BR0007713A - Processo para a secagem de cristais de proteìnas - Google Patents
Processo para a secagem de cristais de proteìnasInfo
- Publication number
- BR0007713A BR0007713A BR0007713-5A BR0007713A BR0007713A BR 0007713 A BR0007713 A BR 0007713A BR 0007713 A BR0007713 A BR 0007713A BR 0007713 A BR0007713 A BR 0007713A
- Authority
- BR
- Brazil
- Prior art keywords
- drying
- protein crystals
- water
- suspension
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 8
- 108090000623 proteins and genes Proteins 0.000 title abstract 8
- 239000013078 crystal Substances 0.000 title abstract 7
- 238000001035 drying Methods 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 2
- 239000000725 suspension Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Extraction Or Liquid Replacement (AREA)
- Drying Of Solid Materials (AREA)
Abstract
Patente de Invenção: "PROCESSO PARA A SECAGEM DECRISTAIS DE PROTEìNAS". A presente invenção refere-se a umprocesso para a secagem de cristais de proteína partindo de umasuspensão de cristais de proteína aquosa, o qual se destaca pelofato, de que a suspensão de cristais de proteína é seca em umasecadora centrífuga, sendo que de preferência, os cristais deproteína após a filtração dos mesmos da suspensão de cristais deproteína são levados para um meio de secagem, que se constituide uma mistura de água e de um solvente não aquoso, miscívelcom água em qualquer razão, o qual possui uma pressão de vapormenor do que a água. Com isso, aplica-se vantajosamente um gásde secagem, o qual é umedecido com água. A suspensão decristais de proteína é transportada, com a finalidade de secagem,vantajosamente para um leito turbilhonar.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19903125A DE19903125B4 (de) | 1999-01-27 | 1999-01-27 | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
| PCT/EP2000/000287 WO2000044767A2 (de) | 1999-01-27 | 2000-01-15 | Verfahren zur trocknung von proteinkristallen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0007713A true BR0007713A (pt) | 2001-11-27 |
| BRPI0007713B1 BRPI0007713B1 (pt) | 2016-06-14 |
| BRPI0007713B8 BRPI0007713B8 (pt) | 2021-05-25 |
Family
ID=7895502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0007713A BRPI0007713B8 (pt) | 1999-01-27 | 2000-01-15 | processo para a secagem de cristais de proteínas |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6408536B1 (pt) |
| EP (1) | EP1185548B1 (pt) |
| JP (1) | JP4465120B2 (pt) |
| KR (1) | KR100652471B1 (pt) |
| CN (1) | CN1211397C (pt) |
| AT (1) | ATE323101T1 (pt) |
| AU (1) | AU764353B2 (pt) |
| BR (1) | BRPI0007713B8 (pt) |
| CA (1) | CA2361397C (pt) |
| CY (1) | CY1105256T1 (pt) |
| CZ (1) | CZ300915B6 (pt) |
| DE (2) | DE19903125B4 (pt) |
| DK (1) | DK1185548T3 (pt) |
| ES (1) | ES2259994T3 (pt) |
| HK (1) | HK1044548B (pt) |
| HU (1) | HU226697B1 (pt) |
| PL (1) | PL197694B1 (pt) |
| PT (1) | PT1185548E (pt) |
| RU (1) | RU2235730C2 (pt) |
| WO (1) | WO2000044767A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
| GB0219815D0 (en) * | 2002-08-24 | 2002-10-02 | Accentus Plc | Preparation of small crystals |
| DE102004049241A1 (de) * | 2004-10-09 | 2006-04-20 | Sanofi-Aventis Deutschland Gmbh | Trockner und Verfahren zum Steuern eines Trockners |
| EP1870649A1 (en) | 2006-06-20 | 2007-12-26 | Octapharma AG | Lyophilisation targetting defined residual moisture by limited desorption energy levels |
| US20090271021A1 (en) * | 2008-04-28 | 2009-10-29 | Popp Shane M | Execution system for the monitoring and execution of insulin manufacture |
| RU2014124001A (ru) | 2011-11-16 | 2015-12-27 | Байер Интеллектуэль Проперти Гмбх | Устройство для фильтрации, сушки и хранения твердых веществ из суспензии |
