WO1998004692A3 - Human neuronatin - Google Patents

Human neuronatin Download PDF

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Publication number
WO1998004692A3
WO1998004692A3 PCT/US1997/012735 US9712735W WO9804692A3 WO 1998004692 A3 WO1998004692 A3 WO 1998004692A3 US 9712735 W US9712735 W US 9712735W WO 9804692 A3 WO9804692 A3 WO 9804692A3
Authority
WO
WIPO (PCT)
Prior art keywords
hneu
provides
expression
polynucleotide
treatment
Prior art date
Application number
PCT/US1997/012735
Other languages
French (fr)
Other versions
WO1998004692A2 (en
Inventor
Roger Coleman
Susan G Stuart
Original Assignee
Incyte Pharma Inc
Roger Coleman
Susan G Stuart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Roger Coleman, Susan G Stuart filed Critical Incyte Pharma Inc
Priority to AU38069/97A priority Critical patent/AU3806997A/en
Publication of WO1998004692A2 publication Critical patent/WO1998004692A2/en
Publication of WO1998004692A3 publication Critical patent/WO1998004692A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a polynucleotide which identifies and encodes a novel human neuronatin (HNEU). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HNEU. The invention also provides for the use of substantially purified HNEU and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HNEU. Additionally, the invention provides for the use of antisense molecules to HNEU in pharmaceutical compositions for treatment of diseases associated with the expression of HNEU. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HNEU or anti-HNEU antibodies which specifically bind to HNEU.
PCT/US1997/012735 1996-07-31 1997-07-21 Human neuronatin WO1998004692A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38069/97A AU3806997A (en) 1996-07-31 1997-07-21 Human neuronatin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69009496A 1996-07-31 1996-07-31
US08/690,094 1996-07-31

Publications (2)

Publication Number Publication Date
WO1998004692A2 WO1998004692A2 (en) 1998-02-05
WO1998004692A3 true WO1998004692A3 (en) 1998-10-08

Family

ID=24771058

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012735 WO1998004692A2 (en) 1996-07-31 1997-07-21 Human neuronatin

Country Status (2)

Country Link
AU (1) AU3806997A (en)
WO (1) WO1998004692A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1399178A2 (en) * 2001-06-07 2004-03-24 Azign Bioscience A/S Method of treating metabolic disorders using neuronatin polypeptides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034640A1 (en) * 1994-06-13 1995-12-21 Henry Ford Health System A novel neuronal-neonatal gene: neuronatin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995034640A1 (en) * 1994-06-13 1995-12-21 Henry Ford Health System A novel neuronal-neonatal gene: neuronatin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOSEPH R. AND DOU D.: "Neuronatin is a novel "proteolipid" involved in human neurogenesis", NEUROLOGY, vol. 46, no. 2, February 1996 (1996-02-01), pages A148, XP002065834 *
JOSEPH R. ET AL.: "Molecular cloning of a novel mRNA (Neuronatin) that is highly expressed in neonatal mammalian brain", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 201, no. 3, 30 June 1994 (1994-06-30), pages 1227 - 1234, XP002065470 *

Also Published As

Publication number Publication date
AU3806997A (en) 1998-02-20
WO1998004692A2 (en) 1998-02-05

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