HUP0201242A2 - Antikoaguláns hatású szubsztituált policiklusos aril- és heteroaril-pirimidinon és triazinonvegyületek és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Antikoaguláns hatású szubsztituált policiklusos aril- és heteroaril-pirimidinon és triazinonvegyületek és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0201242A2
HUP0201242A2 HU0201242A HUP0201242A HUP0201242A2 HU P0201242 A2 HUP0201242 A2 HU P0201242A2 HU 0201242 A HU0201242 A HU 0201242A HU P0201242 A HUP0201242 A HU P0201242A HU P0201242 A2 HUP0201242 A2 HU P0201242A2
Authority
HU
Hungary
Prior art keywords
substituted
group
polycyclic aryl
anticoagulants
pharmaceutical compositions
Prior art date
Application number
HU0201242A
Other languages
English (en)
Inventor
Ashton T. II. Hamme
Darin E. Jones
William Neumann
Melvin L. Rueppel
Michael S. South
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of HUP0201242A2 publication Critical patent/HUP0201242A2/hu
Publication of HUP0201242A3 publication Critical patent/HUP0201242A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya (I) általános képletű vegyületekre vagy sóikra ésilyen vegyületeket tartalmazó gyógyszerkészítményekre vonatkozik. Az(I) általános képletben J jelentése O, S vagy szubsztituált CH- vagyN-csoport, A jelentése alkil- vagy alkil-szulfonilcsoport, B jelentésefenil-, alkil- vagy cikloalkil-csoport, y jelentése O, C(O), C(S), S,S(O), S(O)2 vagy szubsztituált N-, ON-, P(O) vagy C, M jelentése Nvagy szubsztituált C atom, R2 jelentése egy adott esetbenszubsztituált arilcsoport, vagy heteroarilcsoport, K jelentéseszubsztituált alkiléncsoport, E0 jelentése előnyösen egy szubsztituáltN-atom, Y0 jelentése előnyösen egy adott esetben szubsztituáltfenilcsoport vagy 5- vagy 6-tagú heterociklusos gyűrű, amelyheteroatomként O, S, N atomokat tartalmaz. A találmány szerintivegyületek és ezeket tartalmazó gyógyszerkészítmények alkalmasaktrombotikus állapotok, így a koronáriás artéria és cerebrovaszkulárisbetegségek megelőzésére és kezelésére. A találmány szerintiszubsztituált policiklusos aril- és heteroaril-pirimidinon- vegyületekgátolják a koagulációs kaszkádban a szerinproteázok működését. Ó
HU0201242A 1999-05-19 2000-05-17 Substituted polycyclic aryl and heteroaryl pyrimidinone and triazinone derivatives useful as anticoagulants and pharmaceutical compositions containing them HUP0201242A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13479499P 1999-05-19 1999-05-19
PCT/US2000/009806 WO2000069832A1 (en) 1999-05-19 2000-05-17 Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants

Publications (2)

Publication Number Publication Date
HUP0201242A2 true HUP0201242A2 (hu) 2002-12-28
HUP0201242A3 HUP0201242A3 (en) 2003-02-28

Family

ID=22465042

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201242A HUP0201242A3 (en) 1999-05-19 2000-05-17 Substituted polycyclic aryl and heteroaryl pyrimidinone and triazinone derivatives useful as anticoagulants and pharmaceutical compositions containing them

Country Status (22)

Country Link
EP (1) EP1178970A1 (hu)
JP (1) JP2002544262A (hu)
KR (1) KR20010114271A (hu)
CN (1) CN1157380C (hu)
AR (1) AR030021A1 (hu)
AU (2) AU771718B2 (hu)
BR (1) BR0010758A (hu)
CA (1) CA2373614A1 (hu)
CZ (1) CZ20014116A3 (hu)
EA (1) EA004867B1 (hu)
HU (1) HUP0201242A3 (hu)
IL (1) IL146243A0 (hu)
MX (1) MXPA01011804A (hu)
NO (1) NO20015604L (hu)
NZ (1) NZ514874A (hu)
PE (1) PE20010229A1 (hu)
PL (1) PL352827A1 (hu)
SK (1) SK15852001A3 (hu)
TW (1) TWI222445B (hu)
UY (1) UY26156A1 (hu)
WO (1) WO2000069832A1 (hu)
ZA (2) ZA200109339B (hu)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
CN1152023C (zh) * 1999-05-19 2004-06-02 法玛西雅公司 作为抗凝血剂的取代的多环芳基与杂芳基尿嘧啶
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
WO2001068605A1 (en) 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
CA2405306A1 (en) 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
WO2001077097A2 (en) 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
US20040171616A9 (en) 2000-04-17 2004-09-02 South Michael S. Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
AU2001222501A1 (en) * 2000-05-18 2001-11-26 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
CA2430037A1 (en) 2000-11-20 2002-05-30 Michael S. South Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
BR0213099A (pt) 2001-10-03 2004-10-19 Pharmacia Corp Compostos policìclicos de 5 membros substituìdos úteis para inibição seletiva da cascata de coagulação
CA2462647A1 (en) * 2001-10-03 2003-04-10 Michael S. South 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade
CA2462305A1 (en) 2001-10-03 2003-04-10 Michael S. South 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
MXPA04007026A (es) * 2002-02-22 2004-10-11 Pharmacia & Up John Company Pirimidinonas y pirimidintionas sustituidas.
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
WO2004103270A2 (en) 2003-04-02 2004-12-02 Suntory Pharmaceutical Research Laboratories Llc Compounds and methods for treatment of thrombosis
US7182738B2 (en) 2003-04-23 2007-02-27 Marctec, Llc Patient monitoring apparatus and method for orthosis and other devices
US8350043B2 (en) * 2005-06-07 2013-01-08 Pharmacopeia, Inc. Azinone and diazinone V3 inhibitors for depression and stress disorders
CN104311537B (zh) * 2014-09-19 2016-08-24 广东东阳光药业有限公司 含有嘧啶酮乙酰基取代基吡唑类化合物及其组合物及用途
CN115779953B (zh) * 2022-12-19 2024-06-21 中南大学 铜负载碳基单原子材料及其制备方法和应用

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US5441960A (en) * 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5948785A (en) * 1995-04-27 1999-09-07 The Green Cross Corporation Heterocyclic amide compounds and pharmaceutical use of the same

Also Published As

Publication number Publication date
AU4973400A (en) 2000-12-05
CN1351593A (zh) 2002-05-29
MXPA01011804A (es) 2003-09-04
EA200101214A1 (ru) 2002-06-27
CZ20014116A3 (cs) 2002-06-12
NZ514874A (en) 2004-11-26
ZA200400448B (en) 2004-09-29
ZA200109339B (en) 2004-05-26
CA2373614A1 (en) 2000-11-23
EA004867B1 (ru) 2004-08-26
AU771718B2 (en) 2004-04-01
EP1178970A1 (en) 2002-02-13
HUP0201242A3 (en) 2003-02-28
NO20015604L (no) 2002-01-11
SK15852001A3 (sk) 2003-06-03
IL146243A0 (en) 2002-07-25
CN1157380C (zh) 2004-07-14
AU2004202375A1 (en) 2004-06-24
NO20015604D0 (no) 2001-11-16
PL352827A1 (en) 2003-09-08
BR0010758A (pt) 2003-06-10
PE20010229A1 (es) 2001-03-07
KR20010114271A (ko) 2001-12-31
WO2000069832A1 (en) 2000-11-23
AR030021A1 (es) 2003-08-13
UY26156A1 (es) 2000-12-29
TWI222445B (en) 2004-10-21
JP2002544262A (ja) 2002-12-24

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