BG64189B1 - Комбиниран препарат, съдържащ (4-трифлуорометил)-анилид на 5-метилизоксазол-4-карбоксилна киселина и амид на n-(4-трифлуорометилфенил)-2-циан-3-хидроксикротонова киселина - Google Patents
Комбиниран препарат, съдържащ (4-трифлуорометил)-анилид на 5-метилизоксазол-4-карбоксилна киселина и амид на n-(4-трифлуорометилфенил)-2-циан-3-хидроксикротонова киселина Download PDFInfo
- Publication number
- BG64189B1 BG64189B1 BG102697A BG10269798A BG64189B1 BG 64189 B1 BG64189 B1 BG 64189B1 BG 102697 A BG102697 A BG 102697A BG 10269798 A BG10269798 A BG 10269798A BG 64189 B1 BG64189 B1 BG 64189B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- ingredient
- combination preparation
- preparation according
- cancer
- compound
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19610955A DE19610955A1 (de) | 1996-03-20 | 1996-03-20 | Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid |
PCT/EP1997/001167 WO1997034600A1 (de) | 1996-03-20 | 1997-03-07 | Kombinationspräparat, enthaltend 5-methylisoxazol-4-carbonsäure-(4-trifluormethyl)-anilid und n-(4-trifluormethylphenyl)-2-cyan-3-hydroxycrotonsäureamid |
Publications (2)
Publication Number | Publication Date |
---|---|
BG102697A BG102697A (en) | 1999-09-30 |
BG64189B1 true BG64189B1 (bg) | 2004-04-30 |
Family
ID=7788856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102697A BG64189B1 (bg) | 1996-03-20 | 1998-08-17 | Комбиниран препарат, съдържащ (4-трифлуорометил)-анилид на 5-метилизоксазол-4-карбоксилна киселина и амид на n-(4-трифлуорометилфенил)-2-циан-3-хидроксикротонова киселина |
Country Status (23)
Country | Link |
---|---|
US (1) | US7071222B2 (tr) |
EP (1) | EP0896537B1 (tr) |
JP (1) | JP4206131B2 (tr) |
KR (1) | KR100464693B1 (tr) |
CN (1) | CN1141095C (tr) |
AT (1) | ATE183393T1 (tr) |
AU (1) | AU705692B2 (tr) |
BG (1) | BG64189B1 (tr) |
BR (1) | BR9708108A (tr) |
CY (1) | CY2209B1 (tr) |
CZ (1) | CZ289446B6 (tr) |
DE (2) | DE19610955A1 (tr) |
ES (1) | ES2137055T3 (tr) |
GR (1) | GR3031637T3 (tr) |
HK (1) | HK1018742A1 (tr) |
HU (1) | HU226677B1 (tr) |
NO (1) | NO315595B1 (tr) |
NZ (1) | NZ331933A (tr) |
PL (1) | PL188052B1 (tr) |
RU (1) | RU2198655C2 (tr) |
TR (1) | TR199801862T2 (tr) |
UA (1) | UA46103C2 (tr) |
WO (1) | WO1997034600A1 (tr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6355678B1 (en) | 1998-06-29 | 2002-03-12 | Parker Hughes Institute | Inhibitors of the EGF-receptor tyrosine kinase and methods for their use |
DE19960443C2 (de) | 1999-12-15 | 2002-05-08 | Aventis Pharma Gmbh | Verfahren zur Auffindung von Nukleotidsyntheseinhibitoren mit weniger Nebenwirkungen |
KR20020067545A (ko) * | 1999-12-16 | 2002-08-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 레플루노마이드의 신규 제조 방법 및 이의 신규 결정형 |
DE10112925A1 (de) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | Verwendung von Zuckerphosphaten, Zuckerphosphatanalogen, Aminosäuren, Aminosäureanalogen zur Modulation von Transaminasen und/oder der Assoziation p36/Malat Dehydrogenase |
US20040152772A1 (en) * | 2001-03-13 | 2004-08-05 | Erich Eigenbrodt | 1-butyric acid derivatives and the use thereof |
DE10112924A1 (de) * | 2001-03-13 | 2002-10-02 | Erich Eigenbrodt | 1-Butansäurederivate, pharmazeutische Zusammensetzungen enthaltend solche Derivate und Verwendungen solcher Derivate |
GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
MXPA04000224A (es) | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
MXPA05006889A (es) | 2002-12-23 | 2006-04-07 | 4Sc Ag | Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos. |
ES2319596B1 (es) | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
