BR0211927A - Composições sólidas para adsorção seletiva a partir de misturas complexas - Google Patents

Composições sólidas para adsorção seletiva a partir de misturas complexas

Info

Publication number
BR0211927A
BR0211927A BR0211927-7A BR0211927A BR0211927A BR 0211927 A BR0211927 A BR 0211927A BR 0211927 A BR0211927 A BR 0211927A BR 0211927 A BR0211927 A BR 0211927A
Authority
BR
Brazil
Prior art keywords
solid
selective adsorption
inorganic substance
complex mixtures
solid compositions
Prior art date
Application number
BR0211927-7A
Other languages
English (en)
Inventor
Richard Franklin Wormsbecher
Original Assignee
Grace W R & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grace W R & Co filed Critical Grace W R & Co
Publication of BR0211927A publication Critical patent/BR0211927A/pt

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/288—Polar phases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28009—Magnetic properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"COMPOSIçõES SóLIDAS PARA ADSORçãO SELETIVA A PARTIR DE MISTURAS COMPLEXAS". A presente invenção refere-se a um sólido e método úteis para separar componentes químicos em uma mistura complexa quando pelo menos um dos componentes químicos é capaz de ser adsorvido seletivamente. O sólido da presente invenção compreende uma substância inorgânica e grupamentos (R~ 10~) localizados sobre pelo menos uma superfície da substância inorgânica, onde a dita substância inorgânica é óxido inorgânico e o grupamento da superfície é selecionado no grupo que consiste de -CH~ 2~OH, -CH(OH)~ 2~, -CH(OH)CH~ 3~, -CH~ 2~CH~ 2~OH, C (OH)~ 2~CH~ 3~, -CH~ 2~CH (OH)~ 2~ e -CH (OH) CH~ 2~ (OH). O grupamento ligante, opcionalmente anexado à substância inorgânica por intermédio de um ligante, também pode estar localizado sobre a superfície do sólido.
BR0211927-7A 2001-08-14 2002-08-12 Composições sólidas para adsorção seletiva a partir de misturas complexas BR0211927A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/929,621 US6802966B2 (en) 2001-08-14 2001-08-14 Solid compositions for selective adsorption from complex mixtures
PCT/US2002/025351 WO2003015915A1 (en) 2001-08-14 2002-08-12 Solid compositions for selective adsorption from complex mixtures

Publications (1)

Publication Number Publication Date
BR0211927A true BR0211927A (pt) 2004-10-26

Family

ID=25458172

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211927-7A BR0211927A (pt) 2001-08-14 2002-08-12 Composições sólidas para adsorção seletiva a partir de misturas complexas

Country Status (16)

Country Link
US (3) US6802966B2 (pt)
EP (1) EP1423191B1 (pt)
JP (1) JP4235547B2 (pt)
KR (1) KR100955124B1 (pt)
CN (1) CN100374197C (pt)
AU (1) AU2002355940B2 (pt)
BR (1) BR0211927A (pt)
CA (1) CA2457730A1 (pt)
EA (1) EA006059B1 (pt)
HR (1) HRP20040148A2 (pt)
IL (2) IL160321A0 (pt)
MX (1) MXPA04001366A (pt)
NO (1) NO20040652L (pt)
PL (1) PL367789A1 (pt)
WO (1) WO2003015915A1 (pt)
ZA (1) ZA200401183B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987079B2 (en) * 2001-08-14 2006-01-17 W.R. Grace & Co.-Conn. Supported catalyst systems
US8137548B2 (en) * 2003-10-17 2012-03-20 Zirchrom Separations, Inc. Chelator-modified inorganic oxide particles
EP1538481A1 (en) * 2003-12-05 2005-06-08 Sony International (Europe) GmbH A method of activating a silicon surface for subsequent patterning of molecules onto said surface
EP1735082A1 (en) * 2004-03-17 2006-12-27 Ciphergen Biosystems, Inc. Materials, methods, and systems for separating and identifying proteins from mixtures
WO2006008143A2 (en) * 2004-07-19 2006-01-26 Grace Gmbh & Co. Kg Apparatus components and methods of using apparatus components to detect the presence of an analyte
TW200739068A (en) 2005-09-29 2007-10-16 Alltech Associates Inc Composite chromatography column
US8597959B2 (en) * 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
EP2137533A2 (en) * 2007-04-19 2009-12-30 3M Innovative Properties Company Uses of water-dispersible silica nanoparticles for attaching biomolecules
US20090004231A1 (en) * 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
ES2319063B1 (es) * 2007-09-28 2010-02-12 Universidad De Granada Compuesto de silica-vinilsulfona, sintesis y usos del mismo.
RU2523484C2 (ru) * 2009-03-12 2014-07-20 Сисейдо Компани, Лтд. Способ получения наполнителя, наполнитель и колонка
US11628381B2 (en) 2012-09-17 2023-04-18 W.R. Grace & Co. Conn. Chromatography media and devices
EP3094390B1 (en) 2014-01-16 2021-07-07 W.R. Grace & CO. - CONN. Affinity chromatography media and chromatography devices
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 官能化担体材料並びに官能化担体材料を作製及び使用する方法
CN107921407B (zh) 2015-06-05 2022-07-05 格雷斯公司 生物处理吸附澄清剂及其制备和使用方法
CN110152630B (zh) * 2019-06-04 2022-03-22 南京信息工程大学 一种高效吸附剂及其应用
WO2021153717A1 (ja) * 2020-01-31 2021-08-05 池田　壽文 人工核酸に基づくアフィニティークロマトグラフィー

