BG52073B2 - Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine - Google Patents

Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Info

Publication number
BG52073B2
BG52073B2 BG9100690A BG9100690A BG52073B2 BG 52073 B2 BG52073 B2 BG 52073B2 BG 9100690 A BG9100690 A BG 9100690A BG 9100690 A BG9100690 A BG 9100690A BG 52073 B2 BG52073 B2 BG 52073B2
Authority
BG
Bulgaria
Prior art keywords
interferon
preparation
recombinant human
noncystein
free
Prior art date
Application number
BG9100690A
Other languages
English (en)
Inventor
Ljuben N Marekov
Rositsa A Vasileva
Veselin P Ivanov
Adriana A Sarafova
Rumen G Tsanev
Ivan G Ivanov
Vesela S Ivanova
Original Assignee
Inst Molekuljarna Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Molekuljarna Biolog filed Critical Inst Molekuljarna Biolog
Priority to BG9100690A priority Critical patent/BG52073B2/xx
Priority to ES91100777T priority patent/ES2066237T3/es
Priority to DE1991606407 priority patent/DE69106407T2/de
Priority to EP19910100777 priority patent/EP0446582B1/en
Priority to SU4894482 priority patent/RU2054044C1/ru
Priority to JP707491A priority patent/JPH05176789A/ja
Publication of BG52073B2 publication Critical patent/BG52073B2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
BG9100690A 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine BG52073B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BG9100690A BG52073B2 (en) 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine
ES91100777T ES2066237T3 (es) 1990-01-24 1991-01-22 Procedimiento para producir gamma-interferon humano recombinante sin cisteina carente de metionina en el extremo n-terminal.
DE1991606407 DE69106407T2 (de) 1990-01-24 1991-01-22 Verfahren zur Herstellung von rekombinantem menschlichem gamma-Interferon ohne Cystein und ohne Methionin am N-Terminal.
EP19910100777 EP0446582B1 (en) 1990-01-24 1991-01-22 Method for producing of recombinant human cysteineless gamma-interferon free of methionine at n-terminal
SU4894482 RU2054044C1 (ru) 1990-01-24 1991-01-24 Способ получения рекомбинантного человеческого свободного от метионина на n-конце гамма-интерферона
JP707491A JPH05176789A (ja) 1990-01-24 1991-01-24 Ｎ−末端にメチオニンを含有しない、遺伝子組換えによるヒト・システイン非含有γ− インターフェロンの製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BG9100690A BG52073B2 (en) 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Publications (1)

Publication Number Publication Date
BG52073B2 true BG52073B2 (en) 1996-04-30

Family

ID=3922678

Family Applications (1)

Application Number Title Priority Date Filing Date
BG9100690A BG52073B2 (en) 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Country Status (6)

Country Link
EP (1) EP0446582B1 (es)
JP (1) JPH05176789A (es)
BG (1) BG52073B2 (es)
DE (1) DE69106407T2 (es)
ES (1) ES2066237T3 (es)
RU (1) RU2054044C1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1309423C (zh) 1999-11-12 2007-04-11 马克西根控股公司 干扰素γ偶联物
JP2003513681A (ja) 1999-11-12 2003-04-15 マキシゲン・ホールディングス・リミテッド インターフェロンガンマ・コンジュゲート
US20040214271A1 (en) * 2000-07-31 2004-10-28 Hidekazu Sawada Process for producing recombined protein
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
MXPA03009082A (es) * 2001-04-06 2004-11-22 Maxygen Holdings Ltd Variantes polipeptidicas de interferon gamma.
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US7524931B2 (en) 2002-07-03 2009-04-28 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
BG66458B1 (bg) 2005-03-21 2014-10-31 Иван Иванов Средство за конкурентно инхибиране на ендогенен гама интерферон
US9359421B2 (en) 2008-04-08 2016-06-07 Tigo Gmbh Suppressor of the endogenous interferon-gamma
BG66517B1 (bg) 2008-04-08 2016-02-29 Tigo Gmbh Супресор на ендогенния човешки гама - интерферон
FR3052462A1 (fr) 2016-06-14 2017-12-15 Dna Script Variants d'une adn polymerase de la famille polx

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
EP0168008A3 (en) * 1984-07-10 1986-12-30 Takeda Chemical Industries, Ltd. Stable composition of gamma-interferon
KR930007429B1 (ko) * 1984-12-27 1993-08-10 산도리 가부시기가이샤 인터페론의 정제방법
JPS61177996A (ja) * 1985-02-02 1986-08-09 Green Cross Corp:The インタ−フエロン−γの製造法
DK623188A (da) * 1987-11-09 1989-05-10 Otsuka Pharma Co Ltd Fremgangsmaade til inkubation af rekombinante proteinekspressionsceller

Also Published As

Publication number Publication date
ES2066237T3 (es) 1995-03-01
DE69106407D1 (de) 1995-02-16
EP0446582A1 (en) 1991-09-18
JPH05176789A (ja) 1993-07-20
DE69106407T2 (de) 1995-05-18
RU2054044C1 (ru) 1996-02-10
EP0446582B1 (en) 1995-01-04

Similar Documents

Publication Publication Date Title
BG52073B2 (en) Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine
ATE165617T1 (de) Präparation von reinkulturen von humanen post- mitotischen neuronen
KR910015309A (ko) 종양괴사인자(tnf) 억제제 및 그 제조방법
CA1176980A (en) Extraction of interferon from bacteria
WO1983002461A1 (en) Multiclass hybrid interferons
CA2174104A1 (en) Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
HU883981D0 (en) Process for the production of medical preparations with antiviral or antibacterial effect
PT82575B (fr) Procede de preparation d'un produit conjugue constitue d'une adhesine de s.mutans de nature proteique d'une composition a activite immunogene et d'un polysaccharide de s.mutans et son utilisation notamment dans des vaccins anti-caries
PT1062325E (pt) Purificacao de preparacoes de virus
CA2019363A1 (en) Dna and use thereof
KR910008645B1 (ko) 항생물질 l 17046의 제조방법
ZA852900B (en) The preparation of polypeptides having human gamma interferon activity
PT85885A (en) Process for preparing novel de-acyl a 40926 antibiotics
HK34896A (en) Novel polypeptide and production thereof
WO1997028812A3 (en) Pharmaceutical compositions for biological treatment of infections by enterococcus faecium strains resistant to antibiotics and to vancomycin in particular (vre)
JPS6456699A (en) Method for obtaining alpha 1-antitrypsin concentrate from human plasma and its utilization as drug
EP0354568A3 (en) Novel catechol derivatives
EP0642348A4 (en) ANTIBIOTIC CRYPTDINPEPTIDE AND METHODS OF USE.
Hochuli Large-scale recovery of interferon alpha-2 a synthesized in bacteria.
EP0304897A3 (de) Mittel zur Immunisierung des menschlichen Körpers bei HIV-Infektionen
JPS565495A (en) Antibiotic substance bn-240-b and its preparation
UA5743C2 (uk) Препарат тканинних біологічно активних речовин, який має регенаторну дію, та спосіб його одержання
CN1326947A (zh) 人胸腺素α原基因突变体合成、表达及应用
JPS5675095A (en) Preparation of heat-resistant acetic acid kinase
AU7891591A (en) Process and articles contributing to the epidermic hydration of the skin by the active transport of dermic water molecules