BG105803A - Epotylon derivatives, method for their production and pharmaceutical use thereof - Google Patents

Epotylon derivatives, method for their production and pharmaceutical use thereof

Info

Publication number
BG105803A
BG105803A BG105803A BG10580301A BG105803A BG 105803 A BG105803 A BG 105803A BG 105803 A BG105803 A BG 105803A BG 10580301 A BG10580301 A BG 10580301A BG 105803 A BG105803 A BG 105803A
Authority
BG
Bulgaria
Prior art keywords
methyl
pyridyl
oxazolyl
thiazolyl
atom
Prior art date
Application number
BG105803A
Other languages
Bulgarian (bg)
English (en)
Inventor
Ulrich Klar
Werner Skuballa
Bernd Buchmann
Wolfgang Schwede
Michael Schirner
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107480 external-priority patent/DE19907480A1/de
Priority claimed from DE19954229A external-priority patent/DE19954229A1/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of BG105803A publication Critical patent/BG105803A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG105803A 1999-02-11 2001-08-09 Epotylon derivatives, method for their production and pharmaceutical use thereof BG105803A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999107480 DE19907480A1 (de) 1999-02-11 1999-02-11 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19954229A DE19954229A1 (de) 1999-11-04 1999-11-04 Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
PCT/EP2000/001104 WO2000047584A2 (de) 1999-02-11 2000-02-11 Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung

Publications (1)

Publication Number Publication Date
BG105803A true BG105803A (en) 2002-03-29

Family

ID=26051977

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105803A BG105803A (en) 1999-02-11 2001-08-09 Epotylon derivatives, method for their production and pharmaceutical use thereof

Country Status (21)

Country Link
US (2) US7001916B1 (zh)
EP (1) EP1161430A2 (zh)
JP (1) JP2002536450A (zh)
KR (1) KR20010094763A (zh)
CN (1) CN1340053A (zh)
AU (1) AU4101800A (zh)
BG (1) BG105803A (zh)
BR (1) BR0008206A (zh)
CA (1) CA2360952A1 (zh)
CZ (1) CZ20012886A3 (zh)
EA (1) EA200100833A1 (zh)
EE (1) EE200100422A (zh)
HK (1) HK1044946A1 (zh)
HU (1) HUP0105330A2 (zh)
IL (1) IL144370A0 (zh)
MX (1) MXPA01008148A (zh)
NO (1) NO20013900L (zh)
PL (1) PL350190A1 (zh)
SK (1) SK11452001A3 (zh)
WO (1) WO2000047584A2 (zh)
YU (1) YU57601A (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2273083C (en) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
AU772750C (en) * 1999-04-30 2005-02-24 Schering Aktiengesellschaft 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
US7723339B2 (en) * 2001-02-27 2010-05-25 Novartis Ag Combination comprising a signal transduction inhibitor and an epothilone derivative
AU2002331171A1 (en) * 2001-08-23 2003-03-10 Novartis Pharma Gmbh Cyclopropyl and cyclobutyl epothilone analogs
ES2337134T3 (es) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company Derivados de c3-ciano-epotilona.
CN101816792A (zh) * 2002-06-10 2010-09-01 诺瓦提斯公司 包含埃坡霉素的组合及其药学用途
CN1671856B (zh) * 2002-07-31 2010-05-12 卫材R&D管理株式会社 生理活性物质
US20050215604A1 (en) * 2004-03-26 2005-09-29 Kosan Biosciences, Inc. Combination therapies with epothilones and carboplatin
EP1589011A1 (en) * 2004-04-22 2005-10-26 Schering Aktiengesellschaft Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation
EP2634252B1 (en) 2005-02-11 2018-12-19 University of Southern California Method of expressing proteins with disulfide bridges
WO2007130501A2 (en) * 2006-05-01 2007-11-15 University Of Southern California Combination therapy for treatment of cancer
US20100113128A1 (en) * 2008-11-05 2010-05-06 Snow Richard N Methods and apparatus for determining a reel strip position
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
US20100125146A1 (en) * 2008-11-19 2010-05-20 Johnson Matthey Public Limited Company Method for making pharmaceutical compounds
EP3566719A1 (en) 2010-05-18 2019-11-13 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
EP3371176A4 (en) * 2015-10-16 2019-09-04 William Marsh Rice University EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND MEDICAMENT CONJUGATES THEREOF
WO2017096559A1 (en) * 2015-12-09 2017-06-15 Rhodia Operations Production of xylene derivatives

