BG102554A - Vectors and methods for gene transfer into cells - Google Patents
Vectors and methods for gene transfer into cellsInfo
- Publication number
- BG102554A BG102554A BG102554A BG10255498A BG102554A BG 102554 A BG102554 A BG 102554A BG 102554 A BG102554 A BG 102554A BG 10255498 A BG10255498 A BG 10255498A BG 102554 A BG102554 A BG 102554A
- Authority
- BG
- Bulgaria
- Prior art keywords
- vectors
- methods
- cells
- gene transfer
- chimeral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/563,368 US5965541A (en) | 1995-11-28 | 1995-11-28 | Vectors and methods for gene transfer to cells |
US08/700,846 US5962311A (en) | 1994-09-08 | 1996-08-21 | Short-shafted adenoviral fiber and its use |
US08/701,124 US5846782A (en) | 1995-11-28 | 1996-08-21 | Targeting adenovirus with use of constrained peptide motifs |
PCT/US1996/019150 WO1997020051A2 (fr) | 1995-11-28 | 1996-11-27 | Vecteurs et procedes permettant de transferer des genes dans des cellules |
Publications (1)
Publication Number | Publication Date |
---|---|
BG102554A true BG102554A (en) | 1999-04-30 |
Family
ID=27415918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102554A BG102554A (en) | 1995-11-28 | 1998-06-18 | Vectors and methods for gene transfer into cells |
Country Status (17)
Country | Link |
---|---|
EP (3) | EP0863987B1 (fr) |
JP (1) | JP3420586B2 (fr) |
AT (1) | ATE382694T1 (fr) |
AU (1) | AU724189B2 (fr) |
BG (1) | BG102554A (fr) |
BR (1) | BR9612685A (fr) |
CA (1) | CA2236912C (fr) |
CZ (1) | CZ162398A3 (fr) |
EA (1) | EA199800475A1 (fr) |
EE (1) | EE9800160A (fr) |
IL (1) | IL124654A0 (fr) |
IS (1) | IS4754A (fr) |
NO (1) | NO982417L (fr) |
NZ (1) | NZ323834A (fr) |
PL (1) | PL327038A1 (fr) |
SK (1) | SK72298A3 (fr) |
WO (1) | WO1997020051A2 (fr) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5962311A (en) * | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
AU762036B2 (en) | 1997-10-31 | 2003-06-19 | Board Of Regents Of The University Of Oklahoma, The | Hyaluronan synthase gene and uses thereof |
CA2317941A1 (fr) * | 1998-01-16 | 1999-07-22 | Genzyme Corporation | Vecteurs d'adenovirus comprenant des proteines capsidiques modifiees |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
JP2002523105A (ja) | 1998-08-27 | 2002-07-30 | アバンテイス・フアルマ・エス・アー | 異種遺伝子の運搬用の標的化アデノウイルスベクター |
IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
EP1020529B1 (fr) * | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Vecteurs d'apport de gènes munis d'un tropisme pour les cellules des muscles lisses et/ou les cellules endothéliales |
AU776067B2 (en) * | 1999-03-04 | 2004-08-26 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
EP1196435A1 (fr) * | 1999-07-06 | 2002-04-17 | Got-A-Gene AB | Adenovirus recombinant |
US6955808B2 (en) * | 1999-09-24 | 2005-10-18 | Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
WO2001081607A2 (fr) * | 2000-04-26 | 2001-11-01 | Crucell Holland B.V. | Vecteurs d'adenovirus a fibres sans spicule, et leurs utilisations |
WO2001092547A2 (fr) * | 2000-05-31 | 2001-12-06 | University Of Saskatchewan | Adenovirus bovin modifie avec modification du tropisme |
US6579522B1 (en) | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
GB0017720D0 (en) * | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
US6573092B1 (en) | 2000-10-10 | 2003-06-03 | Genvec, Inc. | Method of preparing a eukaryotic viral vector |
US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
AU2004238979B2 (en) | 2003-05-14 | 2008-12-18 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Broadening adenovirus tropism |
WO2005051432A1 (fr) | 2003-11-14 | 2005-06-09 | Genvec, Inc. | Regime therapeutique pour le traitement du cancer |
JP2007228802A (ja) * | 2004-03-31 | 2007-09-13 | Dnavec Research Inc | 標的細胞への遺伝子の導入方法 |
US20070207166A1 (en) | 2004-04-12 | 2007-09-06 | Genvec, Inc. | Method of Using Adenoviral Vectors to Induce an Immune Response |
WO2006033679A2 (fr) | 2004-05-25 | 2006-03-30 | Chimeracore, Inc. | Systeme d'administration de medicaments a base de nanoparticules a autoassemblage |
BRPI0615400A2 (pt) | 2005-08-31 | 2011-05-17 | Genvec Inc | vacinas para malária baseadas em vetor adenoviral |
BRPI0618441B8 (pt) | 2005-11-10 | 2021-07-27 | Genvec Inc | vetor adenoviral |
DE602007005366D1 (de) | 2006-04-07 | 2010-04-29 | Chimeros Inc | Zusammensetzungen und verfahren zur behandlung von b-zellen-malignomen |
