BR0311824A - Esterilização, estabilização e preservação de biológicos funcionais - Google Patents
Esterilização, estabilização e preservação de biológicos funcionaisInfo
- Publication number
- BR0311824A BR0311824A BR0311824-0A BR0311824A BR0311824A BR 0311824 A BR0311824 A BR 0311824A BR 0311824 A BR0311824 A BR 0311824A BR 0311824 A BR0311824 A BR 0311824A
- Authority
- BR
- Brazil
- Prior art keywords
- preservation
- sterilization
- biologicals
- functional
- sterilized
- Prior art date
Links
- 238000004321 preservation Methods 0.000 title abstract 4
- 229960000074 biopharmaceutical Drugs 0.000 title abstract 3
- 230000001954 sterilising effect Effects 0.000 title abstract 3
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 3
- 230000006641 stabilisation Effects 0.000 title abstract 2
- 238000011105 stabilization Methods 0.000 title abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000005855 radiation Effects 0.000 abstract 2
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 230000004879 molecular function Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0294—Electromagnetic, i.e. using electromagnetic radiation or electromagnetic fields
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
"ESTERILIZAçãO, ESTABILIZAçãO E PRESERVAçãO DE BIOLóGICOS FUNCIONAIS". Métodos são descritos para a esterilização de materiais biológicos em funcionamento, entidades bioquímicas e moléculas biologicamente ativas e para sua preservação para armazenamento em temperatura ambiente. Contaminantes biológicos são significativamente reduzidos no título ou eliminados enquanto mantendo a preservação da integridade funcional dos produtos esterilizados e estabilizados derivados dos presentes métodos. Esses materiais podem ser principalmente estruturais na função, tal como osso, ou podem demonstrar função molecular ativa, como no caso da hemoglobina e anticorpos. Tratamentos para estabilizar os biológicos esterilizados incluem a alteração da temperatura do material, controle da taxa da dose de radiação, otimização do tempo de irradiação, controle do conteúdo de oxigênio, o uso de estabilizadores, especificação de pH, inclusão de solventes particulares e alteração do tipo da radiação aplicada. Um produto biológico esterilizado e estabilizado tratado desse modo pode ser armazenado em temperatura ambiente, dessa maneira tornando-o muito mais disponível e mais fácil para usar contra biológicos liofilizados, congelados convencionais ou armazenados a frio.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38717702P | 2002-06-07 | 2002-06-07 | |
PCT/US2003/017669 WO2003103390A1 (en) | 2002-06-07 | 2003-06-06 | Sterilization, stabilization and preservation of functional biologics |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311824A true BR0311824A (pt) | 2005-03-15 |
Family
ID=29736277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311824-0A BR0311824A (pt) | 2002-06-07 | 2003-06-06 | Esterilização, estabilização e preservação de biológicos funcionais |
Country Status (11)
Country | Link |
---|---|
US (1) | US20040126880A1 (pt) |
EP (1) | EP1511377A1 (pt) |
JP (1) | JP2005533041A (pt) |
KR (1) | KR20070118200A (pt) |
CN (1) | CN1665388A (pt) |
AU (1) | AU2003237391B2 (pt) |
BR (1) | BR0311824A (pt) |
CA (1) | CA2487826A1 (pt) |
MX (1) | MXPA04012771A (pt) |
WO (1) | WO2003103390A1 (pt) |
ZA (1) | ZA200409859B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100316727A1 (en) * | 2003-07-31 | 2010-12-16 | Latino Joseph S | Treatment of inflammatory disorders with ozone |
US20050189302A1 (en) * | 2003-07-31 | 2005-09-01 | Latino Joseph S. | Viral inactivation using ozone |
US20100318014A1 (en) * | 2003-07-31 | 2010-12-16 | Latino Joseph S | Treatment of acute ischemic brain stroke with ozone |
US20100316730A1 (en) * | 2003-07-31 | 2010-12-16 | Latino Joseph S | Treatment of cardiovascular diseases with ozone |
JP5096148B2 (ja) * | 2004-06-07 | 2012-12-12 | コア・ダイナミクス・リミテッド | 生物学的試料の殺菌方法 |
US20070134814A1 (en) * | 2005-12-09 | 2007-06-14 | Kajander E O | Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease |
WO2007106582A2 (en) * | 2006-03-15 | 2007-09-20 | Promethean Lifesciences, Inc. | Preparation and storage of stable, biologically active materials |
