BG60267B2 - Process for the preparation of amidoxime derivatives - Google Patents
Process for the preparation of amidoxime derivativesInfo
- Publication number
- BG60267B2 BG60267B2 BG92805A BG9280590A BG60267B2 BG 60267 B2 BG60267 B2 BG 60267B2 BG 92805 A BG92805 A BG 92805A BG 9280590 A BG9280590 A BG 9280590A BG 60267 B2 BG60267 B2 BG 60267B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- amidoxime
- preparation
- piperidino
- propyl
- hydroxy
- Prior art date
Links
- SFZULDYEOVSIKM-UHFFFAOYSA-N chembl321317 Chemical class C1=CC(C(=N)NO)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=N)NO)O1 SFZULDYEOVSIKM-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 229960003512 nicotinic acid Drugs 0.000 abstract 2
- 235000001968 nicotinic acid Nutrition 0.000 abstract 2
- 239000011664 nicotinic acid Substances 0.000 abstract 2
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Networks Using Active Elements (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU8970A HUT54347A (en) | 1989-01-10 | 1989-01-10 | Improved process for producing amidoximes |
| PCT/HU1990/000003 WO1990008131A1 (en) | 1989-01-10 | 1990-01-10 | Improved process for the preparation of amidoxime derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG60267B1 BG60267B1 (bg) | 1994-03-31 |
| BG60267B2 true BG60267B2 (en) | 1994-03-31 |
Family
ID=10947753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG92805A BG60267B2 (en) | 1989-01-10 | 1990-09-07 | Process for the preparation of amidoxime derivatives |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5239077A (no) |
| EP (1) | EP0406386B1 (no) |
| JP (1) | JPH03504016A (no) |
| AT (1) | ATE132485T1 (no) |
| AU (1) | AU639223B2 (no) |
| BG (1) | BG60267B2 (no) |
| CA (1) | CA2024808A1 (no) |
| DE (1) | DE69024546T2 (no) |
| ES (1) | ES2082847T3 (no) |
| FI (1) | FI904393A0 (no) |
| HU (1) | HUT54347A (no) |
| NO (1) | NO177821C (no) |
| RU (1) | RU2074854C1 (no) |
| WO (1) | WO1990008131A1 (no) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HU222994B1 (hu) | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| US6458371B1 (en) * | 1995-12-22 | 2002-10-01 | Medgene, Limited | Cosmetic composition and a method for the prevention and/or reduction of the photoaging processes of the skin |
| HU220971B1 (hu) * | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
| HU9701081D0 (en) | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
| UA65635C2 (uk) | 1998-09-03 | 2004-04-15 | Н-Гене Кутато Кфт. | НЕНАСИЧЕНІ ПОХІДНІ ГІДРОКСИМОВОЇ КИСЛОТИ, ЩО МАЮТЬ ВЛАСТИВОСТІ ІНГІБІТОРІВ NAD<sup>+</sup>-ADP-РИБОЗИЛТРАНСФЕРАЗИ |
| ATE265998T1 (de) | 2000-03-20 | 2004-05-15 | N Gene Res Lab Inc | Propancarbonsäure-amidoxim derivate, ein verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die diese entahlten |
| PL371251A1 (en) | 2002-01-11 | 2005-06-13 | Biorex Kutato Es Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) * | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| US20080227813A1 (en) * | 2006-09-26 | 2008-09-18 | Jack Raymond Barber | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
| EP4247792A1 (en) | 2020-11-19 | 2023-09-27 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7503311A (nl) * | 1975-03-20 | 1976-09-22 | Philips Nv | Verbindingen met antidepressieve werking. |
| HU177578B (en) * | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
| US4308399A (en) * | 1977-08-30 | 1981-12-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| DE2927117A1 (de) * | 1979-07-05 | 1981-01-08 | Basf Ag | Verfahren zur herstellung von o-substituierten ketoximen |
| EP0121701B1 (en) * | 1983-04-04 | 1988-08-24 | Allied Corporation | Process for the production of o-substituted oximes |
| DE3620166A1 (de) * | 1986-06-14 | 1987-12-17 | Bayer Ag | Verfahren zur herstellung von hydroxybenzaldoxim-o-ethern |
-
1989
- 1989-01-10 HU HU8970A patent/HUT54347A/hu unknown
-
1990
- 1990-01-10 ES ES90901653T patent/ES2082847T3/es not_active Expired - Lifetime
- 1990-01-10 US US07/602,287 patent/US5239077A/en not_active Expired - Fee Related
- 1990-01-10 WO PCT/HU1990/000003 patent/WO1990008131A1/en active IP Right Grant
- 1990-01-10 CA CA002024808A patent/CA2024808A1/en not_active Abandoned
- 1990-01-10 EP EP90901653A patent/EP0406386B1/en not_active Expired - Lifetime
- 1990-01-10 RU SU904831212A patent/RU2074854C1/ru active
- 1990-01-10 DE DE69024546T patent/DE69024546T2/de not_active Expired - Fee Related
- 1990-01-10 AU AU48237/90A patent/AU639223B2/en not_active Ceased
- 1990-01-10 AT AT90901653T patent/ATE132485T1/de not_active IP Right Cessation
- 1990-01-10 JP JP2501643A patent/JPH03504016A/ja active Pending
- 1990-09-06 FI FI904393A patent/FI904393A0/fi not_active IP Right Cessation
- 1990-09-07 NO NO903921A patent/NO177821C/no unknown
- 1990-09-07 BG BG92805A patent/BG60267B2/xx unknown
-
1993
- 1993-02-19 US US08/019,603 patent/US5278309A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2024808A1 (en) | 1990-07-11 |
| DE69024546D1 (de) | 1996-02-15 |
| ATE132485T1 (de) | 1996-01-15 |
| AU639223B2 (en) | 1993-07-22 |
| JPH03504016A (ja) | 1991-09-05 |
| NO903921D0 (no) | 1990-09-07 |
| US5239077A (en) | 1993-08-24 |
| ES2082847T3 (es) | 1996-04-01 |
| HUT54347A (en) | 1991-02-28 |
| EP0406386B1 (en) | 1996-01-03 |
| WO1990008131A1 (en) | 1990-07-26 |
| DE69024546T2 (de) | 1996-08-29 |
| FI904393A0 (fi) | 1990-09-06 |
| RU2074854C1 (ru) | 1997-03-10 |
| AU4823790A (en) | 1990-08-13 |
| NO177821B (no) | 1995-08-21 |
| BG60267B1 (bg) | 1994-03-31 |
| US5278309A (en) | 1994-01-11 |
| EP0406386A1 (en) | 1991-01-09 |
| NO177821C (no) | 1995-11-29 |
| NO903921L (no) | 1990-09-07 |
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