BG62930B1 - Селективни инхибитори на ароматазата, по-специално дифенилтриазолови производни - Google Patents
Селективни инхибитори на ароматазата, по-специално дифенилтриазолови производни Download PDFInfo
- Publication number
- BG62930B1 BG62930B1 BG99699A BG9969995A BG62930B1 BG 62930 B1 BG62930 B1 BG 62930B1 BG 99699 A BG99699 A BG 99699A BG 9969995 A BG9969995 A BG 9969995A BG 62930 B1 BG62930 B1 BG 62930B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- formula
- compound
- choh
- cyanophenyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9226209A GB2273704B (en) | 1992-12-16 | 1992-12-16 | Triazolyl diaryl selective aromatase inhibiting compounds |
| PCT/FI1993/000539 WO1994013645A1 (en) | 1992-12-16 | 1993-12-14 | Novel selective aromatase inhibiting compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG99699A BG99699A (bg) | 1996-04-30 |
| BG62930B1 true BG62930B1 (bg) | 2000-11-30 |
Family
ID=10726697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG99699A BG62930B1 (bg) | 1992-12-16 | 1995-06-05 | Селективни инхибитори на ароматазата, по-специално дифенилтриазолови производни |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US5703109A (ru) |
| EP (1) | EP0674626B1 (ru) |
| JP (1) | JP3186771B2 (ru) |
| KR (1) | KR100347639B1 (ru) |
| CN (1) | CN1056835C (ru) |
| AT (1) | ATE194833T1 (ru) |
| AU (1) | AU682332B2 (ru) |
| BG (1) | BG62930B1 (ru) |
| CA (1) | CA2150904A1 (ru) |
| CZ (1) | CZ283043B6 (ru) |
| DE (1) | DE69329072T2 (ru) |
| DK (1) | DK0674626T3 (ru) |
| EE (1) | EE03155B1 (ru) |
| ES (1) | ES2148312T3 (ru) |
| FI (1) | FI952867A (ru) |
| GB (1) | GB2273704B (ru) |
| GR (1) | GR3034618T3 (ru) |
| HR (1) | HRP931494B1 (ru) |
| IL (1) | IL107714A (ru) |
| LT (1) | LT3151B (ru) |
| NO (1) | NO310237B1 (ru) |
| NZ (1) | NZ258588A (ru) |
| PL (1) | PL176413B1 (ru) |
| PT (1) | PT674626E (ru) |
| RO (1) | RO113986B1 (ru) |
| RU (1) | RU2131418C1 (ru) |
| SI (1) | SI9300663B (ru) |
| SK (1) | SK281667B6 (ru) |
| TW (1) | TW327169B (ru) |
| WO (1) | WO1994013645A1 (ru) |
| ZA (1) | ZA938717B (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0891334A1 (en) * | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6063930A (en) * | 1996-04-03 | 2000-05-16 | Merck & Co., Inc. | Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| US6080870A (en) * | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
| US5972921A (en) * | 1997-12-12 | 1999-10-26 | Hormos Medical Oy Ltd. | Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men |
| EP1303270B1 (en) * | 2000-07-10 | 2006-03-29 | Hormos Medical Ltd. | Method for treating cryptorchidism |
| FI20010905A0 (fi) * | 2001-05-02 | 2001-05-02 | Vetcare Oy | Uusi eläinlääke |
| JP2005515207A (ja) * | 2001-12-11 | 2005-05-26 | エモリー ユニバーシティ | 乳癌の予防において使用するためのビス（シアノフェニル）メチル−トリアゾール |
| EP1431292A1 (en) * | 2002-12-16 | 2004-06-23 | Laboratoire Theramex | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors |
| JP2004196795A (ja) * | 2002-12-16 | 2004-07-15 | Wyeth | 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル |
| US7345073B2 (en) | 2003-02-07 | 2008-03-18 | Hormos Medical Ltd. | Method for treating cryptorchidism |
| US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
| CA2549603A1 (en) * | 2003-12-15 | 2005-06-30 | Laboratoire Theramex | 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them |
| MX2008014825A (es) * | 2006-05-22 | 2008-12-01 | Hormos Medical Ltd | Moduladores selectivos del receptor de estrogeno o inhibidores de aromatasa para tratar prostatitis cronica no bacteriana. |
| GB0914767D0 (en) * | 2009-08-24 | 2009-09-30 | Sterix Ltd | Compound |
| WO2011127232A2 (en) | 2010-04-08 | 2011-10-13 | Emory University | Substituted androst-4-ene diones |
| JP5870093B2 (ja) * | 2010-05-27 | 2016-02-24 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 殺菌剤としてのヘテロ環式アルカノール誘導体 |
