BR0211649A - 3,5-dihidróxi-2,2-dimetil-valeroamidas protegidas, para a sìntese de epotilonas e derivados e processos para produção e o uso - Google Patents

3,5-dihidróxi-2,2-dimetil-valeroamidas protegidas, para a sìntese de epotilonas e derivados e processos para produção e o uso

Info

Publication number
BR0211649A
BR0211649A BR0211649-9A BR0211649A BR0211649A BR 0211649 A BR0211649 A BR 0211649A BR 0211649 A BR0211649 A BR 0211649A BR 0211649 A BR0211649 A BR 0211649A
Authority
BR
Brazil
Prior art keywords
derivatives
production
valeroamides
epothilones
dihydroxy
Prior art date
Application number
BR0211649-9A
Other languages
English (en)
Inventor
Juergen Westermann
Orlin Petrov
Johannes Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BR0211649A publication Critical patent/BR0211649A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Abstract

"3,5-DIHIDRóXI-2,2-DIMETIL-VALEROAMIDAS PROTEGIDAS, PARA A SìNTESE DE EPOTILONAS E DERIVADOS E PROCESSOS PARA PRODUçãO E O USO". A presente invenção refere-se a novas 3,5-dihidróxi-2,2-dimetil-valeroamidas protegidas, para a síntese de epotilonas e derivados e a um processo para produção e ao uso dos novos compostos, para produção de epotilonas ou derivados de epotilona.
BR0211649-9A 2001-08-03 2002-08-05 3,5-dihidróxi-2,2-dimetil-valeroamidas protegidas, para a sìntese de epotilonas e derivados e processos para produção e o uso BR0211649A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10138348A DE10138348A1 (de) 2001-08-03 2001-08-03 Geschützte 3,5-Dihydroxy-2,2-dimethyl-valeroamide für die Synthese von Epothilonen und Derivaten und Verfahren zur Herstellung und die Verwendung
PCT/EP2002/008726 WO2003014063A2 (de) 2001-08-03 2002-08-05 Geschützte 3,5-dihydroxy-2,2-dimethyl-valeroamide für die synthese von epothilonen und derivaten und verfarhen zur herstellung und die verwendung

Publications (1)

Publication Number Publication Date
BR0211649A true BR0211649A (pt) 2004-07-13

Family

ID=7694415

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211649-9A BR0211649A (pt) 2001-08-03 2002-08-05 3,5-dihidróxi-2,2-dimetil-valeroamidas protegidas, para a sìntese de epotilonas e derivados e processos para produção e o uso

Country Status (16)

Country Link
EP (1) EP1412322A2 (pt)
JP (1) JP2004537589A (pt)
KR (1) KR20040029394A (pt)
CN (2) CN1807403A (pt)
AR (1) AR036207A1 (pt)
BR (1) BR0211649A (pt)
CA (1) CA2456255A1 (pt)
DE (1) DE10138348A1 (pt)
IL (1) IL160159A0 (pt)
MX (1) MXPA04000954A (pt)
NO (1) NO20040912L (pt)
PE (1) PE20030345A1 (pt)
PL (1) PL367430A1 (pt)
RU (1) RU2004106530A (pt)
WO (1) WO2003014063A2 (pt)
ZA (1) ZA200401727B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU756699B2 (en) 1996-12-03 2003-01-23 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO2003029195A1 (fr) 2001-09-28 2003-04-10 Sumika Fine Chemicals Co., Ltd. Intermediaires pour l'elaboration d'un derive de l'epothilone, et leur procede de production
DE10326195A1 (de) * 2003-06-07 2004-12-23 Schering Ag Geschützte 5,7-Dihydroxy-4,4-dimethyl-3-oxoheptansäureester und 5,7-Dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptansäureester für die Synthese von Epothilonen- und Derivaten und Verfahren zur Herstellung dieser Ester
CN110857276B (zh) * 2018-08-22 2021-03-02 中国科学院化学研究所 一类手性β-羟基酰胺类化合物及其制备方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4824980A (en) * 1988-09-02 1989-04-25 Dow Corning Corporation Process to produce O-silyl O,N-ketene acetals
US6211412B1 (en) * 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones

Also Published As

Publication number Publication date
PE20030345A1 (es) 2003-04-10
WO2003014063A2 (de) 2003-02-20
WO2003014063A3 (de) 2003-05-01
PL367430A1 (en) 2005-02-21
CA2456255A1 (en) 2003-02-20
MXPA04000954A (es) 2004-04-20
EP1412322A2 (de) 2004-04-28
RU2004106530A (ru) 2005-07-27
CN1538952A (zh) 2004-10-20
AR036207A1 (es) 2004-08-18
IL160159A0 (en) 2004-07-25
NO20040912L (no) 2004-03-02
CN1807403A (zh) 2006-07-26
DE10138348A1 (de) 2003-02-27
JP2004537589A (ja) 2004-12-16
KR20040029394A (ko) 2004-04-06
ZA200401727B (en) 2005-04-12

Similar Documents

Publication Publication Date Title
BR0209580A (pt) Derivados de ciclohexan-1, 4 diamina substituìdos
BR9909844A (pt) Processo para sintetizar um composto, e, composto.
UY26813A1 (es) Compuestos para tratar enfermedad de alzheimer
BR0113161A (pt) Arilóxi piperidinas não imidazóis
WO1999067253A3 (en) Desmethyl epothilones
BR0212733A (pt) Composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
BR0116067A (pt) Derivado de metanossulfonamido-benzofurano, seu processo de preparação e sua utilização como intermediário de sìntese
BR0115452A (pt) Compostos tendo atividade fungicida e processos para fabricação e uso dos mesmos
BR0112093A (pt) Derivados de sulfonil-pirrolidina úteis no tratamento de distúrbios neurológicos
DK1109817T3 (da) Phosphohalogenhydriner, deres fremstilling og anvendelse
HK1070350A1 (en) Protected 3.5-dihydroxy-2.2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof
BR0212772A (pt) Processo para a preparação de repaglinida
BR0211649A (pt) 3,5-dihidróxi-2,2-dimetil-valeroamidas protegidas, para a sìntese de epotilonas e derivados e processos para produção e o uso
BR0114380A (pt) Derivados-1-aminobutan-3-ol-substituìdos
PT1102765E (pt) Processo para a sintese de derivados de (1h)-benzo¬c|quinolizin-3-onas
BRPI0411245A (pt) composto, composição farmacêutica, uso de um composto, e, métodos para tratamento ou profilaxia de vìrus oncogênicos e para tratamento ou profilaxia de condições ou distúrbios devidos a infecção por hpv
BRPI0411652A (pt) processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos
BR0317693A (pt) Derivados de epotilona
BR0211223A (pt) Derivados de 4-aminociclohexanol substituìdos
ATE245147T1 (de) Substituierte aminochinazolinon (thion) derivate
BR0116721A (pt) Processo para a preparação de (±)-trans-4-p-fluorofenil-3-hidroximetil-1-metilpiperi dina
PT703232E (pt) Derivados do 2,3-di-hidro-1h-isoindole processo para a sua preparacao e o seu uso como inibidores da reassimilacao da serotonina
HUP0000966A2 (hu) Izoflavonszármazékok és ilyen vegyületeket hatóanyagként tartalmazó gyógyszerkészítmények
PT816353E (pt) Novos derivados de coumarina, processos para a sua preparacao e sua utilizacao
PT709378E (pt) Aminoalquiloximas processo para a sua preparacao sua utilizacao como medicamentos e compostos intermediarios

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.