BG64167B1 - Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация - Google Patents

Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация Download PDF

Info

Publication number
BG64167B1
BG64167B1 BG104466A BG10446600A BG64167B1 BG 64167 B1 BG64167 B1 BG 64167B1 BG 104466 A BG104466 A BG 104466A BG 10446600 A BG10446600 A BG 10446600A BG 64167 B1 BG64167 B1 BG 64167B1
Authority
BG
Bulgaria
Prior art keywords
formula
och
hydrogen
use according
radical
Prior art date
Application number
BG104466A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104466A (en
Inventor
Thomas Fahrig
Irene Gerlach
Ervin Horvath
Reinhard Jork
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG104466A publication Critical patent/BG104466A/xx
Publication of BG64167B1 publication Critical patent/BG64167B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BG104466A 1997-11-24 2000-05-22 Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация BG64167B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19751949A DE19751949A1 (de) 1997-11-24 1997-11-24 Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
PCT/EP1998/007197 WO1999026621A1 (de) 1997-11-24 1998-11-11 Verwendung von substituierten aminomethyl-chromanen zur verhinderung der neuronalen degeneration und zur förderung der neuronalen regeneration

Publications (2)

Publication Number Publication Date
BG104466A BG104466A (en) 2001-02-28
BG64167B1 true BG64167B1 (bg) 2004-03-31

Family

ID=7849618

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104466A BG64167B1 (bg) 1997-11-24 2000-05-22 Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация

Country Status (30)

Country Link
US (2) US6235774B1 (hu)
EP (1) EP1051170B1 (hu)
JP (1) JP2001523716A (hu)
KR (1) KR20010032357A (hu)
CN (1) CN1134256C (hu)
AR (1) AR016973A1 (hu)
AT (1) ATE206615T1 (hu)
AU (1) AU745759B2 (hu)
BG (1) BG64167B1 (hu)
CA (1) CA2311126A1 (hu)
DE (2) DE19751949A1 (hu)
DK (1) DK1051170T3 (hu)
ES (1) ES2164465T3 (hu)
HN (1) HN1998000169A (hu)
HU (1) HUP0004369A3 (hu)
IL (1) IL135904A (hu)
IS (1) IS5496A (hu)
MY (1) MY118414A (hu)
NO (1) NO20002638L (hu)
NZ (1) NZ504656A (hu)
PE (1) PE134999A1 (hu)
PL (1) PL340674A1 (hu)
PT (1) PT1051170E (hu)
RU (1) RU2217140C2 (hu)
SI (1) SI1051170T1 (hu)
SV (1) SV1998000138A (hu)
TR (1) TR200001471T2 (hu)
TW (1) TW524690B (hu)
WO (1) WO1999026621A1 (hu)
ZA (1) ZA9810668B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
UA73981C2 (en) * 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
AU2001238552A1 (en) * 2000-03-17 2001-10-03 Alcon, Inc. Compounds with 5-HT2 and 5-HT1A agonist activity for treating glaucoma
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
DE10058119A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Pepinotan-Kit
SE0004455D0 (sv) * 2000-12-01 2000-12-01 Milos Pekny Method for neuron regeneration in the central nervous system
DE10101917A1 (de) * 2001-01-16 2002-07-18 Bayer Ag Verwendung von Chromanen
ATE352302T1 (de) * 2001-07-26 2007-02-15 Merck Patent Gmbh Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze
JP2005522410A (ja) * 2001-09-12 2005-07-28 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 動作障害および錐体外路性動作障害を処置するために投与された薬剤により誘発された悪影響の処置のための置換アミノメチルクロマンの新規な使用
DE10155075A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclische Sulfonamide
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
US7514461B2 (en) * 2003-09-19 2009-04-07 Edison Pharmaceuticals, Inc. Chroman derivatives
DE102004017627A1 (de) * 2004-04-10 2005-10-27 Bayer Healthcare Ag Verwendung von vollen 5-HT1A-Agonisten zur Hemmung der opiat/opioid-induzierten Atemdepression
WO2018023070A1 (en) 2016-07-29 2018-02-01 Sunovion Pharmaceuticals, Inc. Compounds and compositions and uses thereof
MX2019000980A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
RU2651756C1 (ru) * 2017-05-10 2018-04-23 Федеральное государственное бюджетное образовательное учреждение Высшего Образования Кубанский Государственный Медицинский Университет Министерства Здравоохранения Российской Федерации, КубГМУ Препарат для предотвращения образования глиальных рубцов
WO2019028165A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. ISOCHROMAN COMPOUNDS AND USES THEREOF
JP2022525169A (ja) 2019-03-14 2022-05-11 サノビオン ファーマシューティカルズ インク イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300523A (en) 1988-07-28 1994-04-05 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
DE19522088A1 (de) 1995-06-19 1997-01-02 Bayer Ag Benzisothiazolyl-substituierte Aminomethylchromane
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration

Also Published As

Publication number Publication date
PT1051170E (pt) 2002-02-28
US6331561B2 (en) 2001-12-18
HN1998000169A (es) 1999-11-03
ATE206615T1 (de) 2001-10-15
IL135904A (en) 2003-07-06
MY118414A (en) 2004-10-30
DK1051170T3 (da) 2001-12-27
AR016973A1 (es) 2001-08-01
EP1051170A1 (de) 2000-11-15
CN1134256C (zh) 2004-01-14
KR20010032357A (ko) 2001-04-16
IS5496A (is) 2000-05-15
EP1051170B1 (de) 2001-10-10
SV1998000138A (es) 1999-05-25
TR200001471T2 (tr) 2000-10-23
DE59801724D1 (de) 2001-11-15
ES2164465T3 (es) 2002-02-16
AU745759B2 (en) 2002-03-28
US20010018530A1 (en) 2001-08-30
BG104466A (en) 2001-02-28
RU2217140C2 (ru) 2003-11-27
CA2311126A1 (en) 1999-06-03
HUP0004369A3 (en) 2002-04-29
AU1668599A (en) 1999-06-15
ZA9810668B (en) 1999-05-26
DE19751949A1 (de) 1999-05-27
NO20002638D0 (no) 2000-05-23
IL135904A0 (en) 2001-05-20
NZ504656A (en) 2002-02-01
HUP0004369A2 (hu) 2001-04-28
NO20002638L (no) 2000-05-23
TW524690B (en) 2003-03-21
CN1279604A (zh) 2001-01-10
SI1051170T1 (en) 2001-12-31
PL340674A1 (en) 2001-02-12
US6235774B1 (en) 2001-05-22
WO1999026621A1 (de) 1999-06-03
JP2001523716A (ja) 2001-11-27
PE134999A1 (es) 2000-03-05

Similar Documents

Publication Publication Date Title
BG64167B1 (bg) Използване на заместени аминометил-хромани за профилактика на невронална дегенерация и за стимулиране на невронална регенерация
EP2258372B1 (en) A2A antagonists for use in the treatment of motor disorders
DE68913756T2 (de) In vivo cytoprotektiv wirkende neurotrope alkohole.
JP2007526277A (ja) 経口投与を目的としたトルペリゾンの徐放性医薬組成物
US6165515A (en) Method for treatment of osteoporosis
AU2019414329A1 (en) Methods for treating parkinson's disease by administering resiniferatoxin
DE19858789A1 (de) Kombination von Cerivastatin und Fibraten
JP2002534379A (ja) 新規なブレチリウム組成物およびキットならびに心血管症状の予防および治療におけるそれらの使用
JPH03184918A (ja) ホスファチジルカルニチンを含有するヒトの神経損傷関連疾患治療剤
EP0214933A2 (de) Kombinationspräparate zur Behandlung von Malaria
DE102010015242A1 (de) Kombination aus Vitamin K und Nikotinamid
KR100794204B1 (ko) 신경 친화성 타크로리무스 유사체
JP7344422B2 (ja) 糖尿病予防・治療用の医薬品組成物及びその用途
US20060160887A1 (en) Medicinal composition
DE60212813T2 (de) Metronomische dosierung von taxanen zur hemmung von krebswachstum
EP1038526A1 (de) Behandlung von funktionellen Störungen der unteren Darmwege und einhergehenden visceralen Schmerzen mit Moxonidin
US20040077676A1 (en) Neurotrophic tacrolimus analogs
CN115105520B (zh) 黄芩苷在制备用于治疗弱视的药物中的应用
CA2147357A1 (en) Methods and compositions (+) doxazosin for the treatment of hypertension
CN116801866A (zh) α-细辛脑在制备预防或治疗出血性脑卒中药物中的应用
CN114096314A (zh) 痴呆症的治疗和预防药
MXPA00005054A (en) Application of substituted aminomethyl chromans in order to prevent neural degeneration and to promote neural regeneration
WO1997031638A1 (de) VERWENDUNG VON α1-ADRENOCEPTOR-ANTAGONISTEN