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
US5469145A (en) 1992-05-29 1995-11-21 Johnson; Lonnie Wet diaper detector
PT1186606E (pt) 1995-11-17 2004-08-31 Biotechnolog Forschung Mbh Gbf Derivados do epotilone sua preparacao e utilizacao
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US5969145A (en) 1996-08-30 1999-10-19 Novartis Ag Process for the production of epothilones and intermediate products within the process
NZ334821A (en) 1996-08-30 2000-12-22 Novartis Ag Method for producing epothilones
DE19636343C1 (de) 1996-08-30 1997-10-23 Schering Ag Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
CA2273083C (en) * 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6867305B2 (en) * 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
DE19701758A1 (de) 1997-01-20 1998-07-23 Wessjohann Ludgar A Dr Epothilone-Synthesebausteine
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US7407975B2 (en) 1997-08-09 2008-08-05 Bayer Schering Pharma Ag Epothilone derivatives, method for producing same and their pharmaceutical use
WO1999067253A2 (en) 1998-06-22 1999-12-29 Novartis Ag Desmethyl epothilones
AU6208701A (en) 2000-03-09 2001-09-17 Schering Aktiengesellschaft Radioactively labeled epothilone derivatives, method for the production thereof, and their biochemical and pharmaceutical use
CA2359267A1 (en) 2000-10-19 2002-04-19 Manabu Takami Wavelength selecting module and wavelength selecting apparatus
EP1340498A1 (en) * 2002-03-01 2003-09-03 Schering Aktiengesellschaft Use of epothilones in the treatment of brain diseases associated with proliferative processes
JP2006505627A (ja) * 2002-07-31 2006-02-16 シエーリング アクチエンゲゼルシャフト 新規エフェクター接合体、それらの生成方法及びそれらの医薬使用
US7138279B2 (en) 2002-08-13 2006-11-21 Kosan Biosciences, Inc. Transposon-based transformation system

Also Published As

Publication number Publication date
IL144370A0 (en) 2002-05-23
CN1340053A (zh) 2002-03-13
HUP0105330A2 (hu) 2002-05-29
EA200100833A1 (ru) 2002-02-28
WO2000047584A2 (de) 2000-08-17
CZ20012886A3 (cs) 2001-11-14
YU57601A (sh) 2005-06-10
US20060040990A1 (en) 2006-02-23
WO2000047584A3 (de) 2000-12-28
EE200100422A (et) 2002-12-16
SK11452001A3 (sk) 2002-04-04
BR0008206A (pt) 2002-02-19
EP1161430A2 (de) 2001-12-12
AU4101800A (en) 2000-08-29
NO20013900D0 (no) 2001-08-10
KR20010094763A (ko) 2001-11-01
US7001916B1 (en) 2006-02-21
MXPA01008148A (es) 2003-07-21
NO20013900L (no) 2001-10-11
HK1044946A1 (zh) 2002-11-08
CA2360952A1 (en) 2000-08-17
JP2002536450A (ja) 2002-10-29
PL350190A1 (en) 2002-11-18

Similar Documents

Publication Publication Date Title
BG105803A (en) Epotylon derivatives, method for their production and pharmaceutical use thereof
HUP0302380A2 (hu) Cisztein-proteázok reverzibilis inhibitoraiként alkalmazható új spiroheterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0302274A2 (hu) 2,4,8-Triszubsztituált-8H-pirido[2,3-d]pirimidin-7-on-vegyületek és felhasználásuk CSBP/p38 kináz által mediált betegségek kezelésére, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0300527A2 (hu) Pirrolopirimidinon-származékok, a vegyületek előállítása és alkalmazása
HUP0302167A2 (hu) Metabotropikus glutamát receptor antagonista hatású kinolinszármazékok, a vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
HUP0400837A2 (hu) 2-feniltiazol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
HUP0300148A2 (en) Dipeptide nitrile cathepsin k inhibitors, process for their preparation and pharmaceutical compositions containing them
HUP0303037A2 (hu) Alzheimer-kór kezelésére alkalmas vegyületek és ezeket tartalmazó gyógyszerkészítmények
HUP9901652A2 (hu) Piperidin-karbonsav-származékok alkalmazása vérglükózkoncentráció csökkentésére alkalmas gyógyszerkészítmények előállítására
HUP0102084A2 (hu) Kinolinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
HUP0303283A2 (hu) Új piridinilcsoporttal szubsztituált pirazolopiridin-származékok, előállításuk és alkalmazásuk szív- és keringési betegségek kezelésére alkalmas gyógyszerkészítmény előállítására
HUP0301389A2 (hu) Purinszármazékok
AR047557A1 (es) Compuestos derivados de piridazina y su uso como agentes terapeuticos
HUP0300693A2 (hu) Eljárás epotilon-analógok és -intermedierek előállítására
HUP0204431A1 (hu) 1,5-Diszubsztituált-3,4-dihidro-1H-pirimido[4,5-d]pirimidin-2-on-vegyületek és falhasználásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
NZ336302A (en) Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia
ATE123771T1 (de) Stickstoff enthaltende heterozyklische verbindungen, ihre herstellung und verwendung.
ATE247123T1 (de) Neue piperidin und piperazin-derivate als p2x7- rezeptor antagonisten
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
ATE302778T1 (de) N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
HUP0204354A2 (hu) Új heterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE60011889D1 (en) 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren
HUP0400238A2 (hu) Pirrolidin-oxadiazol- és tiadiazolszármazékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
ATE211137T1 (de) Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung
TR200002831A2 (tr) Kinolin-4-İl türevleri I