BR0206311A - Composto, composição farmacêutica, e, utilização de um composto - Google Patents
Composto, composição farmacêutica, e, utilização de um compostoInfo
- Publication number
- BR0206311A BR0206311A BR0206311-5A BR0206311A BR0206311A BR 0206311 A BR0206311 A BR 0206311A BR 0206311 A BR0206311 A BR 0206311A BR 0206311 A BR0206311 A BR 0206311A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- notably
- representing
- radicals
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, UTILIZAçãO DE UM COMPOSTO". A invenção tem por objeto novos derivados de micanolídeo, seus processos de preparação assim como suas aplicações terapêuticas, notadamente como agentes anti-cancerosos e anti-virais. Os compostos da invenção respondem à fórmula geral (1) correspondendo às sub-fórmulas gerais (1)~ 1~ e (I)~ 2~ em que R~ 1~ representa H, SR~ 4~, ou NR~ 4~R~ 5~, R~ 2~ representa SR~ 6~ ou NR~ 6~R~ 7~; R~ 3~ representa OH, O(CO)R~ 14~, OSiR~ 15~R~ 16~R~ 17~, O(CO)OR~ 18~ ou O(CO)NHR~ 18~; cada um dos radicais R~ 4~, R~ 6~, R~ 15~, R~ 16~ e R~ 17~ representando independentemente (notadamente) um radical alquila, os radicais R~ 5~ e R~ 7~ representando (notadamente) os radicais escolhidos independentemente dentre um átomo de hidrogênio e um radical alquila, e cada um dos radicais R~ 14~ e R~ 18~ representando independentemente (notadamente) um radical alquila ou cicloalquila, ou ainda um dos radicais arila, heteroarila, aralquila ou heteroaralquila eventualmente substituidos; sendo entendido todavia que quando os compostos respondem à sub-fórmula geral (I)~ 2~, então R~ 1~ não representa um átomo de hidrogênio.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0100397A FR2819513B1 (fr) | 2001-01-12 | 2001-01-12 | Nouveaux derives du mikanolide, leur preparation et leurs applications therapeutiques |
| FR0114688 | 2001-11-14 | ||
| PCT/FR2002/000092 WO2002055523A1 (fr) | 2001-01-12 | 2002-01-11 | Derives du mikanolide, leur preparation et leurs applications therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0206311A true BR0206311A (pt) | 2004-02-17 |
Family
ID=26212826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0206311-5A BR0206311A (pt) | 2001-01-12 | 2002-01-11 | Composto, composição farmacêutica, e, utilização de um composto |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6887869B2 (pt) |
| EP (1) | EP1353926B1 (pt) |
| JP (1) | JP4418627B2 (pt) |
| KR (1) | KR100859227B1 (pt) |
| CN (1) | CN1234711C (pt) |
| AR (1) | AR035681A1 (pt) |
| AT (1) | ATE319716T1 (pt) |
| AU (1) | AU2002229870B2 (pt) |
| BR (1) | BR0206311A (pt) |
| CA (1) | CA2433981A1 (pt) |
| CZ (1) | CZ20032167A3 (pt) |
| DE (1) | DE60209698T2 (pt) |
| ES (1) | ES2260417T3 (pt) |
| MX (1) | MXPA03006162A (pt) |
| MY (1) | MY130454A (pt) |
| NZ (1) | NZ526690A (pt) |
| PL (1) | PL365342A1 (pt) |
| RU (1) | RU2278121C2 (pt) |
| TW (1) | TWI293302B (pt) |
| WO (1) | WO2002055523A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2369083T3 (es) * | 2003-07-11 | 2011-11-25 | University Of Kentucky Research Foundation | Uso de derivados de partenolida como agentes antileucémicos y citotóxicos. |
| US7678904B2 (en) | 2003-07-11 | 2010-03-16 | University Of Kentucky | Use of parthenolide derivatives as antileukemic and cytotoxic agents |
| CN103004761B (zh) * | 2012-12-27 | 2013-12-04 | 中山火炬职业技术学院 | 一种薇甘菊正丁醇提取物及其制备方法和用途 |