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3669841A (en) 1970-02-11 1972-06-13 Monsanto Co Attachment of enzymes to siliceous materials
US3715278A (en) 1970-02-11 1973-02-06 Monsanto Co Enzyme-polymer product attached to surface of siliceous materials thereof
US3795313A (en) * 1970-05-22 1974-03-05 Du Pont Chromatographic packing with chemically bonded organic stationary phases
US3666530A (en) * 1970-10-22 1972-05-30 Research Corp Novel silicious silicone bonded materials
US3873426A (en) 1973-07-02 1975-03-25 Miles Lab Insoluble enzymes
US3983299A (en) * 1974-03-04 1976-09-28 Purdue Research Foundation Bonded carbohydrate stationary phases for chromatography
FR2267992A1 (pt) 1974-04-19 1975-11-14 Rhone Poulenc Ind
GB1514707A (en) 1974-06-25 1978-06-21 Atomic Energy Authority Uk Immobilization of biologically active substances
US3954678A (en) 1974-07-11 1976-05-04 E. I. Du Pont De Nemours And Company Semipermeable microcapsules containing a silica gel
US4043905A (en) * 1974-08-26 1977-08-23 Indiana University Foundation Chromatographic separation columns with selectively modified active surfaces and methods for their preparations
US4029583A (en) * 1975-02-28 1977-06-14 Purdue Research Foundation Chromatographic supports and methods and apparatus for preparing the same
US3983000A (en) 1976-04-01 1976-09-28 Corning Glass Works Bonding proteins to inorganic supports
DE2621974A1 (de) * 1976-05-18 1977-11-24 Max Planck Gesellschaft Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials
DE2963866D1 (en) 1978-02-16 1982-11-25 Rhone Poulenc Spec Chim Support-enzyme complexes and method for preparing them
US4206259A (en) 1978-10-16 1980-06-03 Uop Inc. Support matrices for immobilized enzymes
US4268423A (en) 1979-11-16 1981-05-19 Uop Inc. Support matrices for immobilized enzymes
US4430496A (en) 1980-01-17 1984-02-07 Varian Associates, Inc. Strong anion exchange composition and methods
US4298500A (en) * 1980-05-05 1981-11-03 Varian Associates, Inc. Mixed phase chromatographic compositions
CA1130228A (en) 1980-05-21 1982-08-24 Chiang-Chang Liao Support matrix for amino-containing biologically active substances
ZA827728B (en) 1981-11-17 1983-08-31 Nestle Sa A process for the production of enzymatically active biocatalysts and the products obtained
US4415663A (en) 1982-08-25 1983-11-15 Uop Inc. Support matrix for immobilized enzymes
US4540586A (en) * 1983-07-01 1985-09-10 Moore William P Method of preserving fodders with a nutritive coating
US4540486A (en) 1983-11-25 1985-09-10 J. T. Baker Chemical Company Polyethylenimine bound chromatographic packing
US4469630A (en) 1983-11-25 1984-09-04 J. T. Baker Chemical Co. Purification of monoclonal antibodies
DE3342870A1 (de) 1983-11-26 1985-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Digitalis-antikoerper, verfahren zu ihrer herstellung und ihre verwendung zur therapie von digitalis-intoxikationen
US4520122A (en) 1983-12-05 1985-05-28 Uop Inc. Immobilization of organic species on refractory inorganic oxides
US5110784A (en) * 1984-04-09 1992-05-05 Dow Corning Corporation Dual surface porous material
US4544485A (en) * 1984-08-31 1985-10-01 Purdue Research Foundation Chromatographic method and means
