WO2003014063A2 - Geschützte 3,5-dihydroxy-2,2-dimethyl-valeroamide für die synthese von epothilonen und derivaten und verfarhen zur herstellung und die verwendung - Google Patents
Geschützte 3,5-dihydroxy-2,2-dimethyl-valeroamide für die synthese von epothilonen und derivaten und verfarhen zur herstellung und die verwendung Download PDFInfo
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- WO2003014063A2 WO2003014063A2 PCT/EP2002/008726 EP0208726W WO03014063A2 WO 2003014063 A2 WO2003014063 A2 WO 2003014063A2 EP 0208726 W EP0208726 W EP 0208726W WO 03014063 A2 WO03014063 A2 WO 03014063A2
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- Prior art keywords
- general formula
- benzyl
- compounds
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- alkyl
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- DSCVUWPBPIAKHU-UHFFFAOYSA-N I[IH]N1CCOCC1 Chemical compound I[IH]N1CCOCC1 DSCVUWPBPIAKHU-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N C1NCCOC1 Chemical compound C1NCCOC1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
Definitions
- the invention relates to the subject matter characterized in the claims, that is new intermediates and processes for their preparation and use.
- the process for the preparation of new intermediates is based on inexpensive starting materials, provides the intermediates in high enantiomeric purities, in high chemical purity, in good yields and allows large-scale production.
- Epothilones are 16-membered macrolide rings isolated from cultures of the myxobacterium Sorangium cellosum and are representative of a class of promising antitumor agents that have been tested as effective against a variety of cancer lineages.
- An overview of the syntheses is given by J. Mulzer et al. in J. Org. Chem. 2000, 65, 7456-7467.
- Sg1 and Sg2 are protecting groups well known to those skilled in the art, e.g. the TBDMS group.
- a possible production of the A building block is described, for example, in WO00 / 58254 (University of Wisconsin). Therein a synthesis of ⁇ -keto esters is disclosed, which can be converted in multi-stage sequences in the building block A. The chirality is introduced by an asymmetric hydrogenation of a Noyori ⁇ -ketoester:
- the conversion of the ester group into a ketone can only be achieved by means of a multistage sequence.
- the ester group (C-5 atom) is reduced to the alcohol, the oxidation to the aldehyde takes place, the Grignard addition of an alkyl radical with an alkylmagnesium or alkyllithium compound provides a secondary alcohol, which is subsequently oxidized.
- a total of 6 steps are required.
- the direct reaction of an ester is not selective because the intermediately produced product continues to react.
- the following scheme shows the entire synthetic pathway:
- J. Org. Chem. 2000, 65, 7456-7467 further describes an asymmetric synthesis of a ß-ketoester, wherein a variant is carried out in asymmetric form as aldol reaction.
- the catalyst used in this method is D-Ts-valine, which can be prepared from the expensive amino acid D-valine. This method returns an ee value of 90%.
- RE Taylor, Y. Chen, Org. Lett. (2001), 3 (14), 2221-2224 describes an asymmetric aldol reaction in which the yield is 71%.
- the present invention has the object to be able to produce a universally usable starting intermediate of the general formula I and the optically pure antipodes of the general formulas Ia, Ib.
- R1, R2 can be identical or different and independently of one another for an alcohol protecting group familiar to the person skilled in the art, for example benzyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl, THP, TBDMS, TMS, TES, TIP, TBDPS, MEM, MOM, allyl, trityl,
- the compounds according to the invention are stable on storage and are for the most part crystalline solids and can be purified by crystallization. In this way, high chemical and optical yields (e.e.> 98%) can be achieved.
- R 1 is a protective group as defined above, by cleavage of the protecting group R 1 according to the methods known to those skilled in the deprotection of alcohols produce (PJ Kocienski in "Protecting Groups", Georg Thieme Verlag Stuttgart , New York 1994 / Houben Weyl, 4 th Ed Vol Vl / 1b P. 737, Thieme Stuttgart 1984)
- Y and R1 are as defined above and L is a silyl protecting group, e.g. TBDMS, TMS, TES, TIP, TBDPS is prepared in a manner known per se to those skilled in the art by the techniques of aldol condensation.
- TBDMS silyl protecting group
- TMS TMS
- TES TES
- TIP TBDPS
- R1 THP in JOC, 1984, 49, 2301-2309
- R1 benzyl in J. Chem. Soc. Perk. Trans 1, 2000, 2429-2454.
- R1 TBDMS in JOC, 2000, 65, 7456-7467
- Optically active compounds of the general formula IIIa are accessible as follows 1. Separation of the racemic compound of the general formula III on chiral phase (Ref. G. Roussel, P. Pirs, Chirabase, Pure and Applied Chemistry, 1993, 65, 235-244), especially by SMB technique: (A. Seidel-Morgenstern et al., Chromat A 1998, 827/2, 175-191).
