BR0114304A - Composições de micropartìculas e métodos para a manufatura das mesmas - Google Patents

Composições de micropartìculas e métodos para a manufatura das mesmas

Info

Publication number
BR0114304A
BR0114304A BR0114304-2A BR0114304A BR0114304A BR 0114304 A BR0114304 A BR 0114304A BR 0114304 A BR0114304 A BR 0114304A BR 0114304 A BR0114304 A BR 0114304A
Authority
BR
Brazil
Prior art keywords
antigens
microparticles
methods
lactide
daltons
Prior art date
Application number
BR0114304-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Jia-Hwa Fang
Maninder Hora
Derek O'hagan
Manmohan Singh
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of BR0114304A publication Critical patent/BR0114304A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Biological Depolymerization Polymers (AREA)
BR0114304-2A 2000-09-28 2001-09-28 Composições de micropartìculas e métodos para a manufatura das mesmas BR0114304A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23607700P 2000-09-28 2000-09-28
PCT/US2001/030541 WO2002026212A2 (en) 2000-09-28 2001-09-28 Microparticle compositions and methods for the manufacture thereof

Publications (1)

Publication Number Publication Date
BR0114304A true BR0114304A (pt) 2003-07-29

Family

ID=22888043

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114304-2A BR0114304A (pt) 2000-09-28 2001-09-28 Composições de micropartìculas e métodos para a manufatura das mesmas

Country Status (14)

Country Link
US (2) US6753015B2 (https=)
EP (1) EP1322292B1 (https=)
JP (2) JP2004509914A (https=)
CN (2) CN1535140A (https=)
AT (1) ATE350015T1 (https=)
AU (2) AU9489801A (https=)
BR (1) BR0114304A (https=)
CA (1) CA2420621C (https=)
DE (1) DE60125795T2 (https=)
ES (1) ES2278786T3 (https=)
MX (1) MXPA03002643A (https=)
RU (1) RU2257198C2 (https=)
WO (1) WO2002026212A2 (https=)
ZA (1) ZA200301743B (https=)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT991403E (pt) * 1997-01-30 2003-08-29 Chiron Corp Uso de microparticulas com antigenio adsorvido para estimular respostas imunes
US6884435B1 (en) * 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
JP4812942B2 (ja) * 1999-02-26 2011-11-09 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル ＣＧモチーフを含むオリゴヌクレオチドを用いるＮｅｉｓｓｅｒｉａ抗原殺菌活性の増強
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
DE60044146D1 (de) * 1999-12-22 2010-05-20 Aventis Pasteur D ihre verwendungen
EP1322655B1 (en) 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynucleotide and its use to induce an immune response
MXPA03002640A (es) * 2000-09-28 2003-06-19 Chiron Corp Microparticulas para la distribucion de acidos nucleicos heterologos.
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
CZ20033515A3 (cs) * 2001-06-29 2005-01-12 Chiron Corporation Kompozice vakcíny HCV E1E2
US7666674B2 (en) 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
WO2003020884A2 (en) 2001-08-14 2003-03-13 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method for rapid generation of mature dendritic cells
US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
AU2002366710A1 (en) 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
EP2572707A3 (en) * 2002-02-20 2013-11-06 Novartis Vaccines and Diagnostics, Inc. Microparticles with adsorbed polypeptide-containing molecules
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
AU2003288902A1 (en) * 2002-09-06 2004-04-08 Genteric, Inc. Microcapsules and methods of use
US8263091B2 (en) 2002-09-18 2012-09-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
JP2006502228A (ja) * 2002-10-07 2006-01-19 カイロン コーポレイション Ｈｉｖワクチン処方物
EP1562982B1 (en) 2002-11-15 2010-05-05 Novartis Vaccines and Diagnostics S.r.l. Unexpected surface proteins in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
AU2003299994A1 (en) 2002-12-27 2004-07-29 Chiron Corporation Immunogenic compositions containing phospholpid
US20050191358A1 (en) * 2003-01-14 2005-09-01 Derek O' Hagan Microparticles with adsorbed polynucleotide-containing species
GB0300881D0 (en) * 2003-01-15 2003-02-12 Secr Defence Therapeutic treatment
ATE485056T1 (de) * 2003-03-24 2010-11-15 Intercell Ag Verbesserte impfstoffe
CA2523266A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Compositions comprising cationic microparticles and hcv e1e2 dna and methods of use thereof
EP1631264B8 (en) * 2003-06-02 2017-05-24 GlaxoSmithKline Biologicals SA Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
GB2407500A (en) * 2003-11-03 2005-05-04 Ist Superiore Sanita Use of microparticles for antigen delivery
US7682009B1 (en) * 2004-06-01 2010-03-23 Sliwa Jr John W Cooling, condensation and freezing of atmospheric water or of a microfluidic working-material in or on microfluidic devices
ES2434029T3 (es) * 2004-11-15 2013-12-13 Novartis Vaccines And Diagnostics, Inc. Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido
JP2006169336A (ja) * 2004-12-15 2006-06-29 Nissan Motor Co Ltd 情報化核酸含有透明樹脂組成物
JP2006169337A (ja) * 2004-12-15 2006-06-29 Nissan Motor Co Ltd 不透明樹脂組成物
ATE526036T1 (de) * 2005-08-02 2011-10-15 Novartis Vaccines & Diagnostic Reduzierung der interferenz zwischen ölhaltigen adjuvanzien und surfactanthaltigen antigenen
WO2008051245A2 (en) * 2005-12-02 2008-05-02 Novartis Ag Nanoparticles for use in immunogenic compositions
RU2327170C2 (ru) * 2006-02-27 2008-06-20 Закрытое акционерное общество "ДиТест" Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса
RU2326655C1 (ru) * 2006-11-09 2008-06-20 Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации" Способ инкапсулирования белоксодержащих веществ в микросферы из сополимера полилактид-полигликолид
ES2667945T3 (es) 2007-10-08 2018-05-16 Aurinia Pharmaceuticals Inc. Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
CA2722765C (en) * 2008-04-28 2016-10-04 Novartis Ag Nanoparticles for use in pharmaceutical compositions
RU2392668C1 (ru) * 2008-12-15 2010-06-20 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ индукции антипролиферативного, цитотоксического эффекта в опухолевых клетках линейных и свежевыделенных культур
EP2440185B1 (en) 2009-06-09 2015-04-08 Aurinia Pharmaceuticals Inc. Topical drug delivery systems for ophthalmic use
RU2413311C1 (ru) * 2009-07-29 2011-02-27 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ индукции антипролиферативного действия в эксперименте
ES2536429T3 (es) * 2010-01-24 2015-05-25 Novartis Ag Micropartículas de polímero biodegradables irradiadas
EP2550362B1 (en) 2010-03-25 2017-01-04 Oregon Health&Science University Cmv glycoproteins and recombinant vectors
MX343505B (es) * 2010-04-09 2016-11-04 Immuron Ltd * Metodos y composiciones para inhibir la transmision del vih.
EP2590625B1 (en) 2010-07-06 2017-09-20 GlaxoSmithKline Biologicals SA Cationic oil-in-water emulsions
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
SG10201605512WA (en) 2011-07-06 2016-09-29 Novartis Ag Oil-in-water emulsions that contain nucleic acids
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
US20140105970A1 (en) * 2011-12-01 2014-04-17 Flow Pharma, Inc. Adjuvant and antigen particle formulation
EP2679596B1 (en) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 env glycoprotein variant
EP2928500B1 (en) 2012-12-04 2019-03-06 Phosphorex Inc. Microparticles and nanoparticles having negative surface charges
EP2848937A1 (en) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Methods of identifying novel HIV-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
WO2015183716A1 (en) * 2014-05-27 2015-12-03 Artificial Cell Technologies, Inc. Automated layer by layer construction of multilayer coated cores by tff
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP4494650A3 (en) * 2015-09-03 2025-03-26 Novavax, Inc. Vaccine compositions having improved stability and immunogenicity
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
AU2018300080B2 (en) 2017-07-11 2024-09-19 Sustained Nano Systems Llc Hypercompressed pharmaceutical formulations
EP3461857A1 (en) * 2017-09-28 2019-04-03 Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH Surface-functionalised polymeric object and method of its production
US12220486B2 (en) 2018-03-02 2025-02-11 Saint Joseph's University Polymer compositions for storage and release of polypeptides

