BR0007553A - Derivados de 2,3-o-isopropilideno demonossacarìdeos com atividade inibidora deaderência celular - Google Patents

Derivados de 2,3-o-isopropilideno demonossacarìdeos com atividade inibidora deaderência celular

Info

Publication number
BR0007553A
BR0007553A BR0007553-1A BR0007553A BR0007553A BR 0007553 A BR0007553 A BR 0007553A BR 0007553 A BR0007553 A BR 0007553A BR 0007553 A BR0007553 A BR 0007553A
Authority
BR
Brazil
Prior art keywords
isopropylidene
derivatives
present
monosaccharide
compounds
Prior art date
Application number
BR0007553-1A
Other languages
English (en)
Inventor
Sudershan Arora
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of BR0007553A publication Critical patent/BR0007553A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"DERIVADOS DE 2,3-O-ISOPROPILIDENO DEMONOSSACARìDEOS COM ATIVIDADE INIBIDORA DEADERêNCIA CELULAR". A presente invenção se referegeralmente a compostos e processos para sintetizar derivados doácido 2,3-O-isopropilideno-<244>-L-xilo-2-hexulofuranosónico defórmula (I). Os compostos da presente invenção são de utilidade,dentre outras, na inibição e prevenção de aderência celular epatologias mediadas por aderência celular, incluindo doençasinflamatórias e autoimunes, tais como asma bronquial, artritereumatóide, diabetes tipo I, esclerose múltipla, rejeição atransplantes e psoríase. A presente invenção também se refere acomposições farmacológicas contendo os derivados do ácido2,3-<UM>O<MV>-isopropilideno-<244>-L-xilo-2-hexulofuranosónicoe aos métodos de tratamento de tais patologias listadas acima.
BR0007553-1A 1999-01-15 2000-01-10 Derivados de 2,3-o-isopropilideno demonossacarìdeos com atividade inibidora deaderência celular BR0007553A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN86DE1999 IN190975B (pt) 1999-01-15 1999-01-15
US09/276,368 US6590085B1 (en) 1999-01-15 1999-03-25 Derivatives of monosaccharides as cell adhesion inhibitors
PCT/IB2000/000022 WO2000042054A1 (en) 1999-01-15 2000-01-10 2,3-o-isopropylidene derivatives of monosaccharides as cell adhesion inhibitors

Publications (1)

Publication Number Publication Date
BR0007553A true BR0007553A (pt) 2001-12-18

Family

ID=11088155

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007553-1A BR0007553A (pt) 1999-01-15 2000-01-10 Derivados de 2,3-o-isopropilideno demonossacarìdeos com atividade inibidora deaderência celular

Country Status (31)

Country Link
US (5) US6590085B1 (pt)
EP (1) EP1147119B1 (pt)
JP (1) JP2002534530A (pt)
CN (1) CN1167707C (pt)
AR (1) AR022235A1 (pt)
AT (1) ATE250074T1 (pt)
AU (1) AU768511B2 (pt)
BG (1) BG105745A (pt)
BR (1) BR0007553A (pt)
CA (1) CA2359986A1 (pt)
CO (1) CO5180591A1 (pt)
CR (1) CR6423A (pt)
CZ (1) CZ20012540A3 (pt)
DE (1) DE60005300T2 (pt)
DK (1) DK1147119T3 (pt)
ES (1) ES2206176T3 (pt)
HK (1) HK1041270A1 (pt)
HR (1) HRP20010529B1 (pt)
HU (1) HUP0105116A3 (pt)
ID (1) ID30351A (pt)
IN (1) IN190975B (pt)
MA (1) MA25342A1 (pt)
MX (1) MXPA01007187A (pt)
MY (1) MY121135A (pt)
NZ (2) NZ512852A (pt)
PA (1) PA8489901A1 (pt)
PT (1) PT1147119E (pt)
SK (1) SK284241B6 (pt)
TR (1) TR200102043T2 (pt)
WO (1) WO2000042054A1 (pt)
YU (1) YU50701A (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN190975B (pt) * 1999-01-15 2003-09-06 Ranbaxy Lab Ltd
NZ543741A (en) 2003-05-30 2009-10-30 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as HMG-Co inhibitors
EP1789428A1 (en) * 2004-09-02 2007-05-30 Ranbaxy Laboratories Limited Monosaccharide derivatives
EP1902063A2 (en) * 2004-12-22 2008-03-26 Ranbaxy Laboratories Limited Derivatives of pentose monosaccharides as anti-inflammatory compounds
EP1915160A2 (en) * 2005-07-22 2008-04-30 Ranbaxy Laboratories Limited Derivatives of monosaccharides for the treatment of copd and allergic rhinitis
US8026377B2 (en) * 2005-11-08 2011-09-27 Ranbaxy Laboratories, Limited Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
EP1842855A3 (en) * 2006-03-29 2007-12-05 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-inflammatory and/or anti-cancer agents
US7790689B2 (en) * 2006-05-30 2010-09-07 Ranbaxy Laboratories Limited Monosaccharide derivatives
EP1953170A1 (en) * 2006-10-03 2008-08-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-inflammatory agents
US10034995B2 (en) * 2007-09-20 2018-07-31 Resmed Limited Retractable tube for CPAP