- R3 is a C1-C6 alkyl group or an allyl-phenyl, or benzyl group, prepared according to methods known in the art esterification. and saponified by enzymatic or microbiological methods enantioselectively.
- the resulting alcohol differs significantly in its Rf value from the ester used, so that both can be conveniently separated from each other, e.g. by
- Nu is a leaving group such as CI, Br, imidazole, -OPh, -O-C6H4NO2, -O-C1-C4 alkyl, etc.
- R 4 is a methyl, ethyl, benzyl group
- R 4 is a methyl, ethyl, benzyl group
- R4 is a C1-C6 alkyl, methyl, ethyl, tert-butyl, phenyl or benzyl group are prepared by introducing the protective group R2 by methods known in the art (see above).
- Q stands for a hydrogen atom or a COOH group. If Q is a hydrogen atom, XIIIa is treated with an organic base, e.g. LDA deprotonated and then reacted with the activated acid derivative according to the methods known in the art. In the case of Q equal to COOH, condensation is carried out by the methods of the malonic acid half ester condensation, e.g. in J. Am. Chem. Soc. 1999, 121, 7050-7062, Synth. Commun. 1997, 27, 3227-3234.
- racemic diol of general formula II can also starting from ß-keto esters of general formula XIII
- A represents the residue of an optically active ketone, such as e.g. (-) menthone, (-) camphor, etc., and then splits off the ketal group according to the methods of protecting group chemistry known to those skilled in the art.
- an optically active ketone such as e.g. (-) menthone, (-) camphor, etc.
- the TBDMS group is preferred.
- R 1 is a ketal-protecting group, particular preference is given to - (C (CH 3) 2) -.
- the group Y may be preferred for the radicals:
- N, N-dimethyl- (5-benzyloxy-2,2-dimethyl-3 (S) -hydroxy-pentanoic acid) amide 29.8 g (0.11 mol) of N-toluenesulfonyl-D-valine (Lit: J. Am. Chem. Soc., 1937, 59, 116-118) are dissolved at 0 ° C. in 100 ml of dichloromethane.
- 100 ml of BH 3 -THF solution (1 molar) are added dropwise over 30 minutes and the mixture is stirred for a further 30 minutes. The solution is cooled to -78 ° C.
- N, N-dimethyl- (3 (S) -3,5-di-tert-butyldimethylsilyloxy-2,2,2-dimethylpentanoic acid) amide To a solution of 3.96 g (20.95 mmol) of N, N-dimethyl- (3 (S) -3,5-dihydroxy-2,2-dimethyl-pentanoic acid) amide of the title compound of Example 1e, in 20 Dissolved ml of dimethylformamide, are added 7.13g (104.75 mmol) of imidazole and 7.9 g (52.37 mmol) of tert-butyldimethylsilyl chloride and stirred for 16 hours at room temperature.
- the solution is poured into 200 ml of water and extracted 2 times with 50 ml of cyclohexane.
- the organic phases are combined and evaporated to dryness in vacuo.
- the residue is purified by flash chromatography on silica gel (hexane / MTB ether).
- N-methyl-N-phenyl- (5-benzyloxy-2,2, -dimethyl-3 (S) -hydroxy-pentanoic acid) amide 500 mg of N-methyl-N-phenyl- (5-benzyloxy-2,2-dimethyl-3-oxo-pentanoic acid) amide of the title compound from Example 6b are reacted with a catalyst (prepared from 23.3 mg RuCl 2 (Ph) 2 and 62.6 mg S-BiNAP according to R. Selke, Angew Chem. 1998, 110, 1927-1930) (2 d at 40 ° C / 100 bar). Yield: Quantative Elemental Analysis:
- N-methyl-N-phenyl- (3 (S) -3,5-dichlorodiphenylsilane -2,2, -dimethylpentanoic acid) amide To a solution of 5.26 g (20.95 mmol) of N-methyl-N-phenyl- (3 (S) -3,5-dihydroxy-2,2-dimethyl-pentanoic acid) amide of the title compound of Example 6d, dissolved in 20 ml of dimethylformamide are added 3.14 g (46.09 mmol) of imidazole and 5.83 g (23.05 mmol) of dichlorodiphenylsilane and stirred for 16 hours at room temperature.
