BR0009483A - Anticorpo monoclonal contra leucina aminopeptidase estimulada por estrogênio - Google Patents
Anticorpo monoclonal contra leucina aminopeptidase estimulada por estrogênioInfo
- Publication number
- BR0009483A BR0009483A BR0009483-8A BR0009483A BR0009483A BR 0009483 A BR0009483 A BR 0009483A BR 0009483 A BR0009483 A BR 0009483A BR 0009483 A BR0009483 A BR 0009483A
- Authority
- BR
- Brazil
- Prior art keywords
- estrogen
- monoclonal antibody
- antibody against
- leucine aminopeptidase
- lapase
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
"ANTICORPO MONOCLONAL CONTRA LEUCINA AMINOPEPTIDASE ESTIMULADA POR ESTROGêNIO". A identificação e caracterização de fatores de risco e suas implicações moleculares na fisiopatologia de doenças humanas tal como câncer é essencial para projetar testes de diagnósticos e compostos terapêuticos. Esteróides estrogênicos sob condições fisiológicas normais, demonstraram desempenhar uma função crítica em diversos tecidos. A resposta de uma tal variedade de tecidos à estimulação por estrogênio pode explicar em parte seu papel ativo no desenvolvimento e progressão de diferentes doenças humanas, particularmente Câncer de Mama. Pesquisando os fatores celulares que respondem ao estrogênio em células matriz de carcinomas de mama humanos primários obtidos por biópsias de tumores foi identificada uma isoenzima da putativa Leucina Aminopeptidase (LAPase; EC 3.4.11.1). Os resultados demonstraram que este marcador foi descoberto ser elevado nos soros de mulheres com carcinomas ductais invasivos e matastáticos. Um anticorpo monoclonal contra este marcador celular foi produzido. Esta invenção refere-se ao uso de anticorpos monoclonais de LAPase para teste baseado em sangue confirmatório de primeira linha para Câncer de Mama.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002267481A CA2267481A1 (en) | 1999-03-30 | 1999-03-30 | Critical interdependency: from the role of estrogen on breast cancer to the susceptibility of women towards hiv infection |
PCT/CA2000/000332 WO2000059944A1 (en) | 1999-03-30 | 2000-03-30 | A monoclonal antibody against estrogen stimulated leucine aminopeptidase |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0009483A true BR0009483A (pt) | 2002-02-05 |
Family
ID=4163415
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0009484-6A BR0009484A (pt) | 1999-03-30 | 2000-03-30 | Imunoensaio em série para câncer |
BR0009483-8A BR0009483A (pt) | 1999-03-30 | 2000-03-30 | Anticorpo monoclonal contra leucina aminopeptidase estimulada por estrogênio |
BR0009485-4A BR0009485A (pt) | 1999-03-30 | 2000-03-30 | Método e composições para evitar ou reduzir infecção por hiv pelo uso de inibidores para leucina aminopeptidase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0009484-6A BR0009484A (pt) | 1999-03-30 | 2000-03-30 | Imunoensaio em série para câncer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0009485-4A BR0009485A (pt) | 1999-03-30 | 2000-03-30 | Método e composições para evitar ou reduzir infecção por hiv pelo uso de inibidores para leucina aminopeptidase |
Country Status (8)
Country | Link |
---|---|
US (4) | US6406701B1 (pt) |
EP (3) | EP1114322A1 (pt) |
CN (3) | CN1351714A (pt) |
AU (3) | AU3413100A (pt) |
BR (3) | BR0009484A (pt) |
CA (1) | CA2267481A1 (pt) |
MX (3) | MXPA01010985A (pt) |
WO (3) | WO2000060357A1 (pt) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10054899C2 (de) | 2000-12-08 | 2003-08-21 | Tubag Trass Zement Stein | Vorrichtung und Verfahren zum Aufbringen von Dünnbettmörtel |
