BR0208140A - Polipeptìdeo, agente imunoterapêutico para o tratamento de psorìase, sequência de ácido nucléico isolada ou seu complemento, vetores de filamento único, e de filamento duplo, sequência de ácido nucléico isolada ou variante imunogênica da mesma, métodos para a produção de polipeptìdeos, e para o tratamento e a remissão clìnica de psorìase, e, célula hospedeira microbiana - Google Patents
Polipeptìdeo, agente imunoterapêutico para o tratamento de psorìase, sequência de ácido nucléico isolada ou seu complemento, vetores de filamento único, e de filamento duplo, sequência de ácido nucléico isolada ou variante imunogênica da mesma, métodos para a produção de polipeptìdeos, e para o tratamento e a remissão clìnica de psorìase, e, célula hospedeira microbianaInfo
- Publication number
- BR0208140A BR0208140A BR0208140-7A BR0208140A BR0208140A BR 0208140 A BR0208140 A BR 0208140A BR 0208140 A BR0208140 A BR 0208140A BR 0208140 A BR0208140 A BR 0208140A
- Authority
- BR
- Brazil
- Prior art keywords
- psoriasis
- nucleic acid
- treatment
- polypeptides
- clinical remission
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"POLIPEPTìDEO, AGENTE IMUNOTERAPêUTICO PARA O TRATAMENTO DE PSORìASE, SEQuêNCIA DE áCIDO NUCLéICO ISOLADA OU SEU COMPLEMENTO, VETORES DE FILAMENTO úNICO, E DE FILAMENTO DUPLO, SEQuêNCIA DE áCIDO NUCLéICO ISOLADA OU VARIANTE IMUNOGêNICA DA MESMA, MéTODOS PARA A PRODUçãO DE POLIPEPTìDEOS, E PARA O TRATAMENTO E A REMISSãO CLìNICA DE PSORìASE, E, CéLULA HOSPEDEIRA MICROBIANA" Polipeptídeos, que compreendem seq³ências de aminoácido de antígenos em partículas a partir de várias espécies de Leshmania protozoa, ou variantes imunogênicas dos mesmos, são expostos para o tratamento e a remissão clínica de psoríase. São também expostas seq³ências de ácido nucléico, que codificam os referidos polipeptídeos, vetores que incorporam tais seq³ências de ácido nucléico, métodos para a engenharia genética de células hospedeiras microbianas para produzir tais polipeptídeos, e tais células hospedeiras microbianas recombinantes. Em outra modalidade, agentes imunoterapêuticos, que incorporam os polipeptídeos ou as seq³ências de ácido nucléico são expostos para o tratamento e a remissão clínica de psoríase. Em outra modalidade, métodos para a produção dos polipeptídeos usando células hospedeiras microbianas recombinantes são expostos. Finalmente, métodos para o tratamento e a remissão clínica de psoríase, que compreendem a administração de uma composição farmacêutica, que compreende um ou mais dos polipeptídeos ou uma ou mais das seq³ências de ácido nucléico são expostas. Os polipeptídeos induziram uma resposta imune celular de THI, uma reação intradérmica positiva, e uma resposta blastogênica em linfócitos do sangue periférico após a remissão clínica de lesões. Populações de linfócitos do sangue periférico, que são alteradas em pacientes com psoríase, retomaram a valores normais em pacientes, que receberam os polipeptídeos e experimentaram remissão clínica de lesões após o tratamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/809,003 US6673351B1 (en) | 2001-03-16 | 2001-03-16 | Compositions and methods for the treatment and clinical remission of psoriasis |
| PCT/US2002/006496 WO2002074239A2 (en) | 2001-03-16 | 2002-03-04 | Compositions and methods for the treatment and clinical remission of psoriasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0208140A true BR0208140A (pt) | 2005-12-13 |
Family
ID=25200314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0208140-7A BR0208140A (pt) | 2001-03-16 | 2002-03-04 | Polipeptìdeo, agente imunoterapêutico para o tratamento de psorìase, sequência de ácido nucléico isolada ou seu complemento, vetores de filamento único, e de filamento duplo, sequência de ácido nucléico isolada ou variante imunogênica da mesma, métodos para a produção de polipeptìdeos, e para o tratamento e a remissão clìnica de psorìase, e, célula hospedeira microbiana |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6673351B1 (pt) |
