BG63082B1 - Фенилови хетероциклени съединения като инхибиторина циклооксигеназа-2 - Google Patents
Фенилови хетероциклени съединения като инхибиторина циклооксигеназа-2 Download PDFInfo
- Publication number
- BG63082B1 BG63082B1 BG100350A BG10035096A BG63082B1 BG 63082 B1 BG63082 B1 BG 63082B1 BG 100350 A BG100350 A BG 100350A BG 10035096 A BG10035096 A BG 10035096A BG 63082 B1 BG63082 B1 BG 63082B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- phenyl
- furanone
- methylsulfonyl
- fluorophenyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/179,467 US5474995A (en) | 1993-06-24 | 1994-01-10 | Phenyl heterocycles as cox-2 inhibitors |
PCT/CA1994/000688 WO1995018799A1 (en) | 1994-01-10 | 1994-12-19 | Phenyl heterocycles as cox-2 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BG100350A BG100350A (bg) | 1996-12-31 |
BG63082B1 true BG63082B1 (bg) | 2001-03-30 |
Family
ID=22656713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG100350A BG63082B1 (bg) | 1994-01-10 | 1996-02-12 | Фенилови хетероциклени съединения като инхибиторина циклооксигеназа-2 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0739340A1 (zh) |
JP (1) | JP2788677B2 (zh) |
CN (1) | CN1143365A (zh) |
AU (1) | AU1269495A (zh) |
BG (1) | BG63082B1 (zh) |
BR (1) | BR9408478A (zh) |
CA (1) | CA2180651A1 (zh) |
FI (1) | FI108792B (zh) |
HU (1) | HUT74986A (zh) |
NO (1) | NO960393L (zh) |
SG (1) | SG43841A1 (zh) |
WO (1) | WO1995018799A1 (zh) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9420616D0 (en) * | 1994-10-12 | 1994-11-30 | Merck Sharp & Dohme | Method, compositions and use |
AU715676B2 (en) * | 1993-03-12 | 2000-02-10 | Merck Frosst Canada & Co. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5840746A (en) * | 1993-06-24 | 1998-11-24 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
US5585504A (en) * | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
SK5298A3 (en) * | 1995-07-19 | 1998-12-02 | Merck & Co Inc | Use of nsaid for producing a medicament for retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma |
US6593361B2 (en) | 1995-07-19 | 2003-07-15 | Merck & Co Inc | Method of treating colonic adenomas |
US5968974A (en) | 1995-07-19 | 1999-10-19 | Merck & Co., Inc. | Method of treating colonic adenomas |
HUP9902889A3 (en) * | 1996-05-17 | 2002-04-29 | Merck Frosst Canada & Co Kirkl | The use of 3-phenyl-4-(4-methylsulphonyl)-phenyl-2-(5h)-furanone for producing anti inflammatory medicaments and such medicaments |
AU775030B2 (en) * | 1996-05-17 | 2004-07-15 | Merck Frosst Company | Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases |
GB9615867D0 (en) * | 1996-07-03 | 1996-09-11 | Merck & Co Inc | Process of preparing phenyl heterocycles useful as cox-2 inhibitors |
US5939069A (en) * | 1996-08-23 | 1999-08-17 | University Of Florida | Materials and methods for detection and treatment of immune system dysfunctions |
US6004960A (en) * | 1997-03-14 | 1999-12-21 | Merck Frosst Canada, Inc. | Pyridazinones as inhibitors of cyclooxygenase-2 |
JP2001514669A (ja) * | 1997-03-14 | 2001-09-11 | メルク フロスト カナダ アンド カンパニー | シクロオキシゲナーゼ−2阻害薬としてのピリダジノン類 |
ATE231504T1 (de) * | 1997-04-11 | 2003-02-15 | Grelan Pharmaceutical Co | Pyrazolderivate und sie enthaltende cox- inhibitoren |
WO1998051667A1 (fr) * | 1997-05-16 | 1998-11-19 | Chugai Seiyaku Kabushiki Kaisha | Derives d'indole et derives de mono- et diazaindole |
AU744997B2 (en) | 1997-09-05 | 2002-03-07 | Glaxo Group Limited | 2,3-diaryl-pyrazolo(1,5-B)pyridazines derivatives, their preparation and their use as cyclooxygenase 2 (COX-2) inhibitors |
NZ333399A (en) | 1997-12-24 | 2000-05-26 | Sankyo Co | Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis |
SA99191255B1 (ar) | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
BR0108077A (pt) | 2000-02-04 | 2002-10-22 | Children S Hospital Res Founda | Processo para reduzir placas ateroscleróticas em um mamìfero, método para tratamento da aterosclerose em um mamìfero, composição, métodos para prover proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo ou mistura deles, para células de um mamìfero tendo deficiência na proteìna ou polipeptìdeo hidrolisante de lipìdeo biologicamente ativo , para prover lipase de ácido lisossomal biologicamente ativa para células de um mamìfero tendo deficiência de lipase de ácido lisossomal biologicamente ativa, para prover lipase de ácido lisossoal biologicamente ativa para células de um mamìfero com aterosclerose, para tratamento da doença de wolman em um mamìfero, para tratamento de doença de armazenagem de colesteril éster em um mamìfero, e, para tratamento da aterosclerose em um mamìfero |
US6465509B2 (en) | 2000-06-30 | 2002-10-15 | Merck Frosst Canada & Co. | Pyrones as inhibitors of cyclooxygenase-2 |
