BR0116186A - Sistema de gelificação reversìvel para liberação de droga ocular - Google Patents

Sistema de gelificação reversìvel para liberação de droga ocular

Info

Publication number
BR0116186A
BR0116186A BR0116186-5A BR0116186A BR0116186A BR 0116186 A BR0116186 A BR 0116186A BR 0116186 A BR0116186 A BR 0116186A BR 0116186 A BR0116186 A BR 0116186A
Authority
BR
Brazil
Prior art keywords
drug release
eye drug
gelling system
centipoise
reversible
Prior art date
Application number
BR0116186-5A
Other languages
English (en)
Inventor
Erning Xia
Richard V Smerbeck
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Publication of BR0116186A publication Critical patent/BR0116186A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)

Abstract

"SISTEMA DE GELIFICAçãO REVERSìVEL PARA LIBERAçãO DE DROGA OCULAR". A invenção provê urna composição aquosa oftálmica para administração tópica, compreendendo (a) um copolímero em bloco de óxido de propileno e óxido de etileno em uma concentração suficiente para prover viscosidade de menos que cerca de 25 centipoise à temperatura ambiente e viscosidade de cerca de 25 a cerca de 55 centipoise quando aplicada topicamente a um paciente e (b) hidroxipropil metilcelulose em concentração suficiente para melhorar a durabilidade do gel formado pelo copolímero em bloco. A invenção provê ainda um método para administrar farmacêuticos oftálmicos.
BR0116186-5A 2000-12-06 2001-12-03 Sistema de gelificação reversìvel para liberação de droga ocular BR0116186A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/731,290 US6703039B2 (en) 2000-12-06 2000-12-06 Reversible gelling system for ocular drug delivery
PCT/US2001/046498 WO2002045683A2 (en) 2000-12-06 2001-12-03 Reversible gelling system for ocular drug delivery

Publications (1)

Publication Number Publication Date
BR0116186A true BR0116186A (pt) 2003-12-16

Family

ID=24938883

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116186-5A BR0116186A (pt) 2000-12-06 2001-12-03 Sistema de gelificação reversìvel para liberação de droga ocular

Country Status (13)