WO2008128161A2 (en) * | 2007-04-13 | 2008-10-23 | University Of Florida Research Foundation Inc. | Identification of cardiac specific myosin light chain kinase |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
US20110250670A1 (en) * | 2010-04-08 | 2011-10-13 | University Of Calcutta | Light energy-induced stability of biomaterials |
EP2555799B1 (en) * | 2010-04-08 | 2018-03-07 | University Of Calcutta | Light energy-induced stability of biomaterials |
EP4091645A1 (en) | 2010-08-25 | 2022-11-23 | Hemanext Inc. | Method for enhancing red blood cell quality and survival during storage |
EP4218412A1 (en) * | 2010-11-05 | 2023-08-02 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
CN103732056B (zh) * | 2011-07-05 | 2016-08-17 | 新健康科学股份有限公司 | 用于红细胞之延长贮藏的系统及使用方法 |
PT3533507T (pt) | 2011-08-10 | 2022-07-25 | Hemanext Inc | Dispositivo de filtragem integrado para depleção de leucócitos, oxigénio e/ou co2 e separação de plasma |
KR101446265B1 (ko) * | 2011-10-17 | 2014-11-03 | 메디칸(주) | 면역성이 제거된 생체지방소재 및 이의 제조방법 |
US9877476B2 (en) | 2013-02-28 | 2018-01-30 | New Health Sciences, Inc. | Gas depletion and gas addition devices for blood treatment |
JP6997622B2 (ja) | 2015-03-10 | 2022-02-04 | ヘマネクスト インコーポレイテッド | 使い捨ての酸素低減キット、器具及びそれらの使用方法 |
JP7175611B2 (ja) | 2015-04-23 | 2022-11-21 | ヘマネクスト インコーポレイテッド | 嫌気性血液保存容器 |
EP3297641A4 (en) | 2015-05-18 | 2019-02-06 | New Health Sciences, Inc. | METHODS FOR TOTAL BLOOD STORAGE AND CORRESPONDING COMPOSITIONS |
CN109195632A (zh) | 2016-05-27 | 2019-01-11 | 新健康科学股份有限公司 | 厌氧血液储存和病原体失活方法 |
JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ,エルエルシー | 凍結乾燥方法 |
WO2019126494A1 (en) * | 2017-12-20 | 2019-06-27 | Cook Regentec Llc | Pathogen reduced platelet compositions and related methods |
US11604026B2 (en) | 2019-03-14 | 2023-03-14 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
AU2021262493A1 (en) * | 2020-05-01 | 2022-12-08 | Askel Healthcare Ltd. | Method for preparing a three-dimensional scaffold for medical use |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179338A (en) * | 1977-09-19 | 1979-12-18 | Gordon Maurice R | Microbiological medium suitable for sterilization by ionizing radiation |
US4620908A (en) * | 1983-10-03 | 1986-11-04 | Biocell Laboratories, Inc. | Method for destroying microbial contamination in protein materials |
NL8700067A (nl) * | 1986-02-07 | 1987-09-01 | Argatom Ing Constr | Werkwijze voor het verkrijgen van geconserveerd vlees. |
US4866282A (en) * | 1986-08-26 | 1989-09-12 | Baxter International Inc. | Irradiation of blood products |
US4878891A (en) * | 1987-06-25 | 1989-11-07 | Baylor Research Foundation | Method for eradicating infectious biological contaminants in body tissues |
GB8807187D0 (en) * | 1988-03-25 | 1988-04-27 | Harrison J F | Improvements in/relating to inactivation of infectious agents |
US4874690A (en) * | 1988-08-26 | 1989-10-17 | Cryopharm Corporation | Lyophilization of red blood cells |
US5418130A (en) * | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
JP2894458B2 (ja) * | 1990-08-02 | 1999-05-24 | 川澄化学工業 株式会社 | 検査用血液保存容器 |
JPH04285561A (ja) * | 1991-03-14 | 1992-10-09 | Terumo Corp | 医療用材料の滅菌方法および医療用器具の製造方法 |
US5534026A (en) * | 1992-04-02 | 1996-07-09 | The Penn State Research Foundation | Preparation of inexpensive, HIV-free human skin allograft |
US5362442A (en) * | 1993-07-22 | 1994-11-08 | 2920913 Canada Inc. | Method for sterilizing products with gamma radiation |
JP3765108B2 (ja) * | 1994-09-30 | 2006-04-12 | 三菱ウェルファーマ株式会社 | 静脈注射用グロブリン製剤 |
ATE244024T1 (de) * | 1996-02-05 | 2003-07-15 | Asahi Medical Co | Sterilisationsschutzmittel und verfahren zur sterilisation |
JP3656242B2 (ja) * | 1999-10-26 | 2005-06-08 | スズキ株式会社 | 車両のモータ制御装置 |
US20030012687A1 (en) * | 2000-03-23 | 2003-01-16 | Macphee Martin J. | Methods of sterilizing biological materials |
US6682695B2 (en) * | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
US6696060B2 (en) * | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
US20030031584A1 (en) * | 2001-08-10 | 2003-02-13 | Wilson Burgess | Methods for sterilizing biological materials using dipeptide stabilizers |
US20030064000A1 (en) * | 2001-09-24 | 2003-04-03 | Wilson Burgess | Methods of sterilizing biological mixtures using stabilizer mixtures |
US20030190272A1 (en) * | 2002-04-08 | 2003-10-09 | Dennis Raine | Sterilization containers and methods for radiation sterilization of liquid products |
-
2003