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2715121A (en) 1950-09-09 1955-08-09 American Home Prod Alkyl sugar derivatives and their preparation
US4056322A (en) 1973-12-14 1977-11-01 Strategic Medical Research Corporation Preparation of ethers of monosaccharides
US4735934A (en) 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4996195A (en) * 1989-01-09 1991-02-26 Greenwich Pharmaceuticals Inc. Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5010058A (en) * 1989-06-22 1991-04-23 501 Greenwich Pharmaceuticals Incorporated 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives
FR2652540B1 (fr) 1989-10-02 1995-06-02 Imaje Sa Circuit d'encre notamment destine a la mise en pression d'une encre a pigments pour imprimante a jet d'encre.
US5192746A (en) 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
US5258402A (en) 1992-06-11 1993-11-02 Mcneil-Ppc, Inc. Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates
US5432163A (en) 1992-11-13 1995-07-11 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
US5637570A (en) * 1995-05-09 1997-06-10 Chemora Pharmochem Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid having anti-cancer, anti-inflammatory and anti-proliferative activity
IN190975B (pt) * 1999-01-15 2003-09-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
AR022235A1 (es) 2002-09-04
MXPA01007187A (es) 2002-04-24
CA2359986A1 (en) 2000-07-20
CZ20012540A3 (cs) 2002-02-13
MY121135A (en) 2005-12-30
EP1147119B1 (en) 2003-09-17
YU50701A (sh) 2005-06-10
AU768511B2 (en) 2003-12-18
TR200102043T2 (tr) 2001-11-21
US20040019191A1 (en) 2004-01-29
SK284241B6 (en) 2004-11-03
HRP20010529A2 (en) 2002-08-31
NZ527483A (en) 2005-02-25
HUP0105116A3 (en) 2003-05-28
DE60005300T2 (de) 2004-07-15
SK10132001A3 (sk) 2002-01-07
ATE250074T1 (de) 2003-10-15
AU1886100A (en) 2000-08-01
BG105745A (en) 2002-05-31
IN190975B (pt) 2003-09-06
DK1147119T3 (da) 2004-01-19
CO5180591A1 (es) 2002-07-30
CN1167707C (zh) 2004-09-22
HUP0105116A2 (hu) 2003-04-28
EP1147119A1 (en) 2001-10-24
US7037899B2 (en) 2006-05-02
JP2002534530A (ja) 2002-10-15
ID30351A (id) 2001-11-22
US7005516B2 (en) 2006-02-28
HK1041270A1 (en) 2002-07-05
NZ512852A (en) 2004-02-27
PA8489901A1 (es) 2000-09-29
US20040018995A1 (en) 2004-01-29
WO2000042054A1 (en) 2000-07-20
CR6423A (pt) 2004-03-09
US7005422B2 (en) 2006-02-28
DE60005300D1 (de) 2003-10-23
MA25342A1 (fr) 2001-12-31
CN1343213A (zh) 2002-04-03
US6590085B1 (en) 2003-07-08
HRP20010529B1 (en) 2005-02-28
US20040029820A1 (en) 2004-02-12
ES2206176T3 (es) 2004-05-16
PT1147119E (pt) 2004-02-27
US20040023900A1 (en) 2004-02-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.