| CN106719727A (zh) * | 2016-12-13 | 2017-05-31 | 安徽东健化工科技有限公司 | 一种除虫剂 |
| CN111484503B (zh) * | 2020-01-10 | 2022-05-27 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一种薇甘菊内酯衍生物及其制备方法和应用 |
| CN115918668B (zh) * | 2022-12-13 | 2024-03-22 | 西南林业大学 | 倍半萜内酯作抗烟草花叶病毒药物的应用及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2801792B1 (fr) | 1999-12-01 | 2003-04-18 | Sod Conseils Rech Applic | Un nouveau medicament, le dihydromikanolide, son obtention par extraction de la plante mikania micrantha et son utilisation comme agent anti-proliferatif |
-
2001
- 2001-12-25 TW TW090132164A patent/TWI293302B/zh active
- 2001-12-31 MY MYPI20015945A patent/MY130454A/en unknown
-
2002
- 2002-01-11 RU RU2003124760/04A patent/RU2278121C2/ru not_active IP Right Cessation
- 2002-01-11 CZ CZ20032167A patent/CZ20032167A3/cs unknown
- 2002-01-11 MX MXPA03006162A patent/MXPA03006162A/es active IP Right Grant
- 2002-01-11 AT AT02710969T patent/ATE319716T1/de not_active IP Right Cessation
- 2002-01-11 WO PCT/FR2002/000092 patent/WO2002055523A1/fr active IP Right Grant
- 2002-01-11 CA CA002433981A patent/CA2433981A1/fr not_active Abandoned
- 2002-01-11 US US10/250,383 patent/US6887869B2/en not_active Expired - Fee Related
- 2002-01-11 NZ NZ526690A patent/NZ526690A/en unknown
- 2002-01-11 PL PL02365342A patent/PL365342A1/xx not_active Application Discontinuation
- 2002-01-11 JP JP2002556192A patent/JP4418627B2/ja not_active Expired - Fee Related
- 2002-01-11 CN CNB02803614XA patent/CN1234711C/zh not_active Expired - Fee Related
- 2002-01-11 AU AU2002229870A patent/AU2002229870B2/en not_active Ceased
- 2002-01-11 DE DE60209698T patent/DE60209698T2/de not_active Expired - Lifetime
- 2002-01-11 EP EP02710969A patent/EP1353926B1/fr not_active Expired - Lifetime
- 2002-01-11 AR ARP020100095A patent/AR035681A1/es unknown
- 2002-01-11 ES ES02710969T patent/ES2260417T3/es not_active Expired - Lifetime
- 2002-01-11 BR BR0206311-5A patent/BR0206311A/pt not_active IP Right Cessation
- 2002-01-11 KR KR1020037009279A patent/KR100859227B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI293302B (en) | 2008-02-11 |
| WO2002055523A1 (fr) | 2002-07-18 |
| RU2003124760A (ru) | 2005-01-10 |
| JP4418627B2 (ja) | 2010-02-17 |
| US6887869B2 (en) | 2005-05-03 |
| DE60209698D1 (de) | 2006-05-04 |
| CN1234711C (zh) | 2006-01-04 |
| CA2433981A1 (fr) | 2002-07-18 |
| NZ526690A (en) | 2005-02-25 |
| US20040122084A1 (en) | 2004-06-24 |
| AR035681A1 (es) | 2004-06-23 |
| AU2002229870B2 (en) | 2006-07-13 |
| RU2278121C2 (ru) | 2006-06-20 |
| ATE319716T1 (de) | 2006-03-15 |
| MXPA03006162A (es) | 2003-09-16 |
| CN1484646A (zh) | 2004-03-24 |
| KR100859227B1 (ko) | 2008-09-18 |
| KR20030066806A (ko) | 2003-08-09 |
| EP1353926A1 (fr) | 2003-10-22 |
| DE60209698T2 (de) | 2006-11-16 |
| CZ20032167A3 (en) | 2004-05-12 |
| MY130454A (en) | 2007-06-29 |
| JP2004520353A (ja) | 2004-07-08 |
| PL365342A1 (en) | 2004-12-27 |
| ES2260417T3 (es) | 2006-11-01 |
| EP1353926B1 (fr) | 2006-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A ANUIDADE |
|
| B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESAPCHO PUBLICADO NA RPI 2025 DE 27/10/2009, ITEM 8.6. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 10A. ANUIDADE(S), |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |