BG64764B1 - Многочастична фармацевтична форма със забавено и пулсационно освобождаване и метод за получаването й - Google Patents
Многочастична фармацевтична форма със забавено и пулсационно освобождаване и метод за получаването й Download PDFInfo
- Publication number
- BG64764B1 BG64764B1 BG104963A BG10496300A BG64764B1 BG 64764 B1 BG64764 B1 BG 64764B1 BG 104963 A BG104963 A BG 104963A BG 10496300 A BG10496300 A BG 10496300A BG 64764 B1 BG64764 B1 BG 64764B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- polymer
- coating
- water
- pharmaceutical form
- active ingredient
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title description 7
- 229920000642 polymer Polymers 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 23
- 239000011248 coating agent Substances 0.000 claims abstract description 21
- 238000000576 coating method Methods 0.000 claims abstract description 21
- 230000035699 permeability Effects 0.000 claims abstract description 10
- 239000002245 particle Substances 0.000 claims abstract description 9
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 9
- 230000003111 delayed effect Effects 0.000 claims abstract description 8
- 239000000945 filler Substances 0.000 claims abstract description 8
- 230000002496 gastric effect Effects 0.000 claims abstract description 6
- 230000000968 intestinal effect Effects 0.000 claims abstract description 6
- 150000007524 organic acids Chemical class 0.000 claims abstract description 6
- 229920003176 water-insoluble polymer Polymers 0.000 claims abstract description 6
- 230000001419 dependent effect Effects 0.000 claims abstract description 4
- 230000007935 neutral effect Effects 0.000 claims abstract description 3
- 239000004480 active ingredient Substances 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 10
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 7
- 229960004166 diltiazem Drugs 0.000 claims description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 5
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 5
- 229920000178 Acrylic resin Polymers 0.000 claims description 5
- 239000004925 Acrylic resin Substances 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 229960001722 verapamil Drugs 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 125000005395 methacrylic acid group Chemical group 0.000 claims description 4
- 239000000454 talc Substances 0.000 claims description 4
- 229910052623 talc Inorganic materials 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000011247 coating layer Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 230000003266 anti-allergic effect Effects 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 229940125715 antihistaminic agent Drugs 0.000 claims description 2
- 239000000739 antihistaminic agent Substances 0.000 claims description 2
- 210000000748 cardiovascular system Anatomy 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims description 2
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims description 2
- -1 hydroxypropylmethyl Chemical group 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims 2
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 230000000541 pulsatile effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- FLKPEMZONWLCSK-UHFFFAOYSA-N phthalic acid di-n-ethyl ester Natural products CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 229920003159 Eudragit® RS 100 Polymers 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 5
- 229920003155 Eudragit® RL 100 Polymers 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 229910002012 Aerosil® Inorganic materials 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 229920003134 Eudragit® polymer Polymers 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000000622 irritating effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010007522 Cardiac asthma Diseases 0.000 description 1
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 229920003139 Eudragit® L 100 Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 208000004327 Paroxysmal Dyspnea Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 239000006255 coating slurry Substances 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9806384A FR2778848B1 (fr) | 1998-05-20 | 1998-05-20 | Forme pharmaceutique multiparticulaire a liberation programmee et pulsee et son procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG104963A BG104963A (en) | 2001-07-31 |
| BG64764B1 true BG64764B1 (bg) | 2006-03-31 |
Family
ID=9526556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104963A BG64764B1 (bg) | 1998-05-20 | 2000-11-17 | Многочастична фармацевтична форма със забавено и пулсационно освобождаване и метод за получаването й |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1077687B1 (enExample) |
| JP (1) | JP2002515423A (enExample) |
| KR (1) | KR100583065B1 (enExample) |
| CN (1) | CN1186014C (enExample) |
| AT (1) | ATE214598T1 (enExample) |
| AU (1) | AU758299B2 (enExample) |
| BG (1) | BG64764B1 (enExample) |
