BG64390B1 - Карбоцикличен нуклеозиден хемисулфат и неговото използване при лечението на вирусни инфекции - Google Patents

Карбоцикличен нуклеозиден хемисулфат и неговото използване при лечението на вирусни инфекции Download PDF

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Publication number
BG64390B1
BG64390B1 BG103959A BG10395999A BG64390B1 BG 64390 B1 BG64390 B1 BG 64390B1 BG 103959 A BG103959 A BG 103959A BG 10395999 A BG10395999 A BG 10395999A BG 64390 B1 BG64390 B1 BG 64390B1
Authority
BG
Bulgaria
Prior art keywords
salt
methanol
cyclopropylamino
purin
amino
Prior art date
Application number
BG103959A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103959A (en
Inventor
Alastair BRODIE
Martin Jones
John SEAGER
Christopher Wallis
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10812407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64390(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of BG103959A publication Critical patent/BG103959A/xx
Publication of BG64390B1 publication Critical patent/BG64390B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Seasonings (AREA)
BG103959A 1997-05-17 1999-12-07 Карбоцикличен нуклеозиден хемисулфат и неговото използване при лечението на вирусни инфекции BG64390B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9709945.1A GB9709945D0 (en) 1997-05-17 1997-05-17 A novel salt
PCT/EP1998/002835 WO1998052949A1 (en) 1997-05-17 1998-05-14 Carbocyclic nucleoside hemisulfate and its use in treating viral infections

Publications (2)

Publication Number Publication Date
BG103959A BG103959A (en) 2000-12-29
BG64390B1 true BG64390B1 (bg) 2004-12-30

Family

ID=10812407

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103959A BG64390B1 (bg) 1997-05-17 1999-12-07 Карбоцикличен нуклеозиден хемисулфат и неговото използване при лечението на вирусни инфекции

Country Status (51)

Country Link
US (1) US6294540B1 (sk)
EP (1) EP0983271B1 (sk)
JP (2) JP3150711B2 (sk)
KR (1) KR100521292B1 (sk)
CN (2) CN1150194C (sk)
AP (1) AP2009A (sk)
AR (2) AR015668A1 (sk)
AT (1) ATE259811T1 (sk)
AU (1) AU739953B2 (sk)
BG (1) BG64390B1 (sk)
BR (1) BRPI9809126B8 (sk)
CA (1) CA2289753C (sk)
CO (1) CO4940435A1 (sk)
DE (1) DE69821758T2 (sk)
DK (1) DK0983271T3 (sk)
DZ (1) DZ2493A1 (sk)
EA (1) EA001809B1 (sk)
EE (1) EE03924B1 (sk)
EG (1) EG23836A (sk)
ES (1) ES2214712T3 (sk)
GB (3) GB9709945D0 (sk)
GE (1) GEP20022680B (sk)
HK (1) HK1024236A1 (sk)
HN (1) HN1998000071A (sk)
HR (1) HRP980265B1 (sk)
HU (1) HU226563B1 (sk)
ID (1) ID24910A (sk)
IL (2) IL132793A0 (sk)
IS (1) IS2207B (sk)
JO (1) JO2032B1 (sk)
MA (1) MA26498A1 (sk)
MY (1) MY120151A (sk)
NO (1) NO324731B1 (sk)
NZ (2) NZ510622A (sk)
OA (1) OA11304A (sk)
PA (1) PA8451301A1 (sk)
PE (1) PE78799A1 (sk)
PL (1) PL189527B1 (sk)
PT (1) PT983271E (sk)
RS (1) RS49655B (sk)
SA (1) SA98190179B1 (sk)
SI (1) SI0983271T1 (sk)
SK (1) SK285159B6 (sk)
SV (1) SV1998000057A (sk)
TN (1) TNSN98065A1 (sk)
TR (1) TR199902810T2 (sk)
TW (1) TW480259B (sk)
UA (1) UA56231C2 (sk)
UY (1) UY25004A1 (sk)
WO (1) WO1998052949A1 (sk)
ZA (2) ZA984085B (sk)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9802472D0 (en) * 1998-02-06 1998-04-01 Glaxo Group Ltd Pharmaceutical compositions
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
GB0320738D0 (en) 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
CA2662586A1 (en) * 2006-09-28 2008-04-03 Esteve Quimica, S.A. Process for the preparation of abacavir
EP1905772A1 (en) 2006-09-28 2008-04-02 Esteve Quimica, S.A. Process for the preparation of abacavir
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
EP2218721A1 (en) * 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
EP2305680A3 (en) 2009-09-30 2011-05-18 Aurobindo Pharma Limited Novel salts of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
UA105556C2 (uk) 2010-01-27 2014-05-26 Віів Гелскер Компані Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
WO2012137227A2 (en) 2011-04-08 2012-10-11 Laurus Labs Private Limited Solid forms of antiretroviral compounds, process for the preparation and their pharmaceutical composition thereof
WO2014133085A1 (ja) 2013-02-27 2014-09-04 国立大学法人京都大学 がんの予防または治療用医薬組成物
CN104788451A (zh) * 2014-01-21 2015-07-22 浙江九洲药业股份有限公司 一种阿巴卡韦的制备方法
CN105315280A (zh) * 2014-06-06 2016-02-10 上海迪赛诺化学制药有限公司 一种阿巴卡韦结晶体及其制备方法
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434450A2 (en) * 1989-12-22 1991-06-26 The Wellcome Foundation Limited Therapeutic nucleosides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9417249D0 (en) * 1994-08-26 1994-10-19 Wellcome Found A novel salt
MY115461A (en) * 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
TR199802703T2 (xx) 1996-06-25 1999-03-22 Glaxo Group Limited HIV tedavisinde Vx478, Zidov�din, ve/veya 1592U89 i�eren kombinasyonlar�n kullan�m�.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434450A2 (en) * 1989-12-22 1991-06-26 The Wellcome Foundation Limited Therapeutic nucleosides

