WO2008059130A9 - Thionucléosides et applications pharmaceutiques - Google Patents

Thionucléosides et applications pharmaceutiques Download PDF

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Publication number
WO2008059130A9
WO2008059130A9 PCT/FR2007/001784 FR2007001784W WO2008059130A9 WO 2008059130 A9 WO2008059130 A9 WO 2008059130A9 FR 2007001784 W FR2007001784 W FR 2007001784W WO 2008059130 A9 WO2008059130 A9 WO 2008059130A9
Authority
WO
WIPO (PCT)
Prior art keywords
atoms
nucleoside
compounds
carbon
thionucleosides
Prior art date
Application number
PCT/FR2007/001784
Other languages
English (en)
Other versions
WO2008059130A1 (fr
Inventor
Jean-Luc Decout
Beatrice Gerland
Jerome Desire
Michel Lepoivre
Jan Balzarini
Original Assignee
Univ Grenoble 1
Jean-Luc Decout
Beatrice Gerland
Jerome Desire
Michel Lepoivre
Jan Balzarini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Grenoble 1, Jean-Luc Decout, Beatrice Gerland, Jerome Desire, Michel Lepoivre, Jan Balzarini filed Critical Univ Grenoble 1
Priority to JP2009533905A priority Critical patent/JP2010507637A/ja
Priority to CA002667569A priority patent/CA2667569A1/fr
Priority to EP07866456A priority patent/EP2084153A1/fr
Priority to US12/447,346 priority patent/US20100075917A1/en
Publication of WO2008059130A1 publication Critical patent/WO2008059130A1/fr
Publication of WO2008059130A9 publication Critical patent/WO2008059130A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne une composition pharmaceutique comprenant, à titre de principe actif, au moins un composé choisi parmi les composés répondant à la formule (II) suivante: où l'atome S est lié au carbone en T ou au carbone en 3 ' du nucléoside, et les composés répondant à la formule (III) suivante : formules dans lesquelles B représente une base nucléotidique, naturelle ou modifiée, x est égal à O, 1 ou 2, et Rl, R représentent un groupement carboné ou un reste moléculaire hydrocarboné pouvant être substitué et/ou interrompu par un ou des atomes et/ou par un ou des groupements comprenant un ou des atomes, lesdits atomes étant choisis parmi N, O, P, S, Si, X où X représente un halogène, et un excipient pharmaceutiquement acceptable.
PCT/FR2007/001784 2006-10-27 2007-10-29 Thionucléosides et applications pharmaceutiques WO2008059130A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009533905A JP2010507637A (ja) 2006-10-27 2007-10-29 チオヌクレオシドとその医薬品への適用
CA002667569A CA2667569A1 (fr) 2006-10-27 2007-10-29 Thionucleosides et applications pharmaceutiques
EP07866456A EP2084153A1 (fr) 2006-10-27 2007-10-29 Thionucléosides et applications pharmaceutiques
US12/447,346 US20100075917A1 (en) 2006-10-27 2007-10-29 Thionucleosides and pharmaceutical applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0609460A FR2907786B1 (fr) 2006-10-27 2006-10-27 Thionucleosides et applications pharmaceutiques
FR0609460 2006-10-27

Publications (2)

Publication Number Publication Date
WO2008059130A1 WO2008059130A1 (fr) 2008-05-22
WO2008059130A9 true WO2008059130A9 (fr) 2009-07-23

Family

ID=37951510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/001784 WO2008059130A1 (fr) 2006-10-27 2007-10-29 Thionucléosides et applications pharmaceutiques

Country Status (6)

Country Link
US (1) US20100075917A1 (fr)
EP (1) EP2084153A1 (fr)
JP (1) JP2010507637A (fr)
CA (1) CA2667569A1 (fr)
FR (1) FR2907786B1 (fr)
WO (1) WO2008059130A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534448A (ja) * 2006-04-24 2009-09-24 ユニヴェルシテ・ジョセフ・フーリエ（グルノーブル・１） ジスルフィドおよびチオスルフィネート化合物の調製工程
JP2015536954A (ja) * 2012-11-07 2015-12-24 ズカイ スオ 置換ゲムシタビンアリールアミド類似体
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
CA3088287A1 (fr) 2018-01-10 2019-07-18 Nucorion Pharmaceuticals, Inc. Composes de phosphore(n)amidatacetal et phosph(on)atalcetal
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
US12110311B2 (en) 2019-07-17 2024-10-08 Nucorion Pharmaceuticals, Inc. Cyclic deoxyribonucleotide compounds
WO2021216427A1 (fr) 2020-04-21 2021-10-28 Ligand Pharmaceuticals, Inc. Composés de promédicaments nucléotidiques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ216172A (en) * 1985-05-15 1989-08-29 Wellcome Found Nucleosides and pharmaceutical compositions
EP0348170A3 (fr) * 1988-06-21 1990-12-05 Moses Nam Fong Lee Dérivés antiviraux de pyrimidine
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
SK284054B6 (sk) * 1996-10-16 2004-08-03 Icn Pharmaceuticals, Inc. Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie
EP1411954B1 (fr) * 2000-10-18 2010-12-15 Pharmasset, Inc. Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale

Also Published As

Publication number Publication date
US20100075917A1 (en) 2010-03-25
FR2907786A1 (fr) 2008-05-02
EP2084153A1 (fr) 2009-08-05
WO2008059130A1 (fr) 2008-05-22
JP2010507637A (ja) 2010-03-11
CA2667569A1 (fr) 2008-05-22
FR2907786B1 (fr) 2009-09-18

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