BG103921A - 3-заместени пиридо[3,4;4,5]тиено[2,3-d]пиримидинови производни, тяхното получаване и използване - Google Patents

3-заместени пиридо[3,4;4,5]тиено[2,3-d]пиримидинови производни, тяхното получаване и използване

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Publication number
BG103921A
BG103921A BG103921A BG10392199A BG103921A BG 103921 A BG103921 A BG 103921A BG 103921 A BG103921 A BG 103921A BG 10392199 A BG10392199 A BG 10392199A BG 103921 A BG103921 A BG 103921A
Authority
BG
Bulgaria
Prior art keywords
substituted
alkyl
optionally
thieno
cyano
Prior art date
Application number
BG103921A
Other languages
English (en)
Inventor
Gerd Steiner
Uta Dullweber
Dorothea Starck
Alfred Bach
Karsten Wicke
Hans-Juergen Teschendorf
Francisco - Javier GARCIA-LADONA
Franz Emling
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of BG103921A publication Critical patent/BG103921A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до 3-заместени 3,4,5,6,7,8-хексахидропиридо[3',4':4,5]тиено[2,3-d]пиримидинови производни с формула@@в която R1 e водород, С1-С4-алкилова група, ацетилова група, фенилалкил-С1-С4-остатък, при което ароматният остатък в даден случай е заместен с халоген, С1-С4-алкил, трифлуорметил, хидрокси-, С1-С4-алкокси-, амино, циано илинитрогрупи или означава фенилалканонов остатък, вкойто фениловата група може да бъде заместена с халоген, R2 е в даден случай моно- или дизаместен схалогенни атоми, С1-С4-алкил, трифлуорметил, трифлуорметокси, хидрокси, С1-С4-алкокси, амино, монометиламино, диметиламино, циано или нитрогрупа фенилов, пиридилов, пиримидинилов или пиразинилов остатък, който в даден случай може да бъде анелиран с един бензенов пръстен, който, в даден случай, може да бъде моно- или диазаместен с халогенни атоми,С1-С4-алкил, хидрокси, трифлуорметил, С1-С4-алкокси, амино, циано или нитрогрупа, и в даден случай може да съдържа 1 азотен атом или да бъде анелиранс 5- или 6-членен пръстен, който може да съдържа от 1 до 2 кислородни атома, А е NH или кислороден атом, Y е групата СН2, СН2-СН2, СН2-СН2-СН2 или СН2-СН, Z e азотен атом, въглероден атом или СН, прикоето връзката между Y и Z може да бъде двойна, иn е числото 2, 3 и 4. Изобретението се отнася също до физиологично приемливи соли на 3-заместените пиридо[3',4':4,5]-тиено[2,3-d]пиримидинови производни. Съединенията проявяват висока степен на афинитет спрямо серотониновите рецептори 5-НТ
BG103921A 1997-06-13 1999-11-24 3-заместени пиридо[3,4;4,5]тиено[2,3-d]пиримидинови производни, тяхното получаване и използване BG103921A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19724979A DE19724979A1 (de) 1997-06-13 1997-06-13 3-substituierte Pyrido [3,4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung
PCT/EP1998/003231 WO1998056793A1 (de) 1997-06-13 1998-05-29 3-SUBSTITUIERTE PYRIDO [3',4':4,5] THIENO [2,3-d] PYRIMIDIN-DERIVATE, IHRE HERSTELLUNG UND VERWENDUNG

Publications (1)

Publication Number Publication Date
BG103921A true BG103921A (bg) 2000-07-31

Family

ID=7832351

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103921A BG103921A (bg) 1997-06-13 1999-11-24 3-заместени пиридо[3,4;4,5]тиено[2,3-d]пиримидинови производни, тяхното получаване и използване

Country Status (27)

Country Link
US (1) US6159981A (bg)
EP (1) EP1023296B1 (bg)
JP (1) JP2002504104A (bg)
KR (1) KR20010013698A (bg)
CN (1) CN1259954A (bg)
AR (1) AR014354A1 (bg)
AT (1) ATE256686T1 (bg)
AU (1) AU748697B2 (bg)
BG (1) BG103921A (bg)
BR (1) BR9810008A (bg)
CA (1) CA2293440A1 (bg)
CO (1) CO4940481A1 (bg)
DE (2) DE19724979A1 (bg)
ES (1) ES2215312T3 (bg)
HR (1) HRP980318A2 (bg)
HU (1) HUP0002736A3 (bg)
ID (1) ID24045A (bg)
IL (1) IL132985A0 (bg)
MY (1) MY132993A (bg)
NO (1) NO996045L (bg)
NZ (1) NZ502237A (bg)
PL (1) PL337454A1 (bg)
SK (1) SK174399A3 (bg)
TR (1) TR199903061T2 (bg)
TW (1) TW479059B (bg)
WO (1) WO1998056793A1 (bg)
ZA (1) ZA985120B (bg)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19900673A1 (de) * 1999-01-11 2000-07-13 Basf Ag Verwendung von Bindungspartnern für 5-HT5-Rezeptoren zur Behandlung neurodegenerativer und neuropsychiatrischer Störungen
DE19900545A1 (de) 1999-01-11 2000-07-13 Basf Ag Verwendung von Pyrimidinderivaten zur Prophylaxe und Therapie der zerebralen Ischämie
DE10031389A1 (de) * 2000-07-03 2002-01-17 Knoll Ag Pyrimidinderivate und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie
DE10259382A1 (de) * 2002-12-18 2004-07-01 Abbott Gmbh & Co. Kg 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-4-on-Derivate, ihre Herstellung und Verwendung
US8877316B2 (en) * 2002-12-20 2014-11-04 The Procter & Gamble Company Cloth-like personal care articles
MX2009008507A (es) 2007-02-07 2009-08-20 Astellas Pharma Inc Derivado de acilguanidina.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001130A (en) * 1988-02-18 1991-03-19 Bristol-Myers Company Psychotropic heterobicycloalkylpiperazine derivatives
US4835157A (en) * 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
DE19636769A1 (de) * 1996-09-10 1998-03-12 Basf Ag 3-Substituierte Pyrido [4',3':4,5]thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
TR199903061T2 (xx) 2000-07-21
CO4940481A1 (es) 2000-07-24
IL132985A0 (en) 2001-03-19
NZ502237A (en) 2001-08-31
PL337454A1 (en) 2000-08-14
HRP980318A2 (en) 1999-04-30
EP1023296B1 (de) 2003-12-17
MY132993A (en) 2007-10-31
DE19724979A1 (de) 1998-12-17
CA2293440A1 (en) 1998-12-17
ATE256686T1 (de) 2004-01-15
CN1259954A (zh) 2000-07-12
ZA985120B (en) 1999-12-13
BR9810008A (pt) 2000-09-19
HUP0002736A2 (hu) 2001-02-28
AU748697B2 (en) 2002-06-13
KR20010013698A (ko) 2001-02-26
SK174399A3 (en) 2000-05-16
WO1998056793A1 (de) 1998-12-17
AR014354A1 (es) 2001-02-28
EP1023296A1 (de) 2000-08-02
JP2002504104A (ja) 2002-02-05
US6159981A (en) 2000-12-12
NO996045D0 (no) 1999-12-08
AU8535798A (en) 1998-12-30
TW479059B (en) 2002-03-11
NO996045L (no) 1999-12-08
ID24045A (id) 2000-07-06
DE59810485D1 (de) 2004-01-29
ES2215312T3 (es) 2004-10-01
HUP0002736A3 (en) 2001-04-28

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