BR0016703A - Polipeptìdeo e ácido nucléico relacionado a heparanase humana - Google Patents
Polipeptìdeo e ácido nucléico relacionado a heparanase humanaInfo
- Publication number
- BR0016703A BR0016703A BR0016703-7A BR0016703A BR0016703A BR 0016703 A BR0016703 A BR 0016703A BR 0016703 A BR0016703 A BR 0016703A BR 0016703 A BR0016703 A BR 0016703A
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptides
- polypeptide
- polynucleotides
- relates
- heparanase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01139—Alpha-glucuronidase (3.2.1.139)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"POLIPEPTìDEO E áCIDO NUCLéICO RELACIONADO A HEPARANASE HUMANA". A presente invenção refere-se a polinucleotídeos recentemente identificados, e polipeptídeos codificados por tais polinucleotídeos, o uso de tais polipeptídeos, bem como a produção de tais polinucleotídeos e polipeptídeos. Mais particularmente, um polipeptídeo da presente invenção é uma endo-glucuronidase relacionada a heparanase. A invenção também refere-se a vetores e células hospedeiras compreendendo um polinucleotídeo da invenção. Além do mais, a invenção refere-se a anticorpos direcionados a polipeptídeos de acordo com a presente invenção e a composições farmacêuticas e reagentes de diagnóstico compreendendo tais anticorpos, polipeptídeos ou polinucleotídeos. A invenção além disso refere-se a um método de alterar, modificar ou de outro modo modular o nível de expressão da endoglucuronidase relacionada a heparanase em uma célula ou em um organismo. Um aspecto adicional da invenção é sistemas de ensaio adequados para identificar moduladores, por exemplo agonistas e antagonistas de tais polipeptídeos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99125831 | 1999-12-23 | ||
PCT/EP2000/012909 WO2001048161A2 (en) | 1999-12-23 | 2000-12-18 | Human heparanase-related polypeptide and nucleic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0016703A true BR0016703A (pt) | 2002-09-24 |
Family
ID=8239724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0016703-7A BR0016703A (pt) | 1999-12-23 | 2000-12-18 | Polipeptìdeo e ácido nucléico relacionado a heparanase humana |
Country Status (20)
Country | Link |
---|---|
US (1) | US20040161745A1 (pt) |
EP (1) | EP1244778A2 (pt) |
JP (1) | JP2003518381A (pt) |
KR (1) | KR20020062375A (pt) |
CN (1) | CN1413249A (pt) |
AU (1) | AU3013901A (pt) |
BG (1) | BG106842A (pt) |
BR (1) | BR0016703A (pt) |
CA (1) | CA2392703A1 (pt) |
CZ (1) | CZ20022147A3 (pt) |
EE (1) | EE200200353A (pt) |
HU (1) | HUP0203724A2 (pt) |
IL (1) | IL149506A0 (pt) |
MX (1) | MXPA02005077A (pt) |
NO (1) | NO20023015D0 (pt) |
PL (1) | PL362867A1 (pt) |
RU (1) | RU2002119561A (pt) |
SK (1) | SK8882002A3 (pt) |
WO (1) | WO2001048161A2 (pt) |
ZA (1) | ZA200205852B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001072973A2 (en) * | 2000-02-24 | 2001-10-04 | Bayer Aktiengesellschaft | Regulation of human heparanase-like enzyme |
GB0008912D0 (en) * | 2000-04-11 | 2000-05-31 | Janssen Pharmaceutica Nv | Mammalian heparanase |
EP1276862A2 (en) * | 2000-04-20 | 2003-01-22 | Pharmacia & Upjohn Company | Heparanase ii, a human heparanase paralog |
