PT703232E - Derivados do 2,3-di-hidro-1h-isoindole processo para a sua preparacao e o seu uso como inibidores da reassimilacao da serotonina - Google Patents

Derivados do 2,3-di-hidro-1h-isoindole processo para a sua preparacao e o seu uso como inibidores da reassimilacao da serotonina

Info

Publication number
PT703232E
PT703232E PT95112395T PT95112395T PT703232E PT 703232 E PT703232 E PT 703232E PT 95112395 T PT95112395 T PT 95112395T PT 95112395 T PT95112395 T PT 95112395T PT 703232 E PT703232 E PT 703232E
Authority
PT
Portugal
Prior art keywords
dihydro
preparation
serotonin
inhibitors
reassimilation
Prior art date
Application number
PT95112395T
Other languages
English (en)
Inventor
Gregory Shutske
Kevin J Kapples
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of PT703232E publication Critical patent/PT703232E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PT95112395T 1994-08-11 1995-08-07 Derivados do 2,3-di-hidro-1h-isoindole processo para a sua preparacao e o seu uso como inibidores da reassimilacao da serotonina PT703232E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/288,844 US5567718A (en) 1994-08-11 1994-08-11 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors

Publications (1)

Publication Number Publication Date
PT703232E true PT703232E (pt) 2004-09-30

Family

ID=23108905

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95112395T PT703232E (pt) 1994-08-11 1995-08-07 Derivados do 2,3-di-hidro-1h-isoindole processo para a sua preparacao e o seu uso como inibidores da reassimilacao da serotonina

Country Status (9)

Country Link
US (5) US5567718A (pt)
EP (1) EP0703232B1 (pt)
JP (1) JP3339996B2 (pt)
AT (1) ATE270287T1 (pt)
CA (1) CA2155796C (pt)
DE (1) DE69533214T2 (pt)
DK (1) DK0703232T3 (pt)
ES (1) ES2219652T3 (pt)
PT (1) PT703232E (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL130605A0 (en) * 1996-12-23 2000-06-01 Hoechst Marion Roussel Inc 3-aryl-2- (1-substituted-4-piperidinyl)-1 (1-DI)oxo-3H-benzo¬D¾-isothiazole derivatives their preparation and their use as modulators of neurotransmitter function
US6004977A (en) * 1996-12-27 1999-12-21 Hoechst Marion Roussel, Inc. N-(pyridinylamino) isoindolines and related compounds
US6339093B1 (en) * 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives
US20060079554A1 (en) * 2002-12-06 2006-04-13 Barry Peter C Inhibitors of monomine uptake
CA2627426A1 (en) * 2005-11-11 2007-05-18 Markus Boehringer Carbocyclic fused cyclic amines as inhibitors of the coagulation factor xa
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
WO2009042907A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084167A (en) * 1954-12-09 1963-04-02 Geschickter Fund Med Res Isoindoles
US2957872A (en) * 1957-10-21 1960-10-25 Ciba Pharm Prod Inc Phthalimidines and process for manufacturing same
US3031458A (en) * 1958-02-05 1962-04-24 Ciba Pharm Prod Inc Isoindolines
DE1135461B (de) * 1959-05-08 1962-08-30 Knoll Ag Verfahren zur Herstellung von basisch substituierten Phthalimidinen
US3322631A (en) * 1965-06-30 1967-05-30 Merck & Co Inc Method of treatment of hypertension
SE368009B (pt) * 1971-09-16 1974-06-17 Kabi Ab
GB1416872A (en) * 1972-03-10 1975-12-10 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
BE795730A (fr) * 1972-04-01 1973-08-21 Knoll Ag Composition antiarythmique
GB1425578A (en) * 1972-10-21 1976-02-18 Wyeth John & Brother Ltd Piperidine derivatives
US3875165A (en) * 1973-02-22 1975-04-01 Wyeth John & Brother Ltd (4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
US4053615A (en) * 1972-10-21 1977-10-11 John Wyeth & Brother Limited Phthalimidopiperidines and anti-convulsant compositions thereof
DK141752B (da) * 1974-07-31 1980-06-09 Ciba Geigy Ag Aalogifremgangsmåde til fremstilling af piperidiner eller salte deraf.
US4000287A (en) * 1974-12-16 1976-12-28 Ciba-Geigy Corporation Isoindolinopiperidines
AT345806B (de) * 1975-03-06 1978-10-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer substituierter arylalkylamine und deren salze
DD123741A5 (pt) * 1975-03-06 1977-01-12
FR2374847A1 (fr) * 1976-12-22 1978-07-21 Monsanto Co Phtalimides substituees pour la regulation de la croissance des plantes
US4072499A (en) * 1976-12-22 1978-02-07 Monsanto Company Use of pyridyl phthalimides as plant growth regulants
US4115398A (en) * 1977-01-05 1978-09-19 Kowa Company Ltd. Isoindoline derivatives and the acid addition salts thereof and process for the preparation of same
US4124375A (en) * 1977-10-12 1978-11-07 Monsanto Company Substituted phthalimides for regulating the growth of plants
US4309541A (en) * 1978-09-20 1982-01-05 Ciba-Geigy Corporation Piperidinyl-lactams
US4291042A (en) * 1979-01-26 1981-09-22 John Wyeth & Brother Limited Antidepressant piperidine derivatives
SE7907121L (sv) * 1979-08-27 1981-02-28 Astra Laekemedel Ab Ftalimidinderivat
DE3030695A1 (de) * 1980-08-14 1982-03-18 Farmigea S.P.A., Pisa (beta) -diaethylaminoaethylphthalimide mit lokalanaesthetischer und antiarrytmischer akktivitaet, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
GB2082569A (en) * 1980-08-21 1982-03-10 Farmigea Spa Phthalimides
US4724235A (en) * 1981-05-20 1988-02-09 A. H. Robins Company, Incorporated N-(arylthioalkyl)-N'-(aminoalkyl)ureas useful in the treatment of arrhythmia
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
JPH01138321U (pt) * 1988-01-25 1989-09-21
JP2699511B2 (ja) * 1988-01-29 1998-01-19 武田薬品工業株式会社 置換アミン類
FR2628425B1 (fr) * 1988-03-08 1992-04-03 Rhone Poulenc Sante Derives d'isoindolinone, leurs procedes de preparation et les medicaments les contenant
US5026707A (en) * 1988-05-23 1991-06-25 Eli Lilly And Company Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes
US5114976A (en) * 1989-01-06 1992-05-19 Norden Michael J Method for treating certain psychiatric disorders and certain psychiatric symptoms
US5053413A (en) * 1989-09-05 1991-10-01 G. D. Searle & Co. N-benzylpiperidineisoindolinones
FR2667068B1 (fr) * 1990-09-26 1994-09-09 Adir Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
CA2189963A1 (en) * 1994-05-18 1995-11-23 Haruhiko Kikuchi Novel pyrimidine derivative