| JP7213254B2 (ja) | 2017-09-26 | 2023-01-26 | バイオコン バイオロジックス インディア リミテッド | ペプチド結晶の分離、洗浄および乾燥のための統合され、自動化された濾過 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139637A (en) * | 1972-12-28 | 1979-02-13 | Maurice Rouchy | Quinone derivatives useful as medicaments |
| US4133716A (en) * | 1976-11-22 | 1979-01-09 | Crc Compagnia Ricerca Chimca, S.A. | Method for the biosynthesis of a microbial insecticide |
| US5234503A (en) * | 1987-02-02 | 1993-08-10 | A.E. Saley Manufacturing Co. | Integrated process for producing crystalline fructose and a high-fructose, liquid-phase sweetener |
| DE3717370A1 (de) * | 1987-05-22 | 1988-12-01 | Hoechst Ag | Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus |
| DE4013388A1 (de) * | 1990-04-26 | 1991-10-31 | Titus Hans Joachim | Zentrifugen-trockner |
| US5526581A (en) * | 1992-10-30 | 1996-06-18 | Philip Morris Incorporated | Process for adjusting the moisture content of organic materials |
| DE59409816D1 (de) * | 1993-04-27 | 2001-09-13 | Hoechst Ag | Amorphe monosphärische Formen von Insulinderivaten |
| US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
| US5544425A (en) * | 1995-05-17 | 1996-08-13 | Mallinckrodt Medical, Inc. | Aggressive convective drying in a nutsche type filter/dryer |
| GB9522302D0 (en) * | 1995-10-31 | 1996-01-03 | Univ Liverpool | Growth promoters |
| US5932212A (en) * | 1996-05-24 | 1999-08-03 | Altus Biologics, Inc. | Crosslinked protein crystal formulations and their use as catalysts in organic solvents |
| US5743840A (en) * | 1996-06-24 | 1998-04-28 | Carr Separations, Inc. | Centrifuge with a heating jacket for drying collected solids |
| IL131796A0 (en) * | 1997-03-20 | 2001-03-19 | Novo Nordisk As | Zinc free insulin crystals for use in pulmonary compositions |
| DE19903125B4 (de) * | 1999-01-27 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Trocknung von Kristallen von Insulin oder Insulinanaloga |
-
1999
- 1999-01-27 DE DE19903125A patent/DE19903125B4/de not_active Expired - Lifetime
-
2000
- 2000-01-13 US US09/482,117 patent/US6408536B1/en not_active Expired - Lifetime
- 2000-01-15 RU RU2001123684/04A patent/RU2235730C2/ru active
- 2000-01-15 EP EP00903580A patent/EP1185548B1/de not_active Expired - Lifetime
- 2000-01-15 HU HU0105427A patent/HU226697B1/hu unknown
- 2000-01-15 CA CA2361397A patent/CA2361397C/en not_active Expired - Lifetime
- 2000-01-15 DE DE50012577T patent/DE50012577D1/de not_active Expired - Lifetime
- 2000-01-15 BR BRPI0007713A patent/BRPI0007713B8/pt not_active IP Right Cessation
- 2000-01-15 ES ES00903580T patent/ES2259994T3/es not_active Expired - Lifetime
- 2000-01-15 WO PCT/EP2000/000287 patent/WO2000044767A2/de active IP Right Grant
- 2000-01-15 DK DK00903580T patent/DK1185548T3/da active
- 2000-01-15 PT PT00903580T patent/PT1185548E/pt unknown
- 2000-01-15 JP JP2000596023A patent/JP4465120B2/ja not_active Expired - Lifetime
- 2000-01-15 AU AU25418/00A patent/AU764353B2/en not_active Expired
- 2000-01-15 AT AT00903580T patent/ATE323101T1/de active
- 2000-01-15 PL PL350169A patent/PL197694B1/pl unknown
- 2000-01-15 CZ CZ20012630A patent/CZ300915B6/cs not_active IP Right Cessation
- 2000-01-15 CN CNB008031851A patent/CN1211397C/zh not_active Expired - Lifetime
- 2000-01-15 KR KR1020017009394A patent/KR100652471B1/ko active IP Right Grant
-
2002
- 2002-08-22 HK HK02106159.2A patent/HK1044548B/zh not_active IP Right Cessation
-
2006
- 2006-06-21 CY CY20061100837T patent/CY1105256T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/06/2016, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/01/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 15/01/2020 |