WO2002004645A2 (en) * | 2000-07-12 | 2002-01-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | A second human heparanase, and splice variants thereof, with a predominant expression in skeletal muscle, heart and pancreas |
FR2818131B1 (fr) * | 2000-12-14 | 2005-02-11 | Oreal | Composition cosmetique comprenant de l'heparanase |
CN101311188B (zh) * | 2007-05-21 | 2010-12-29 | 中国人民解放军军事医学科学院生物工程研究所 | 人乙酰肝素酶的小分子多肽抑制剂 |
CN101670115B (zh) * | 2009-07-31 | 2011-07-27 | 中国人民解放军第三军医大学 | 乙酰肝素酶与热休克蛋白的复合物及其制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
IL135823A0 (en) * | 1997-10-28 | 2001-05-20 | Univ Australian | Isolated nucleic acid molecule encoding mammalian endoglucuronidase and uses therefor |
CN1370178A (zh) * | 1999-06-25 | 2002-09-18 | 洞察战略及销售有限公司 | 多核苷酸及其编码的与乙酰肝素酶同源较远的多肽 |
EP1214423A1 (en) * | 1999-09-23 | 2002-06-19 | MERCK PATENT GmbH | Heparanase-2, a member of the heparanase protein family |
-
2000
- 2000-12-18 CA CA002392703A patent/CA2392703A1/en not_active Abandoned
- 2000-12-18 CZ CZ20022147A patent/CZ20022147A3/cs unknown
- 2000-12-18 RU RU2002119561/13A patent/RU2002119561A/ru unknown
- 2000-12-18 CN CN00817680A patent/CN1413249A/zh active Pending
- 2000-12-18 AU AU30139/01A patent/AU3013901A/en not_active Abandoned
- 2000-12-18 BR BR0016703-7A patent/BR0016703A/pt not_active Application Discontinuation
- 2000-12-18 IL IL14950600A patent/IL149506A0/xx unknown
- 2000-12-18 HU HU0203724A patent/HUP0203724A2/hu unknown
- 2000-12-18 EE EEP200200353A patent/EE200200353A/xx unknown
- 2000-12-18 JP JP2001548674A patent/JP2003518381A/ja active Pending
- 2000-12-18 US US10/168,795 patent/US20040161745A1/en not_active Abandoned
- 2000-12-18 SK SK888-2002A patent/SK8882002A3/sk unknown
- 2000-12-18 WO PCT/EP2000/012909 patent/WO2001048161A2/en not_active Application Discontinuation
- 2000-12-18 KR KR1020027008186A patent/KR20020062375A/ko not_active Application Discontinuation
- 2000-12-18 MX MXPA02005077A patent/MXPA02005077A/es unknown
- 2000-12-18 PL PL00362867A patent/PL362867A1/xx not_active Application Discontinuation
- 2000-12-18 EP EP00990789A patent/EP1244778A2/en not_active Withdrawn
-
2002
- 2002-06-19 BG BG106842A patent/BG106842A/xx unknown
- 2002-06-21 NO NO20023015A patent/NO20023015D0/no not_active Application Discontinuation
- 2002-07-22 ZA ZA200205852A patent/ZA200205852B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1413249A (zh) | 2003-04-23 |
NO20023015L (no) | 2002-06-21 |
WO2001048161A3 (en) | 2002-02-14 |
EP1244778A2 (en) | 2002-10-02 |
US20040161745A1 (en) | 2004-08-19 |
PL362867A1 (en) | 2004-11-02 |
SK8882002A3 (en) | 2002-11-06 |
HUP0203724A2 (hu) | 2003-03-28 |
MXPA02005077A (es) | 2002-11-07 |
CZ20022147A3 (cs) | 2002-09-11 |
BG106842A (en) | 2003-05-30 |
JP2003518381A (ja) | 2003-06-10 |
WO2001048161A2 (en) | 2001-07-05 |
RU2002119561A (ru) | 2004-02-10 |
EE200200353A (et) | 2003-10-15 |
AU3013901A (en) | 2001-07-09 |
IL149506A0 (en) | 2002-11-10 |
ZA200205852B (en) | 2003-10-22 |
NO20023015D0 (no) | 2002-06-21 |
CA2392703A1 (en) | 2001-07-05 |
KR20020062375A (ko) | 2002-07-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Tanzer | Current concepts of extracellular matrix | |
