BG103900A - 3-заместени 3,4-дихидро-тиено (2,3-d) пиримидинови производни, тяхното получаване и използване - Google Patents

3-заместени 3,4-дихидро-тиено (2,3-d) пиримидинови производни, тяхното получаване и използване

Info

Publication number
BG103900A
BG103900A BG103900A BG10390099A BG103900A BG 103900 A BG103900 A BG 103900A BG 103900 A BG103900 A BG 103900A BG 10390099 A BG10390099 A BG 10390099A BG 103900 A BG103900 A BG 103900A
Authority
BG
Bulgaria
Prior art keywords
optionally
substituted
pyrimidine derivatives
thieno
dihydro
Prior art date
Application number
BG103900A
Other languages
English (en)
Inventor
Gerd Steiner
Uta Dullweber
Dorothea Starck
Alfred Bach
Karsten Wicke
Hans-Juergen Teschendorf
Francisco - Javier GARCIA-LADONA
Franz Emling
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of BG103900A publication Critical patent/BG103900A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до 3-заместени 3,4-дихидро-тиено-[2,3-d]пиримидинови производни с формула@@в която R1 и R2 са водород или С1-С4-алкилова група, R3 е в даден случай моно- или дизаместен с халогенни атоми С1-С4-алкил, трифлуорметил, трифлуорметокси, хидрокси, С1-С4-алкокси, амино, монометиламино, диметиламино, циано или нитрогрупа фенилов, пиридилов, пиримидинилов или пиразинилов остатък, който, в даден случай, може да бъде анелиран с единбензенов пръстен, който в даден случай може да бъде моно- или дизаместен с халогенни атоми С1-С4-алкил, хидрокси, трифлуорметил, С1-С4-алкокси, амино, циано или нитрогрупа и, в даден случай, може да съдържа един азотен атом или да бъде анелиран с 5-или 6-членен пръстен, който може да съдържа 1 до 2 кислородни атома, А е NH или кислороден атом, Y е групата СН2, СН2-СН2, СН2-СН2-СН2 или СН2-СН, Z е азотен атом, въглероден атом или СН, при което връзката между Y и Z може да бъде двойна и n има стойност 2, 3 или 4. Изобретението се отнася също дофизиологично съвместими соли на 3-заместени 3,4-дихидро-тиено[2,3-d]пиримидиновите производни.
BG103900A 1997-06-13 1999-11-17 3-заместени 3,4-дихидро-тиено (2,3-d) пиримидинови производни, тяхното получаване и използване BG103900A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19724980A DE19724980A1 (de) 1997-06-13 1997-06-13 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
PCT/EP1998/003230 WO1998056792A1 (de) 1997-06-13 1998-05-29 3-substituierte 3,4-dihydro-thieno[2,3-d]pyrimidin-derivate, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
BG103900A true BG103900A (bg) 2000-06-30

Family

ID=7832352

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103900A BG103900A (bg) 1997-06-13 1999-11-17 3-заместени 3,4-дихидро-тиено (2,3-d) пиримидинови производни, тяхното получаване и използване

Country Status (25)

Country Link
US (1) US6159962A (bg)
EP (1) EP0988306B1 (bg)
JP (1) JP2002504103A (bg)
KR (1) KR20010013696A (bg)
CN (1) CN1260797A (bg)
AR (1) AR015712A1 (bg)
AT (1) ATE244720T1 (bg)
AU (1) AU749320B2 (bg)
BG (1) BG103900A (bg)
BR (1) BR9810017A (bg)
CA (1) CA2293816A1 (bg)
CO (1) CO4940507A1 (bg)
CZ (1) CZ290464B6 (bg)
DE (2) DE19724980A1 (bg)
HR (1) HRP980319A2 (bg)
HU (1) HUP0002902A3 (bg)
ID (1) ID23421A (bg)
IL (1) IL132967A0 (bg)
NO (1) NO996043L (bg)
NZ (1) NZ502238A (bg)
PL (1) PL337453A1 (bg)
SK (1) SK168499A3 (bg)
TR (1) TR199903062T2 (bg)
WO (1) WO1998056792A1 (bg)
ZA (1) ZA985121B (bg)