WO2002060933A2 (en) * | 2001-01-30 | 2002-08-08 | The Provost, Fellows And Scholars Of The College Of The Holy And Unidivided Trinity Of Queen Elizabeht | Thioredoxin derived from h. pylori, which is capable of inhibiting nf-kappa b activation |
DK2341350T3 (en) * | 2003-09-20 | 2018-02-05 | Electrophoretics Ltd | DIAGNOSTIC PROCEDURE FOR BRAKE INJURY-RELATED DISORDERS BASED ON DJ-1 DETECTION |
GB0404419D0 (en) | 2004-02-27 | 2004-03-31 | Intelligent Textiles Ltd | Electrical components and circuits constructed as textiles |
US7197427B2 (en) * | 2004-03-31 | 2007-03-27 | Genworth Financial Inc. | Method for risk based testing |
WO2010048415A1 (en) * | 2008-10-22 | 2010-04-29 | Cedars-Sinai Medical Center | Methods of using jak3 genetic variants to diagnose and predict crohn's disease |
AU2005314089B2 (en) * | 2004-12-08 | 2011-03-03 | Cedars-Sinai Medical Center | Methods for diagnosis and treatment of Crohn's disease |
CN100376680C (zh) * | 2005-11-01 | 2008-03-26 | 暨南大学 | 双重靶效应基因嵌合重组体及其构建方法和应用 |
DE102006023535B4 (de) * | 2006-05-19 | 2008-12-18 | Keiper Gmbh & Co.Kg | Getriebestufe für einen Stellantrieb |
US20100021917A1 (en) * | 2007-02-14 | 2010-01-28 | Cedars-Sinai Medical Center | Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease |
WO2008106451A2 (en) * | 2007-02-26 | 2008-09-04 | Cedars-Sinai Medical Center | Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease |
WO2010039931A2 (en) * | 2008-10-01 | 2010-04-08 | Cedars-Sinai Medical Center | Methods of using il17rd and il23-il17 pathway genes to diagnose crohn's disease |
US20100015156A1 (en) * | 2007-03-06 | 2010-01-21 | Cedars-Sinai Medical Center | Diagnosis of inflammatory bowel disease in children |
WO2008116150A2 (en) | 2007-03-21 | 2008-09-25 | Cedars-Sinai Medical Center | Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease |
US20100184050A1 (en) * | 2007-04-26 | 2010-07-22 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease in the puerto rican population |
US20100144903A1 (en) * | 2007-05-04 | 2010-06-10 | Cedars-Sinai Medical Center | Methods of diagnosis and treatment of crohn's disease |
US20080318063A1 (en) * | 2007-06-22 | 2008-12-25 | Anderson Jerrel C | Glass laminates with improved weatherability |
US20110104121A1 (en) * | 2008-05-21 | 2011-05-05 | Wira Charles R | Female Reproductive Tract and Anal Prophylaxes |
US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
WO2010075579A2 (en) | 2008-12-24 | 2010-07-01 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy |
EP2550362B1 (en) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv glycoproteins and recombinant vectors |
RS57397B8 (sr) | 2011-06-10 | 2020-01-31 | Univ Oregon Health & Science | Cmv glikoproteini i rekombinantni vektori |
EP2568289A3 (en) | 2011-09-12 | 2013-04-03 | International AIDS Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
EP2679596B1 (en) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 env glycoprotein variant |
WO2014160883A1 (en) | 2013-03-27 | 2014-10-02 | Cedars-Sinai Medical Center | Treating fibrosis and inflammation by inhibiting tl1a |
WO2015010108A1 (en) | 2013-07-19 | 2015-01-22 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
EP2848937A1 (en) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Methods of identifying novel HIV-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
WO2015133935A1 (ru) * | 2014-03-04 | 2015-09-11 | Григорий Дмитриевич КАМИНСКИЙ | Способ и устройство прогнозирования времени развития вич-инфекции у женщин после родов |
EP3069730A3 (en) | 2015-03-20 | 2017-03-15 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
EP3072901A1 (en) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Soluble hiv-1 envelope glycoprotein trimers |