BR0015635A (pt) | Planta, polinucleotìdeo, vetor, célula, composição, polipeptìdeo, métodos para produzir uma planta e para identificar um fator que é modulado por, ou interage com, um polipetìdeo codificado, uma molécula que module a atividade ou a expressão de um polinucleotìdeo ou polipetìdeo de interesse e uma sequência similar ou homóloga a um ou mais polinucleotìdeos e sistema integrado, meio computadorizado ou legìvel em computador | |
Srinivasan et al. | Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R | |
Turner | Molecules in focus Paxillin | |
Malmström et al. | Iduronic acid in chondroitin/dermatan sulfate: biosynthesis and biological function | |
BR0211614A (pt) | polipeptìdeo tacis e br3 e empregos dos mesmos | |
BR0315666A (pt) | Dna de a34 e a33 do tipo 3, proteìnas, seus anticorpos e métodos de tratamento usando os mesmos | |
TW200626176A (en) | Pharmaceutical compositions for increasing cholesterol efflux from cells of a mammalian subject | |
WO1998031818A3 (en) | Tace-like and matrilysin-like polypeptides | |
Campbell et al. | The solution structures of epidermal growth factor and transforming growth factor alpha | |
NZ323795A (en) | Isolated nucleic acid molecules encoding AUR-1 (aurora-1) and AUR-2 polypeptides | |
BR9608558A (pt) | Processos e usos de fator de crescimento de tecido conjuntivo como um agente de indução | |
HK1018707A1 (en) | Extracellular matrix signalling molecules | |
WO2001055310A3 (en) | Nucleic acids, proteins, and antibodies | |
BRPI0408158A (pt) | amilases, ácidos nucléicos codificando-as e métodos para preparar e empregá-las | |
ATE269402T1 (de) | Ikk-beta proteine, nukleinsäuren und verfahren | |
BR9813296A (pt) | Molécula isolada de ácido nucleico, processo para identificar uma molécula de ácido nucleico codificando um polipeptìdeo de endoglucuronidase de mamìfero, vetor de expressão, peptìdeo de heparanase isolado, polipeptìdeo recombinante ou isolado, molécula de anticorpo, processo para identificar um modulador da atividade de heparanase, uso de um oligossacarìdeo sulfatado, um sulfonato ou hspg compreendendo os mesmos, processos para tratamento de uma condição fisiológica ou médica em um sujeito humano ou animal em que a atividade de heparanase no referido sujeito é elevada, para intensificar a cura de feridas em um sujeito humano ou animal e para diagnosticar uma condição fisiológica ou médica associada com a super-expressão de heparanase, e, célula | |
Wojtas et al. | Glycosaminoglycans accelerate biomimetic collagen mineralization in a tissue-based in vitro model | |
BR0016703A (pt) | Polipeptìdeo e ácido nucléico relacionado a heparanase humana | |
DK1590467T3 (da) | Anvendelse af regulatoriske sekvenser til specifik, transient ekspression i neuronalt bestemte celler | |
DE3685411D1 (de) | Immunstimulierend wirkende polysaccharide aus zellkulturen von echinacea purpurea (linne) moench und echinacea angustifolia (de vandolle), verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen. | |
BR9802403A (pt) | Proteìna tendo atividade transglutaminase, dna, transformante, e, processo para produzir uma proteìna tendo uma atividade transglutaminase. | |
BR9917159A (pt) | Método que usa genes para modificar carotenoides para a produção de ketocarotenoides genes de ketolase de carotenoides e produtos da genese | |
WO2001055326A3 (en) | Nucleic acids, proteins, and antibodies | |
DK0902085T3 (da) | Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |