BR0306730A - Processo e intermediários para agentes antidiabéticos de piridazinona - Google Patents
Processo e intermediários para agentes antidiabéticos de piridazinonaInfo
- Publication number
- BR0306730A BR0306730A BR0306730-0A BR0306730A BR0306730A BR 0306730 A BR0306730 A BR 0306730A BR 0306730 A BR0306730 A BR 0306730A BR 0306730 A BR0306730 A BR 0306730A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetic
- pyridazinone
- intermediates
- antidiabetic agents
- relates
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical compound OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003472 antidiabetic agent Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940125708 antidiabetic agent Drugs 0.000 title 1
- 239000003288 aldose reductase inhibitor Substances 0.000 abstract 2
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 2
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 206010063547 Diabetic macroangiopathy Diseases 0.000 abstract 1
- 206010054044 Diabetic microangiopathy Diseases 0.000 abstract 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000009101 diabetic angiopathy Diseases 0.000 abstract 1
- 208000033679 diabetic kidney disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PROCESSO E INTERMEDIáRIOS PARA AGENTES ANTIDIABéTICOS DE PIRIDAZINONA". A presente invenção refere-se a um processo para preparar inibidores de aldose redutase de piridazinona que são úteis na prevenção e/ou tratamento de complicações diabéticas tais como neuropatia diabética, retinopatia diabética, nefropatia diabética, cardiomiopatia diabética, microangiopatia diabética e macroangiopatia diabética nos mamíferos. A invenção também refere-se a novos intermediários úteis na preparação daqueles inibidores de aldose redutase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34767902P | 2002-01-09 | 2002-01-09 | |
| PCT/IB2003/000013 WO2003057691A1 (en) | 2002-01-09 | 2003-01-03 | Process and intermediates for pyridazinone antidiabetic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0306730A true BR0306730A (pt) | 2004-12-21 |
Family
ID=23364775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0306730-0A BR0306730A (pt) | 2002-01-09 | 2003-01-03 | Processo e intermediários para agentes antidiabéticos de piridazinona |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6759534B2 (pt) |
| EP (1) | EP1463725B1 (pt) |
| JP (1) | JP2005514421A (pt) |
| KR (1) | KR100604502B1 (pt) |
| CN (1) | CN1269814C (pt) |
| AR (1) | AR038267A1 (pt) |
| AT (1) | ATE302201T1 (pt) |
| AU (1) | AU2003200847A1 (pt) |
| BR (1) | BR0306730A (pt) |
| CA (1) | CA2472331A1 (pt) |
| DE (1) | DE60301324T2 (pt) |
| DK (1) | DK1463725T3 (pt) |
| ES (1) | ES2246464T3 (pt) |
| HK (1) | HK1072598A1 (pt) |
| HU (1) | HUP0500031A2 (pt) |
| IL (1) | IL162594A0 (pt) |
| MX (1) | MXPA04005646A (pt) |
| PL (1) | PL371258A1 (pt) |
| PT (1) | PT1463725E (pt) |
| RU (1) | RU2278116C2 (pt) |
| TW (1) | TWI250980B (pt) |
| WO (1) | WO2003057691A1 (pt) |
| ZA (1) | ZA200404798B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60217930T2 (de) * | 2001-03-30 | 2007-10-18 | Pfizer Products Inc., Groton | Pyridazinon Aldose Reductase Inhibitoren |
| CN103333144B (zh) * | 2013-06-17 | 2014-12-10 | 温州大学 | 一种2-硫基-3-卤代苯并呋喃化合物及其合成方法和用途 |
