BR0207270A - Compostos de triazol como inibidores de mmp - Google Patents

Compostos de triazol como inibidores de mmp

Info

Publication number
BR0207270A
BR0207270A BR0207270-0A BR0207270A BR0207270A BR 0207270 A BR0207270 A BR 0207270A BR 0207270 A BR0207270 A BR 0207270A BR 0207270 A BR0207270 A BR 0207270A
Authority
BR
Brazil
Prior art keywords
description
group
triazole compounds
optionally
mmp inhibitors
Prior art date
Application number
BR0207270-0A
Other languages
English (en)
Inventor
Charles Andrianjara
Henry Jacobelli
Bernard Gaudilliere
Francine Breuzard
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0207270A publication Critical patent/BR0207270A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTOS DE TRIAZOL COMO INIBIDORES DE MMP". Um composto selecionado daqueles da fórmula (I): na qual W representa N ou C-R~ 1~; no qual R~ 1~ é como definido na descrição, X representa N ou C-R~ 2~ no qual R~ 2~ é como definido na descrição, X representa N ou C-R~ 2~ no qual R~ 2~ é como definido na descrição, Y representa um grupo selecionado de oxigênio, enxofre, -NH, e -Nalquila, Z representa um grupo selecionado de oxigênio, enxofre, -NR~ 8~ no qual R~ 8~ é como definido na descrição, e opcionalmente carbono dependendo da definição de Y, n é um número inteiro de 0 a 8 inclusive, Z, representa um grupo -CR~ 9~R~ 10~ onde R~ 9~ e R~ 10~, são como definidos na descrição, cujo grupo contém opcionalmente ligações múltiplas ou heteroátomos, A representa um grupo cíclico, m é um número inteiro de 0 a 7 inclusive, os grupos R~ 4~ são como definidos na descrição, R~ 3~ representa um grupo selecionado de hidrogênio, alquila, alquenila, alquinila, e o grupo da fórmula (II): na qual p, Z~ 2~, B, q e R~ 13~ são como definidos na descrição, opcionalmente, suas formas racêmicas, isómeros destes, N-óxidos destes, e seus sais farmaceuticamente aceitáveis destes, e produtos médicos contendo o mesmo são úteis como inibidores específicos de metaloprotease de matriz-13.
BR0207270-0A 2001-02-14 2002-02-11 Compostos de triazol como inibidores de mmp BR0207270A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26875701P 2001-02-14 2001-02-14
PCT/EP2002/001961 WO2002064595A1 (en) 2001-02-14 2002-02-11 Triazolo compounds as mmp inhibitors

Publications (1)

Publication Number Publication Date
BR0207270A true BR0207270A (pt) 2004-02-10

Family

ID=23024335

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207270-0A BR0207270A (pt) 2001-02-14 2002-02-11 Compostos de triazol como inibidores de mmp

Country Status (15)

Country Link
US (1) US6849637B2 (pt)
EP (1) EP1362048B1 (pt)
JP (1) JP2004521908A (pt)
AR (1) AR032677A1 (pt)
AT (1) ATE294805T1 (pt)
BR (1) BR0207270A (pt)
CA (1) CA2437588A1 (pt)
DE (1) DE60203995T2 (pt)
ES (1) ES2239216T3 (pt)
HN (1) HN2002000038A (pt)
MX (1) MXPA03007249A (pt)
PA (1) PA8539501A1 (pt)
PE (1) PE20020885A1 (pt)
SV (1) SV2002000875A (pt)
WO (1) WO2002064595A1 (pt)

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AU2003249505A1 (en) * 2002-07-17 2004-02-02 Warner-Lambert Company Llc Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
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PA8578101A1 (es) 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
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WO2004014908A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Heterobicylcic metalloproteinase inhibitors
EP1530472A1 (en) * 2002-08-13 2005-05-18 Warner-Lambert Company LLC Isoquinoline derivatives as matrix metalloproteinase inhibitors
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AU2003249539A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors
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Also Published As

Publication number Publication date
MXPA03007249A (es) 2005-02-14
DE60203995D1 (de) 2005-06-09
US20020151558A1 (en) 2002-10-17
ATE294805T1 (de) 2005-05-15
HN2002000038A (es) 2002-09-05
JP2004521908A (ja) 2004-07-22
AR032677A1 (es) 2003-11-19
SV2002000875A (es) 2002-10-04
EP1362048B1 (en) 2005-05-04
DE60203995T2 (de) 2005-09-22
US6849637B2 (en) 2005-02-01
PE20020885A1 (es) 2002-10-26
PA8539501A1 (es) 2002-09-30
CA2437588A1 (en) 2002-08-22
EP1362048A1 (en) 2003-11-19
WO2002064595A1 (en) 2002-08-22
ES2239216T3 (es) 2005-09-16

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O E 7O ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2029 DE 24/11/2009.