MXPA03005713A - Derivados de tetrahidropiridina, su preparacion y su uso como inhibidores de proliferacion celular. - Google Patents

Derivados de tetrahidropiridina, su preparacion y su uso como inhibidores de proliferacion celular.

Info

Publication number
MXPA03005713A
MXPA03005713A MXPA03005713A MXPA03005713A MXPA03005713A MX PA03005713 A MXPA03005713 A MX PA03005713A MX PA03005713 A MXPA03005713 A MX PA03005713A MX PA03005713 A MXPA03005713 A MX PA03005713A MX PA03005713 A MXPA03005713 A MX PA03005713A
Authority
MX
Mexico
Prior art keywords
preparation
cell proliferation
proliferation inhibitors
tetrahydropyridine derivatives
tetrahydropyridine
Prior art date
Application number
MXPA03005713A
Other languages
English (en)
Inventor
Von Der Saal Wolfgang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA03005713A publication Critical patent/MXPA03005713A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
MXPA03005713A 2000-12-23 2001-12-21 Derivados de tetrahidropiridina, su preparacion y su uso como inhibidores de proliferacion celular. MXPA03005713A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00128487 2000-12-23
PCT/EP2001/015390 WO2002051842A1 (en) 2000-12-23 2001-12-21 Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
MXPA03005713A true MXPA03005713A (es) 2003-10-06

Family

ID=8170814

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03005713A MXPA03005713A (es) 2000-12-23 2001-12-21 Derivados de tetrahidropiridina, su preparacion y su uso como inhibidores de proliferacion celular.

Country Status (27)

Country Link
US (1) US6800638B2 (es)
EP (1) EP1353921B1 (es)
JP (1) JP2004516325A (es)
KR (1) KR100836545B1 (es)
CN (1) CN1213046C (es)
AR (1) AR035513A1 (es)
AT (1) ATE323700T1 (es)
AU (1) AU2002226397B2 (es)
BG (1) BG107935A (es)
BR (1) BR0116402A (es)
CA (1) CA2431471A1 (es)
CZ (1) CZ20031940A3 (es)
DE (1) DE60118975T2 (es)
EC (1) ECSP034664A (es)
ES (1) ES2261519T3 (es)
HU (1) HUP0400554A2 (es)
IL (1) IL156131A0 (es)
MA (1) MA26976A1 (es)
MX (1) MXPA03005713A (es)
NO (1) NO20032830L (es)
NZ (1) NZ526189A (es)
PL (1) PL365531A1 (es)
RU (1) RU2276140C2 (es)
SK (1) SK9122003A3 (es)
WO (1) WO2002051842A1 (es)
YU (1) YU48803A (es)
ZA (1) ZA200304264B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
US20040087657A1 (en) 2001-10-16 2004-05-06 Richon Victoria M. Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors
WO2003083323A1 (en) 2002-04-01 2003-10-09 Ranko Rakanovic Rubber elastic element
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
US7375228B2 (en) 2003-03-17 2008-05-20 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2004113336A1 (en) * 2003-06-16 2004-12-29 Chroma Therapeutics Limited Carboline and betacarboline derivatives for use as hdac enzyme inhibitors
US20090023718A1 (en) * 2003-11-26 2009-01-22 Aton Pharma, Inc. Diamine and Iminodiacetic Acid Hydroxamic Acid Derivatives
US20050159470A1 (en) * 2003-12-19 2005-07-21 Syrrx, Inc. Histone deacetylase inhibitors
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
WO2006066133A2 (en) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7772245B2 (en) 2005-02-14 2010-08-10 Miikana Therapeutics, Inc. Inhibitors of histone deacetylase
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
WO2006122319A2 (en) 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
ZA200800901B (en) * 2005-07-14 2010-05-26 Takeda San Diego Inc Histone deacetylase inhibitors
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP1976835A2 (en) * 2006-01-13 2008-10-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉－１－酮衍生物或其鹽
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
ES2736200T3 (es) * 2009-07-22 2019-12-26 Univ Illinois Inhibidores de HDAC y métodos terapéuticos que utilizan los mismos
CN102153549B (zh) * 2010-12-14 2012-11-14 华东理工大学 γ咔啉化合物、制备方法和用途
NZ712696A (en) 2013-04-29 2016-07-29 Chong Kun Dang Pharm Corp Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
EP3052662B1 (en) 2013-10-01 2019-05-15 The J. David Gladstone Institutes Compositions, systems and methods for gene expression noise drug screening and uses thereof
CN108084178B (zh) * 2018-01-04 2020-09-01 济南大学 一类含有四氢-β-咔碄结构的异羟肟酸类化合物的用途
CN108558653A (zh) * 2018-05-14 2018-09-21 湖南华腾制药有限公司 赛乐西帕中间体及赛乐西帕的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002119A1 (en) * 1988-08-18 1990-03-08 Banyu Pharmaceutical Co., Ltd. 1,2,3,4-tetrahydroisoquinoline derivatives
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
WO1998007421A1 (fr) * 1996-08-16 1998-02-26 Ishihara Sangyo Kaisha, Ltd. Composition medicinale
WO1998015525A1 (fr) 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Acides hydroxamiques
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
AU3312100A (en) * 1999-03-22 2000-10-09 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives

Also Published As

Publication number Publication date
ATE323700T1 (de) 2006-05-15
BG107935A (bg) 2004-08-31
EP1353921A1 (en) 2003-10-22
CA2431471A1 (en) 2002-07-04
RU2003122190A (ru) 2005-02-27
DE60118975T2 (de) 2006-12-21
ES2261519T3 (es) 2006-11-16
HUP0400554A2 (hu) 2004-06-28
PL365531A1 (en) 2005-01-10
NZ526189A (en) 2004-10-29
ZA200304264B (en) 2004-08-30
RU2276140C2 (ru) 2006-05-10
YU48803A (sh) 2006-05-25
BR0116402A (pt) 2003-11-11
NO20032830L (no) 2003-08-04
CN1483033A (zh) 2004-03-17
AR035513A1 (es) 2004-06-02
KR20030063424A (ko) 2003-07-28
DE60118975D1 (de) 2006-05-24
SK9122003A3 (en) 2004-02-03
JP2004516325A (ja) 2004-06-03
NO20032830D0 (no) 2003-06-20
CZ20031940A3 (cs) 2003-10-15
AU2002226397B2 (en) 2006-10-05
IL156131A0 (en) 2003-12-23
US20040053960A1 (en) 2004-03-18
CN1213046C (zh) 2005-08-03
ECSP034664A (es) 2003-07-25
EP1353921B1 (en) 2006-04-19
KR100836545B1 (ko) 2008-06-10
US6800638B2 (en) 2004-10-05
WO2002051842A1 (en) 2002-07-04
MA26976A1 (fr) 2004-12-20

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