | 2004-04-29 | 2005-11-17 | Osram Opto Semiconductors Gmbh | Optoelektronischer Halbleiterchip und Verfahren zum Ausbilden einer Kontaktstruktur zur elektrischen Kontaktierung eines optoelektronischen Halbleiterchips |
EA014166B1 (ru) * | 2005-12-13 | 2010-10-29 | Киото Юниверсити | Ядерный фактор перепрограммирования |
CN101802174B (zh) * | 2007-09-11 | 2013-06-05 | 北海道公立大学法人札幌医科大学 | 细胞增殖方法以及用于组织修复及再生的药物 |
RU2524655C2 (ru) * | 2008-03-28 | 2014-07-27 | Лабо Дзюверса Ко., Лтд. | Средство для лечения старения кожи и рубцов |
RU2493250C2 (ru) * | 2011-07-08 | 2013-09-20 | Общество с ограниченной ответственностью Научно-производственное предприятие "ПанЭко" | Малосывороточная среда для культивирования фибробластов человека |
JP5598864B2 (ja) * | 2011-12-05 | 2014-10-01 | 北海道公立大学法人 札幌医科大学 | 細胞増殖方法ならびに組織の修復および再生のための医薬 |
RU2506309C2 (ru) * | 2012-03-11 | 2014-02-10 | Екатерина Алексеевна Федорова | Способ культивирования миобластов in vitro для получения биомассы миоцитов для пищевых целей |
TWI643953B (zh) * | 2014-12-11 | 2018-12-11 | 訊聯生物科技股份有限公司 | 以自體血漿培養原始細胞的方法 |
CN106110304A (zh) * | 2016-07-28 | 2016-11-16 | 广州赛莱拉干细胞科技股份有限公司 | 一种祛疤组合物和敷料 |
KR102093810B1 (ko) * | 2017-09-19 | 2020-03-26 | 서울대학교산학협력단 | 면역원성 감소 방법 |
CA3137836C (en) * | 2019-04-23 | 2024-04-09 | Cellatoz Therapeutics, Inc. | Method for regulation of selective differentiation of musculoskeletal stem cells |
CN112501035B (zh) * | 2020-12-09 | 2022-09-20 | 云南大学 | 基于捕食线虫真菌细胞膜破裂和内体增多而产生捕食器官的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4735726A (en) * | 1981-07-22 | 1988-04-05 | E. I. Du Pont De Nemours And Company | Plasmapheresis by reciprocatory pulsatile filtration |
US4668399A (en) * | 1982-02-16 | 1987-05-26 | E. I. Du Pont De Nemours And Company | Hollow fiber plasmapheresis process |
US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
NL9101680A (nl) * | 1991-10-04 | 1993-05-03 | Tno | Werkwijze voor het genetisch modificeren van beenmergcellen van primaten, alsmede daarbij bruikbare cellen die recombinante retrovirale vectoren produceren. |
JPH06113829A (ja) * | 1992-10-09 | 1994-04-26 | Tabai Espec Corp | 動物細胞培地添加血清の調製方法、動物細胞培地の調製方法及び培養装置 |
US5728581A (en) * | 1995-06-07 | 1998-03-17 | Systemix, Inc. | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein |
CA2283641A1 (en) * | 1997-03-18 | 1998-09-24 | Introgene B.V. | Methods and compositions for genetically modifying primate bone marrow cells |
EP1007092B1 (en) * | 1997-08-26 | 2006-08-09 | Amgen Fremont Inc. | A process for inhibiting complement activation via the alternative pathway |
US6962698B1 (en) * | 1998-02-17 | 2005-11-08 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
US6624141B1 (en) * | 1999-03-17 | 2003-09-23 | The Regents Of The University Of Michigan | Protamine fragment compositions and methods of use |
US6673604B1 (en) * | 1999-07-23 | 2004-01-06 | Diacrin, Inc. | Muscle cells and their use in cardiac repair |
US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US20020124855A1 (en) * | 2001-03-12 | 2002-09-12 | Chachques Juan C. | Method of providing a dynamic cellular cardiac support |
US20030044766A1 (en) * | 2001-08-29 | 2003-03-06 | Anne Scholz | Methods and devices for detecting cell-cell interactions |
-
2002
- 2002-07-02 ES ES200201540A patent/ES2198216B1/es not_active Expired - Fee Related
-
2003
- 2003-06-11 KR KR1020057000034A patent/KR100960173B1/ko not_active IP Right Cessation
- 2003-06-11 NZ NZ537397A patent/NZ537397A/en not_active IP Right Cessation
- 2003-06-11 CN CNB038155990A patent/CN100572527C/zh not_active Expired - Fee Related
- 2003-06-11 KR KR1020087023967A patent/KR20080091874A/ko active Search and Examination
- 2003-06-11 JP JP2004518793A patent/JP5379340B2/ja not_active Expired - Fee Related
- 2003-06-11 EP EP03730223A patent/EP1972684A1/en not_active Withdrawn
- 2003-06-11 BR BR0312365-0A patent/BR0312365A/pt not_active IP Right Cessation
- 2003-06-11 US US10/519,974 patent/US20060110368A1/en not_active Abandoned
- 2003-06-11 RU RU2005102061/13A patent/RU2312141C2/ru not_active IP Right Cessation
- 2003-06-11 AU AU2003240857A patent/AU2003240857B2/en not_active Ceased
- 2003-06-11 MX MXPA04012601A patent/MXPA04012601A/es active IP Right Grant
- 2003-06-11 WO PCT/ES2003/000285 patent/WO2004005494A1/es active Application Filing
-
2004
- 2004-12-23 IL IL16596904A patent/IL165969A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR20080091874A (ko) | 2008-10-14 |
RU2005102061A (ru) | 2005-10-10 |
US20060110368A1 (en) | 2006-05-25 |
JP5379340B2 (ja) | 2013-12-25 |
KR20050037549A (ko) | 2005-04-22 |
AU2003240857A1 (en) | 2004-01-23 |
JP2005531322A (ja) | 2005-10-20 |
EP1972684A1 (en) | 2008-09-24 |
ES2198216B1 (es) | 2005-04-16 |
RU2312141C2 (ru) | 2007-12-10 |
IL165969A0 (en) | 2006-01-15 |
KR100960173B1 (ko) | 2010-05-26 |
CN100572527C (zh) | 2009-12-23 |
WO2004005494A1 (es) | 2004-01-15 |
NZ537397A (en) | 2008-09-26 |
MXPA04012601A (es) | 2005-09-30 |
AU2003240857B2 (en) | 2008-06-26 |
CN1665922A (zh) | 2005-09-07 |
ES2198216A1 (es) | 2004-01-16 |
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Owner name: INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A Free format text: TRANSFERIDO DE: JUAN CARLOS CHACQUES |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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B15K | Others concerning applications: alteration of classification |
Ipc: C12N 5/077 (2010.01), A61K 35/12 (2015.01), A61P 2 |