BR0013883A - Alvejamento de droga mediada por integrina - Google Patents

Alvejamento de droga mediada por integrina

Info

Publication number
BR0013883A
BR0013883A BR0013883-5A BR0013883A BR0013883A BR 0013883 A BR0013883 A BR 0013883A BR 0013883 A BR0013883 A BR 0013883A BR 0013883 A BR0013883 A BR 0013883A
Authority
BR
Brazil
Prior art keywords
integrin
drug targeting
mediated drug
cytostatic
result
Prior art date
Application number
BR0013883-5A
Other languages
English (en)
Inventor
Hans-Georg Lerchen
Joerg Baumgarten
Ulf Brueggemeier
Markus Albers
Andreas Schoop
Thomas Schulze
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR0013883A publication Critical patent/BR0013883A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: "ALVEJAMENTO DE DROGA MEDIADA POR INTEGRINA". A presente invenção diz respeito aos citostáticos que t~em a ação específica de tumor como um resultado da ligação de antagonistas de integrina <244>~v~<225>~3~ por meio de unidades de ligação preferidas. As unidades de ligação preferidas garantem estabilidade de soro do conjugado do citostático e do antagonista de integrina <244>~v<225>~3~ e ao mesmo tempo a ação intramolecular desejada em células tumorais como um resultado de sua capacidade de clivagem enzimática ou hidrolítica com a liberação de citostático.
BR0013883-5A 1999-09-08 2000-08-28 Alvejamento de droga mediada por integrina BR0013883A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39216799A 1999-09-08 1999-09-08
US60677200A 2000-06-29 2000-06-29
PCT/EP2000/008361 WO2001017563A2 (en) 1999-09-08 2000-08-28 Integrin-mediated drug targeting

Publications (1)

Publication Number Publication Date
BR0013883A true BR0013883A (pt) 2002-05-07

Family

ID=27013781

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013883-5A BR0013883A (pt) 1999-09-08 2000-08-28 Alvejamento de droga mediada por integrina

Country Status (16)

Country Link
US (1) US20060189544A1 (pt)
EP (1) EP1235595B8 (pt)
JP (1) JP2003508497A (pt)
CN (1) CN1402643A (pt)
AT (1) ATE438413T1 (pt)
AU (1) AU773781B2 (pt)
BR (1) BR0013883A (pt)
CA (1) CA2383981A1 (pt)
DE (1) DE60042700D1 (pt)
ES (1) ES2330079T3 (pt)
HU (1) HUP0203899A3 (pt)
MX (1) MXPA02002488A (pt)
NZ (1) NZ517620A (pt)
PL (1) PL354268A1 (pt)
RU (1) RU2002109215A (pt)
WO (1) WO2001017563A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219305A1 (en) * 2000-12-27 2002-07-03 Bayer Aktiengesellschaft Conjugates of integrin receptor antagonists and a cytostatic agent having specifically cleavable linking units
EP1238678A1 (en) * 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzyme-activated cytostatic conjugates with integrin ligands
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
ITRM20040241A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 20 con antagonisti delle integrine.
CN105566338B (zh) * 2014-10-08 2017-11-21 兰州大学 一种喜树碱类化合物及其制备方法和用途
CN108456154A (zh) * 2018-04-13 2018-08-28 昆明理工大学 一种n-叔丁氧羰基烃基胍的制备方法
EP4412656A1 (en) * 2021-10-04 2024-08-14 Vincerx Pharma GmbH Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorders
WO2023057813A1 (en) * 2021-10-04 2023-04-13 Vincerx Pharma Gmbh Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2132091C (en) * 1992-04-03 2008-09-16 Kyung J. Kim Antibodies to alphavbeta3 integrin
WO1997039021A1 (en) * 1995-12-21 1997-10-23 The Scripps Research Institute Targeted therapeutic or diagnostic agents and methods of making and using same

Also Published As

Publication number Publication date
DE60042700D1 (de) 2009-09-17
HUP0203899A3 (en) 2004-09-28
WO2001017563A2 (en) 2001-03-15
EP1235595B1 (en) 2009-08-05
AU7648700A (en) 2001-04-10
CA2383981A1 (en) 2001-03-15
WO2001017563A3 (en) 2002-07-11
US20060189544A1 (en) 2006-08-24
CN1402643A (zh) 2003-03-12
ATE438413T1 (de) 2009-08-15
HUP0203899A2 (hu) 2003-02-28
PL354268A1 (en) 2003-12-29
NZ517620A (en) 2004-02-27
RU2002109215A (ru) 2003-12-10
EP1235595A2 (en) 2002-09-04
ES2330079T3 (es) 2009-12-04
AU773781B2 (en) 2004-06-03
MXPA02002488A (es) 2002-08-12
EP1235595B8 (en) 2009-10-07
JP2003508497A (ja) 2003-03-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.

B15K Others concerning applications: alteration of classification

Ipc: A61K 47/55 (2017.01)