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL134977C (https=) 1962-07-11
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
NZ261250A (en) * 1993-01-06 1997-08-22 Kinerton Ltd Ionic conjugates of polypeptides
EP0678034B1 (en) 1993-01-11 1999-05-26 Dana Farber Cancer Institute Inducing cytotoxic t lymphocyte responses
GB9311454D0 (en) 1993-06-03 1993-07-21 Agricultural & Food Res Pharmaceutical compositions
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
EP0804249A2 (en) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeric gene delivery system
GB9412273D0 (en) 1994-06-18 1994-08-10 Univ Nottingham Administration means
EP0805678B1 (en) 1995-01-05 2003-10-29 THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN Surface-modified nanoparticles and method of making and using same
GB9514285D0 (en) 1995-07-13 1995-09-13 Univ Nottingham Polymeric lamellar substrate particles for drug delivery
JPH09255590A (ja) * 1996-03-21 1997-09-30 Japan Synthetic Rubber Co Ltd 徐放性薬剤
US6451592B1 (en) 1996-04-05 2002-09-17 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
DE69738521T2 (de) 1996-04-05 2009-05-07 Novartis Vaccines and Diagnostics, Inc., Emeryville Alphaviren-vektors mit einer reduzierten inhibierung der synthese von zellmakromolekülen
GB9619002D0 (en) 1996-09-11 1996-10-23 Oxford Biosciences Ltd Particle delivery
US6491925B2 (en) * 1996-08-15 2002-12-10 Emory University Compositions and methods for cancer prophylaxis and/or treatment
US5842723A (en) 1996-11-25 1998-12-01 Burex Automotive America, Inc. Flexible connection arrangement for connecting a pipe of an exhaust system to an engine, especially in a motor vehicle
US5783567A (en) 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
PT991403E (pt) * 1997-01-30 2003-08-29 Chiron Corp Uso de microparticulas com antigenio adsorvido para estimular respostas imunes
US5840970A (en) * 1997-10-03 1998-11-24 Eastman Chemical Company Process for the purification of naphthalenedicarboxylic acid
ES2175668T3 (es) 1997-12-16 2002-11-16 Chiron Corp Uso de microparticulas combinadas con emulsiones de aceite en agua submicronicas.
US6395253B2 (en) * 1998-04-23 2002-05-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production
AU763975B2 (en) * 1998-07-29 2003-08-07 Novartis Vaccines And Diagnostics, Inc. Microparticles with adsorbent surfaces, methods of making same, and uses thereof
US8206749B1 (en) 1999-02-26 2012-06-26 Novartis Vaccines And Diagnostics, Inc. Microemulsions with adsorbed macromolecules and microparticles
US20020009466A1 (en) * 1999-08-31 2002-01-24 David J. Brayden Oral vaccine compositions
CA2389206C (en) * 1999-10-27 2011-01-04 Chiron Corporation Activation of hcv-specific t cells
JP5597335B2 (ja) 1999-11-19 2014-10-01 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 樹状細胞の微粒子ベースのトランスフェクションおよび活性化
US20010046967A1 (en) * 2000-03-10 2001-11-29 Gary Van Nest Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
WO2001081609A2 (en) 2000-03-22 2001-11-01 Chiron Corporation Compositions and methods for generating an immune response utilizing alphavirus-based vector systems

