BG105745A - 2,3-о-изопропилиденови производни на монозахаридикато инхибитори на клетъчна адхезия - Google Patents

2,3-о-изопропилиденови производни на монозахаридикато инхибитори на клетъчна адхезия

Info

Publication number
BG105745A
BG105745A BG105745A BG10574501A BG105745A BG 105745 A BG105745 A BG 105745A BG 105745 A BG105745 A BG 105745A BG 10574501 A BG10574501 A BG 10574501A BG 105745 A BG105745 A BG 105745A
Authority
BG
Bulgaria
Prior art keywords
cell adhesion
isopropylidene
monosaccharides
derivatives
xylo
Prior art date
Application number
BG105745A
Other languages
English (en)
Inventor
Sudershan Arora
Nawal Kishore
Jang Gupta
Vishwas JOSHI
Original Assignee
Ranbaxy Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Limited filed Critical Ranbaxy Laboratories Limited
Publication of BG105745A publication Critical patent/BG105745A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретението се отнася до съединения и методи засинтез на производни на 2,3-О- изопропилиден -алфа-L-ксило-2- хексулофуранова киселина с формула. Съединенията съгласно изобретението са приложими, за инхибиране и предотвратяване на клетъчна адхезияи медиирани от нея патологии, включващи възпалителни и автоимунни заболявания, като бронхиална астма, ревматоиден артрит, диабет тип I, мултиплена склероза, отхвърляне на алотрансплантанти и псориазис. Изобретението се отнася и до фармацевтични състави, съдържащи съединенията, и до методи за лечение на посочените заболявания.
BG105745A 1999-01-15 2001-07-26 2,3-о-изопропилиденови производни на монозахаридикато инхибитори на клетъчна адхезия BG105745A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN86DE1999 IN190975B (bg) 1999-01-15 1999-01-15
US09/276,368 US6590085B1 (en) 1999-01-15 1999-03-25 Derivatives of monosaccharides as cell adhesion inhibitors
PCT/IB2000/000022 WO2000042054A1 (en) 1999-01-15 2000-01-10 2,3-o-isopropylidene derivatives of monosaccharides as cell adhesion inhibitors

Publications (1)

Publication Number Publication Date
BG105745A true BG105745A (bg) 2002-05-31

Family

ID=11088155

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105745A BG105745A (bg) 1999-01-15 2001-07-26 2,3-о-изопропилиденови производни на монозахаридикато инхибитори на клетъчна адхезия

Country Status (31)

Country Link
US (5) US6590085B1 (bg)
EP (1) EP1147119B1 (bg)
JP (1) JP2002534530A (bg)
CN (1) CN1167707C (bg)
AR (1) AR022235A1 (bg)
AT (1) ATE250074T1 (bg)
AU (1) AU768511B2 (bg)
BG (1) BG105745A (bg)
BR (1) BR0007553A (bg)
CA (1) CA2359986A1 (bg)
CO (1) CO5180591A1 (bg)
CR (1) CR6423A (bg)
CZ (1) CZ20012540A3 (bg)
DE (1) DE60005300T2 (bg)
DK (1) DK1147119T3 (bg)
ES (1) ES2206176T3 (bg)
HK (1) HK1041270A1 (bg)
HR (1) HRP20010529B1 (bg)
HU (1) HUP0105116A3 (bg)
ID (1) ID30351A (bg)
IN (1) IN190975B (bg)
MA (1) MA25342A1 (bg)
MX (1) MXPA01007187A (bg)
MY (1) MY121135A (bg)
NZ (2) NZ512852A (bg)
PA (1) PA8489901A1 (bg)
PT (1) PT1147119E (bg)
SK (1) SK284241B6 (bg)
TR (1) TR200102043T2 (bg)
WO (1) WO2000042054A1 (bg)
YU (1) YU50701A (bg)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN190975B (bg) * 1999-01-15 2003-09-06 Ranbaxy Lab Ltd
KR20060021870A (ko) 2003-05-30 2006-03-08 랜박시 래보러터리스 리미티드 치환된 피롤 유도체와 ｈｍｇ―ｃｏ 억제제로서의 이의용도
US20090221515A1 (en) * 2004-09-02 2009-09-03 Viswajanani Jitendra Sattigeri Monosaccharide derivatives
WO2007063356A2 (en) * 2004-12-22 2007-06-07 Ranbaxy Laboratories Limited Derivatives of pentose monosaccharides as anti-inflammatory compounds
WO2007010499A2 (en) * 2005-07-22 2007-01-25 Ranbaxy Laboratories Limited Derivatives of monosaccharides for the treatment of copd and allergic rhinitis
WO2007054896A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US20070238716A1 (en) * 2006-03-14 2007-10-11 Murthy Ayanampudi S R Statin stabilizing dosage formulations
EP1842855A3 (en) * 2006-03-29 2007-12-05 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-inflammatory and/or anti-cancer agents
EP1864992A2 (en) * 2006-05-30 2007-12-12 Ranbaxy Laboratories, Ltd. Monosaccharide derivatives
EP1953170A1 (en) * 2006-10-03 2008-08-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-inflammatory agents
AU2008221506B2 (en) * 2007-09-20 2011-01-20 ResMed Pty Ltd Retractable Tube for CPAP

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US2715121A (en) 1950-09-09 1955-08-09 American Home Prod Alkyl sugar derivatives and their preparation
US4056322A (en) 1973-12-14 1977-11-01 Strategic Medical Research Corporation Preparation of ethers of monosaccharides
US4735934A (en) 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4996195A (en) * 1989-01-09 1991-02-26 Greenwich Pharmaceuticals Inc. Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5010058A (en) * 1989-06-22 1991-04-23 501 Greenwich Pharmaceuticals Incorporated 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives
FR2652540B1 (fr) 1989-10-02 1995-06-02 Imaje Sa Circuit d'encre notamment destine a la mise en pression d'une encre a pigments pour imprimante a jet d'encre.
US5192746A (en) 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
US5258402A (en) 1992-06-11 1993-11-02 Mcneil-Ppc, Inc. Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates
US5432163A (en) 1992-11-13 1995-07-11 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
US5637570A (en) * 1995-05-09 1997-06-10 Chemora Pharmochem Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid having anti-cancer, anti-inflammatory and anti-proliferative activity
IN190975B (bg) * 1999-01-15 2003-09-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
PT1147119E (pt) 2004-02-27
CR6423A (bg) 2004-03-09
HUP0105116A3 (en) 2003-05-28
MY121135A (en) 2005-12-30
US20040019191A1 (en) 2004-01-29
PA8489901A1 (es) 2000-09-29
MA25342A1 (fr) 2001-12-31
CZ20012540A3 (cs) 2002-02-13
AU768511B2 (en) 2003-12-18
WO2000042054A1 (en) 2000-07-20
CN1343213A (zh) 2002-04-03
JP2002534530A (ja) 2002-10-15
EP1147119A1 (en) 2001-10-24
CO5180591A1 (es) 2002-07-30
CN1167707C (zh) 2004-09-22
MXPA01007187A (es) 2002-04-24
US20040023900A1 (en) 2004-02-05
NZ512852A (en) 2004-02-27
ES2206176T3 (es) 2004-05-16
HRP20010529B1 (en) 2005-02-28
TR200102043T2 (tr) 2001-11-21
BR0007553A (pt) 2001-12-18
HK1041270A1 (en) 2002-07-05
AU1886100A (en) 2000-08-01
ATE250074T1 (de) 2003-10-15
DE60005300T2 (de) 2004-07-15
HRP20010529A2 (en) 2002-08-31
ID30351A (id) 2001-11-22
US20040029820A1 (en) 2004-02-12
CA2359986A1 (en) 2000-07-20
US7005516B2 (en) 2006-02-28
YU50701A (sh) 2005-06-10
NZ527483A (en) 2005-02-25
US7037899B2 (en) 2006-05-02
SK284241B6 (en) 2004-11-03
US7005422B2 (en) 2006-02-28
SK10132001A3 (sk) 2002-01-07
AR022235A1 (es) 2002-09-04
US20040018995A1 (en) 2004-01-29
IN190975B (bg) 2003-09-06
DK1147119T3 (da) 2004-01-19
US6590085B1 (en) 2003-07-08
HUP0105116A2 (hu) 2003-04-28
EP1147119B1 (en) 2003-09-17
DE60005300D1 (de) 2003-10-23

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