WO2010120874A2 (fr) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Agents thérapeutiques chimériques, compositions, et leurs procédés d'utilisation |
WO2011047316A1 (fr) | 2009-10-16 | 2011-04-21 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Séquences d'acides nucléiques codant pour des protéines mosaïques extensibles du vih |
US9133248B2 (en) | 2009-11-09 | 2015-09-15 | Genvec, Inc. | Methods of propagating monkey adenoviral vectors |
WO2011057254A2 (fr) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Vaccins à base de vecteur adénoviral simien |
WO2012021730A2 (fr) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Vaccin contre le virus syncytial respiratoire (vsr) |
WO2012083297A2 (fr) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Vecteurs adénoviraux avec régions d'hexon modifiées |
EP2654786B1 (fr) | 2010-12-20 | 2019-02-20 | GenVec, Inc. | Vaccin contre la dengue à base d'un vecteur adénoviral |
CA2847888A1 (fr) | 2011-09-09 | 2013-03-14 | Biomed Realty, L.P. | Procedes et compositions de regulation d'un assemblage de proteines virales |
US10004811B2 (en) * | 2012-04-13 | 2018-06-26 | Cornell University | Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction |
WO2013181128A1 (fr) | 2012-05-29 | 2013-12-05 | Genvec, Inc. | Vecteurs adénoviraux de sérotype 28 modifiés |
JP6618360B2 (ja) | 2012-08-03 | 2019-12-11 | セダーズ−シナイ メディカル センター | 薬物送達タンパク質の輸送向上変異体の単離 |
EP2971008B1 (fr) | 2013-03-14 | 2018-07-25 | Salk Institute for Biological Studies | Compositions d'adénovirus oncolytiques |
TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
CA3013637A1 (fr) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | Dosage a haut debit pour mesurer la cinetique de replication d'un adenovirus |
JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
CA3038968A1 (fr) | 2016-09-30 | 2018-04-05 | Genvec, Inc. | Adenovecteurs pour l'administration d'un materiel genetique therapeutique dans des lymphocytes t |
CN110062630A (zh) | 2016-12-12 | 2019-07-26 | 萨克生物研究学院 | 肿瘤靶向合成腺病毒及其用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
-
1996
- 1996-11-27 CZ CZ981623A patent/CZ162398A3/cs unknown
- 1996-11-27 IL IL12465496A patent/IL124654A0/xx unknown
- 1996-11-27 EP EP96940927A patent/EP0863987B1/fr not_active Expired - Lifetime
- 1996-11-27 JP JP52072097A patent/JP3420586B2/ja not_active Expired - Fee Related
- 1996-11-27 EE EE9800160A patent/EE9800160A/xx unknown
- 1996-11-27 AU AU10868/97A patent/AU724189B2/en not_active Ceased
- 1996-11-27 CA CA002236912A patent/CA2236912C/fr not_active Expired - Fee Related
- 1996-11-27 WO PCT/US1996/019150 patent/WO1997020051A2/fr active IP Right Grant
- 1996-11-27 PL PL96327038A patent/PL327038A1/xx unknown
- 1996-11-27 SK SK722-98A patent/SK72298A3/sk unknown
- 1996-11-27 EA EA199800475A patent/EA199800475A1/ru unknown
- 1996-11-27 EP EP05021223A patent/EP1616961A1/fr not_active Withdrawn
- 1996-11-27 AT AT96940927T patent/ATE382694T1/de not_active IP Right Cessation
- 1996-11-27 NZ NZ323834A patent/NZ323834A/xx unknown
- 1996-11-27 BR BR9612685A patent/BR9612685A/pt not_active Application Discontinuation
- 1996-11-27 EP EP04028530A patent/EP1518933A1/fr not_active Withdrawn
-
1998
- 1998-05-25 IS IS4754A patent/IS4754A/is unknown
- 1998-05-27 NO NO982417A patent/NO982417L/no not_active Application Discontinuation
- 1998-06-18 BG BG102554A patent/BG102554A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2236912A1 (fr) | 1997-06-05 |
WO1997020051A3 (fr) | 1997-08-28 |
WO1997020051A2 (fr) | 1997-06-05 |
JPH11501219A (ja) | 1999-02-02 |
ATE382694T1 (de) | 2008-01-15 |
EP0863987A2 (fr) | 1998-09-16 |
EP1616961A1 (fr) | 2006-01-18 |
NO982417D0 (no) | 1998-05-27 |
PL327038A1 (en) | 1998-11-09 |
EP1518933A1 (fr) | 2005-03-30 |
BR9612685A (pt) | 1999-07-20 |
IL124654A0 (en) | 1998-12-06 |
CZ162398A3 (cs) | 1998-10-14 |
EA199800475A1 (ru) | 1998-12-24 |
NZ323834A (en) | 2000-01-28 |
IS4754A (is) | 1998-05-25 |
NO982417L (no) | 1998-07-06 |
MX9804203A (es) | 1998-10-31 |
EP0863987B1 (fr) | 2008-01-02 |
EE9800160A (et) | 1998-12-15 |
AU1086897A (en) | 1997-06-19 |
CA2236912C (fr) | 2006-04-25 |
AU724189B2 (en) | 2000-09-14 |
JP3420586B2 (ja) | 2003-06-23 |
SK72298A3 (en) | 1998-12-02 |
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