BG107935A - '...'рахидропиридинови производни, 'яхно'о пол"-аван... и използван...'о им ка'о инхиби'ори на кл...'ъ-на проли"...ра-ия - Google Patents

'...'рахидропиридинови производни, 'яхно'о пол"-аван... и използван...'о им ка'о инхиби'ори на кл...'ъ-на проли"...ра-ия Download PDF

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Publication number
BG107935A
BG107935A BG107935A BG10793503A BG107935A BG 107935 A BG107935 A BG 107935A BG 107935 A BG107935 A BG 107935A BG 10793503 A BG10793503 A BG 10793503A BG 107935 A BG107935 A BG 107935A
Authority
BG
Bulgaria
Prior art keywords
group
dihydro
alkyl
formula
compound
Prior art date
Application number
BG107935A
Other languages
Bulgarian (bg)
English (en)
Inventor
Guy Georges
Adelbert Grossmann
Olaf Mundigl
Wolfgang Von Der Saal
Tim Sattelkau
Original Assignee
F. Hoffmann- La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann- La Roche Ag filed Critical F. Hoffmann- La Roche Ag
Publication of BG107935A publication Critical patent/BG107935A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
BG107935A 2000-12-23 2003-06-23 '...'рахидропиридинови производни, 'яхно'о пол"-аван... и използван...'о им ка'о инхиби'ори на кл...'ъ-на проли"...ра-ия BG107935A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00128487 2000-12-23
PCT/EP2001/015390 WO2002051842A1 (en) 2000-12-23 2001-12-21 Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
BG107935A true BG107935A (bg) 2004-08-31

Family

ID=8170814

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107935A BG107935A (bg) 2000-12-23 2003-06-23 '...'рахидропиридинови производни, 'яхно'о пол"-аван... и използван...'о им ка'о инхиби'ори на кл...'ъ-на проли"...ра-ия

Country Status (27)

Country Link
US (1) US6800638B2 (zh)
EP (1) EP1353921B1 (zh)
JP (1) JP2004516325A (zh)
KR (1) KR100836545B1 (zh)
CN (1) CN1213046C (zh)
AR (1) AR035513A1 (zh)
AT (1) ATE323700T1 (zh)
AU (1) AU2002226397B2 (zh)
BG (1) BG107935A (zh)
BR (1) BR0116402A (zh)
CA (1) CA2431471A1 (zh)
CZ (1) CZ20031940A3 (zh)
DE (1) DE60118975T2 (zh)
EC (1) ECSP034664A (zh)
ES (1) ES2261519T3 (zh)
HU (1) HUP0400554A2 (zh)
IL (1) IL156131A0 (zh)
MA (1) MA26976A1 (zh)
MX (1) MXPA03005713A (zh)
NO (1) NO20032830L (zh)
NZ (1) NZ526189A (zh)
PL (1) PL365531A1 (zh)
RU (1) RU2276140C2 (zh)
SK (1) SK9122003A3 (zh)
WO (1) WO2002051842A1 (zh)
YU (1) YU48803A (zh)
ZA (1) ZA200304264B (zh)

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US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
EP2269609A3 (en) 2001-10-16 2012-07-11 Sloan-Kettering Institute for Cancer Research Treatment of neurodegenerative diseases and cancer of the brain with SAHA
AU2003218508A1 (en) 2002-04-01 2003-10-13 Ranko Rakanovic Rubber elastic element
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
JP2006520796A (ja) 2003-03-17 2006-09-14 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼインヒビター
WO2004113336A1 (en) * 2003-06-16 2004-12-29 Chroma Therapeutics Limited Carboline and betacarboline derivatives for use as hdac enzyme inhibitors
EP1694329A4 (en) * 2003-11-26 2009-06-03 Aton Pharma Inc DIAMOND AND IMINODIACETIC ACID HYDROXAMINIC DERIVATIVES
WO2005065681A1 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
EP1824831A2 (en) 2004-12-16 2007-08-29 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7772245B2 (en) 2005-02-14 2010-08-10 Miikana Therapeutics, Inc. Inhibitors of histone deacetylase
GB0509223D0 (en) * 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
WO2006122319A2 (en) 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
JP2009501236A (ja) * 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2007084390A2 (en) * 2006-01-13 2007-07-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉－１－酮衍生物或其鹽
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2456757B1 (en) * 2009-07-22 2019-05-01 The Board of Trustees of the University of Illionis Hdac inhibitors and therapeutic methods using the same
CN102153549B (zh) * 2010-12-14 2012-11-14 华东理工大学 γ咔啉化合物、制备方法和用途
JP6117430B2 (ja) 2013-04-29 2017-04-19 チョン クン ダン ファーマシューティカル コーポレーション 選択的ヒストン脱アセチル化酵素抑制剤としての新規化合物およびこれを含む薬剤学的組成物
EP3052662B1 (en) 2013-10-01 2019-05-15 The J. David Gladstone Institutes Compositions, systems and methods for gene expression noise drug screening and uses thereof
CN108084178B (zh) * 2018-01-04 2020-09-01 济南大学 一类含有四氢-β-咔碄结构的异羟肟酸类化合物的用途
CN108558653A (zh) * 2018-05-14 2018-09-21 湖南华腾制药有限公司 赛乐西帕中间体及赛乐西帕的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002119A1 (en) * 1988-08-18 1990-03-08 Banyu Pharmaceutical Co., Ltd. 1,2,3,4-tetrahydroisoquinoline derivatives
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
WO1998007421A1 (fr) * 1996-08-16 1998-02-26 Ishihara Sangyo Kaisha, Ltd. Composition medicinale
WO1998015525A1 (fr) 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Acides hydroxamiques
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
US6465468B1 (en) * 1999-03-22 2002-10-15 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives

Also Published As

Publication number Publication date
MA26976A1 (fr) 2004-12-20
CZ20031940A3 (cs) 2003-10-15
ES2261519T3 (es) 2006-11-16
ATE323700T1 (de) 2006-05-15
BR0116402A (pt) 2003-11-11
HUP0400554A2 (hu) 2004-06-28
AU2002226397B2 (en) 2006-10-05
MXPA03005713A (es) 2003-10-06
NO20032830L (no) 2003-08-04
YU48803A (sh) 2006-05-25
ECSP034664A (es) 2003-07-25
CN1213046C (zh) 2005-08-03
KR100836545B1 (ko) 2008-06-10
CN1483033A (zh) 2004-03-17
PL365531A1 (en) 2005-01-10
CA2431471A1 (en) 2002-07-04
RU2276140C2 (ru) 2006-05-10
JP2004516325A (ja) 2004-06-03
IL156131A0 (en) 2003-12-23
NZ526189A (en) 2004-10-29
RU2003122190A (ru) 2005-02-27
DE60118975T2 (de) 2006-12-21
EP1353921A1 (en) 2003-10-22
ZA200304264B (en) 2004-08-30
KR20030063424A (ko) 2003-07-28
DE60118975D1 (de) 2006-05-24
US6800638B2 (en) 2004-10-05
AR035513A1 (es) 2004-06-02
EP1353921B1 (en) 2006-04-19
NO20032830D0 (no) 2003-06-20
SK9122003A3 (en) 2004-02-03
US20040053960A1 (en) 2004-03-18
WO2002051842A1 (en) 2002-07-04

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