BR0009484A - Imunoensaio em série para câncer - Google Patents

Imunoensaio em série para câncer

Info

Publication number
BR0009484A
BR0009484A BR0009484-6A BR0009484A BR0009484A BR 0009484 A BR0009484 A BR 0009484A BR 0009484 A BR0009484 A BR 0009484A BR 0009484 A BR0009484 A BR 0009484A
Authority
BR
Brazil
Prior art keywords
cancer
serial
breast cancer
ndp
kinase
Prior art date
Application number
BR0009484-6A
Other languages
English (en)
Inventor
Gabriel Pulido-Cejudo
Original Assignee
Canbreal Therodiagnostics Ca
Mini Health Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canbreal Therodiagnostics Ca, Mini Health Canada filed Critical Canbreal Therodiagnostics Ca
Publication of BR0009484A publication Critical patent/BR0009484A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

"IMUNOENSAIO EM SéRIE PARA CâNCER". A identificação e caracterização de fatores de risco e suas implicações moleculares na fisiopatologia de doenças humanas tal como câncer é essencial para projetar exames de diagnóstico eficientes e compostos terapêuticos. Esteróides estrogênicos, sob condições fisiológicas normais, demonstraram desempenhar uma função crítica em diversos tecidos. A resposta de tal variedade de tecidos à estimulação por estrogênio pode explicar em parte seu papel ativo no desenvolvimento e progressão de doenças humanas diferentes, particularmente câncer de mama. Na busca de fatores celulares que respondem ao estrogênio em células matriz de carcinomas de mama humanos primários obtidos de biópsias de tumor, dois marcadores celulares, uma isoenzima de leucina aminopeptidase putativa (LAPase; EC 3.4.11.1) de celulas matriz de carcinomas de mama humanos primários obtidos de biópsias de tumor, e NDP-Quinase/Nm23 (EC 2.7.4.6) citosólica de células HL60 foram identificados. Anticorpos monoclonais contra cada marcador celular foram produzidos. Determinação da presença destes dois marcadores, quer sozinho ou em combinação pode ser utilizada para detectar câncer de mama, e em particular, metástase associada. Assim, esta invenção refere-se ao uso de ambos os anticorpos monoclonais LAP e NDP-Quinase/Nm23 em conjunto num imunoensaio baseado em matriz sólida em série para teste de primeira linha confirmatório baseado em sangue para câncer de mama.
BR0009484-6A 1999-03-30 2000-03-30 Imunoensaio em série para câncer BR0009484A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002267481A CA2267481A1 (en) 1999-03-30 1999-03-30 Critical interdependency: from the role of estrogen on breast cancer to the susceptibility of women towards hiv infection
PCT/CA2000/000330 WO2000060357A1 (en) 1999-03-30 2000-03-30 Tandem immuno-assay for cancer

Publications (1)

Publication Number Publication Date
BR0009484A true BR0009484A (pt) 2002-02-05

Family

ID=4163415

Family Applications (3)

Application Number Title Priority Date Filing Date
BR0009484-6A BR0009484A (pt) 1999-03-30 2000-03-30 Imunoensaio em série para câncer
BR0009483-8A BR0009483A (pt) 1999-03-30 2000-03-30 Anticorpo monoclonal contra leucina aminopeptidase estimulada por estrogênio
BR0009485-4A BR0009485A (pt) 1999-03-30 2000-03-30 Método e composições para evitar ou reduzir infecção por hiv pelo uso de inibidores para leucina aminopeptidase

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR0009483-8A BR0009483A (pt) 1999-03-30 2000-03-30 Anticorpo monoclonal contra leucina aminopeptidase estimulada por estrogênio
BR0009485-4A BR0009485A (pt) 1999-03-30 2000-03-30 Método e composições para evitar ou reduzir infecção por hiv pelo uso de inibidores para leucina aminopeptidase

Country Status (8)

Country Link
US (4) US6649743B1 (pt)
EP (3) EP1114322A1 (pt)
CN (3) CN1362970A (pt)
AU (3) AU3413100A (pt)
BR (3) BR0009484A (pt)
CA (1) CA2267481A1 (pt)
MX (3) MXPA01010984A (pt)
WO (3) WO2000059944A1 (pt)