Also Published As

Publication number Publication date
AU9489801A (en) 2002-04-08
US7846479B2 (en) 2010-12-07
RU2257198C2 (ru) 2005-07-27
ATE350015T1 (de) 2007-01-15
JP2004509914A (ja) 2004-04-02
ES2278786T3 (es) 2007-08-16
CA2420621A1 (en) 2002-04-04
EP1322292A2 (en) 2003-07-02
JP2013147514A (ja) 2013-08-01
DE60125795D1 (de) 2007-02-15
DE60125795T2 (de) 2007-10-18
CN101428006A (zh) 2009-05-13
US6753015B2 (en) 2004-06-22
MXPA03002643A (es) 2003-06-19
CA2420621C (en) 2011-05-24
CN1535140A (zh) 2004-10-06
EP1322292B1 (en) 2007-01-03
US20020136776A1 (en) 2002-09-26
ZA200301743B (en) 2004-10-04
AU2001294898B2 (en) 2006-02-02
WO2002026212A2 (en) 2002-04-04
US20040156913A1 (en) 2004-08-12
WO2002026212A3 (en) 2003-03-27

Similar Documents

Publication Publication Date Title
BR0114304A (pt) Composições de micropartìculas e métodos para a manufatura das mesmas
EP2572707A3 (en) Microparticles with adsorbed polypeptide-containing molecules
PT1100468E (pt) Microparticulas com superficies adsorventes, processos de fabrico e utilizacao das mesmas
EP1671981A3 (en) Nucleic acids and proteins from streptococcus group A
ATE272681T1 (de) Ternäre mischung biologisch abbaubarer polyester und damit erhaltene produkte
ATE269367T1 (de) Kosmetisches mittel
ATE256160T1 (de) Kondensationpolymere die esteralkylamid-säure endgruppen enthalten
DE60226413D1 (de) Ternäre mischungen von bioabbaubaren polyestern und daraus hergestellte produkte
EP2412242A3 (en) Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
RU2003112239A (ru) Композиции микрочастиц и способы их получения
EP1574210A3 (en) Microemulsions with adsorbed macromolecules and microparticles
JP2006526649A5 (https=)
BR0314184A (pt) Sistema de polìmeros, composição para limpeza e método para limpeza de local
JP2003522514A5 (https=)
ATE198213T1 (de) Schutzkolloidstabilisierte polymer- zusammensetzungen
IT1298574B1 (it) Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
EP1409694A4 (en) POLYNUCLEOTIDES ENCODING ANTIGENIC POLYPEPTIDES OF HIV SUBTYPE B AND / OR SUBTYPE C, POLYPEPTIDES AND USES THEREOF
BR0309714A (pt) copolìmeros de aminoácidos e métodos de produção dos mesmos
WO2002075507A3 (en) Anti-bacterial vaccine compositions
BR9608894A (pt) Produtos extracelulares abundantes e processos para suas producões e usos
WO2003020876A3 (en) Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
JP2004519532A5 (https=)
WO2023046321A8 (en) Pharmaceutical formulation comprising tacrolimus, method for the preparation thereof and use
He et al. New synthetic method for soluble starlike C60‐bonding polymers
WO2024020355A3 (en) Azlactone-based polymers as a scaffold for diverse applications in drug and gene delivery

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US)

Free format text: ALTERADO DE: CHIRON CORPORATION

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]