Also Published As

Publication number Publication date
CA2289753A1 (en) 1998-11-26
GB9926839D0 (en) 2000-01-12
HU226563B1 (en) 2009-04-28
EP0983271B1 (en) 2004-02-18
IL132793A0 (en) 2001-03-19
MY120151A (en) 2005-09-30
AR015668A1 (es) 2001-05-16
GB2348202B (en) 2001-08-08
SI0983271T1 (en) 2004-06-30
HRP980265A2 (en) 1999-02-28
EA199900944A1 (ru) 2000-06-26
CN100408580C (zh) 2008-08-06
JP2000514096A (ja) 2000-10-24
ATE259811T1 (de) 2004-03-15
GB2340491A (en) 2000-02-23
SK285159B6 (sk) 2006-07-07
EE9900537A (et) 2000-06-15
CO4940435A1 (es) 2000-07-24
TR199902810T2 (xx) 2000-02-21
IL132793A (en) 2006-10-31
GB0010222D0 (en) 2000-06-14
DZ2493A1 (fr) 2004-06-20
GB2348202A (en) 2000-09-27
KR100521292B1 (ko) 2005-10-17
DK0983271T3 (da) 2004-05-10
SV1998000057A (es) 1999-03-02
BRPI9809126B8 (pt) 2021-07-06
YU59599A (sk) 2002-08-12
AP2009A (en) 2009-06-26
CA2289753C (en) 2007-01-23
EP0983271A1 (en) 2000-03-08
UA56231C2 (uk) 2003-05-15
HN1998000071A (es) 1999-03-19
AU7765598A (en) 1998-12-11
WO1998052949A1 (en) 1998-11-26
BRPI9809126B1 (pt) 2018-02-06
OA11304A (en) 2003-10-22
EG23836A (en) 2007-10-02
BG103959A (en) 2000-12-29
HUP0002754A3 (en) 2003-01-28
PL189527B1 (pl) 2005-08-31
CN1515572A (zh) 2004-07-28
SK156199A3 (en) 2000-07-11
HK1024236A1 (en) 2000-10-05
BR9809126A (pt) 2000-08-01
CN1150194C (zh) 2004-05-19
NO995622L (no) 2000-01-14
RS49655B (sr) 2007-09-21
ZA984083B (en) 1999-11-15
MA26498A1 (fr) 2004-12-20
NZ510622A (en) 2002-04-26
JP3150711B2 (ja) 2001-03-26
EE03924B1 (et) 2002-12-16
PL336888A1 (en) 2000-07-17
PT983271E (pt) 2004-07-30
ZA984085B (en) 2000-01-26
KR20010012623A (ko) 2001-02-26
AP9901688A0 (en) 1999-12-31
CN1263529A (zh) 2000-08-16
DE69821758D1 (de) 2004-03-25
AU739953B2 (en) 2001-10-25
ID24910A (id) 2000-08-31
ES2214712T3 (es) 2004-09-16
JP2000327679A (ja) 2000-11-28
IS5246A (is) 1999-11-11
AR059120A2 (es) 2008-03-12
NO995622D0 (no) 1999-11-16
PE78799A1 (es) 1999-08-31
SA98190179B1 (ar) 2006-08-15
HUP0002754A2 (hu) 2001-06-28
NZ500865A (en) 2001-04-27
TNSN98065A1 (fr) 2005-03-15
DE69821758T2 (de) 2005-01-13
PA8451301A1 (es) 2000-05-24
GB9709945D0 (en) 1997-07-09
GEP20022680B (en) 2002-04-25
US6294540B1 (en) 2001-09-25
UY25004A1 (es) 2000-10-31
GB2340491B (en) 2000-10-18
EA001809B1 (ru) 2001-08-27
IS2207B (is) 2007-02-15
NO324731B1 (no) 2007-12-03
JO2032B1 (en) 1999-05-15
TW480259B (en) 2002-03-21
HRP980265B1 (en) 2004-10-31

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