BG108032A - Азолови съединения като противогъбични средства - Google Patents
Азолови съединения като противогъбични средства Download PDFInfo
- Publication number
- BG108032A BG108032A BG108032A BG10803203A BG108032A BG 108032 A BG108032 A BG 108032A BG 108032 A BG108032 A BG 108032A BG 10803203 A BG10803203 A BG 10803203A BG 108032 A BG108032 A BG 108032A
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- Bulgaria
- Prior art keywords
- group
- alkyl
- alkoxy
- hydrogen
- carboxyl
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- 230000000843 anti-fungal effect Effects 0.000 title abstract description 13
- 150000003851 azoles Chemical class 0.000 title abstract description 9
- 229940121375 antifungal agent Drugs 0.000 title description 14
- 150000001875 compounds Chemical class 0.000 claims abstract description 66
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- 238000000034 method Methods 0.000 claims abstract description 19
- 206010017533 Fungal infection Diseases 0.000 claims abstract description 17
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- -1 diastereomers Chemical class 0.000 claims description 80
- 229910052739 hydrogen Inorganic materials 0.000 claims description 43
- 239000001257 hydrogen Substances 0.000 claims description 43
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 31
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 27
- 125000003118 aryl group Chemical group 0.000 claims description 26
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 25
- 125000000217 alkyl group Chemical group 0.000 claims description 24
- 229910052736 halogen Inorganic materials 0.000 claims description 22
- 150000002367 halogens Chemical class 0.000 claims description 22
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 20
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- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 239000002243 precursor Substances 0.000 claims description 15
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
- 125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 claims description 14
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- 230000004071 biological effect Effects 0.000 description 1
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- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 239000002037 dichloromethane fraction Substances 0.000 description 1
- WBKFWQBXFREOFH-UHFFFAOYSA-N dichloromethane;ethyl acetate Chemical compound ClCCl.CCOC(C)=O WBKFWQBXFREOFH-UHFFFAOYSA-N 0.000 description 1
- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 description 1
- 229960004413 flucytosine Drugs 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 201000000079 gynecomastia Diseases 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
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- VHVPQPYKVGDNFY-ZPGVKDDISA-N itraconazole Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-ZPGVKDDISA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1197DE2000 | 2000-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG108032A true BG108032A (bg) | 2004-12-30 |
Family
ID=11097140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG108032A BG108032A (bg) | 2000-12-26 | 2003-07-25 | Азолови съединения като противогъбични средства |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6710049B2 (cs) |
| EP (1) | EP1347758A1 (cs) |
| JP (1) | JP2004518667A (cs) |
| CN (1) | CN1489465A (cs) |
| AR (1) | AR035525A1 (cs) |
| BG (1) | BG108032A (cs) |
| BR (1) | BR0116570A (cs) |
| CA (1) | CA2433259A1 (cs) |
| CZ (1) | CZ20032028A3 (cs) |
| EA (1) | EA200300725A1 (cs) |
| EC (1) | ECSP034673A (cs) |
| HU (1) | HUP0400725A2 (cs) |
| MA (1) | MA26066A1 (cs) |
| MX (1) | MXPA03005899A (cs) |
| PL (1) | PL362051A1 (cs) |
| SK (1) | SK9522003A3 (cs) |
| WO (1) | WO2002051408A1 (cs) |
| ZA (1) | ZA200304980B (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN191819B (cs) * | 2001-07-19 | 2004-01-03 | Ranbaxy Lab Ltd | |
| AU2002328176A1 (en) * | 2002-08-26 | 2004-03-11 | Ranbaxy Laboratories Limited | Azole derivatives as antifungal agents |
| WO2007047394A2 (en) * | 2005-10-13 | 2007-04-26 | Epix Delaware, Inc. | Thiotriazolyl derivatives |
| CA2811192C (en) * | 2010-10-01 | 2018-02-27 | Taisho Pharmaceutical Co., Ltd. | 1,2,4-triazolone derivative |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB567981A (en) | 1943-03-30 | 1945-03-13 | Malcolm Edward Johnson | Improvements in or relating to control valves for vehicle servo brakes |
| TW218017B (cs) | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
| CA2134417A1 (en) * | 1993-12-22 | 1995-06-23 | Katsumi Itoh | Optically active azole derivatives, their production and use |
| US5677464A (en) | 1994-05-31 | 1997-10-14 | Takeda Chemical Industries, Ltd. | Production of optically active triazole compounds and their intermediates |
| TW318841B (cs) | 1995-02-17 | 1997-11-01 | Takeda Pharm Industry Co Ltd | |
| DE19620407A1 (de) * | 1996-05-21 | 1997-11-27 | Bayer Ag | Thiocyano-triazolyl-Derivate |
| PL365072A1 (en) | 2000-03-07 | 2004-12-27 | Ranbaxy Laboratories Limited | Azole compounds as therapeutic agents for fungal infections |
-
2001
- 2001-12-21 EA EA200300725A patent/EA200300725A1/ru unknown
- 2001-12-21 CZ CZ20032028A patent/CZ20032028A3/cs unknown
- 2001-12-21 US US10/026,235 patent/US6710049B2/en not_active Expired - Fee Related
- 2001-12-21 CN CNA018225721A patent/CN1489465A/zh active Pending
- 2001-12-21 HU HU0400725A patent/HUP0400725A2/hu unknown
- 2001-12-21 JP JP2002552553A patent/JP2004518667A/ja active Pending
- 2001-12-21 MX MXPA03005899A patent/MXPA03005899A/es not_active Application Discontinuation
- 2001-12-21 CA CA002433259A patent/CA2433259A1/en not_active Abandoned
- 2001-12-21 WO PCT/IB2001/002620 patent/WO2002051408A1/en not_active Application Discontinuation
- 2001-12-21 BR BR0116570-4A patent/BR0116570A/pt not_active Application Discontinuation
- 2001-12-21 EP EP01272204A patent/EP1347758A1/en not_active Withdrawn
- 2001-12-21 PL PL01362051A patent/PL362051A1/xx not_active Application Discontinuation
- 2001-12-21 SK SK952-2003A patent/SK9522003A3/sk unknown
- 2001-12-26 AR ARP010106040A patent/AR035525A1/es unknown
-
2003
- 2003-06-26 ZA ZA200304980A patent/ZA200304980B/en unknown
- 2003-06-26 EC EC2003004673A patent/ECSP034673A/es unknown
- 2003-06-26 MA MA27214A patent/MA26066A1/fr unknown
- 2003-07-25 BG BG108032A patent/BG108032A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1347758A1 (en) | 2003-10-01 |
| SK9522003A3 (en) | 2003-12-02 |
| EA200300725A1 (ru) | 2004-04-29 |
| US20020119984A1 (en) | 2002-08-29 |
| CZ20032028A3 (cs) | 2003-11-12 |
| MXPA03005899A (es) | 2004-01-26 |
| AR035525A1 (es) | 2004-06-02 |
| US6710049B2 (en) | 2004-03-23 |
| BR0116570A (pt) | 2005-04-12 |
| CA2433259A1 (en) | 2002-07-04 |
| ZA200304980B (en) | 2004-04-28 |
| JP2004518667A (ja) | 2004-06-24 |
| CN1489465A (zh) | 2004-04-14 |
| PL362051A1 (en) | 2004-10-18 |
| ECSP034673A (es) | 2003-08-29 |
| HUP0400725A2 (hu) | 2004-07-28 |
| WO2002051408A1 (en) | 2002-07-04 |
| MA26066A1 (fr) | 2004-04-01 |
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