BR0309778A - Compostos 3,4-di-hidroquinolin-2(1h)-ona como antagonistas do receptor nr2b - Google Patents

Compostos 3,4-di-hidroquinolin-2(1h)-ona como antagonistas do receptor nr2b

Info

Publication number
BR0309778A
BR0309778A BR0309778-1A BR0309778A BR0309778A BR 0309778 A BR0309778 A BR 0309778A BR 0309778 A BR0309778 A BR 0309778A BR 0309778 A BR0309778 A BR 0309778A
Authority
BR
Brazil
Prior art keywords
compound
dihydroquinolin
compounds
nr2b receptor
receptor antagonists
Prior art date
Application number
BR0309778-1A
Other languages
English (en)
Inventor
Mitsuhiro Kawamura
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR0309778A publication Critical patent/BR0309778A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

"COMPOSTOS 3,4-DI-HIDROQUINOLIN-2(1H)-ONA COMO ANTAGONISTAS DO RECEPTOR NR2B". Esta invenção proporciona um composto sendo (R)-6-[2-[4-(3fluorofenil)-4-hidróxi-1-piperidinil]-1 -hidroxietil]-3,4-di-hidroquinolin-2(1H)-ona ou um éster farmaceuticamente aceitável deste composto, ou um seu sal farmaceuticamente aceitável. O composto é útil para o tratamento de doenças causadas por sobre-ativação do receptor NR2B de NMDA, tal como dor, acidente vascular cerebral, traumatismo craniano, doença de Parkinson, doença de Alzheimer, depressão, ansiedade ou enxaqueca. Esta invenção proporciona também uma composição farmacêutica compreendendo o composto acima.
BR0309778-1A 2002-04-26 2003-04-15 Compostos 3,4-di-hidroquinolin-2(1h)-ona como antagonistas do receptor nr2b BR0309778A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37593902P 2002-04-26 2002-04-26
PCT/IB2003/001556 WO2003091241A1 (en) 2002-04-26 2003-04-15 3, 4-dihydroquinolin-2(1h)-one compounds as nr2b receptor antagonists

Publications (1)

Publication Number Publication Date
BR0309778A true BR0309778A (pt) 2005-03-08

Family

ID=29270728

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309778-1A BR0309778A (pt) 2002-04-26 2003-04-15 Compostos 3,4-di-hidroquinolin-2(1h)-ona como antagonistas do receptor nr2b

Country Status (15)

Country Link
US (1) US6713490B2 (pt)
EP (1) EP1499606B8 (pt)
JP (1) JP2005524696A (pt)
AR (1) AR039663A1 (pt)
AT (1) ATE325117T1 (pt)
AU (1) AU2003219398A1 (pt)
BR (1) BR0309778A (pt)
CA (1) CA2483636A1 (pt)
DE (1) DE60305026T2 (pt)
ES (1) ES2258716T3 (pt)
MX (1) MXPA04010549A (pt)
PA (1) PA8572601A1 (pt)
TW (1) TW200406402A (pt)
UY (1) UY27776A1 (pt)
WO (1) WO2003091241A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
CA2541162A1 (en) * 2003-10-08 2005-04-21 Pfizer Inc. Fused lactam compounds
ES2246687B2 (es) * 2004-02-11 2006-11-16 Miguel Muñoz Saez Utilizacion de antagonistas no peptidicos de receptores nk1 para la produccion de apoptosis en celulas tumorales.
EP1736474A4 (en) * 2004-04-07 2010-04-21 Kyowa Hakko Kirin Co Ltd piperidine
HU226977B1 (en) * 2004-07-29 2010-04-28 Richter Gedeon Nyrt Kynurenic acid amide derivatives, pharmaceutical compositions containing them and process for producing them
US9744137B2 (en) * 2006-08-31 2017-08-29 Supernus Pharmaceuticals, Inc. Topiramate compositions and methods of enhancing its bioavailability
US8008253B2 (en) 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
WO2010036937A1 (en) 2008-09-27 2010-04-01 Taraxos Inc. Topical formulations for treatment of neuropathy
EP2437740B1 (en) * 2009-03-31 2015-04-29 Tinnitus Research Initiative (TRI) Treatment of tinnitus and associated auditory dysfunctions
WO2011145062A1 (en) 2010-05-21 2011-11-24 Link Research & Grants Corporation Treatment of tinnitus and related auditory dysfunctions
WO2012042314A1 (en) 2010-10-02 2012-04-05 Link Research & Grants Corporation Treatment of tinnitus and related auditory dysfunctions
JP6042968B2 (ja) 2012-04-20 2016-12-14 ユセベ ファルマ ソシエテ アノニム パーキンソン病の処置方法
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902695A (en) 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
ES2146578T3 (es) 1990-05-10 2000-08-16 Pfizer Indolona neuroprotectora y derivados relacionados.
DE69309297T2 (de) 1992-10-30 1997-07-03 Pfizer Neuroprotektive 3,4-dihydro-2(1h)-chinolone
PA8525601A1 (es) 2000-08-21 2002-04-25 Hoffmann La Roche Profarmacos de (3s,4s)-4-bencil-1-[2-(4-hidroxi-bencenosulfonil)-etil]-piperidin-3-ol