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DE10054899C2 (de) 2000-12-08 2003-08-21 Tubag Trass Zement Stein Vorrichtung und Verfahren zum Aufbringen von Dünnbettmörtel
AU2002230049A1 (en) * 2001-01-30 2002-08-12 The Provost, Fellows And Scholars Of The College Of The Holy And Unidivided Trinity Of Queen Elizabe Thioredoxin derived from h. pylori, which is capable of inhibiting nf-kappa b activation
EP2341350B1 (en) * 2003-09-20 2017-11-08 Electrophoretics Limited Diagnostic method for brain damage-related disorders based on detection of dj-1
GB0404419D0 (en) 2004-02-27 2004-03-31 Intelligent Textiles Ltd Electrical components and circuits constructed as textiles
US7197427B2 (en) * 2004-03-31 2007-03-27 Genworth Financial Inc. Method for risk based testing
WO2008101133A2 (en) * 2007-02-14 2008-08-21 Cedars-Sinai Medical Center Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
ATE477497T1 (de) * 2004-12-08 2010-08-15 Cedars Sinai Medical Center Verfahren zur diagnose von morbus crohn
WO2008109782A2 (en) * 2007-03-06 2008-09-12 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease in children
CN100376680C (zh) * 2005-11-01 2008-03-26 暨南大学 双重靶效应基因嵌合重组体及其构建方法和应用
DE102006023535B4 (de) * 2006-05-19 2008-12-18 Keiper Gmbh & Co.Kg Getriebestufe für einen Stellantrieb
US20100190162A1 (en) * 2007-02-26 2010-07-29 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
WO2008137762A2 (en) * 2007-05-04 2008-11-13 Cedars-Sinai Medical Center Methods of diagnosis and treatment of crohn's disease
WO2008116150A2 (en) 2007-03-21 2008-09-25 Cedars-Sinai Medical Center Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease
US20100184050A1 (en) * 2007-04-26 2010-07-22 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
US20080318063A1 (en) * 2007-06-22 2008-12-25 Anderson Jerrel C Glass laminates with improved weatherability
WO2009143309A2 (en) * 2008-05-21 2009-11-26 Trustees Of Dartmouth College Female reproductive tract and anal prophylaxes
US20110177969A1 (en) * 2008-10-01 2011-07-21 Cedars-Sinai Medical Center The role of il17rd and the il23-1l17 pathway in crohn's disease
US20110189685A1 (en) * 2008-10-22 2011-08-04 Cedars-Sinai Medical Center Methods of using jak3 genetic variants to diagnose and predict crohn's disease
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
WO2010075579A2 (en) 2008-12-24 2010-07-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
EP2550362B1 (en) 2010-03-25 2017-01-04 Oregon Health&Science University Cmv glycoproteins and recombinant vectors
PT2691530T (pt) 2011-06-10 2018-05-10 Univ Oregon Health & Science Glicoproteínas e vectores recombinantes cmv
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
ES2631608T3 (es) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Variante de la glicoproteína Env del VIH-1
CN112870368A (zh) 2013-03-27 2021-06-01 西达-赛奈医疗中心 通过抑制tl1a的功能和相关信号传导途径来减轻并逆转纤维化和炎症
EP3022295A4 (en) 2013-07-19 2017-03-01 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (en) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
WO2015133935A1 (ru) * 2014-03-04 2015-09-11 Григорий Дмитриевич КАМИНСКИЙ Способ и устройство прогнозирования времени развития вич-инфекции у женщин после родов
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
KR20180103823A (ko) 2015-12-18 2018-09-19 인텔리전트 텍스타일 리미티드 전도성 직물, 전도성 직물 직조방법 및 이에 관한 장치
EP3430172A4 (en) 2016-03-17 2019-08-21 Cedars-Sinai Medical Center METHOD FOR DIAGNOSIS OF INFLAMMATORY ENDURANCE THROUGH RNASET2

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EP0900381A1 (en) * 1996-04-26 1999-03-10 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions

Also Published As

Publication number Publication date
CN1362970A (zh) 2002-08-07
CN1351714A (zh) 2002-05-29
EP1113812A1 (en) 2001-07-11
BR0009483A (pt) 2002-02-05
WO2000059534A1 (en) 2000-10-12
EP1114064A1 (en) 2001-07-11
AU3546400A (en) 2000-10-23
CA2267481A1 (en) 2000-09-30
WO2000059944A1 (en) 2000-10-12
MXPA01010995A (es) 2002-06-04
US6406701B1 (en) 2002-06-18
WO2000060357A1 (en) 2000-10-12
AU3413200A (en) 2000-10-23
US20040106143A1 (en) 2004-06-03
US6521415B1 (en) 2003-02-18
CN1382059A (zh) 2002-11-27
MXPA01010985A (es) 2002-06-04
EP1114322A1 (en) 2001-07-11
MXPA01010984A (es) 2002-06-04
US6649743B1 (en) 2003-11-18
BR0009485A (pt) 2002-02-05
AU3413100A (en) 2000-10-23

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