Country Link
US (1) US6703039B2 (pt)
EP (1) EP1339386B1 (pt)
JP (1) JP2004514731A (pt)
KR (1) KR100840438B1 (pt)
CN (1) CN100350976C (pt)
AU (2) AU2002233978B2 (pt)
BR (1) BR0116186A (pt)
CA (1) CA2430995C (pt)
DE (1) DE60126321T2 (pt)
ES (1) ES2278799T3 (pt)
HK (1) HK1059728A1 (pt)
MX (1) MXPA03005044A (pt)
WO (1) WO2002045683A2 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935332B2 (en) 2000-08-16 2011-05-03 Encore Health, Llc Presbyopia treatment by lens alteration
US8697109B2 (en) * 2000-08-16 2014-04-15 Encore Health, Llc Caged mercaptan and seleno-mercaptan compounds and methods of using them
US8647612B2 (en) * 2008-03-05 2014-02-11 Encore Health, Llc Dithiol compounds, derivatives, and treatment of presbyopia
US7914815B2 (en) * 2000-08-16 2011-03-29 Encore Health, Llc Method for delivery of pharmaceuticals for treating or preventing presbyopia
US8940311B2 (en) * 2004-10-21 2015-01-27 Tae-Hong Lim In situ controlled release drug delivery system
US9238003B2 (en) 2005-02-04 2016-01-19 Auburn University Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules
US8388995B1 (en) 2006-02-03 2013-03-05 Auburn University Controlled and extended delivery of hyaluronic acid and comfort molecules via a contact lens platform
JP2008529606A (ja) * 2005-02-04 2008-08-07 オーバーン ユニバーシティ 接触薬物送達システム
US8349352B2 (en) * 2005-02-04 2013-01-08 Auburn University Therapeutic contact lenses with anti-fungal delivery
US20080138408A1 (en) * 2006-11-13 2008-06-12 Siddharth Venkatesh Drug delivery system and method
WO2008067403A2 (en) * 2006-11-28 2008-06-05 Encore Health Llc Presbyopia treatment by lens alteration
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US20090142292A1 (en) * 2007-12-03 2009-06-04 Blackwell Richard I Method For The Mitigation of Symptoms of Dry Eye
US9044439B2 (en) * 2008-03-05 2015-06-02 Encore Health, Llc Low dose lipoic and pharmaceutical compositions and methods
WO2009111635A2 (en) 2008-03-05 2009-09-11 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
US8409606B2 (en) 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
EP2398499B1 (en) * 2009-02-18 2017-09-06 Eyeon Particle Sciences LLC Bi-functional co-polymer use for ophthalmic and other topical and local applications
PL2442647T3 (pl) 2009-06-15 2016-09-30 Związki ditiolowe, pochodne i ich zastosowania
WO2010147962A1 (en) * 2009-06-15 2010-12-23 Encore Health, Llc Choline esters
ES2634551T3 (es) 2010-04-03 2017-09-28 Praful Doshi Métodos para revestir una lente de contacto
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
EP2699229A2 (en) * 2011-04-22 2014-02-26 Alcon Research, Ltd. Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
KR102140989B1 (ko) 2012-05-03 2020-08-04 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
CA2871745C (en) 2012-05-03 2023-01-24 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
JP6039861B2 (ja) * 2013-07-17 2016-12-07 ダウ グローバル テクノロジーズ エルエルシー ヒドロキシアルキルメチルセルロースを含む粘膜適用組成物
AU2015227307A1 (en) 2014-03-03 2016-10-13 Encore Vision, Inc. Lipoic acid choline ester compositions and methods of use
WO2016025394A2 (en) 2014-08-11 2016-02-18 Board Of Supervisors Of Louisiana State University And Agriculatural And Mechanical College Delivery of bioactive, nanoencapsulated antioxidants
AU2016413933B2 (en) 2016-07-06 2023-06-15 Calm Water Therapeutics Llc Bi-functional co-polymer use for ophthalmic and other topical and local applications
CN112203666A (zh) * 2018-05-29 2021-01-08 学校法人神野学园 外用组合物
CN115919754B (zh) * 2023-01-06 2023-09-12 广州家安化妆品有限公司 一种用于灭活病毒的粘膜消毒凝胶及其制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2703777A (en) 1950-05-02 1955-03-08 Iso Sol Company Inc Ophthalmological preparations and vehicles and method of making the same
US3549747A (en) 1968-02-20 1970-12-22 Flow Pharma Inc Contact lens wetting solution and method of using same
US3856919A (en) 1970-06-08 1974-12-24 Burton Parsons Chemicals Inc Ophthalmic solution
US3947573A (en) 1969-12-01 1976-03-30 Burton, Parsons And Company, Inc. Opthalmic solution
US3767788A (en) 1970-06-08 1973-10-23 Burton Parsons Chemicals Inc Ophthalmic solution
US3767789A (en) 1971-06-21 1973-10-23 Burton Parsons & Co Inc Method of providing a synthetic mucus in vivo
US3987163A (en) 1973-07-27 1976-10-19 Burton, Parsons And Company, Inc. Polystyrene sulfonate containing opthalmic solutions
US3907985A (en) 1973-07-27 1975-09-23 Burton Parsons And Company Inc Polystyrene sulfonate containing opthalmic solutions
US4029817A (en) 1973-09-24 1977-06-14 Allergan Pharmaceuticals Soft contact lens preserving solutions
US4120949A (en) 1977-10-05 1978-10-17 Cooper Laboratories, Inc. Ophthalmic solution
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4525346A (en) 1981-09-28 1985-06-25 Alcon Laboratories, Inc. Aqueous antimicrobial ophthalmic solutions
IL80298A (en) 1986-10-14 1993-01-31 Res & Dev Co Ltd Eye drops
GB2203039B (en) 1987-03-02 1990-10-24 American Cyanamid Co Stable ophthalmic preparations containing acetazolamide
US5141665A (en) 1987-03-31 1992-08-25 Sherman Laboratories, Inc. Cleaning, conditioning, storing and wetting system and method for rigid gas permeable contact lenses and other contact lenses
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US5705485A (en) * 1987-09-18 1998-01-06 Ethicon, Inc. Gel formulations containing growth factors
US5405878A (en) * 1993-06-18 1995-04-11 Wilmington Partners L.P. Contact lens solution containing cationic glycoside
CA2125060C (en) 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
US5585108A (en) 1994-12-30 1996-12-17 Nanosystems L.L.C. Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays

Also Published As

Publication number Publication date
KR20030060977A (ko) 2003-07-16
AU2002233978B2 (en) 2006-05-18
CA2430995C (en) 2008-10-14
US20020114778A1 (en) 2002-08-22
ES2278799T3 (es) 2007-08-16
WO2002045683A3 (en) 2003-01-16
EP1339386B1 (en) 2007-01-24
MXPA03005044A (es) 2003-09-05
EP1339386A2 (en) 2003-09-03
KR100840438B1 (ko) 2008-06-20
AU3397802A (en) 2002-06-18
WO2002045683A2 (en) 2002-06-13
CN100350976C (zh) 2007-11-28
DE60126321D1 (de) 2007-03-15
CN1479631A (zh) 2004-03-03
JP2004514731A (ja) 2004-05-20
CA2430995A1 (en) 2002-06-13
DE60126321T2 (de) 2007-06-21
US6703039B2 (en) 2004-03-09
HK1059728A1 (en) 2004-07-16

Similar Documents

Publication Publication Date Title
BR0116186A (pt) Sistema de gelificação reversìvel para liberação de droga ocular
EP0694310B1 (en) Reversible, thermally gelling water-base medicinal composition
CA2478621A1 (en) Botulinum toxin pharmaceutical compositions
BR0212475A (pt) Composições farmacêuticas
AR065073A2 (es) Una formulacion medicamentosa de sistema de matriz que tiene liberacion controlada de un compuesto activo
BR9901782A (pt) Forma para dosagem de nefazodona.
BRPI0412526A (pt) composto, uso de um composto, composição farmacêutica, formulação em aerossol farmacêutica, e, método para o tratamento de um paciente humano ou animal com uma condição anti-inflamatória e/ou alérgica
ATE376423T1 (de) Gelierende wässrige pharmazeutische zusammensetzungen
AU2002233978A1 (en) Reversible gelling system for ocular drug delivery
CO5130022A1 (es) Sistema de entrega controlado de droga administrado oralmente, que provee control temporal y espacial
PT2442790E (pt) Composições aquosas farmacêuticas que contêm complexos de borato-poliol
ES2221127T3 (es) Uso de acitromicina en el tratamiento topico de infecciones oculares.
Pariser et al. Safety and tolerability of sarecycline for the treatment of acne vulgaris: results from a phase III, multicenter, open-label study and a phase I phototoxicity study
US20100197811A1 (en) Aqueous composition
NO20052408L (no) Farmasoytisk formulering av olanzapin
JP2003206241A (ja) 眼科用剤
BRPI0412430A (pt) polipeptìdeo agonista do receptor de zot e zonulina
AU2003290015A1 (en) Mastitis treatment
JP2006248960A (ja) 水性外用組成物
JP2729859B2 (ja) 可逆性熱ゲル化水性医薬組成物
JP2005008596A (ja) 眼科用組成物
JPH0232013A (ja) 点鼻剤
BR0316123A (pt) Formulação farmacêutica aquosa, uso de uma formulação farmacêutica aquosa, e, método de tratamento de um paciente com necessidade de tratamento antitrombótico
CN1836667B (zh) 滴眼剂
JP2018115160A (ja) 眼科組成物

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]

Free format text: DE ACORDO COM O ART.34 "II" DA LPI (LEI 9279, DE 14/05/96), O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO.

B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]