DE10133665A1 (de) * | 2001-07-11 | 2003-01-30 | Boehringer Ingelheim Pharma | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung |
EP3072978B1 (en) | 2002-05-09 | 2018-07-11 | The Brigham and Women's Hospital, Inc. | 1l1rl-1 as a cardiovascular disease marker |
JP2006501179A (ja) | 2002-06-27 | 2006-01-12 | ニトロメッド インコーポレーティッド | シクロオキシゲナーゼ−2選択的阻害剤、組成物、および使用方法 |
AU2004315596B2 (en) | 2003-08-29 | 2011-11-24 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis |
KR20050051729A (ko) * | 2003-11-28 | 2005-06-02 | 일양약품주식회사 | 사이클로 옥시게나제-2 억제제인 페닐 헤테로사이클의제조방법 |
DE102004027912A1 (de) | 2004-06-09 | 2005-12-29 | Grünenthal GmbH | Substituierte Cyclopenten-Verbindungen |
US9164104B2 (en) | 2004-10-06 | 2015-10-20 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
US7521435B2 (en) | 2005-02-18 | 2009-04-21 | Pharma Diagnostics, N.V. | Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same |
EP1982711A1 (en) | 2005-05-31 | 2008-10-22 | Mylan Laboratories, Inc | Compositions comprsing nebivolol |
US8119358B2 (en) | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
DK3279663T3 (da) | 2006-03-15 | 2021-10-18 | Brigham & Womens Hospital Inc | Anvendelse af gelsolin til diagnosticering og behandling af inflammationssygdomme |
US20080057590A1 (en) | 2006-06-07 | 2008-03-06 | Mickey Urdea | Markers associated with arteriovascular events and methods of use thereof |
WO2008131224A2 (en) | 2007-04-18 | 2008-10-30 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
GB2460915B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
EP2531163A1 (en) | 2010-02-01 | 2012-12-12 | The Hospital For Sick Children | Remote ischemic conditioning for treatment and preventon of restenosis |
CA2795053A1 (en) | 2010-03-31 | 2011-10-06 | The Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
EP2855458B1 (en) | 2012-05-11 | 2018-08-08 | Reset Therapeutics, Inc. | Carbazole-containing sulfonamides as cryptochrome modulators |
EP2968276A4 (en) | 2013-03-15 | 2017-02-15 | President and Fellows of Harvard College | Hybrid necroptosis inhibitors |
TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
US20220031631A1 (en) | 2018-09-19 | 2022-02-03 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
EP3852732A1 (en) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Peg lipids and uses thereof |
EP3883562A4 (en) | 2018-11-21 | 2022-08-03 | Tremeau Pharmaceuticals, Inc. | PURIFIED FORMS OF ROFECOXIB AND METHODS OF MAKING AND USING |
US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0388909A3 (en) * | 1989-03-22 | 1991-05-08 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
JPH05506215A (ja) * | 1990-04-17 | 1993-09-16 | アラーガン、インコーポレイテッド | 抗炎症剤としての5および/または4位で置換した2(5h)―フラノン |
GB9012936D0 (en) * | 1990-06-11 | 1990-08-01 | Fujisawa Pharmaceutical Co | Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
ES2111288T3 (es) * | 1993-01-15 | 1998-03-01 | Searle & Co | Nuevos 3,4-diaril tiofenos y analogos de los mismos utiles como agentes antiinflamatorios. |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
KR960703901A (ko) * | 1993-08-19 | 1996-08-31 | 로즈 암스트롱 | 치환된 2(5H)푸라논, 2(5H)티오페논 및 2(5H)피롤론 유도체, 그의 제조 방법 및 엔도텔린 길항제로서의 그의 용도(Substituted 2(5H)Furanone, 2(5H)Thiophenone and 2(5H)Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists) |
-
1994
- 1994-12-19 EP EP95903727A patent/EP0739340A1/en not_active Withdrawn
- 1994-12-19 CN CN94195045A patent/CN1143365A/zh active Pending
- 1994-12-19 CA CA002180651A patent/CA2180651A1/en not_active Abandoned
- 1994-12-19 JP JP7518234A patent/JP2788677B2/ja not_active Expired - Fee Related
- 1994-12-19 BR BR9408478A patent/BR9408478A/pt not_active Application Discontinuation
- 1994-12-19 SG SG1996002006A patent/SG43841A1/en unknown
- 1994-12-19 AU AU12694/95A patent/AU1269495A/en not_active Abandoned
- 1994-12-19 WO PCT/CA1994/000688 patent/WO1995018799A1/en active IP Right Grant
- 1994-12-19 HU HU9601875A patent/HUT74986A/hu not_active Application Discontinuation
-
1996
- 1996-01-30 NO NO960393A patent/NO960393L/no not_active Application Discontinuation
- 1996-02-12 BG BG100350A patent/BG63082B1/bg unknown
- 1996-07-09 FI FI962800A patent/FI108792B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI962800A (fi) | 1996-09-06 |
HUT74986A (en) | 1997-03-28 |
JP2788677B2 (ja) | 1998-08-20 |
FI962800A0 (fi) | 1996-07-09 |
BG100350A (bg) | 1996-12-31 |
AU1269495A (en) | 1995-08-01 |
CN1143365A (zh) | 1997-02-19 |
FI108792B (fi) | 2002-03-28 |
JPH09506631A (ja) | 1997-06-30 |
NO960393L (no) | 1996-07-09 |
EP0739340A1 (en) | 1996-10-30 |
CA2180651A1 (en) | 1995-07-13 |
WO1995018799A1 (en) | 1995-07-13 |
NO960393D0 (no) | 1996-01-30 |
BR9408478A (pt) | 1997-08-26 |
HU9601875D0 (en) | 1996-09-30 |
SG43841A1 (en) | 1997-11-14 |
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