- 2003-06-06 EP EP03736849A patent/EP1511377A1/en not_active Withdrawn
- 2003-06-06 CN CN038155761A patent/CN1665388A/zh active Pending
- 2003-06-06 WO PCT/US2003/017669 patent/WO2003103390A1/en active Application Filing
- 2003-06-06 KR KR1020077028010A patent/KR20070118200A/ko not_active Application Discontinuation
- 2003-06-06 MX MXPA04012771A patent/MXPA04012771A/es active IP Right Grant
- 2003-06-06 CA CA002487826A patent/CA2487826A1/en not_active Abandoned
- 2003-06-06 BR BR0311824-0A patent/BR0311824A/pt not_active IP Right Cessation
- 2003-06-06 JP JP2004510529A patent/JP2005533041A/ja active Pending
- 2003-06-06 US US10/456,983 patent/US20040126880A1/en not_active Abandoned
- 2003-06-06 AU AU2003237391A patent/AU2003237391B2/en not_active Ceased
-
2004
- 2004-12-06 ZA ZA200409859A patent/ZA200409859B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003237391B2 (en) | 2007-08-30 |
ZA200409859B (en) | 2006-08-30 |
WO2003103390A1 (en) | 2003-12-18 |
MXPA04012771A (es) | 2005-05-27 |
EP1511377A1 (en) | 2005-03-09 |
US20040126880A1 (en) | 2004-07-01 |
AU2003237391A1 (en) | 2003-12-22 |
KR20070118200A (ko) | 2007-12-13 |
JP2005533041A (ja) | 2005-11-04 |
CN1665388A (zh) | 2005-09-07 |
CA2487826A1 (en) | 2003-12-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0311824A (pt) | Esterilização, estabilização e preservação de biológicos funcionais | |
US4623717A (en) | Pasteurized therapeutically active protein compositions | |
US7494502B2 (en) | Alteration of the skin and nail for the prevention and treatment of skin and nail infections | |
Drampalos et al. | Single stage treatment of diabetic calcaneal osteomyelitis with an absorbable gentamicin-loaded calcium sulphate/hydroxyapatite biocomposite: The Silo technique | |
KR960703625A (ko) | 제품의 살균방법(method for sterilizing products) | |
BRPI0515073A (pt) | composição para conservação de madeira, e, método para conservar madeira | |
DE60201783D1 (de) | Pharmazeutische Zusammensetzung enthaltend nicht-MHC-abhängige T-Zellen/NK-Zellen und MHC-abhängige Zellen zur Behandlung von Tumoren | |
BR0309890A (pt) | Composição farmacêutica contendo plasma sanguìneo, ou soro sanguìneo utilizada no tratamento de lesões, bem como seu método e processo de aplicação | |
DE69433901D1 (de) | Verbindungen und pharmazeutische zusammensetzungen zur behandlung und prophylaxe bakterieller infektionen | |
BR0209057A (pt) | Composições herbicidas contendo benzoilciclohexanodionas e protetores | |
BR9712680A (pt) | Composição e método para tratamento de plantas com substâncias quìmicas exógenas | |
CY1106771T1 (el) | Φαρμακευτικη συνθεση η οποια χρησιμοποιειται για τον ελεγχο της γλυκοζης του αιματος σε ασθενεις με διαβητη τυπου 2 | |
Persichini et al. | Cysteine nitrosylation inactivates the HIV-1 protease | |
ATE92343T1 (de) | Sterilisation von behaeltern mittels wasserstoffperoxid, persaeuren und uv-strahlung. | |
Takhtfooladi et al. | Effects of light-emitting diode (LED) therapy on skeletal muscle ischemia reperfusion in rats | |
DK1187530T3 (da) | Forbedret opbevaring og holdbarhed af blodprodukter | |
Reich et al. | Sporicidal efficacy of genipin: a potential theoretical alternative for biomaterial and tissue graft sterilization | |
DE60109897D1 (de) | Zur inaktivierung von infektiösen proteinen behandelte zusammensetzungen | |
CS445488A1 (en) | Biological preparation for osteo- and chondropathies,physiopathological disorders and diseases arisen on base of mineral deficiency in human organism treatment | |
ATE499944T1 (de) | Verwendung von einem extrakt von einem nicht- photosynthetischen faserigen bakterium zur beförderung der herstellung von superoxid- dismutase | |
CA2440914A1 (en) | Process for sterilization of protein containing biological compositions | |
BR0110077A (pt) | Compostos e composições antipicornavirais, seus usos farmacêuticos, e materiais para a sua sìntese | |
BR0312835A (pt) | Derivado de ácido benzóico substituìdo por 3-heterociclila, agente, processos de combate de vegetação indesejada e de dessecação/desfolhamento de plantas, e, uso de derivados de ácido benzóico substituìdo por 3-heterociclila | |
US20070191793A1 (en) | Method and material for reducing biofilm | |
Furuta et al. | Radiation sterilization of enzyme hybrids with biodegradable polymers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2157 DE 08/05/2012. |