| KR101583521B1 (ko) | 2015-07-31 | 2016-01-08 | (주) 엘림비엠에스 | 내오염, 내마모 성능과 시공 작업성 및 광도 성능이 개선된 피브이씨 타일 바닥의 코팅방법 |
| US10905253B2 (en) | 2018-04-19 | 2021-02-02 | Wonderland Switzerland Ag | Child carrier |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1580535A (en) * | 1976-08-27 | 1980-12-03 | Ici Ltd | Substituted ketones and their use as herbicides |
| US4937250A (en) | 1988-03-07 | 1990-06-26 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| US5112845A (en) * | 1986-03-07 | 1992-05-12 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| US4978672A (en) | 1986-03-07 | 1990-12-18 | Ciba-Geigy Corporation | Alpha-heterocyclc substituted tolunitriles |
| US5071861A (en) | 1986-03-07 | 1991-12-10 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| US4749713A (en) * | 1986-03-07 | 1988-06-07 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
| AU627559B2 (en) * | 1989-03-30 | 1992-08-27 | Farmos-Yhtyma Oy | Novel aromatase inhibiting 4(5)-imidazoles |
| DK0408509T3 (da) | 1989-07-14 | 1996-04-01 | Ciba Geigy Ag | Substituerede benzonitriler |
| DE4039559A1 (de) * | 1990-12-07 | 1992-06-11 | Schering Ag | Funktionalisierte vinylazole, verfahren zu deren herstellung, pharmazeutische praeparate die diese vinylazole enthalten sowie deren verwendung zur herstellung von arzneimitteln |
| GB9125924D0 (en) * | 1991-06-18 | 1992-02-05 | Orion Yhtymae Oy | Stereoisomers of an imidazole derivative |
-
1992
- 1992-12-16 GB GB9226209A patent/GB2273704B/en not_active Expired - Fee Related
-
1993
- 1993-11-22 ZA ZA938717A patent/ZA938717B/xx unknown
- 1993-11-23 IL IL10771493A patent/IL107714A/xx not_active IP Right Cessation
- 1993-12-03 LT LTIP1524A patent/LT3151B/lt not_active IP Right Cessation
- 1993-12-14 NZ NZ258588A patent/NZ258588A/en unknown
- 1993-12-14 RU RU95114360/04A patent/RU2131418C1/ru not_active IP Right Cessation
- 1993-12-14 KR KR1019950702444A patent/KR100347639B1/ko not_active IP Right Cessation
- 1993-12-14 TW TW082110583A patent/TW327169B/zh active
- 1993-12-14 CZ CZ951532A patent/CZ283043B6/cs not_active IP Right Cessation
- 1993-12-14 PL PL93309350A patent/PL176413B1/pl unknown
- 1993-12-14 RO RO95-01149A patent/RO113986B1/ro unknown
- 1993-12-14 AU AU56523/94A patent/AU682332B2/en not_active Ceased
- 1993-12-14 ES ES94901975T patent/ES2148312T3/es not_active Expired - Lifetime
- 1993-12-14 US US08/436,389 patent/US5703109A/en not_active Expired - Fee Related
- 1993-12-14 CA CA002150904A patent/CA2150904A1/en not_active Abandoned
- 1993-12-14 DK DK94901975T patent/DK0674626T3/da active
- 1993-12-14 JP JP51384094A patent/JP3186771B2/ja not_active Expired - Fee Related
- 1993-12-14 DE DE69329072T patent/DE69329072T2/de not_active Expired - Fee Related
- 1993-12-14 EP EP94901975A patent/EP0674626B1/en not_active Expired - Lifetime
- 1993-12-14 WO PCT/FI1993/000539 patent/WO1994013645A1/en active IP Right Grant
- 1993-12-14 AT AT94901975T patent/ATE194833T1/de not_active IP Right Cessation
- 1993-12-14 SK SK778-95A patent/SK281667B6/sk unknown
- 1993-12-14 PT PT94901975T patent/PT674626E/pt unknown
- 1993-12-15 HR HR931494A patent/HRP931494B1/xx not_active IP Right Cessation
- 1993-12-15 CN CN93120844A patent/CN1056835C/zh not_active Expired - Fee Related
- 1993-12-16 SI SI9300663A patent/SI9300663B/sl unknown
-
1994
- 1994-11-22 EE EE9400434A patent/EE03155B1/xx not_active IP Right Cessation
-
1995
- 1995-06-05 BG BG99699A patent/BG62930B1/bg unknown
- 1995-06-09 FI FI952867A patent/FI952867A/fi unknown
- 1995-06-15 NO NO19952365A patent/NO310237B1/no unknown
-
1997
- 1997-09-15 US US08/929,424 patent/US5962495A/en not_active Expired - Fee Related
-
2000
- 2000-10-13 GR GR20000402303T patent/GR3034618T3/el not_active IP Right Cessation
Also Published As
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