| EP (1) | EP1458403A4 (pt) |
| JP (1) | JP2004535783A (pt) |
| AU (1) | AU2002254097B2 (pt) |
| BR (1) | BR0208140A (pt) |
| CA (1) | CA2439916A1 (pt) |
| MX (1) | MXPA03008122A (pt) |
| WO (1) | WO2002074239A2 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040241168A1 (en) * | 2001-03-16 | 2004-12-02 | O'daly Jose A. | Compositions and methods for the treatment and clinical remission of psoriasis |
| US20050176144A1 (en) * | 2004-02-06 | 2005-08-11 | O'daly Jose A. | Culture media compositions free of fetal bovine serum |
| US20080159979A1 (en) * | 2005-08-04 | 2008-07-03 | Moore Emma E | Treatment of wounds using il-17b |
| US20140356391A1 (en) * | 2013-05-29 | 2014-12-04 | Jose Antonio O'Daly | Amino acid sequences for clinical remission of psoriasis and related diseases. |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0135108A3 (en) | 1983-08-12 | 1988-07-13 | Rockefeller University | Nucleotide hybridization assay for protozoan parasites |
| WO1986002098A1 (fr) * | 1984-10-01 | 1986-04-10 | Institut Pasteur | Anticorps monoclonaux anti-leishmania, hybridomes secreteurs de ces anticorps, antigenes de leishmania reconnus par ces anticorps, procede d'obtention et applications de ces anticorps monoclonaux et de ces antigenes |
| FR2570947B1 (fr) | 1984-10-01 | 1987-10-02 | Univ Paris Curie | Anticorps monoclonaux anti-leishmania, hybridomes secreteurs de ces anticorps, antigenes de leishmania reconnus par ces anticorps, procede d'obtention et applications de ces anticorps monoclonaux et de ces antigenes |
| US4687666A (en) | 1985-02-19 | 1987-08-18 | Ministerio De Sanidad Y Asistencia Social Instituto Venezolano De Investigationes Cientificas | Vaccine for Leishmaniasis |
| DE3702641A1 (de) | 1987-01-29 | 1988-08-11 | Max Planck Gesellschaft | Parasitose-impfstoff |
| FR2612779B1 (fr) | 1987-03-25 | 1991-05-24 | Univ Paris Curie | Materiel biologique a base de leishmanies et procede pour la production de vaccins anti-leishmaniens |
| FR2615103B1 (fr) | 1987-05-15 | 1990-12-07 | Pasteur Institut | Procede de production de fractions de leishmania presentant des activites immunogenes et lymphoproliferatives et fractions obtenues par ce procede |
| IL82740A0 (en) | 1987-06-01 | 1987-12-20 | Yeda Res & Dev | Assay for leishmaniasis |
| US5726292A (en) | 1987-06-23 | 1998-03-10 | Lowell; George H. | Immuno-potentiating systems for preparation of immunogenic materials |
| FR2619220B1 (fr) | 1987-08-03 | 1993-03-26 | Pasteur Institut | Antigenes specifiques de leishmania et leur procede de preparation, profils antigeniques contenant ces antigenes et leur application au diagnostic des leishmanioses viscerales. |
| US5202320A (en) | 1989-04-06 | 1993-04-13 | Tidwell Richard R | Method for treating leishmaniasis |
| US5674503A (en) | 1990-07-24 | 1997-10-07 | University Of Victoria | Peptides capable of eliciting an immune response to leishmaniasis and methods of using the same |
| FR2682107B1 (fr) | 1991-10-03 | 1995-04-21 | Orstom Inst Fs Rech Scient | Quinoleines 2-substituees pour le traitement des leishmanioses. |
| US5411865A (en) | 1993-01-15 | 1995-05-02 | Iasys Corporation | Method of detecting anti-leishmania parasite antibodies |
| DK99993D0 (da) | 1993-09-03 | 1993-09-03 | Statens Seruminstitut | Treatment and prophylaxis of diseases caused by parasites or bacteria |
| ATE236252T1 (de) | 1993-09-03 | 2003-04-15 | Univ Mcgill | Differentiell exprimierte leishmania gene und proteinen |
| US5961979A (en) | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US5571515A (en) | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
| US6013268A (en) | 1994-04-22 | 2000-01-11 | Corixa Corporation | Methods for enhancement of protective immune responses |
| US5876735A (en) | 1994-04-22 | 1999-03-02 | Corixa Corporation | Methods for enhancement of protective immune responses |
| WO1995029699A1 (en) | 1994-04-29 | 1995-11-09 | Curtis Powell | Vaccine for, diagnostic assay for and method of treating parasitic hemoflagellate protozoa |