| CN105732552B (zh) * | 2016-04-12 | 2017-12-01 | 天津师范大学 | 2位或3‑位硫代苯并呋喃化合物的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3328770A1 (de) * | 1983-08-10 | 1985-02-28 | Basf Ag, 6700 Ludwigshafen | Pyridazinon-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| DE60217930T2 (de) * | 2001-03-30 | 2007-10-18 | Pfizer Products Inc., Groton | Pyridazinon Aldose Reductase Inhibitoren |
-
2003
- 2003-01-03 TW TW092100108A patent/TWI250980B/zh not_active IP Right Cessation
- 2003-01-03 WO PCT/IB2003/000013 patent/WO2003057691A1/en active IP Right Grant
- 2003-01-03 RU RU2004121026/04A patent/RU2278116C2/ru not_active IP Right Cessation
- 2003-01-03 EP EP03700018A patent/EP1463725B1/en not_active Expired - Lifetime
- 2003-01-03 ES ES03700018T patent/ES2246464T3/es not_active Expired - Lifetime
- 2003-01-03 IL IL16259403A patent/IL162594A0/xx unknown
- 2003-01-03 DK DK03700018T patent/DK1463725T3/da active
- 2003-01-03 CA CA002472331A patent/CA2472331A1/en not_active Abandoned
- 2003-01-03 PT PT03700018T patent/PT1463725E/pt unknown
- 2003-01-03 BR BR0306730-0A patent/BR0306730A/pt not_active IP Right Cessation
- 2003-01-03 KR KR1020047010669A patent/KR100604502B1/ko not_active IP Right Cessation
- 2003-01-03 DE DE60301324T patent/DE60301324T2/de not_active Expired - Fee Related
- 2003-01-03 AU AU2003200847A patent/AU2003200847A1/en not_active Abandoned
- 2003-01-03 MX MXPA04005646A patent/MXPA04005646A/es active IP Right Grant
- 2003-01-03 CN CNB038020114A patent/CN1269814C/zh not_active Expired - Fee Related
- 2003-01-03 HU HU0500031A patent/HUP0500031A2/hu unknown
- 2003-01-03 JP JP2003558006A patent/JP2005514421A/ja not_active Withdrawn
- 2003-01-03 PL PL03371258A patent/PL371258A1/xx not_active Application Discontinuation
- 2003-01-03 AT AT03700018T patent/ATE302201T1/de not_active IP Right Cessation
- 2003-01-07 AR ARP030100032A patent/AR038267A1/es active IP Right Grant
- 2003-01-07 US US10/337,635 patent/US6759534B2/en not_active Expired - Fee Related
-
2004
- 2004-06-17 ZA ZA200404798A patent/ZA200404798B/en unknown
-
2005
- 2005-06-22 HK HK05105183A patent/HK1072598A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL162594A0 (en) | 2005-11-20 |
| AU2003200847A1 (en) | 2003-07-24 |
| CN1269814C (zh) | 2006-08-16 |
| HK1072598A1 (en) | 2005-09-02 |
| PT1463725E (pt) | 2005-10-31 |
| EP1463725A1 (en) | 2004-10-06 |
| TW200302098A (en) | 2003-08-01 |
| KR100604502B1 (ko) | 2006-07-25 |
| DE60301324T2 (de) | 2006-05-24 |
| ZA200404798B (en) | 2006-02-22 |
| WO2003057691A1 (en) | 2003-07-17 |
| PL371258A1 (en) | 2005-06-13 |
| KR20040072710A (ko) | 2004-08-18 |
| ATE302201T1 (de) | 2005-09-15 |
| US6759534B2 (en) | 2004-07-06 |
| JP2005514421A (ja) | 2005-05-19 |
| DE60301324D1 (de) | 2005-09-22 |
| DK1463725T3 (da) | 2005-11-21 |
| US20030162969A1 (en) | 2003-08-28 |
| TWI250980B (en) | 2006-03-11 |
| CA2472331A1 (en) | 2003-07-17 |
| MXPA04005646A (es) | 2004-12-06 |
| ES2246464T3 (es) | 2006-02-16 |
| RU2278116C2 (ru) | 2006-06-20 |
| CN1615307A (zh) | 2005-05-11 |
| RU2004121026A (ru) | 2006-01-10 |
| AR038267A1 (es) | 2005-01-12 |
| EP1463725B1 (en) | 2005-08-17 |
| HUP0500031A2 (hu) | 2005-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6O E 7O ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2047 DE 30/03/2010. |