ATE337292T1 - Trans-n- 4-(4-hydroxyphenyl)cyclohexylö-3- phenylpropionamid als subtyp-selektiver nmda rezeptor antagonist - Google Patents

Trans-n- 4-(4-hydroxyphenyl)cyclohexylö-3- phenylpropionamid als subtyp-selektiver nmda rezeptor antagonist

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Publication number
ATE337292T1
ATE337292T1 AT01928803T AT01928803T ATE337292T1 AT E337292 T1 ATE337292 T1 AT E337292T1 AT 01928803 T AT01928803 T AT 01928803T AT 01928803 T AT01928803 T AT 01928803T AT E337292 T1 ATE337292 T1 AT E337292T1
Authority
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Austria
Prior art keywords
cyclohexylö
phenylpropionamide
subtype
hydroxyphenyl
trans
Prior art date
Application number
AT01928803T
Other languages
English (en)
Inventor
Russell Joseph Deorazio
Sham Shridhar Nikam
Ian Leslie Scott
Brian Alan Sherer
Lawrence David Wise
Original Assignee
Warner Lambert Co
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Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE337292T1 publication Critical patent/ATE337292T1/de

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    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
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AT01928803T 2000-04-26 2001-04-24 Trans-n- 4-(4-hydroxyphenyl)cyclohexylö-3- phenylpropionamid als subtyp-selektiver nmda rezeptor antagonist ATE337292T1 (de)

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US19976200P 2000-04-26 2000-04-26

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ATE337292T1 true ATE337292T1 (de) 2006-09-15

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US (1) US6919377B2 (de)
EP (1) EP1278716B1 (de)
JP (1) JP2003531187A (de)
KR (1) KR20020093950A (de)
CN (1) CN1441773A (de)
AP (1) AP2002002664A0 (de)
AT (1) ATE337292T1 (de)
AU (1) AU2001255620A1 (de)
BG (1) BG107258A (de)
BR (1) BR0110247A (de)
CA (1) CA2406272A1 (de)
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EA (1) EA200200952A1 (de)
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US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
AU2003303042A1 (en) * 2002-12-17 2004-07-09 Pfizer Inc. 2-pyridyl and 2-pyrimidyl cycloalkylene amide compounds as nr2b receptor antagonists
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
EA200700117A1 (ru) 2004-06-24 2007-06-29 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
US7687665B2 (en) 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
MX2007001540A (es) * 2004-08-10 2007-04-23 Incyte Corp Compuestos amido y sus usos como farmaceuticos.
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DE60122495D1 (de) 2006-10-05
NO20025136L (no) 2002-12-20
US20030236286A1 (en) 2003-12-25
HUP0300600A2 (hu) 2003-08-28
IL152424A0 (en) 2003-05-29
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EP1278716A1 (de) 2003-01-29
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ZA200208177B (en) 2004-02-11
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IS6569A (is) 2002-09-27
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CA2406272A1 (en) 2001-11-01
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US6919377B2 (en) 2005-07-19
NO20025136D0 (no) 2002-10-25
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