BG107258A - Циклохексиламинови производни като подвид-селективни антагонисти на рецептора на n-метил - d-аспартат - Google Patents

Циклохексиламинови производни като подвид-селективни антагонисти на рецептора на n-метил - d-аспартат Download PDF

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Publication number
BG107258A
BG107258A BG107258A BG10725802A BG107258A BG 107258 A BG107258 A BG 107258A BG 107258 A BG107258 A BG 107258A BG 10725802 A BG10725802 A BG 10725802A BG 107258 A BG107258 A BG 107258A
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BG
Bulgaria
Prior art keywords
cyclohexyl
phenol
alkyl
group
hydrogen
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BG107258A
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Bulgarian (bg)
English (en)
Inventor
Russell DEORAZIO
Sham Nikam
Ian Scott
Brian Sherer
Lawrence WISE
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Warner-Lambert Company
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Publication of BG107258A publication Critical patent/BG107258A/bg

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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
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    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
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    • C07C235/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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BG107258A 2000-04-26 2002-11-08 Циклохексиламинови производни като подвид-селективни антагонисти на рецептора на n-метил - d-аспартат BG107258A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19976200P 2000-04-26 2000-04-26
PCT/US2001/013176 WO2001081295A1 (fr) 2000-04-26 2001-04-24 Derives cyclohexylamines utiles en tant qu'antagonistes selectifs de sous-types de recepteurs nmda

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BG107258A true BG107258A (bg) 2003-07-31

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US (1) US6919377B2 (fr)
EP (1) EP1278716B1 (fr)
JP (1) JP2003531187A (fr)
KR (1) KR20020093950A (fr)
CN (1) CN1441773A (fr)
AP (1) AP2002002664A0 (fr)
AT (1) ATE337292T1 (fr)
AU (1) AU2001255620A1 (fr)
BG (1) BG107258A (fr)
BR (1) BR0110247A (fr)
CA (1) CA2406272A1 (fr)
CZ (1) CZ20023479A3 (fr)
DE (1) DE60122495T2 (fr)
EA (1) EA200200952A1 (fr)
EE (1) EE200200612A (fr)
ES (1) ES2267759T3 (fr)
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IS (1) IS6569A (fr)
MA (1) MA26895A1 (fr)
MX (1) MXPA02009659A (fr)
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OA (1) OA12253A (fr)
PL (1) PL358584A1 (fr)
SK (1) SK15152002A3 (fr)
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ZA (1) ZA200208177B (fr)

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GB0100623D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds IV
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
MXPA05006487A (es) * 2002-12-17 2005-08-26 Pfizer Compuestos cicloalquilenamida como antagonistas de receptor nr2b.
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
EP1768954A4 (fr) * 2004-06-24 2008-05-28 Incyte Corp 2-methylpropanamides et leur utilisation en tant que pharmaceutiques
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BR0110247A (pt) 2003-03-05
US20030236286A1 (en) 2003-12-25
ATE337292T1 (de) 2006-09-15
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HUP0300600A2 (hu) 2003-08-28
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CA2406272A1 (fr) 2001-11-01
CN1441773A (zh) 2003-09-10
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ES2267759T3 (es) 2007-03-16
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