- Example 9a rac. N, N-dimethyl- (3-hydroxy-3-oxo-pentanoic acid) amide
- Example 9b N, N-Dimethyl-3 (S) - (3,5-dihydroxy-2,2-dimethyl-pentanoic acid) amide 1.87 g (10 mmol) of rac. N, N-Dimethyl- (3-hydroxy-3-oxo-pentanoic acid) amide of the title compound of Example 1c are reacted with a catalyst (prepared from 75 mg RuCl 2 (Ph) 2 and 190 mg S-BiNAP according to R. Selke, Angew Chem. 1998, 110, 1927-1930) (2 d at 40 ° C / 100 bar). Yield: Quantative
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Abstract
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Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA04000954A MXPA04000954A (es) | 2001-08-03 | 2002-08-05 | 3,5-dibidroxi-2,2-dimetil-valeroamidas protegidas para la sintesis de epotilonas y derivados, un procedimiento para su preparacion y el empleo de las mismas. |
IL16015902A IL160159A0 (en) | 2001-08-03 | 2002-08-05 | Protected 3,5-dihydroxy-2.2-dimethyl-valeroamides for synthesis of epothilone and derivatives and method for their production and use thereof |
EP02774500A EP1412322A2 (de) | 2001-08-03 | 2002-08-05 | Geschützte 3,5-dihydroxy-2,2-dimethyl-valeroamide für die synthese von epothilonen und derivaten und verfarhen zur herstellung und die verwendung |
JP2003519015A JP2004537589A (ja) | 2001-08-03 | 2002-08-05 | エポチロン及びエポチロン誘導体の合成のための保護された3,5−ジヒドロキシ−2,2−ジメチル−バレロニトリル、その生成方法及び使用 |
BR0211649-9A BR0211649A (pt) | 2001-08-03 | 2002-08-05 | 3,5-dihidróxi-2,2-dimetil-valeroamidas protegidas, para a sìntese de epotilonas e derivados e processos para produção e o uso |
KR10-2004-7001710A KR20040029394A (ko) | 2001-08-03 | 2002-08-05 | 에포틸론 및 유도체의 합성을 위한 보호3,5-디히드록시-2,2-디메틸-발레로아미드 및 그의 제조방법 및 용도 |
CA002456255A CA2456255A1 (en) | 2001-08-03 | 2002-08-05 | Protected 3.5-dihydroxy-2.2-dimethyl-valeroamides for the synthesis of epothilone and derivatives and method for the production and use thereof |
NO20040912A NO20040912L (no) | 2001-08-03 | 2004-03-02 | Beskyttede 3,5-dihydroksy-2,2-dimetyl-valeroamider for syntese av epotiloner og derivater derav, og fremgangsmate for fremstilling og andvendelse derav. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10138348.7 | 2001-08-03 | ||
DE10138348A DE10138348A1 (de) | 2001-08-03 | 2001-08-03 | Geschützte 3,5-Dihydroxy-2,2-dimethyl-valeroamide für die Synthese von Epothilonen und Derivaten und Verfahren zur Herstellung und die Verwendung |
Publications (2)
Publication Number | Publication Date |
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WO2003014063A2 true WO2003014063A2 (de) | 2003-02-20 |
WO2003014063A3 WO2003014063A3 (de) | 2003-05-01 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2002/008726 WO2003014063A2 (de) | 2001-08-03 | 2002-08-05 | Geschützte 3,5-dihydroxy-2,2-dimethyl-valeroamide für die synthese von epothilonen und derivaten und verfarhen zur herstellung und die verwendung |
Country Status (16)
Country | Link |
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EP (1) | EP1412322A2 (de) |
JP (1) | JP2004537589A (de) |
KR (1) | KR20040029394A (de) |
CN (2) | CN1807403A (de) |
AR (1) | AR036207A1 (de) |
BR (1) | BR0211649A (de) |
CA (1) | CA2456255A1 (de) |
DE (1) | DE10138348A1 (de) |
IL (1) | IL160159A0 (de) |
MX (1) | MXPA04000954A (de) |
NO (1) | NO20040912L (de) |
PE (1) | PE20030345A1 (de) |
PL (1) | PL367430A1 (de) |
RU (1) | RU2004106530A (de) |
WO (1) | WO2003014063A2 (de) |
ZA (1) | ZA200401727B (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6730803B2 (en) | 2001-09-28 | 2004-05-04 | Sumika Fine Chemicals Co., Ltd. | Synthetic intermediate for epothilone derivative and production method thereof |
WO2004108697A1 (de) * | 2003-06-07 | 2004-12-16 | Schering Aktiengesellschaft | Geschützte 5,7-dihydroxy-4,4-dimethyl-3-oxoheptansäureester und 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptansäureester für die synthese von epothilonen- und derivaten und verfahren zur herstellung dieser ester |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