| BR (1) | BR9910606A (enExample) |
| CA (1) | CA2333188C (enExample) |
| DE (1) | DE69901062T2 (enExample) |
| DK (1) | DK1077687T3 (enExample) |
| ES (1) | ES2173739T3 (enExample) |
| FR (1) | FR2778848B1 (enExample) |
| GE (1) | GEP20022750B (enExample) |
| HU (1) | HU224193B1 (enExample) |
| IL (1) | IL139774A (enExample) |
| MX (1) | MXPA00011364A (enExample) |
| NO (1) | NO330501B1 (enExample) |
| NZ (1) | NZ508392A (enExample) |
| PL (1) | PL192950B1 (enExample) |
| PT (1) | PT1077687E (enExample) |
| TR (1) | TR200100107T2 (enExample) |
| WO (1) | WO1999059557A1 (enExample) |
| ZA (1) | ZA200006768B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US8802139B2 (en) | 2003-06-26 | 2014-08-12 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| US20060105039A1 (en) | 2004-10-21 | 2006-05-18 | Jin-Wang Lai | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| AU2013273835B2 (en) * | 2005-05-02 | 2016-07-07 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| US9161918B2 (en) * | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| WO2008136016A1 (en) * | 2007-05-08 | 2008-11-13 | Medreich Limited | A stable controlled release oral solid dosage form composition and a process thereof |
| NZ600256A (en) | 2009-12-02 | 2014-05-30 | Aptalis Pharma Ltd | Fexofenadine microcapsules and compositions containing them |
| FR2999432B1 (fr) | 2012-12-17 | 2014-12-12 | Ethypharm Sa | Comprimes orodispersibles obtenus par compression moulage |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2558396B2 (ja) * | 1990-06-28 | 1996-11-27 | 田辺製薬株式会社 | 放出制御型製剤 |
| US5567441A (en) * | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
| FR2754710B1 (fr) * | 1996-10-22 | 1998-12-31 | Prographarm Lab | Procede de preparation d'une forme pharmaceutique multiparticulaire a liberation controlee plurisequentielle |
-
1998
- 1998-05-20 FR FR9806384A patent/FR2778848B1/fr not_active Expired - Lifetime
-
1999
- 1999-05-20 AU AU38302/99A patent/AU758299B2/en not_active Expired
- 1999-05-20 WO PCT/FR1999/001201 patent/WO1999059557A1/fr not_active Ceased
- 1999-05-20 DK DK99920897T patent/DK1077687T3/da active
- 1999-05-20 MX MXPA00011364A patent/MXPA00011364A/es active IP Right Grant
- 1999-05-20 HU HU0102027A patent/HU224193B1/hu active IP Right Grant
- 1999-05-20 IL IL13977499A patent/IL139774A/xx not_active IP Right Cessation
- 1999-05-20 JP JP2000549222A patent/JP2002515423A/ja active Pending
- 1999-05-20 PT PT99920897T patent/PT1077687E/pt unknown
- 1999-05-20 NZ NZ508392A patent/NZ508392A/xx not_active IP Right Cessation
- 1999-05-20 DE DE69901062T patent/DE69901062T2/de not_active Expired - Lifetime
- 1999-05-20 ES ES99920897T patent/ES2173739T3/es not_active Expired - Lifetime
- 1999-05-20 EP EP99920897A patent/EP1077687B1/fr not_active Expired - Lifetime
- 1999-05-20 AT AT99920897T patent/ATE214598T1/de active
- 1999-05-20 TR TR2001/00107T patent/TR200100107T2/xx unknown
- 1999-05-20 PL PL344314A patent/PL192950B1/pl unknown
- 1999-05-20 BR BR9910606-0A patent/BR9910606A/pt not_active Application Discontinuation
- 1999-05-20 CA CA2333188A patent/CA2333188C/fr not_active Expired - Lifetime
- 1999-05-20 KR KR1020007013020A patent/KR100583065B1/ko not_active Expired - Fee Related
- 1999-05-20 CN CNB998074322A patent/CN1186014C/zh not_active Expired - Lifetime
- 1999-05-20 GE GEAP19995632A patent/GEP20022750B/en unknown
-
2000
- 2000-11-17 NO NO20005838A patent/NO330501B1/no not_active IP Right Cessation
- 2000-11-17 BG BG104963A patent/BG64764B1/bg unknown
- 2000-11-20 ZA ZA200006768A patent/ZA200006768B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6039979A (en) | Multiparticulate pharmaceutical form with programmed and pulsed release and process for its preparation | |
| FI78835C (fi) | Foerfarande foer framstaellning av en ny dipyridamol-retardform. | |
| EP0818992B1 (en) | Procedure for encapsulating nsaids | |
| RU2201223C2 (ru) | Фармацевтическая композиция из множества субъединиц и способ ее получения | |
| US5122384A (en) | Oral once-per-day organic nitrate formulation which does not induce tolerance | |
| BG64764B1 (bg) | Многочастична фармацевтична форма със забавено и пулсационно освобождаване и метод за получаването й | |
| JP2016106078A (ja) | アルコール耐性経口医薬形態 | |
| KR970001656B1 (ko) | 조절흡수 딜티아젬 제제 | |
| EP0687466A1 (en) | Homeopathic formulations | |
| US20080069872A1 (en) | Multi-Layered Controlled-Release Methylphenidate Pellet | |
| US6994873B2 (en) | Multiparticulate formulations of lithium salts for oral administration suitable for once-a-day administration | |
| CN101754754B (zh) | 含有包覆的含药物的颗粒的可分散药片及其制备方法 | |
| EP2808019B1 (en) | Improved nitazoxanide composition and preparation method thereof | |
| HK1033271B (en) | Multiparticulate pharmaceutical form with programmed and timed release and preparation method | |
| HK1160402A (en) | Oral pharmaceutical form based on microgranulates with prolonged release resistant to alcohol | |
| KR20030039707A (ko) | 오메프라졸 경구제제의 제조방법 |