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DE69842058D1 (de) * 1997-10-27 2011-01-27 Neurosearch As Heteroaryl Diazacycloalkane als cholinergische Ligande für Nikotin-Acetylcholin-Rezeptoren
DE19900545A1 (de) * 1999-01-11 2000-07-13 Basf Ag Verwendung von Pyrimidinderivaten zur Prophylaxe und Therapie der zerebralen Ischämie
CA2401379A1 (en) * 2000-02-29 2001-09-07 Junichi Kawakami Processes for the production of thienopyrimidine derivatives
DE10031389A1 (de) * 2000-07-03 2002-01-17 Knoll Ag Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
DE10259382A1 (de) * 2002-12-18 2004-07-01 Abbott Gmbh & Co. Kg 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-4-on-Derivate, ihre Herstellung und Verwendung
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
MXPA05009818A (es) * 2003-03-31 2006-03-13 Predix Pharmaceuticals Holding Nuevos compuestos de piperidinilamino-tieno[2,3-d] pirimidina.
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7576211B2 (en) * 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
EP2233472B1 (en) 2006-03-28 2014-01-15 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
EP2896624B1 (en) * 2007-03-28 2016-07-13 Atir Holding S.A. Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
CA2685753A1 (en) * 2007-05-09 2008-11-20 Neuromed Pharmaceuticals Ltd. Bicyclic pyrimidine derivatives as calcium channel blockers
US8114894B2 (en) * 2008-12-03 2012-02-14 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
JP5722781B2 (ja) * 2009-08-26 2015-05-27 武田薬品工業株式会社 縮合複素環誘導体およびその用途
US9353067B2 (en) 2011-04-10 2016-05-31 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
US9671052B2 (en) 2015-10-27 2017-06-06 Whirlpool Corporation Collet securing device for joining two fluid lines and providing lateral support at the connection of the two fluid lines
US10557469B2 (en) 2016-03-22 2020-02-11 Whirlpool Corporation Multi-outlet fluid flow system for an appliance incorporating a bi-directional motor
US10655266B2 (en) 2016-11-30 2020-05-19 Whirlpool Corporation Lint processing fluid pump for a laundry appliance
US10662574B2 (en) 2017-02-27 2020-05-26 Whirlpool Corporation Self cleaning heater exchanger plate
US10480117B2 (en) 2017-02-27 2019-11-19 Whirlpool Corporation Self cleaning sump cover
US10619289B2 (en) 2017-02-27 2020-04-14 Whirlpool Corporation Self cleaning diverter valve
US10634412B2 (en) 2017-04-10 2020-04-28 Whirlpool Corporation Concealed upstream air tower guide vanes
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer

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US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US4835157A (en) * 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
DE19636769A1 (de) * 1996-09-10 1998-03-12 Basf Ag 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
EP0988306A1 (de) 2000-03-29
AU749320B2 (en) 2002-06-20
PL337453A1 (en) 2000-08-14
DE19724980A1 (de) 1998-12-17
CA2293816A1 (en) 1998-12-17
AU7917698A (en) 1998-12-30
HRP980319A2 (en) 1999-04-30
CZ290464B6 (cs) 2002-07-17
ID23421A (id) 2000-04-20
TR199903062T2 (xx) 2000-06-21
EP0988306B1 (de) 2003-07-09
HUP0002902A2 (hu) 2001-02-28
DE59808992D1 (de) 2003-08-14
SK168499A3 (en) 2000-05-16
NO996043D0 (no) 1999-12-08
ZA985121B (en) 1999-12-13
HUP0002902A3 (en) 2002-09-30
CO4940507A1 (es) 2000-07-24
KR20010013696A (ko) 2001-02-26
US6159962A (en) 2000-12-12
JP2002504103A (ja) 2002-02-05
IL132967A0 (en) 2001-03-19
ATE244720T1 (de) 2003-07-15
AR015712A1 (es) 2001-05-16
CN1260797A (zh) 2000-07-19
BR9810017A (pt) 2000-09-19
WO1998056792A1 (de) 1998-12-17
NO996043L (no) 1999-12-08
CZ443199A3 (cs) 2000-06-14
NZ502238A (en) 2001-02-23

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