Also Published As

Publication number Publication date
CA2483636A1 (en) 2003-11-06
ES2258716T3 (es) 2006-09-01
UY27776A1 (es) 2003-11-28
WO2003091241A1 (en) 2003-11-06
AU2003219398A1 (en) 2003-11-10
EP1499606A1 (en) 2005-01-26
ATE325117T1 (de) 2006-06-15
EP1499606B8 (en) 2006-08-30
MXPA04010549A (es) 2005-02-17
DE60305026T2 (de) 2006-10-12
JP2005524696A (ja) 2005-08-18
EP1499606B1 (en) 2006-05-03
DE60305026D1 (de) 2006-06-08
US6713490B2 (en) 2004-03-30
PA8572601A1 (es) 2004-12-16
US20030216430A1 (en) 2003-11-20
TW200406402A (en) 2004-05-01
AR039663A1 (es) 2005-03-02

Similar Documents

Publication Publication Date Title
BR0309778A (pt) Compostos 3,4-di-hidroquinolin-2(1h)-ona como antagonistas do receptor nr2b
JP5656874B2 (ja) Ｐｄｅ９阻害剤として使用されるアミノヘテロ環化合物
JP5345604B2 (ja) ホスホチジルイノシトール（ｐｉ）３−キナーゼインヒビターとしての２，４，６−三置換ピリミジン、および癌の処置におけるその使用
AU2006315514B2 (en) Substituted quinolones and methods of use
TWI500616B (zh) 新穎之雙環吡啶酮
MX2010003346A (es) Piperazino-dihidrotienopirimidinas sustituidas en heterociclo.
WO2004014850A3 (en) Substituted aminopyrimidines as neurokinin antagonists
NZ600674A (en) Quinoline amide m1 receptor positive allosteric modulators
BRPI0408988A (pt) composto de piperidinilamino-tieno[2,3-d]pirimidina
PE20070541A1 (es) Compuestos y composiciones que comprenden isoindol-imidas
SK185399A3 (en) COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION ANDì (54) ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS
TWI629276B (zh) 咪唑并嗒化合物
JP6661605B2 (ja) ６，７−ジヒドロピラゾロ［１，５−ａ］ピラジン−４（５Ｈ）−オン化合物およびＭＧＬＵＲ２受容体の負のアロステリック調節因子としてのそれらの使用
BR0312572A (pt) Derivados de azabiciclo como antagonistas de receptores muscarìnicos
EA016687B8 (ru) Производные циклопропиламида
EA031087B1 (ru) 6,7-ДИГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИН-4(5H)-ОНОВЫЕ СОЕДИНЕНИЯ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ОТРИЦАТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
EA200701879A1 (ru) Замещённые производные оксадиазаспиро [5.5] ундеканона и их применение в качестве антагонистов нейрокинина
ATE357453T1 (de) Comt-inhibitoren
BRPI0409302A (pt) derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
SG158924A1 (en) Modulators of chemokine receptor activity, crystalline forms and process
JP6987746B2 (ja) 治療用化合物及びその使用方法
KR20070012407A (ko) 2-아미노피리미딘 유도체
AR050919A1 (es) Amidas del acido 5 y 6-aminoalquil indol-2-carboxilico 3-sustituidas y analogos relacionados como inhibidores de la caseina cinasa ie
MX2007011079A (es) Derivados de diaza-espiro-[4-4]-nonano como antagonistas de la neurocinina (nk1).
JP2021524466A (ja) ナトリウムチャネル阻害剤としてのピリジン−スルホンアミド誘導体

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.