BG104963A - Multiparticulate pharmaceutical form with programmed and timed release and preparation method - Google Patents

Multiparticulate pharmaceutical form with programmed and timed release and preparation method

Info

Publication number
BG104963A
BG104963A BG104963A BG10496300A BG104963A BG 104963 A BG104963 A BG 104963A BG 104963 A BG104963 A BG 104963A BG 10496300 A BG10496300 A BG 10496300A BG 104963 A BG104963 A BG 104963A
Authority
BG
Bulgaria
Prior art keywords
pharmaceutical form
active principle
timed release
polymer
hours
Prior art date
Application number
BG104963A
Other languages
Bulgarian (bg)
Other versions
BG64764B1 (en
Inventor
Edouard Gendrot
Gerard Cousin
Francoise Ragot
Marie-Christine Clee-Bouvet
Original Assignee
Ethypharm S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm S.A. filed Critical Ethypharm S.A.
Publication of BG104963A publication Critical patent/BG104963A/en
Publication of BG64764B1 publication Critical patent/BG64764B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention concerns a multiparticulate pharmaceutical form with delayed and timed release for starting to make the active principle available 4 to 8 hours after said pharmaceutical form has been ingested, then for gradually releasing the totality of the active principle within the following 8 to 20 hours. The invention is characterised in that it is free of organic acid and it is in the form of medicated spheroids consisting of a neutral spherical carrier comprising a first coating based on a mixture of at least a water soluble polymer and at least a water insoluble polymer wherein are uniformly distributed particles consisting an active principle, the whole comprising a second coating based on at least two independent pH polymers, having degrees of permeability with respect to different gastric and intestinal environments, optionally at least a dependent pH polymer, at least a plasticising agent and at least an inert filler distributed in said coating. 9 claims
BG104963A 1998-05-20 2000-11-17 Multiparticulate pharmaceutical form with programmed and timed release and preparation method BG64764B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9806384A FR2778848B1 (en) 1998-05-20 1998-05-20 MULTIPARTICULATE PHARMACEUTICAL FORMULA WITH PULSED RELEASE AND ITS PREPARATION METHOD

Publications (2)

Publication Number Publication Date
BG104963A true BG104963A (en) 2001-07-31
BG64764B1 BG64764B1 (en) 2006-03-31

Family

ID=9526556

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104963A BG64764B1 (en) 1998-05-20 2000-11-17 Multiparticulate pharmaceutical form with programmed and timed release and preparation method

Country Status (25)

Country Link
EP (1) EP1077687B1 (en)
JP (1) JP2002515423A (en)
KR (1) KR100583065B1 (en)
CN (1) CN1186014C (en)
AT (1) ATE214598T1 (en)
AU (1) AU758299B2 (en)
BG (1) BG64764B1 (en)
BR (1) BR9910606A (en)
CA (1) CA2333188C (en)
DE (1) DE69901062T2 (en)
DK (1) DK1077687T3 (en)
ES (1) ES2173739T3 (en)
FR (1) FR2778848B1 (en)
GE (1) GEP20022750B (en)
HK (1) HK1033271A1 (en)
HU (1) HU224193B1 (en)
IL (1) IL139774A (en)
MX (1) MXPA00011364A (en)
NO (1) NO330501B1 (en)
NZ (1) NZ508392A (en)
PL (1) PL192950B1 (en)
PT (1) PT1077687E (en)
TR (1) TR200100107T2 (en)
WO (1) WO1999059557A1 (en)
ZA (1) ZA200006768B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
WO2004112756A1 (en) 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
EP2417969A1 (en) 2004-10-21 2012-02-15 Aptalis Pharmatech, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
AU2013273835B2 (en) * 2005-05-02 2016-07-07 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US9161918B2 (en) * 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
WO2008136016A1 (en) * 2007-05-08 2008-11-13 Medreich Limited A stable controlled release oral solid dosage form composition and a process thereof
NZ600256A (en) 2009-12-02 2014-05-30 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
FR2999432B1 (en) 2012-12-17 2014-12-12 Ethypharm Sa ORODISPERSIBLE COMPRESSES OBTAINED BY COMPRESSION MOLDING

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2558396B2 (en) * 1990-06-28 1996-11-27 田辺製薬株式会社 Controlled release formulation
US5567441A (en) * 1995-03-24 1996-10-22 Andrx Pharmaceuticals Inc. Diltiazem controlled release formulation
FR2754710B1 (en) * 1996-10-22 1998-12-31 Prographarm Lab PROCESS FOR THE PREPARATION OF A MULTIPARTICULAR PHARMACEUTICAL FORM WITH CONTROLLED RELEASE PLURISEQUENTIELLE

Also Published As

Publication number Publication date
DE69901062D1 (en) 2002-04-25
JP2002515423A (en) 2002-05-28
BG64764B1 (en) 2006-03-31
DK1077687T3 (en) 2002-06-17
GEP20022750B (en) 2002-08-26
IL139774A (en) 2005-09-25
NO330501B1 (en) 2011-05-02
TR200100107T2 (en) 2001-06-21
BR9910606A (en) 2001-10-02
FR2778848B1 (en) 2001-11-23
AU758299B2 (en) 2003-03-20
IL139774A0 (en) 2002-02-10
KR20010052370A (en) 2001-06-25
ES2173739T3 (en) 2002-10-16
NO20005838D0 (en) 2000-11-17
HUP0102027A3 (en) 2002-12-28
DE69901062T2 (en) 2002-10-31
EP1077687B1 (en) 2002-03-20
ATE214598T1 (en) 2002-04-15
EP1077687A1 (en) 2001-02-28
HU224193B1 (en) 2005-06-28
PL192950B1 (en) 2006-12-29
ZA200006768B (en) 2001-11-20
NO20005838L (en) 2001-01-10
CA2333188A1 (en) 1999-11-25
HK1033271A1 (en) 2001-08-24
NZ508392A (en) 2002-09-27
HUP0102027A2 (en) 2002-03-28
AU3830299A (en) 1999-12-06
PL344314A1 (en) 2001-10-22
FR2778848A1 (en) 1999-11-26
CA2333188C (en) 2010-07-06
WO1999059557A1 (en) 1999-11-25
CN1305371A (en) 2001-07-25
MXPA00011364A (en) 2008-09-09
KR100583065B1 (en) 2006-06-08
CN1186014C (en) 2005-01-26
PT1077687E (en) 2002-09-30

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