EP2100881A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Pyrimidyl- or pyridinylaminobenzoic acid derivatives |
EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
EP2239256A1 (en) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor |
EP2314577A1 (en) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid |
US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
UA108760C2 (uk) | 2010-07-01 | 2015-06-10 | Кальцієві солі сполуки як протизапальні, імуномодулюючі та антипроліферативні засоби | |
EP2444086A1 (en) | 2010-10-22 | 2012-04-25 | Almirall, S.A. | Combinations comprising DHODH inhibitors and COX inhibitors |
EP2672963A4 (en) | 2011-02-08 | 2015-06-24 | Childrens Medical Center | METHOD FOR THE TREATMENT OF MELANOMA |
CN103755592A (zh) * | 2013-12-30 | 2014-04-30 | 镇江圣安医药有限公司 | (2z)-氰基-3-羟基-n-[4-(三氟甲基)苯基]-2-丁烯酰胺的衍生物及其应用 |
WO2018136009A1 (en) | 2017-01-20 | 2018-07-26 | Aslan Pharmaceuticals Pte Ltd | Combination therapy |
IL307422A (en) | 2018-03-16 | 2023-12-01 | Immunic Ag | Polymorphs of the calcium salts that suppress dihydrouroatate dehydrogenase, and methods for their production |
CA3176008A1 (en) | 2020-04-21 | 2021-10-28 | Manfred Groppel | Vidofludimus for use in the treatment or prevention of viral diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
US5268382A (en) | 1985-09-27 | 1993-12-07 | Hoechst Aktiengesellschaft | Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus |
US5494911A (en) | 1990-05-18 | 1996-02-27 | Hoechst Aktiengesellschaft | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use |
DE4127737A1 (de) | 1991-08-22 | 1993-02-25 | Hoechst Ag | Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen |
US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
DE19908527C2 (de) | 1999-02-26 | 2001-08-30 | Aventis Pharma Gmbh | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
-
1996
- 1996-03-20 DE DE19610955A patent/DE19610955A1/de not_active Withdrawn
-
1997
- 1997-03-07 CZ CZ19982985A patent/CZ289446B6/cs not_active IP Right Cessation
- 1997-03-07 US US09/101,672 patent/US7071222B2/en not_active Expired - Lifetime
- 1997-03-07 AT AT97907081T patent/ATE183393T1/de active
- 1997-03-07 PL PL97328998A patent/PL188052B1/pl unknown
- 1997-03-07 RU RU98119285/14A patent/RU2198655C2/ru active
- 1997-03-07 NZ NZ331933A patent/NZ331933A/en not_active IP Right Cessation
- 1997-03-07 WO PCT/EP1997/001167 patent/WO1997034600A1/de active IP Right Grant
- 1997-03-07 BR BR9708108A patent/BR9708108A/pt active IP Right Grant
- 1997-03-07 HU HU9902130A patent/HU226677B1/hu unknown
- 1997-03-07 CN CNB971930414A patent/CN1141095C/zh not_active Expired - Lifetime
- 1997-03-07 TR TR1998/01862T patent/TR199801862T2/tr unknown
- 1997-03-07 JP JP53309597A patent/JP4206131B2/ja not_active Expired - Lifetime
- 1997-03-07 ES ES97907081T patent/ES2137055T3/es not_active Expired - Lifetime
- 1997-03-07 KR KR10-1998-0707520A patent/KR100464693B1/ko not_active IP Right Cessation
- 1997-03-07 AU AU19261/97A patent/AU705692B2/en not_active Expired
- 1997-03-07 DE DE59700356T patent/DE59700356D1/de not_active Expired - Lifetime
- 1997-03-07 UA UA98105468A patent/UA46103C2/uk unknown
- 1997-03-07 EP EP97907081A patent/EP0896537B1/de not_active Expired - Lifetime
-
1998
- 1998-08-17 BG BG102697A patent/BG64189B1/bg unknown
- 1998-09-18 NO NO19984343A patent/NO315595B1/no not_active IP Right Cessation
-
1999
- 1999-08-27 HK HK99103705A patent/HK1018742A1/xx not_active IP Right Cessation
- 1999-10-27 GR GR990402726T patent/GR3031637T3/el unknown
-
2000
- 2000-12-01 CY CY0000065A patent/CY2209B1/xx unknown
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