BR0202976A - Subunidade grande de carbamoilfosfato sintetase, carbamoilfosfato sintetase, dna, bactéria, e, processo para produzir o composto - Google Patents

Subunidade grande de carbamoilfosfato sintetase, carbamoilfosfato sintetase, dna, bactéria, e, processo para produzir o composto

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Publication number
BR0202976A
BR0202976A BR0202976-6A BR0202976A BR0202976A BR 0202976 A BR0202976 A BR 0202976A BR 0202976 A BR0202976 A BR 0202976A BR 0202976 A BR0202976 A BR 0202976A
Authority
BR
Brazil
Prior art keywords
carbamoyl phosphate
phosphate synthetase
dna
uridine
monophosphate
Prior art date
Application number
BR0202976-6A
Other languages
English (en)
Inventor
Leonid Ramanovich Ptitsyn
Sergey Vasil Evich Smirnov
Irina Borisovna Altman
Anna Eugenievna Novikova
Veronika Aleksandro Kotliarova
Mikhail Markovich Gusyatiner
Yulia Georgievna Rostova
Tatyana Abramovna Yampolskaya
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR0202976A publication Critical patent/BR0202976A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/385—Pyrimidine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"SUBUNIDADE GRANDE DE CARBAMOILFOSFATO SINTETASE, CARBAMOILFOSFATO SINTETASE, DNA, BACTéRIA, E, PROCESSO PARA PRODUZIR O COMPOSTO". Derivados de pirimidina, citrulina e L-arginina incluindo ácido orótico, uridina, 5'-monofosfato de uridina (UMP), citidina e 5'-monofosfato de citidina (CMP) são produzidos utilizando-se uma bactéria pertencente ao gênero Escherichia abrigando uma carbamoilfosfato sintetase mutante em que a seq³ência de aminoácidos correspondente às posições de 947 a 951 em uma carbamoilfosfato sintetase de tipo selvagem é substituída por qualquer uma das sequências de aminoácidos das SEQ ID NOS: 1 a 9, e a inibição de retroalimentação através de 5'-monofosfato de uridina na bactéria é dessensibilizada.
BR0202976-6A 2001-08-03 2002-08-02 Subunidade grande de carbamoilfosfato sintetase, carbamoilfosfato sintetase, dna, bactéria, e, processo para produzir o composto BR0202976A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2001121697/13A RU2264459C2 (ru) 2001-08-03 2001-08-03 Новая мутантная карбамоилфосфатсинтетаза и способ продукции соединений - производных карбамоилфосфата

Publications (1)

Publication Number Publication Date
BR0202976A true BR0202976A (pt) 2003-05-27

Family

ID=20252297

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0202976-6A BR0202976A (pt) 2001-08-03 2002-08-02 Subunidade grande de carbamoilfosfato sintetase, carbamoilfosfato sintetase, dna, bactéria, e, processo para produzir o composto

Country Status (4)

Country Link
US (2) US6991924B2 (pt)
JP (1) JP4207484B2 (pt)
BR (1) BR0202976A (pt)
RU (1) RU2264459C2 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2208640C2 (ru) 2000-07-06 2003-07-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА, ШТАММ Escherichia coli - ПРОДУЦЕНТ L-АРГИНИНА
RU2230114C2 (ru) * 2001-11-30 2004-06-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Мутантная глутаминсинтетаза, фрагмент днк, штамм escherichia coli - продуцент l-глутамина и способ получения l-аминокислот
JP2009165355A (ja) * 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
RU2396336C2 (ru) 2007-09-27 2010-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
RU2471870C2 (ru) 2010-06-03 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА И L-ЦИТРУЛЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА pepA
RU2501858C2 (ru) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae
RU2482188C2 (ru) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ РОДА Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ОПЕРОН astCADBE
RU2013118637A (ru) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ РАЗРЕГУЛИРОВАН ГЕН yjjK
RU2013140115A (ru) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ НАРУШЕНА ЭКСПРЕССИЯ КЛАСТЕРА ГЕНОВ znuACB
RU2013144250A (ru) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА, КОДИРУЮЩЕГО ФОСФАТНЫЙ ТРАНСПОРТЕР
US10889842B2 (en) * 2014-01-16 2021-01-12 Calysta, Inc. Microorganisms for the enhanced production of amino acids and related methods
RU2014105547A (ru) 2014-02-14 2015-08-20 Адзиномото Ко., Инк. СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, ИМЕЮЩЕЙ СВЕРХЭКСПРЕССИРУЕМЫЙ ГЕН yajL
RU2015120052A (ru) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. Способ получения L-аминокислоты с использованием бактерии семейства Enterobacteriaceae, в которой ослаблена экспрессия гена gshA
CN109121422B (zh) 2016-02-25 2021-12-21 味之素株式会社 使用过表达编码铁输出蛋白基因的肠杆菌科的细菌生产l-氨基酸的方法
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
BR112021011882A2 (pt) 2018-12-27 2021-09-08 Ajinomoto Co., Inc. Método para produzir um l-aminoácido básico
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
BR112021017870A2 (pt) 2019-04-05 2021-12-07 Ajinomoto Kk Método para produzir um l-aminoácido
KR20230136408A (ko) 2022-03-18 2023-09-26 씨제이제일제당 (주) 카르바모일 인산 합성효소 라지 서브유닛 변이체 및 이를 이용한 l-오르니틴 생산 방법
KR20230136407A (ko) 2022-03-18 2023-09-26 씨제이제일제당 (주) 카르바모일 인산 합성효소의 활성이 약화된 l-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산 생산 방법
CN114736884B (zh) * 2022-05-11 2023-10-20 中国科学院合肥物质科学研究院 一种胞苷单磷酸激酶突变体及其基因和应用
US20240117393A1 (en) 2022-09-30 2024-04-11 Ajinomoto Co., Inc. Method for producing l-amino acid
CN117887652B (zh) * 2024-03-14 2024-06-11 天津科技大学 一种乳清酸生产菌株及其定向改造方法与应用

Also Published As

Publication number Publication date
JP4207484B2 (ja) 2009-01-14
US20030129708A1 (en) 2003-07-10
RU2264459C2 (ru) 2005-11-20
US20060035343A1 (en) 2006-02-16
US6991924B2 (en) 2006-01-31
US7211419B2 (en) 2007-05-01
JP2003093083A (ja) 2003-04-02

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 24, 8O C/C 11, 22, 18 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.