BR112018010317A2 (pt) | 2015-12-18 | 2018-12-04 | Intelligent Textiles Ltd | tecido condutor, método de fabricação de um tecido condutor, sistema para o mesmo e artigo de vestuário |
JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Rnaset2により炎症性腸疾患を診断する方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5678600A (en) * | 1979-12-03 | 1981-06-27 | Eiken Kagaku Kk | Method for measuring activity of leucine aminopeptidase in serum |
US5001052A (en) * | 1989-02-09 | 1991-03-19 | Wisconsin Alumni Research Foundation | Immunoassay for FHAP and antibody useful therewith |
US5179008A (en) * | 1989-02-09 | 1993-01-12 | Wisconsin Alumni Research Foundation | Hybridoma and monoclonal antibody to FHAP |
CA2108533C (en) * | 1992-10-16 | 2002-10-08 | Gabriel Pulido-Cejudo | Monoclonal antibodies directed against ndp-kinase |
AU2681997A (en) * | 1996-04-26 | 1997-11-19 | Children's Medical Center Corporation | Non-invasive enzyme screen for tissue remodelling-associated conditions |
-
1999
- 1999-03-30 CA CA002267481A patent/CA2267481A1/en not_active Abandoned
-
2000
- 2000-03-30 WO PCT/CA2000/000330 patent/WO2000060357A1/en not_active Application Discontinuation
- 2000-03-30 BR BR0009484-6A patent/BR0009484A/pt not_active IP Right Cessation
- 2000-03-30 US US09/538,827 patent/US6406701B1/en not_active Expired - Fee Related
- 2000-03-30 AU AU34131/00A patent/AU3413100A/en not_active Abandoned
- 2000-03-30 BR BR0009483-8A patent/BR0009483A/pt not_active IP Right Cessation
- 2000-03-30 EP EP00913983A patent/EP1114322A1/en not_active Withdrawn
- 2000-03-30 BR BR0009485-4A patent/BR0009485A/pt not_active Application Discontinuation
- 2000-03-30 CN CN00807917A patent/CN1351714A/zh active Pending
- 2000-03-30 US US09/538,831 patent/US6649743B1/en not_active Expired - Fee Related
- 2000-03-30 WO PCT/CA2000/000331 patent/WO2000059534A1/en not_active Application Discontinuation
- 2000-03-30 EP EP00912306A patent/EP1113812A1/en not_active Withdrawn
- 2000-03-30 AU AU35464/00A patent/AU3546400A/en not_active Abandoned
- 2000-03-30 EP EP00912307A patent/EP1114064A1/en not_active Withdrawn
- 2000-03-30 CN CN00807919A patent/CN1382059A/zh active Pending
- 2000-03-30 MX MXPA01010985A patent/MXPA01010985A/es unknown
- 2000-03-30 MX MXPA01010984A patent/MXPA01010984A/es unknown
- 2000-03-30 US US09/538,200 patent/US6521415B1/en not_active Expired - Fee Related
- 2000-03-30 WO PCT/CA2000/000332 patent/WO2000059944A1/en not_active Application Discontinuation
- 2000-03-30 MX MXPA01010995A patent/MXPA01010995A/es unknown
- 2000-03-30 AU AU34132/00A patent/AU3413200A/en not_active Abandoned
- 2000-03-30 CN CN00807918A patent/CN1362970A/zh active Pending
-
2003
- 2003-11-12 US US10/705,991 patent/US20040106143A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000059944A1 (en) | 2000-10-12 |
US6521415B1 (en) | 2003-02-18 |
WO2000060357A1 (en) | 2000-10-12 |
CN1351714A (zh) | 2002-05-29 |
AU3413200A (en) | 2000-10-23 |
BR0009485A (pt) | 2002-02-05 |
EP1114064A1 (en) | 2001-07-11 |
US20040106143A1 (en) | 2004-06-03 |
EP1114322A1 (en) | 2001-07-11 |
MXPA01010985A (es) | 2002-06-04 |
MXPA01010995A (es) | 2002-06-04 |
EP1113812A1 (en) | 2001-07-11 |
CN1362970A (zh) | 2002-08-07 |
AU3546400A (en) | 2000-10-23 |
US6649743B1 (en) | 2003-11-18 |
AU3413100A (en) | 2000-10-23 |
MXPA01010984A (es) | 2002-06-04 |
WO2000059534A1 (en) | 2000-10-12 |
CN1382059A (zh) | 2002-11-27 |
US6406701B1 (en) | 2002-06-18 |
BR0009484A (pt) | 2002-02-05 |
CA2267481A1 (en) | 2000-09-30 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1942 DE 25/03/2008. |