BG60208B2 - Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides - Google Patents
Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamidesInfo
- Publication number
- BG60208B2 BG60208B2 BG070071A BG7007185A BG60208B2 BG 60208 B2 BG60208 B2 BG 60208B2 BG 070071 A BG070071 A BG 070071A BG 7007185 A BG7007185 A BG 7007185A BG 60208 B2 BG60208 B2 BG 60208B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- preparingn
- oxindole
- carboxamides
- acyl
- substituted
- Prior art date
Links
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001207 fluorophenyl group Chemical group 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- -1 methoxyphenyl Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60735684A | 1984-05-04 | 1984-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60208B2 true BG60208B2 (en) | 1993-12-30 |
Family
ID=24431933
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG070071A BG60208B2 (en) | 1984-05-04 | 1985-05-03 | Process for preparingn-substituted 3-acyl-2-oxindole-1-carboxamides |
| BG096583A BG60207B2 (en) | 1984-05-04 | 1992-07-08 | Process for preparing n-substituted 3-acyl-2-oxindole-1-carboxamides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG096583A BG60207B2 (en) | 1984-05-04 | 1992-07-08 | Process for preparing n-substituted 3-acyl-2-oxindole-1-carboxamides |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS60243068A (OSRAM) |
| KR (1) | KR870000497B1 (OSRAM) |
| AR (1) | AR241159A1 (OSRAM) |
| BG (2) | BG60208B2 (OSRAM) |
| CS (1) | CS252828B2 (OSRAM) |
| DD (1) | DD232916A5 (OSRAM) |
| EG (1) | EG17193A (OSRAM) |
| ES (2) | ES8609248A1 (OSRAM) |
| FI (1) | FI80016C (OSRAM) |
| HU (1) | HU196057B (OSRAM) |
| IE (1) | IE851103L (OSRAM) |
| IN (1) | IN161509B (OSRAM) |
| MA (1) | MA20424A1 (OSRAM) |
| MW (1) | MW1685A1 (OSRAM) |
| MX (1) | MX5839A (OSRAM) |
| NO (1) | NO163132C (OSRAM) |
| OA (1) | OA08098A (OSRAM) |
| PL (2) | PL147508B1 (OSRAM) |
| PT (1) | PT80375B (OSRAM) |
| RO (2) | RO94455B (OSRAM) |
| RU (1) | RU2017729C1 (OSRAM) |
| SU (1) | SU1468413A3 (OSRAM) |
| YU (1) | YU44998B (OSRAM) |
| ZA (1) | ZA853324B (OSRAM) |
| ZW (1) | ZW7885A1 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| IL95880A (en) * | 1989-10-13 | 1995-12-31 | Pfizer | Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis |
-
1985
- 1985-04-08 IN IN288/DEL/85A patent/IN161509B/en unknown
- 1985-04-30 PT PT80375A patent/PT80375B/pt unknown
- 1985-04-30 YU YU730/85A patent/YU44998B/xx unknown
- 1985-05-02 JP JP60095275A patent/JPS60243068A/ja active Granted
- 1985-05-02 DD DD85275898A patent/DD232916A5/de not_active IP Right Cessation
- 1985-05-02 IE IE851103A patent/IE851103L/xx unknown
- 1985-05-02 AR AR300259A patent/AR241159A1/es active
- 1985-05-02 EG EG275/85A patent/EG17193A/xx active
- 1985-05-03 RO RO123678A patent/RO94455B/ro unknown
- 1985-05-03 MX MX583985A patent/MX5839A/es unknown
- 1985-05-03 MW MW16/85A patent/MW1685A1/xx unknown
- 1985-05-03 MA MA20648A patent/MA20424A1/fr unknown
- 1985-05-03 FI FI851756A patent/FI80016C/fi not_active IP Right Cessation
- 1985-05-03 BG BG070071A patent/BG60208B2/xx unknown
- 1985-05-03 ZW ZW78/85A patent/ZW7885A1/xx unknown
- 1985-05-03 PL PL1985257892A patent/PL147508B1/pl unknown
- 1985-05-03 NO NO851774A patent/NO163132C/no not_active IP Right Cessation
- 1985-05-03 KR KR1019850003013A patent/KR870000497B1/ko not_active Expired
- 1985-05-03 RO RO118604A patent/RO91141B/ro unknown
- 1985-05-03 PL PL1985253203A patent/PL145416B1/pl unknown
- 1985-05-03 ZA ZA853324A patent/ZA853324B/xx unknown
- 1985-05-03 OA OA58583A patent/OA08098A/xx unknown
- 1985-05-03 ES ES542813A patent/ES8609248A1/es not_active Expired
- 1985-05-04 RU SU853891002A patent/RU2017729C1/ru active
- 1985-05-04 CS CS853202A patent/CS252828B2/cs not_active IP Right Cessation
- 1985-05-31 HU HU851693A patent/HU196057B/hu unknown
-
1986
- 1986-01-27 ES ES551275A patent/ES8707182A1/es not_active Expired
- 1986-05-12 SU SU864027453A patent/SU1468413A3/ru active
-
1992
- 1992-07-08 BG BG096583A patent/BG60207B2/xx unknown
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