Also Published As

Publication number Publication date
DE69533214T2 (de) 2005-07-21
US5869502A (en) 1999-02-09
JPH0859655A (ja) 1996-03-05
EP0703232A2 (en) 1996-03-27
EP0703232B1 (en) 2004-06-30
US5869685A (en) 1999-02-09
DE69533214D1 (de) 2004-08-05
US5567718A (en) 1996-10-22
JP3339996B2 (ja) 2002-10-28
EP0703232A3 (en) 1996-10-09
ES2219652T3 (es) 2004-12-01
ATE270287T1 (de) 2004-07-15
CA2155796C (en) 2004-10-19
US5874458A (en) 1999-02-23
US5874583A (en) 1999-02-23
CA2155796A1 (en) 1996-02-12
DK0703232T3 (da) 2004-10-04

Similar Documents

Publication Publication Date Title
BR9909844A (pt) Processo para sintetizar um composto, e, composto.
BR9812837A (pt) Processo para fazer um composto, e, composto
DK0675886T3 (da) Aminomethylensubstituerede ikke-aromatiske heterocykler og deres anvendelse som substance P-antagonister
MX9304756A (es) 9-[(glicilo substituido)amido]-6-desmetil-6-desoxitetraciclinas, metodo para su produccion y composiciones farmaceuticas que las contienen.
BR0212733A (pt) Composto, composição farmacêutica, uso de um composto, e, método para o tratamento de um distúrbio afetivo
BR0307351A (pt) Composto, composição farmacêutica, método para tratar uma condição ou estado de doença mediados pela atividade de p38 quinase ou mediados por citocinas produzidas pela atividade de p38 quinase, uso de um composto, e, processo para preparar um composto
NO308848B1 (no) Kromanforbindelse og farmasøytisk preparat som inneholder den
MX9200817A (es) Derivados de piranil cianoguanidina y proceso para su preparacion.
DK1109817T3 (da) Phosphohalogenhydriner, deres fremstilling og anvendelse
BR0112093A (pt) Derivados de sulfonil-pirrolidina úteis no tratamento de distúrbios neurológicos
PT97796A (pt) Processo para a preparacao de piperidinas substituidas
PT96379A (pt) Processo de preparacao de ciclopropil-n-hidroxi-ureias,-carboxamidas e n-acil-n-hidroxiaminas substituidas e de composicoes farmaceuticas
NO995963D0 (no) Karboksamider anvendelige som 5-HTIF-agonister
PT1274685E (pt) Derivado de piridina-n-oxido e processo para a sua transformacao em compostos farmaceuticamente eficazes
BR0213481A (pt) Sondas
PT703232E (pt) Derivados do 2,3-di-hidro-1h-isoindole processo para a sua preparacao e o seu uso como inibidores da reassimilacao da serotonina
BR0006082A (pt) Fenol-novolacs com propriedades ópticas aperfeiçoadas
BR9808923A (pt) Composto, e, processo para fazer o mesmo
DE69808475T2 (de) Aminosäurederivate zur behandlung von schlaganfall
BR0113650A (pt) N-(3,5-dicloro-2-metoxifenil)-4-metóxi-3-piperazina-1-il a-benzenossulfonamida
BR9612074A (pt) Novos 4-(1h-benzimidazol-2-il)(1,4) diazepanos substituidos úteis para o tratamento de doenças alérgicas
BR9909260A (pt) Processo para o preparo de (r)-alfa-(2,3-dimetóxifenil)-1-[2-(4-fluoro-fenil)etil]-4-pi peridinametanol
BR9806102A (pt) Processo para o ajuste de uma mola de membrana.
PT709378E (pt) Aminoalquiloximas processo para a sua preparacao sua utilizacao como medicamentos e compostos intermediarios
BR0007183A (pt) Isonipectoamidas para o tratamento de distúrbios mediados por integrina