BR0113122A - Métodos para produzir reovìrus de mamìfero e reovìrus infeccioso, e, composição de reovìrus de mamìfero - Google Patents

Métodos para produzir reovìrus de mamìfero e reovìrus infeccioso, e, composição de reovìrus de mamìfero

Info

Publication number
BR0113122A
BR0113122A BR0113122A BR0113122A BR0113122A BR 0113122 A BR0113122 A BR 0113122A BR 0113122 A BR0113122 A BR 0113122A BR 0113122 A BR0113122 A BR 0113122A BR 0113122 A BR0113122 A BR 0113122A
Authority
BR
Brazil
Prior art keywords
reovirus
mammalian
composition
methods
infectious
Prior art date
Application number
BR0113122A
Other languages
English (en)
Inventor
Matthew C Coffey
Bradley G Thompson
Original Assignee
Oncolytics Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncolytics Biotech Inc filed Critical Oncolytics Biotech Inc
Publication of BR0113122A publication Critical patent/BR0113122A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/765—Reovirus; Rotavirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"MéTODOS PARA PRODUZIR REOVìRUS DE MAMìFERO E REOVìRUS INFECCIOSO, E, COMPOSIçãO DE REOVìRUS DE MAMìFERO". Um método simples e eficiente de produzir reovírus de mamífero é desenvolvido usando-se células HEK 293. O método provê produção rápida de reovírus em elevada produção. Além disso, este método provê um procedimento de purificação mais simples do reovírus produzido.
BR0113122A 2000-08-10 2001-07-20 Métodos para produzir reovìrus de mamìfero e reovìrus infeccioso, e, composição de reovìrus de mamìfero BR0113122A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22402600P 2000-08-10 2000-08-10
PCT/CA2001/001054 WO2002012435A1 (en) 2000-08-10 2001-07-20 Method of producing infectious reovirus

Publications (1)

Publication Number Publication Date
BR0113122A true BR0113122A (pt) 2003-07-22

Family

ID=22838987

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113122A BR0113122A (pt) 2000-08-10 2001-07-20 Métodos para produzir reovìrus de mamìfero e reovìrus infeccioso, e, composição de reovìrus de mamìfero

Country Status (19)

Country Link
US (4) US6528305B2 (pt)
EP (2) EP1309672B1 (pt)
JP (2) JP4009532B2 (pt)
AR (1) AR033993A1 (pt)
AT (2) ATE394475T1 (pt)
AU (2) AU2001275628B2 (pt)
BR (1) BR0113122A (pt)
CA (1) CA2415749C (pt)
DE (2) DE60133947D1 (pt)
DK (2) DK1309672T3 (pt)
ES (2) ES2241844T3 (pt)
HK (1) HK1082765A1 (pt)
IL (2) IL153847A0 (pt)
MX (1) MXPA03000846A (pt)
NZ (1) NZ523510A (pt)
PT (2) PT1586634E (pt)
TW (1) TWI289158B (pt)
WO (1) WO2002012435A1 (pt)
ZA (1) ZA200300410B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545492B1 (en) * 1999-09-20 2003-04-08 Europaisches Laboratorium Fur Molekularbiologie (Embl) Multiple local probe measuring device and method
TWI289158B (en) * 2000-08-10 2007-11-01 Oncolytics Biotech Inc Method of producing infectious reovirus
MXPA03007535A (es) 2001-03-16 2003-12-11 Oncolytics Biotech Inc Metodo para extraer virus de cultivo celular.
US20040115170A1 (en) * 2001-11-30 2004-06-17 Brown Earl Garnet Oncolytic virus
CA2374388C (en) 2002-02-28 2005-07-12 Matthew C. Coffey The use of ribozymes in the detection of adventitious agents
US20040005546A1 (en) 2002-02-28 2004-01-08 Oncolytics Biotech Inc. Use of ribozymes in the detection of adventitious agents
CA2426283C (en) * 2002-04-29 2006-06-27 The Trustees Of The University Of Pennsylvania Method for direct rescue and amplification of integrated viruses from cellular dna of tissues
CA2482512C (en) * 2002-04-30 2011-09-20 Oncolytics Biotech Inc. Improved viral purification methods
ES2239928T3 (es) * 2002-05-09 2009-02-16 Oncolytics Biotech Inc. Metodo para reducir el dolor utilizando virus oncoliticos.
EP1944035A1 (en) 2002-05-09 2008-07-16 Oncolytics Biotech Inc. Method for reducing pain using oncolytic viruses
DK1505993T3 (da) * 2002-05-10 2012-05-21 Oncolytics Biotech Inc Sensibilisering af neoplastiske celler for stråleterapi med onkolytiske vira
US7901921B2 (en) 2004-10-22 2011-03-08 Oncolytics Biotech Inc. Viral purification methods
US7600514B2 (en) * 2005-06-17 2009-10-13 Nellcor Puritan Bennett Llc System and method for securing a gas delivery mask onto a subject's head
US10260049B2 (en) 2005-08-01 2019-04-16 Virocure, Inc. Attenuated reovirus
US10668119B2 (en) 2005-08-01 2020-06-02 Virocure, Inc. Attenuated reovirus
CA2640286C (en) * 2006-02-13 2018-01-02 Oncolytics Biotech Inc. Use of local immune suppression to enhance oncolytic viral therapy
US8293498B2 (en) 2006-12-20 2012-10-23 Vanderbilt University System for generation of viable reovirus from cloned cDNA
WO2008127486A2 (en) * 2006-12-29 2008-10-23 Bacilligen, Inc. Replication-proficient dsrna capsids and uses thereof
WO2008110004A1 (en) * 2007-03-12 2008-09-18 Oncolytics Biotech Inc. Reoviruses having modified sequences
US10369171B2 (en) 2007-03-13 2019-08-06 Virocure, Inc. Attenuated reoviruses for selection of cell populations
AR066649A1 (es) * 2007-05-21 2009-09-02 Oncolytics Biotech Inc Reovirus mutantes y metodos de elaboracion y uso de los mismos
JP2011500608A (ja) * 2007-10-22 2011-01-06 オンコリティクス バイオテク，インコーポレーテッド 増殖性障害の治療レジメン
CA2723587C (en) * 2008-05-27 2017-09-26 Oncolytics Biotech Inc. Abrogating proinflammatory cytokine production during oncolytic reovirus therapy
JP2011520993A (ja) * 2008-05-27 2011-07-21 オンコリティクス バイオテク，インコーポレーテッド 間質圧力の調節並びに腫瘍崩壊性ウイルスの送達及び分布
WO2011126976A1 (en) 2010-04-07 2011-10-13 Vanderbilt University Reovirus vaccines and methods of use therefor
WO2011130119A2 (en) 2010-04-14 2011-10-20 Millipore Corporation Methods of producing high titer, high purity virus stocks and methods of use thereof
ES2630012T3 (es) * 2010-12-02 2017-08-17 Oncolytics Biotech Inc. Formulaciones virales liofilizadas
EP2646051A4 (en) 2010-12-02 2014-05-28 Oncolytics Biotech Inc FORMULATIONS OF LIQUID VIRUSES
ES2796950T3 (es) 2013-11-15 2020-11-30 Oncolytics Biotech Inc Virus oncolíticos y regímenes reforzados para tratamiento de cáncer