US5167812A (en) * 1984-11-28 1992-12-01 Trustees Of The Univ. Of Penna. Affinity chromatogry using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
US4681870A (en) 1985-01-11 1987-07-21 Imre Corporation Protein A-silica immunoadsorbent and process for its production
US4551245A (en) 1985-04-22 1985-11-05 J. T. Baker Chemical Co. Acylated polyethylenimine bound chromatographic packing
US4606825A (en) 1985-04-22 1986-08-19 J. T. Baker Chemical Company Purification of immunoglobulin G
CH663728A5 (fr) 1985-06-10 1988-01-15 Battelle Memorial Institute Procede de purification de substances bioactives par adsorption biospecifique.
US4837348A (en) 1986-04-30 1989-06-06 Varian Associates, Inc. Bonded phase chromatographic supports
US4994429A (en) 1986-12-29 1991-02-19 Aluminum Company Of America Active material useful as adsorbent comprising metal oxide/hydroxide particles reacted with phosphorus-containing organic acid group of organic compound having unreacted acid group
JP2509542B2 (ja) * 1987-02-26 1996-06-19 株式会社ワイエムシィ 溶質分離用担体
US5240602A (en) 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
US6251278B1 (en) 1987-06-08 2001-06-26 Chromatochem, Inc. Process for separating a substance from a mixture
CA1320718C (en) * 1987-06-08 1993-07-27 Richard Frederick Hammen Chromatographic material
US4778600A (en) 1987-06-17 1988-10-18 Dow Corning Corporation Liquid chromatography dual zone packing materials
EP0303406A3 (en) 1987-08-14 1991-07-03 Hewlett-Packard Company An immunoaffinity substrate
US5118796A (en) 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
JPH01181790A (ja) 1988-01-18 1989-07-19 Toray Silicone Co Ltd 生理活性物質の固定化方法
US5277813A (en) 1988-06-17 1994-01-11 S.A.C. Corporation Shielded stationary phases
ATE91152T1 (de) 1988-07-22 1993-07-15 Imre Corp Gereinigte protein a-zusammensetzungen und verfahren zu ihrer herstellung.
US5045190A (en) * 1988-11-08 1991-09-03 Carbonell Ruben G Chromatography apparatus
US5077210A (en) 1989-01-13 1991-12-31 Eigler Frances S Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
US5035803A (en) * 1989-02-14 1991-07-30 The Regents Of The University Of California High yield water-soluble polymer silica separation resins
US5043062A (en) * 1989-02-21 1991-08-27 Eastman Kodak Company High performance affinity chromatography column comprising non-porous, nondisperse polymeric packing material
EP0386926A3 (en) 1989-03-02 1991-12-18 Supelco, Inc. Silica gel supports suitable for chromatographic separations
US5085779A (en) 1989-06-07 1992-02-04 J. T. Baker, Inc. Polyethyleneimine matrixes for affinity chromatography
US5055194A (en) * 1989-07-28 1991-10-08 University Of Pennsylvania Support for high performance liquid chromatography in a magnetically stabilized fluidized bed
JPH03218458A (ja) 1989-10-02 1991-09-26 Shiseido Co Ltd カラム充填剤及びその製造方法
US5457195A (en) 1989-12-21 1995-10-10 Board Of Regents, The University Of Texas System Sapphyrin derivatives and conjugates
US5403750A (en) 1991-03-06 1995-04-04 W. R. Grace & Co.-Conn. Biocompatible, low protein adsorption affinity matrix
DE4130475A1 (de) * 1991-09-13 1993-03-18 Merck Patent Gmbh Modifizierte chromatographische traegermaterialien
CA2064683A1 (en) 1992-03-26 1993-09-27 Krishna Mohan Rao Kallury Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices
US5906734A (en) 1992-06-19 1999-05-25 Biosepra Inc. Passivated porous polymer supports and methods for the preparation and use of same
US5374755A (en) 1992-07-17 1994-12-20 Millipore Corporation Liquid chromatography stationary phases with reduced silanol interactions
US5362859A (en) 1992-07-27 1994-11-08 Sepracor, Inc. High-capacity affinity supports and methods for the preparation and use of same
US5316680A (en) 1992-10-21 1994-05-31 Cornell Research Foundation, Inc. Multimodal chromatographic separation media and process for using same
US5371262A (en) 1993-03-10 1994-12-06 Gelest, Inc. Hydroxymethyltrialkoxysilanes and methods of making and using the same
US5406766A (en) * 1993-07-29 1995-04-18 Monier Roof Tile Inc. Multi-color concrete tiles and method and apparatus for making same
DE4334353A1 (de) * 1993-10-08 1995-04-13 Merck Patent Gmbh Verfahren und Träger für die Gelpermeationschromatographie
US5527711A (en) 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
JP3333309B2 (ja) 1994-04-08 2002-10-15 鐘淵化学工業株式会社 ケトアミン含有タンパク質吸着体
US5663051A (en) 1994-08-31 1997-09-02 Activated Cell Therapy, Inc. Separation apparatus and method
US5652348A (en) 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
US6025129A (en) 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US6048964A (en) 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5667674A (en) * 1996-01-11 1997-09-16 Minnesota Mining And Manufacturing Company Adsorption medium and method of preparing same
US6013855A (en) 1996-08-06 2000-01-11 United States Surgical Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces
AU6021798A (en) 1997-01-21 1998-08-07 W.R. Grace & Co.-Conn. Silica adsorbent on magnetic substrate
US5998183A (en) 1997-07-07 1999-12-07 Le Fevre; Gerard N. Enzyme immobilization on a siliceous support with a polyaldehyde cross-linking agent
US5993653C1 (en) 1997-08-11 2001-11-06 Phenomenex Composition and column used in hplc
FR2777355B1 (fr) * 1998-04-10 2000-05-12 Bio Merieux Procede de fixation d'une molecule biologique sur la surface d'un support constitue de silice ou d'oxyde metallique
DE10022529A1 (de) 2000-05-09 2001-11-15 Emtec Magnetics Gmbh Pigmenthaltiges Aufzeichnungsmaterial
US6987079B2 (en) * 2001-08-14 2006-01-17 W.R. Grace & Co.-Conn. Supported catalyst systems
US6375846B1 (en) * 2001-11-01 2002-04-23 Harry Wellington Jarrett Cyanogen bromide-activation of hydroxyls on silica for high pressure affinity chromatography

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US20050003428A1 (en) 2005-01-06
EA200400310A1 (ru) 2004-08-26
EP1423191A1 (en) 2004-06-02
EA006059B1 (ru) 2005-08-25
CA2457730A1 (en) 2003-02-27
CN100374197C (zh) 2008-03-12
KR20040023751A (ko) 2004-03-18
JP2004538479A (ja) 2004-12-24
NO20040652L (no) 2004-05-14
CN1568222A (zh) 2005-01-19
EP1423191B1 (en) 2013-03-20
US20030042203A1 (en) 2003-03-06
MXPA04001366A (es) 2004-05-27
KR100955124B1 (ko) 2010-04-28
HRP20040148A2 (en) 2004-08-31
US6802966B2 (en) 2004-10-12
US7166213B2 (en) 2007-01-23
PL367789A1 (en) 2005-03-07
IL160321A0 (en) 2004-07-25
AU2002355940B2 (en) 2008-10-16
WO2003015915A1 (en) 2003-02-27
ZA200401183B (en) 2004-08-26
JP4235547B2 (ja) 2009-03-11
IL160321A (en) 2007-05-15
US20060011549A1 (en) 2006-01-19

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