CN110857276B (zh) * | 2018-08-22 | 2021-03-02 | 中国科学院化学研究所 | 一类手性β-羟基酰胺类化合物及其制备方法与应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000058254A1 (en) * | 1999-03-29 | 2000-10-05 | The University Of Kansas | Synthesis of epothilones |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US4824980A (en) * | 1988-09-02 | 1989-04-25 | Dow Corning Corporation | Process to produce O-silyl O,N-ketene acetals |
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2001
- 2001-08-03 DE DE10138348A patent/DE10138348A1/de not_active Withdrawn
-
2002
- 2002-08-02 AR ARP020102940A patent/AR036207A1/es unknown
- 2002-08-02 PE PE2002000704A patent/PE20030345A1/es not_active Application Discontinuation
- 2002-08-05 MX MXPA04000954A patent/MXPA04000954A/es unknown
- 2002-08-05 KR KR10-2004-7001710A patent/KR20040029394A/ko not_active Application Discontinuation
- 2002-08-05 EP EP02774500A patent/EP1412322A2/de not_active Withdrawn
- 2002-08-05 CA CA002456255A patent/CA2456255A1/en not_active Abandoned
- 2002-08-05 PL PL02367430A patent/PL367430A1/xx unknown
- 2002-08-05 RU RU2004106530/04A patent/RU2004106530A/ru not_active Application Discontinuation
- 2002-08-05 WO PCT/EP2002/008726 patent/WO2003014063A2/de active Application Filing
- 2002-08-05 IL IL16015902A patent/IL160159A0/xx unknown
- 2002-08-05 BR BR0211649-9A patent/BR0211649A/pt not_active IP Right Cessation
- 2002-08-05 JP JP2003519015A patent/JP2004537589A/ja active Pending
- 2002-08-05 CN CNA2005100764590A patent/CN1807403A/zh active Pending
- 2002-08-05 CN CNA028152379A patent/CN1538952A/zh active Pending
-
2004
- 2004-03-02 NO NO20040912A patent/NO20040912L/no not_active Application Discontinuation
- 2004-03-02 ZA ZA200401727A patent/ZA200401727B/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000058254A1 (en) * | 1999-03-29 | 2000-10-05 | The University Of Kansas | Synthesis of epothilones |
Non-Patent Citations (3)
Title |
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A. FÜRSTNER ET AL.: "Concise total synthesis of epothilone A and C based on alkyne metathesis" CHEM. COMMUN., 2001, Seiten 1057-9, XP002227326 in der Anmeldung erwähnt * |
J. MULZER ET AL.: "Total Synthesis of Epothilones B and D" J. ORG. CHEM., Bd. 65, Nr. 22, 2000, Seiten 7456-67, XP002218886 in der Anmeldung erwähnt * |
R. E. TAYLOR, YUE CHEN: "Total Synthesis of Epothilones B and D" ORGANIC LETTERS, Bd. 3, Nr. 14, 2001, Seiten 2221-4, XP002227325 in der Anmeldung erwähnt * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6730803B2 (en) | 2001-09-28 | 2004-05-04 | Sumika Fine Chemicals Co., Ltd. | Synthetic intermediate for epothilone derivative and production method thereof |
WO2004108697A1 (de) * | 2003-06-07 | 2004-12-16 | Schering Aktiengesellschaft | Geschützte 5,7-dihydroxy-4,4-dimethyl-3-oxoheptansäureester und 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptansäureester für die synthese von epothilonen- und derivaten und verfahren zur herstellung dieser ester |
JP2006527180A (ja) * | 2003-06-07 | 2006-11-30 | シエーリング アクチエンゲゼルシャフト | エポチロン及びエポチロン誘発体の合成のための保護された5,7−ジヒドロキシ−4,4−ジメチル−3−オキソヘプタン酸エステル及び5,7−ジヒドロキシ−2−アルキル−4,4−ジメチル−3−オキソヘプタン酸エステル、及びそれらのエステルの生成方法 |
US7595418B2 (en) | 2003-06-07 | 2009-09-29 | Bayer Schering Pharma Aktiengesellschaft | Protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid esters and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoci acid esters for the synthesizing of epothilone and epothilone derivatives and process for the production of these esters |
Also Published As
Publication number | Publication date |
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PE20030345A1 (es) | 2003-04-10 |
WO2003014063A3 (de) | 2003-05-01 |
BR0211649A (pt) | 2004-07-13 |
PL367430A1 (en) | 2005-02-21 |
CA2456255A1 (en) | 2003-02-20 |
MXPA04000954A (es) | 2004-04-20 |
EP1412322A2 (de) | 2004-04-28 |
RU2004106530A (ru) | 2005-07-27 |
CN1538952A (zh) | 2004-10-20 |
AR036207A1 (es) | 2004-08-18 |
IL160159A0 (en) | 2004-07-25 |
NO20040912L (no) | 2004-03-02 |
CN1807403A (zh) | 2006-07-26 |
DE10138348A1 (de) | 2003-02-27 |
JP2004537589A (ja) | 2004-12-16 |
KR20040029394A (ko) | 2004-04-06 |
ZA200401727B (en) | 2005-04-12 |
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