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070453A (en) * 1976-06-25 1978-01-24 Syntex (U.S.A.) Inc. Diploid porcine embryonic cell strains, cultures produced therefrom, and use of said cultures for production of vaccines
US4559229A (en) * 1982-07-20 1985-12-17 Research Foundation Avian proventriculitis vaccine
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
JPS6344532A (ja) 1986-08-11 1988-02-25 Biseibutsu Kagaku Kenkyusho:Kk 豚のレオウイルス感染症ワクチン
US5658779A (en) * 1992-03-20 1997-08-19 Ligochem, Inc. Method of adsorbing viruses from fluid compositions
JPH08214876A (ja) 1995-02-15 1996-08-27 Chemo Sero Therapeut Res Inst ウイルスの調製法
ES2278399T3 (es) * 1996-11-20 2007-08-01 Introgen Therapeutics, Inc. Metodo mejorado para la produccion y purificacion de vectores adenovirales.
CA2283894A1 (en) 1997-06-24 1998-12-30 Basf Aktiengesellschaft Method for producing 4,4' dihalogendiphenylsulfone
US6110461A (en) * 1997-08-13 2000-08-29 Oncolytics Biotech Inc. Reovirus for the treatment of neoplasia
US6136307A (en) 1997-08-13 2000-10-24 Oncolytics Biotech Inc. Reovirus for the treatment of cellular proliferative disorders
AR028039A1 (es) 2000-05-03 2003-04-23 Oncolytics Biotech Inc Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas
TWI289158B (en) * 2000-08-10 2007-11-01 Oncolytics Biotech Inc Method of producing infectious reovirus

Also Published As

Publication number Publication date
CA2415749A1 (en) 2002-02-14
US6703232B2 (en) 2004-03-09
ES2305940T3 (es) 2008-11-01
AU2001275628B2 (en) 2007-08-30
EP1309672B1 (en) 2005-06-29
US7429485B2 (en) 2008-09-30
EP1309672A1 (en) 2003-05-14
EP1586634B1 (en) 2008-05-07
JP2004505623A (ja) 2004-02-26
HK1082765A1 (en) 2006-06-16
JP2006314336A (ja) 2006-11-24
WO2002012435A1 (en) 2002-02-14
AR033993A1 (es) 2004-01-21
DK1309672T3 (da) 2005-10-10
IL153847A (en) 2007-10-31
ES2241844T3 (es) 2005-11-01
ATE394475T1 (de) 2008-05-15
CA2415749C (en) 2009-05-12
US20030166253A1 (en) 2003-09-04
ZA200300410B (en) 2004-01-26
TWI289158B (en) 2007-11-01
US20060165724A1 (en) 2006-07-27
DE60111747T2 (de) 2006-04-27
IL153847A0 (en) 2003-07-31
PT1586634E (pt) 2008-06-19
MXPA03000846A (es) 2004-04-05
ATE298788T1 (de) 2005-07-15
EP1586634A1 (en) 2005-10-19
PT1309672E (pt) 2005-09-30
NZ523510A (en) 2004-08-27
AU2001275628B8 (en) 2002-02-18
US20040126869A1 (en) 2004-07-01
US20020037576A1 (en) 2002-03-28
US6528305B2 (en) 2003-03-04
JP4009532B2 (ja) 2007-11-14
DE60133947D1 (de) 2008-06-19
DK1586634T3 (da) 2008-08-18
AU7562801A (en) 2002-02-18
US7049127B2 (en) 2006-05-23
DE60111747D1 (de) 2005-08-04

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 9A. E 10A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.