AR032677A1 - Compuestos triazolo como inhibidores de mmp - Google Patents

Compuestos triazolo como inhibidores de mmp

Info

Publication number
AR032677A1
AR032677A1 ARP020100471A ARP020100471A AR032677A1 AR 032677 A1 AR032677 A1 AR 032677A1 AR P020100471 A ARP020100471 A AR P020100471A AR P020100471 A ARP020100471 A AR P020100471A AR 032677 A1 AR032677 A1 AR 032677A1
Authority
AR
Argentina
Prior art keywords
formula
compound
group
sulfur
oxygen
Prior art date
Application number
ARP020100471A
Other languages
English (en)
Inventor
Henry Jacobelli
Francine Breuzard
Charles Andrianjara
Bernard Gaudilliere
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR032677A1 publication Critical patent/AR032677A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de quinazolina ciclada de formula (1) en donde: W representa N o C-R1; en donde R1 es como se define en la memoria; X representa N o C-R2; en donde R2 es como se define en la memoria; Y representa un grupo seleccionado de oxígeno, azufre, -NH y -N alquilo C1-6; Z representa un grupo seleccionado de: oxígeno, azufre y -NR8, en donde R8 es como se define en la memoria; n es un entero de 0 a 8 inclusive; Z1 representa un grupo -CR9R10, en donde R9 y R10, idénticos o diferentes, son como se definen en la memoria; A representa un grupo seleccionado de monociclo aromático o no aromático con 5 o 6 miembros, que abarca de 0 a 4 heteroátomos seleccionados de nitrogeno, oxígeno, y azufre; y biciclo, compuestos de dos anillos aromáticos o no aromáticos con 5 o 6 miembros, que pueden ser idénticos o diferentes, que abarcan de 0 a 4 heteroátomos seleccionados de nitrogeno, oxígeno y azufre; m es un entero de 0 a 7 inclusive; R4 puede ser idéntico o diferente, seleccionado de alquilo C1-6, halogeno, -CN, -NO2, -SCF3, -OCF3, -NR5R11, -OR5, -SR5, -SOR5, -SO2R5, -(CH2)kSO2NR5R11, -X1(CH2)kC(=O)OR5, -(CH2)kC(=O)OR5, -X1(CH2)kC(=O)R5R11, -(CH2)kC(=O)R5R11, y -X2-R12; en donde, X1, k, R5, R11, X2 y R12 son como se definen en la memoria; y R3 representa un grupo seleccionado de: hidrogeno, C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, los que pueden estar opcionalmente sustituidos por uno o más grupos tal como se define en la memoria; y el grupo de la formula (2) en donde, p, Z2, B, q y R13 son como se definen en la memoria. Proceso para la fabricacion del compuesto general de la formula (1) donde W, X, R3, R4, n, m, Z1 y A aparecen ya definidas , Y es O y Z es O, dicho proceso abarca la reaccion del compuesto de formula (3), en donde W, X, y R3 aparecen de acuerdo a lo definido en la formula (1), con el componente (4) para proporcionar el compuesto general de la formula (5) el cual es un caso particular de los compuestos de la formula (1). Composicion farmacéutica que comprende dicho compuesto y un excipiente aceptable. Uso de dicho compuesto para la preparacion de un producto medicinal creado para el tratamiento de una enfermedad o mal que incluye terapia por inhibicion de la matriz del tipo metaloproteasa-13. Dicho compuesto es de aplicacion para tratar artritis, artritis reumatoidea, osteoartritis, osteoporosis, enfermedades periodontales, enfermedades intestinales, psoriasis, esclerosis multiple, insuficiencia cardíaca, arteriosclerosis, asma, enfermedades pulmonares cronicas, degeneracion muscular originada por la edad y cáncer.
ARP020100471A 2001-02-14 2002-02-13 Compuestos triazolo como inhibidores de mmp AR032677A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26875701P 2001-02-14 2001-02-14

Publications (1)

Publication Number Publication Date
AR032677A1 true AR032677A1 (es) 2003-11-19

Family

ID=23024335

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020100471A AR032677A1 (es) 2001-02-14 2002-02-13 Compuestos triazolo como inhibidores de mmp

Country Status (15)

Country Link
US (1) US6849637B2 (es)
EP (1) EP1362048B1 (es)
JP (1) JP2004521908A (es)
AR (1) AR032677A1 (es)
AT (1) ATE294805T1 (es)
BR (1) BR0207270A (es)
CA (1) CA2437588A1 (es)
DE (1) DE60203995T2 (es)
ES (1) ES2239216T3 (es)
HN (1) HN2002000038A (es)
MX (1) MXPA03007249A (es)
PA (1) PA8539501A1 (es)
PE (1) PE20020885A1 (es)
SV (1) SV2002000875A (es)
WO (1) WO2002064595A1 (es)

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PA8539501A1 (es) 2001-02-14 2002-09-30 Warner Lambert Co Compuestos triazolo como inhibidores de mmp
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US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
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MXPA05000754A (es) * 2002-07-17 2005-04-19 Warner Lambert Co Combinacion de un inhibidor carboxilico alosterico de la metaloproteinasa de matriz-13 con celecoxib o valdecoxib.
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WO2004014923A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Pyrimidinone fused bicyclic metalloproteinase inhibitors
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PA8578101A1 (es) 2002-08-13 2004-05-07 Warner Lambert Co Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
MXPA05001785A (es) 2002-08-13 2005-04-25 Warner Lambert Co Derivados de cromona como inhibidores de las metaloproteinasas de matriz.
AU2003250471A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors
MXPA05001784A (es) * 2002-08-13 2005-04-25 Warner Lambert Co Derivados de isoquinolina como inhibidores de metaloproteinasa de matriz.
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WO2004014908A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Heterobicylcic metalloproteinase inhibitors
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WO2004014909A1 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Fused tetrahydropyridine derivatives as matrix metalloproteinase inhibitors
AU2003253176A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Monocyclic derivatives as matrix metalloproteinase inhibitors
BR0313724A (pt) 2002-08-13 2005-06-28 Warner Lambert Co Derivados de azaisoquinolina como inibidores de metaloproteinase de matriz
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US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US20040006077A1 (en) 2002-06-25 2004-01-08 Bernard Gaudilliere Thiazine and oxazine derivatives as MMP-13 inhibitors
WO2004000321A1 (en) 2002-06-25 2003-12-31 Warner-Lambert Company Llc Thiazine and oxazine derivatives as mmp-13 inhibitors for treating arthritis
WO2004014384A2 (en) 2002-08-13 2004-02-19 Warner-Lambert Company Llc Cyclic compounds containing zinc binding groups as matrix metalloproteinase inhibitors

Also Published As

Publication number Publication date
US6849637B2 (en) 2005-02-01
BR0207270A (pt) 2004-02-10
PA8539501A1 (es) 2002-09-30
WO2002064595A1 (en) 2002-08-22
PE20020885A1 (es) 2002-10-26
ATE294805T1 (de) 2005-05-15
EP1362048B1 (en) 2005-05-04
JP2004521908A (ja) 2004-07-22
MXPA03007249A (es) 2005-02-14
EP1362048A1 (en) 2003-11-19
HN2002000038A (es) 2002-09-05
ES2239216T3 (es) 2005-09-16
US20020151558A1 (en) 2002-10-17
DE60203995D1 (de) 2005-06-09
CA2437588A1 (en) 2002-08-22
SV2002000875A (es) 2002-10-04
DE60203995T2 (de) 2005-09-22

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