| FR2719313B1 (fr) | 1994-05-02 | 1996-07-19 | Centre Nat Rech Scient | Protéine majeure de leishmanies, acide nucléique codant pour cette protéine et leurs applications. |
| US6174995B1 (en) | 1994-08-23 | 2001-01-16 | Haodong Li | Human chemokines, CKβ4 and CKβ10/MCP-4 |
| US5496830A (en) | 1994-09-14 | 1996-03-05 | Johns Hopkins University | Inhibition of hemoflagellates by camptothecin compounds |
| EP0703295A1 (en) | 1994-09-26 | 1996-03-27 | Institut Pasteur | Vaccine composition comprising recombinant BCG expressing gp 63 fusion protein |
| US5674748A (en) | 1995-03-14 | 1997-10-07 | Thomas Jefferson University | Human cyclin-dependent kinase-like proteins and methods of using the same |
| US5912166A (en) | 1995-04-21 | 1999-06-15 | Corixa Corporation | Compounds and methods for diagnosis of leishmaniasis |
| US5928928A (en) | 1995-06-07 | 1999-07-27 | Universiteit Van Amsterdam | Human chitinase, its recombinant production, its use for decomposing chitin, its use in therapy or prophylaxis against infection diseases |
| US5965142A (en) | 1995-08-04 | 1999-10-12 | Corixa Corporation | Polypeptides and methods for the detection of L. tropica infection |
| US5658952A (en) | 1995-08-29 | 1997-08-19 | Jacobus Pharmaceutical Co., Inc. | 1-[4-(4'-sulfanilyl)phenyl]urea and derivatives for the treatment of Leishmaniasis |
| US5834592A (en) | 1995-09-22 | 1998-11-10 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis |
| US5767097A (en) | 1996-01-23 | 1998-06-16 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes |
| US6162638A (en) | 1996-05-06 | 2000-12-19 | Universite Laval | Attenuated strains of leishmania and uses thereof |
| US5952194A (en) | 1996-08-01 | 1999-09-14 | Heska Corporation | Flea nucleic acid sequences and uses thereof |
| EP2284186A1 (en) * | 1997-02-12 | 2011-02-16 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis |
| WO1998043656A1 (en) | 1997-04-02 | 1998-10-08 | Bioniche Inc. | Use of bacterial cell wall extract for preventing, treating, or eliminating a protozoal or parasitic disease |
| US5854051A (en) | 1997-09-15 | 1998-12-29 | Heska Corporation | Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof |
| US6087341A (en) | 1998-02-12 | 2000-07-11 | The Board Of Trustees Of The Leland Standford Junior University | Introduction of nucleic acid into skin cells by topical application |
| US5994081A (en) * | 1998-04-27 | 1999-11-30 | Incyte Pharamaceuticals, Inc. | Human keratins |
| DE69940793D1 (de) | 1998-12-23 | 2009-06-04 | Leti Sl Lab | Chimärisches Gen, dass für die antigenischen Determinanten von vier Proteinen aus L. Infantum kodiert |
| EP1114862A3 (de) * | 1999-11-17 | 2003-08-06 | Switch Biotech Aktiengesellschaft | Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankungen sowie ihre Verwendung zur Identifizierung von pharmakologisch aktiven Substanzen |
-
2001
- 2001-03-16 US US09/809,003 patent/US6673351B1/en not_active Expired - Fee Related
-
2002
- 2002-03-04 MX MXPA03008122A patent/MXPA03008122A/es not_active Application Discontinuation
- 2002-03-04 EP EP02723312A patent/EP1458403A4/en not_active Withdrawn
- 2002-03-04 CA CA002439916A patent/CA2439916A1/en not_active Abandoned
- 2002-03-04 WO PCT/US2002/006496 patent/WO2002074239A2/en active Search and Examination
- 2002-03-04 BR BR0208140-7A patent/BR0208140A/pt not_active IP Right Cessation
- 2002-03-04 JP JP2002572950A patent/JP2004535783A/ja active Pending
- 2002-03-04 AU AU2002254097A patent/AU2002254097B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002254097B2 (en) | 2006-09-14 |
| EP1458403A4 (en) | 2005-02-09 |
| WO2002074239A2 (en) | 2002-09-26 |
| MXPA03008122A (es) | 2004-11-12 |
| CA2439916A1 (en) | 2002-09-26 |
| WO2002074239A3 (en) | 2004-07-22 |
| EP1458403A2 (en) | 2004-09-22 |
| JP2004535783A (ja) | 2004-12-02 |
| US6673351B1 (en) | 2004-01-06 |
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Legal Events
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| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 7A E 8A ANUIDADES |
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